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2022 Journal Article Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletionDonovan, Chantal, Kim, Richard Y, Galvao, Izabela, Jarnicki, Andrew G, Brown, Alexandra C, Jones-Freeman, Bernadette, Gomez, Henry M, Wadhwa, Ridhima, Hortle, Elinor, Jayaraman, Ranjith, Khan, Haroon, Pickles, Sophie, Sahu, Priyanka, Chimankar, Vrushali, Tu, Xiaofan, Ali, Md Khadem, Mayall, Jemma R, Nguyen, Duc H, Budden, Kurtis F, Kumar, Vinod, Schroder, Kate, Robertson, Avril AB, Cooper, Matthew A, Wark, Peter AB, Oliver, Brian G, Horvat, Jay C and Hansbro, Philip M (2022). Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion. Immunology and Cell Biology, 100 (4), 235-249. doi: 10.1111/imcb.12537 |
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2022 Journal Article Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosisHettwer, Jan, Hinterdobler, Julia, Miritsch, Benedikt, Deutsch, Marcus-André, Li, Xinghai, Mauersberger, Carina, Moggio, Aldo, Braster, Quinte, Gram, Hermann, Robertson, Avril A. B., Cooper, Matthew A., Groß, Olaf, Krane, Markus, Weber, Christian, Koenig, Wolfgang, Soehnlein, Oliver, Adamstein, Nicholas H., Ridker, Paul, Schunkert, Heribert, Libby, Peter, Kessler, Thorsten and Sager, Hendrik B. (2022). Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis. Cardiovascular Research, 118 (13) cvab337, 2778-2791. doi: 10.1093/cvr/cvab337 |
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2021 Journal Article Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthmaPinkerton, James W., Kim, Richard Y., Brown, Alexandra C., Rae, Brittany E., Donovan, Chantal, Mayall, Jemma R., Carroll, Olivia R., Ali, Md Khadem, Scott, Hayley A., Berthon, Bronwyn S., Baines, Katherine J., Starkey, Malcolm R., Kermani, Nazanin Z., Guo, Yi-Ke, Robertson, Avril A. B., O'Neill, Luke A. J., Adcock, Ian M., Cooper, Matthew A., Gibson, Peter G., Wood, Lisa G., Hansbro, Philip M. and Horvat, Jay C. (2021). Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma. The Journal of Allergy and Clinical Immunology, 149 (4), 1270-1280. doi: 10.1016/j.jaci.2021.10.003 |
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2021 Journal Article Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeuticsYates, Clarissa, Kruse, Jennifer L., Price, J. Blair, Robertson, Avril A. B. and Tye, Susannah J. (2021). Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics. Current Treatment Options in Psychiatry, 8 (4), 229-257. doi: 10.1007/s40501-021-00249-9 |
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2020 Journal Article NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementiaHull, Claire, Dekeryte, Ruta, Buchanan, Heather, Kamli-Salino, Sarah, Robertson, Avril, Delibegovic, Mirela and Platt, Bettina (2020). NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia. Neuropharmacology, 180 108305, 108305. doi: 10.1016/j.neuropharm.2020.108305 |
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2020 Journal Article Metabolic competition between host and pathogen dictates inflammasome responses to fungal infectionTucey, Timothy M., Verma, Jiyoti, Olivier, Françios A. B., Lo, Tricia L., Robertson, Avril A. B., Naderer, Thomas and Traven, Ana (2020). Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection. PLoS Pathogens, 16 (8) e1008695, e1008695. doi: 10.1371/journal.ppat.1008695 |
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2020 Journal Article Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and functionLi, Xaria X., Lee, John D., Massey, Nicholas L., Guan, Carolyn, Robertson, Avril A. B., Clark, Richard J. and Woodruff, Trent M. (2020). Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function. Biochemical Pharmacology, 180 114156, 114156. doi: 10.1016/j.bcp.2020.114156 |
