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2017

Journal Article

Metabolic dysfunctions in amyotrophic lateral sclerosis pathogenesis and potential metabolic treatments

Tefera, Tesfaye W. and Borges, Karin (2017). Metabolic dysfunctions in amyotrophic lateral sclerosis pathogenesis and potential metabolic treatments. Frontiers in Neuroscience, 10 (JAN) 611, 461-473. doi: 10.3389/fnins.2016.00611

Metabolic dysfunctions in amyotrophic lateral sclerosis pathogenesis and potential metabolic treatments

2017

Conference Publication

Anaplerotic triheptanoin preserves mitochondrial function and reduces oxidative stress in pilocarpine-induced status epilepticus

Tan, K. N., Carrasco-Pozo, C. and Borges, K. (2017). Anaplerotic triheptanoin preserves mitochondrial function and reduces oxidative stress in pilocarpine-induced status epilepticus. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, Berlin, Germany, 1-4 April 2017. London, United Kingdom: Sage Publications.

Anaplerotic triheptanoin preserves mitochondrial function and reduces oxidative stress in pilocarpine-induced status epilepticus

2017

Book Chapter

Triheptanoin epilepsy and beyond

Borges, Karin (2017). Triheptanoin epilepsy and beyond. Ketogenic diet and metabolic therapies: expanded roles in health and disease. (pp. 336-346) edited by Susan A. Masino. New York NY, USA: Oxford University Press.

Triheptanoin epilepsy and beyond

2017

Conference Publication

Cortical neuronal glucose metabolism is impaired at mid stage in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

Tefera, T. and Borges, K. (2017). Cortical neuronal glucose metabolism is impaired at mid stage in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis. ISN-ESN Meeting, Paris, France, 20-24 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell .

Cortical neuronal glucose metabolism is impaired at mid stage in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

2016

Journal Article

Alternative fuels in epilepsy and amyotrophic lateral sclerosis

Tefera, Tesfaye W. , Tan, Kah Ni, McDonald, Tanya S.  and Borges, Karin (2016). Alternative fuels in epilepsy and amyotrophic lateral sclerosis. Neurochemical Research, 42 (6), 1-11. doi: 10.1007/s11064-016-2106-7

Alternative fuels in epilepsy and amyotrophic lateral sclerosis

2016

Journal Article

The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: in vitro and in vivo studies

Carrasco-Pozo, Catalina, Tan, Kah Ni, Reyes-Farias, Marjorie, De La Jara, Nicole, Ngo, Shyuan Thieu, Garcia-Diaz, Diego Fernando, Llanos, Paola, Cires, Maria Jose and Borges, Karin (2016). The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: in vitro and in vivo studies. Redox Biology, 9, 229-243. doi: 10.1016/j.redox.2016.08.007

The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: in vitro and in vivo studies

2016

Journal Article

Triheptanoin protects motor neurons and delays the onset of motor symptoms in a mouse model of amyotrophic lateral sclerosis

Tefera, Tesfaye W., Wong, Yide, Barkl-Luke, Mallory E., Ngo, Shyuan T., Thomas, Nicola K., McDonald, Tanya S. and Borges, Karin (2016). Triheptanoin protects motor neurons and delays the onset of motor symptoms in a mouse model of amyotrophic lateral sclerosis. Plos One, 11 (8) e0161816, e0161816. doi: 10.1371/journal.pone.0161816

Triheptanoin protects motor neurons and delays the onset of motor symptoms in a mouse model of amyotrophic lateral sclerosis

2016

Journal Article

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

Tan, Kah Ni, Carrasco-Pozo, Catalina, McDonald, Tanya S., Puchowicz, Michelle and Borges, Karin (2016). Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function. Journal Of Cerebral Blood Flow and Metabolism, 37 (6), 2035-2048. doi: 10.1177/0271678X16659498

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

2015

Journal Article

Sulforaphane is anticonvulsant and improves mitochondrial function

Carrasco-Pozo, Catalina, Tan, Kah Ni and Borges, Karin (2015). Sulforaphane is anticonvulsant and improves mitochondrial function. Journal of Neurochemistry, 135 (5), 932-942. doi: 10.1111/jnc.13361

