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2017 Conference Publication High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent MechanismPinkerton, James, Kim, Richard, Mayall, Jemma, Ali, Md. Khadem, Starkey, Malcolm, Robertson, Avril, O'Neill, Luke, Cooper, Matthew, Hansbro, Philip and Horvat, Jay (2017). High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent Mechanism. HOBOKEN: WILEY. |
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2017 Journal Article Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in miceFuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidliar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andres, Vicente, Hirschi, Karen K., Martin, Kathleen A. and Walsh, Kenneth (2017). Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice. Science, 355 (6327), 842-847. doi: 10.1126/science.aag1381 |
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2017 Journal Article GMP synthase is required for virulence factor production and infection by cryptococcus neoformansChitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533 |
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2017 Journal Article Small-molecule inhibitors of the SOX18 transcription factorFontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017). Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 (3), 346-359. doi: 10.1016/j.chembiol.2017.01.003 |
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2017 Journal Article Pharmacological targeting of the transcription factor SOX18 delays breast cancer in miceOverman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221. doi: 10.7554/eLife.21221 |
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2017 Journal Article Inflammasomes in the lungPinkerton, James W., Kim, Richard Y., Robertson, Avril A. B., Hirota, Jeremy A., Wood, Lisa G., Knight, Darryl A., Cooper, Matthew A., O'Neill, Luke A. J., Horvat, Jay C. and Hansbro, Philip M. (2017). Inflammasomes in the lung. Molecular Immunology, 86, 44-55. doi: 10.1016/j.molimm.2017.01.014 |
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2017 Journal Article PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasomePinar, Anita, Dowling, Jennifer K., Bitto, Natalie J., Robertson, Avril B., Latz, Eicke, Stewart, Cameron R., Drummond, Grant R., Cooper, Matthew A., McAuley, Julie L., Tate, Michelle D. and Mansell, Ashley (2017). PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome. The Journal of Biological Chemistry, 292 (3), 826-836. doi: 10.1074/jbc.M116.756379 |
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2017 Journal Article Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challengeSong, Erfei, Jahng, James W. S., Chong, Lisa P., Sung, Hye K., Han, Meng, Luo, Cuiting, Wu, Donghai, Boo, Stellar, Hinz, Boris, Cooper, Matthew A., Robertson, Avril A. B., Berger, Thorsten, Mak, Tak W., George, Isaac, Schulze, P. Christian, Wang, Yu, Xu, Aimin and Sweeney, Gary (2017). Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge. American Journal of Translational Research, 9 (6) AJTR0048252, 2723-+. |
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2016 Journal Article The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotypeBasiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng and List, Alan F. (2016). The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. Blood, 128 (25), 2960-2975. doi: 10.1182/blood-2016-07-730556 |
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2016 Journal Article Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 miceDempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J. and Lynch, M. A. (2016). Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain, Behavior, and Immunity, 61, 306-316. doi: 10.1016/j.bbi.2016.12.014 |
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2016 Journal Article K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondriaGroß, Christina J., Mishra, Ritu, Schneider, Katharina S., Médard, Guillaume, Wettmarshausen, Jennifer, Dittlein, Daniela C., Shi, Hexin, Gorka, Oliver, Koenig, Paul-Albert, Fromm, Stephan, Magnani, Giovanni, Ćiković, Tamara, Hartjes, Lara, Smollich, Joachim, Robertson, Avril A. B., Cooper, Matthew A., Schmidt-Supprian, Marc, Schuster, Michael, Schroder, Kate, Broz, Petr, Traidl-Hoffmann, Claudia, Beutler, Bruce, Kuster, Bernhard, Ruland, Jürgen, Schneider, Sabine, Perocchi, Fabiana and Groß, Olaf (2016). K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity, 45 (4), 761-773. doi: 10.1016/j.immuni.2016.08.010 |
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2016 Journal Article Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950Salla, Manohar, Butler, Mark S., Pelingon, Ruby, Kaeslin, Geraldine, Croker, Daniel E., Reid, Janet C., Baek, Jong-Min, Bernhardt, Paul V., Gillam, Elizabeth M. J., Cooper, Matthew A. and Robertson, Avril A. B. (2016). Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950. ACS Medicinal Chemistry Letters, 7 (12), 1034-1038. doi: 10.1021/acsmedchemlett.6b00198 |
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2016 Journal Article Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformansBlundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121 |
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2016 Other Outputs Sulfonylureas and related compounds and use of the sameO'Neill, Luke, Coll, Rebecca, Cooper, Matt, Robertson, Avril and Schroder, Kate (2016). Sulfonylureas and related compounds and use of the same. WO2016131098. |
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2016 Conference Publication Delayed inhibition of the NLRP3 inflammasome during pathogenic influenza A virus infection in mice reduces disease severity and prolongs survivalTate, M., Pinar, A., Dowling, J., McAuley, J., Robertson, A., Cooper, M. and Mansell, A. (2016). Delayed inhibition of the NLRP3 inflammasome during pathogenic influenza A virus infection in mice reduces disease severity and prolongs survival. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL. |
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2016 Journal Article IL-1beta is an innate immune sensor of microbial proteolysisLaRock, Christopher N., Todd, Jordan, LaRock, Doris L., Olson, Joshua, O’Donoghue, Anthony J., Robertson, Avril A. B., Cooper, Matthew A., Hoffman, Hal M. and Nizet, Victor (2016). IL-1beta is an innate immune sensor of microbial proteolysis. Science Immunology, 1 (2) eaah3539, eaah3539-eaah3539. doi: 10.1126/sciimmunol.aah3539 |
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2016 Conference Publication Targeting the NLRP3 inflammasome is a viable option for the treatment of pathogenic influenza virus infectionTate, M., Ong, J., Dowling, J., Robertson, A., Cooper, M. and Mansell, A. (2016). Targeting the NLRP3 inflammasome is a viable option for the treatment of pathogenic influenza virus infection. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL. |
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2016 Journal Article The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarctionvan Hout, Gerardus P. J., Bosch, Lena, Ellenbroek, Guilielmus H. J. M., de Haan, Judith J., van Solinge, Wouter W., Cooper, Matthew A., Arslan, Fatih, de Jager, Saskia C. A., Robertson, Avril A. B., Pasterkamp, Gerard and Hoefer, Imo E. (2016). The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. European Heart Journal, 38 (11), 1-10. doi: 10.1093/eurheartj/ehw247 |
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2016 Journal Article T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsArbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210 |
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2016 Journal Article Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibitionTate, Michelle D., Ong, James D. H., Dowling, Jennifer K., McAuley, Julie L., Robertson, Avril B., Latz, Eicke, Drummond, Grant R., Cooper, Matthew A., Hertzog, Paul J. and Mansell, Ashley (2016). Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition. Scientific Reports, 6 (1) 27912, 27912. doi: 10.1038/srep27912 |