Sulforaphane is anticonvulsant and improves mitochondrial function

2015

Journal Article

Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-l-Carnitine

Hadera, Mussie Ghezu, McDonald, Tanya, Smeland, Olav B., Meisingset, Tore W., Eloqayli, Haytham, Jaradat, Saied, Borges, Karin and Sonnewald, Ursula (2015). Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-l-Carnitine. Neurochemical Research, 41 (1-2), 86-95. doi: 10.1007/s11064-015-1728-5

Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-l-Carnitine

2015

Journal Article

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

Benson, Melissa J., Manzanero, Silvia and Borges, Karin (2015). Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models. Epilepsia, 56 (6), 895-905. doi: 10.1111/epi.12960

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

2015

Journal Article

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

Benson, Melissa J, Thomas, Nicola K, Talwar, Sahil, Hodson, Mark P, Lynch, Joseph W, Woodruff, Trent M and Borges, Karin (2015). A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models. Neurobiology of Disease, 76, 87-97. doi: 10.1016/j.nbd.2015.02.004

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

2015

Conference Publication

Tricaprin - a new anticonvulsant with multiple mechanisms of actions

Borges, K., Tan, K. N. and Carrasco, C. (2015). Tricaprin - a new anticonvulsant with multiple mechanisms of actions. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Tricaprin - a new anticonvulsant with multiple mechanisms of actions

2015

Book Chapter

Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches

Tan, Kah Ni, McDonald, Tanya S. and Borges, Karin (2015). Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy. (pp. 461-470) edited by Ronald R Watson and Victor R Preedy. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-12-411462-3.00048-5

Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches

2015

Book Chapter

High Caloric diets for amyotrophic lateral sclerosis

Ngo, Shyuan T., Steyn, Frederik J., McCombe, Pamela A. and Borges, Karin (2015). High Caloric diets for amyotrophic lateral sclerosis. Bioactive nutraceuticals and dietary supplements in neurological and brain disease: prevention and therapy. (pp. 355-361) edited by Ronald Ross Watson and Victor R. Preedy. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-411462-3.00036-9

High Caloric diets for amyotrophic lateral sclerosis

2014

Journal Article

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epileps

Hadera, Mussie G., Smeland, Olav B., McDonald, Tanya S., Tan, Kah Ni, Sonnewald, Ursula and Borges, Karin (2014). Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epileps. Journal of Neurochemistry, 129 (1), 107-119. doi: 10.1111/jnc.12610

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epileps

2014

Journal Article

Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides

McDonald, Tanya S., Tan, Kah Ni, Hodson, Mark P. and Borges, Karin (2014). Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides. Journal Of Cerebral Blood Flow and Metabolism, 34 (1), 153-160. doi: 10.1038/jcbfm.2013.184

Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides

2014

Conference Publication

Triheptanoin alters anaplerosis and glutamate production in the chronic pilocarpine model of epilepsy

McDonald, Tanya, Hodson, Mark and Borges, Karin (2014). Triheptanoin alters anaplerosis and glutamate production in the chronic pilocarpine model of epilepsy. EB2014: Experimental Biology 2014, San Diago, CA United States, 26-30 April, 2014. Bethesda, MD United States: Federation of American Societies for Experimental Biology.

Triheptanoin alters anaplerosis and glutamate production in the chronic pilocarpine model of epilepsy

2013

Journal Article

Slc10A4-what do we know about the function of this "secret ligand carrier" protein?

Borges, Karin (2013). Slc10A4-what do we know about the function of this "secret ligand carrier" protein?. Experimental Neurology, 248, 258-261. doi: 10.1016/j.expneurol.2013.06.019

Slc10A4-what do we know about the function of this "secret ligand carrier" protein?

2013

Journal Article

Anticonvulsant screening of luteolin in four mouse seizure models

Shaikh, Mohd Farooq, Tan, Kah Ni and Borges, Karin (2013). Anticonvulsant screening of luteolin in four mouse seizure models. Neuroscience Letters, 550, 195-199. doi: 10.1016/j.neulet.2013.06.065

Anticonvulsant screening of luteolin in four mouse seizure models