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2020 Journal Article Decontamination of fentanyl and fentanyl analogues in field and laboratory settings: a review of fentanyl degradationBazley, Mikaela M., Logan, Michael, Baxter, Christina, Robertson, Avril A. B. and Blanchfield, Joanne T. (2020). Decontamination of fentanyl and fentanyl analogues in field and laboratory settings: a review of fentanyl degradation. Australian Journal of Chemistry, 73 (10), 868-879. doi: 10.1071/CH19669 |
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2020 Journal Article Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animalsHill, James R., Shao, Xia, Massey, Nicholas L., Stauff, Jenelle, Sherman, Phillip S., Robertson, Avril A. B. and J. H. Scott, Peter (2020). Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals. Bioorganic and Medicinal Chemistry Letters, 30 (12) 127186, 127186. doi: 10.1016/j.bmcl.2020.127186 |
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2020 Journal Article Targeting NLRP3 and staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophagesChow, Seong H., Deo, Pankaj, Yeung, Amy T. Y., Kostoulias, Xenia P., Jeon, Yusun, Gao, Mei-Ling, Seidi, Azadeh, Olivier, Françios Alwyn Benson, Sridhar, Sushmita, Nethercott, Cara, Cameron, David, Robertson, Avril A. B., Robert, Remy, Mackay, Charles R., Traven, Ana, Jin, Zi-Bing, Hale, Christine, Dougan, Gordon, Peleg, Anton Y. and Naderer, Thomas (2020). Targeting NLRP3 and staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophages. Journal of Leukocyte Biology, 108 (3) JLB.4MA0420-497R, 967-981. doi: 10.1002/jlb.4ma0420-497r |
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2020 Journal Article Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathwayIpseiz, Natacha, Pickering, Robert J., Rosas, Marcela, Tyrrell, Victoria J., Davies, Luke C., Orr, Selinda J., Czubala, Magdalena A., Fathalla, Dina, Robertson, Avril A. B., Bryant, Clare E., O'Donnell, Valerie and Taylor, Philip R. (2020). Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. EMBO Journal, 39 (14) e103454, e103454. doi: 10.15252/embj.2019103454 |
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2020 Journal Article NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patientsMalhotra, Sunny, Costa, Carme, Eixarch, Herena, Keller, Christian W., Amman, Lukas, Martínez-Banaclocha, Helios, Midaglia, Luciana, Sarró, Eduard, Machín-Díaz, Isabel, Villar, Luisa M., Triviño, Juan Carlos, Oliver-Martos, Begoña, Parladé, Laura Navarro, Calvo-Barreiro, Laura, Matesanz, Fuencisla, Vandenbroeck, Koen, Urcelay, Elena, Martínez-Ginés, María-Luisa, Tejeda-Velarde, Amalia, Fissolo, Nicolás, Castilló, Joaquín, Sanchez, Alex, Robertson, Avril A. B., Clemente, Diego, Prinz, Marco, Pelegrin, Pablo, Lünemann, Jan D., Espejo, Carmen, Montalban, Xavier and Comabella, Manuel (2020). NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients. Brain, 143 (5), 1414-1430. doi: 10.1093/brain/awaa084 |
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2020 Journal Article Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in miceRen, Pingping, Wu, Darrell, Appel, Richard, Zhang, Lin, Zhang, Chen, Luo, Wei, Robertson, Avril A B, Cooper, Matthew A., Coselli, Joseph S., Milewicz, Dianna M., Shen, Ying H. and LeMaire, Scott A. (2020). Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice. Journal of the American Heart Association, 9 (7) e014044. doi: 10.1161/JAHA.119.014044 |
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2020 Journal Article Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probeHill, James R., Coll, Rebecca C., Schroder, Kate and Robertson, Avril A.B. (2020). Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe. Tetrahedron Letters, 61 (19) 151849, 151849. doi: 10.1016/j.tetlet.2020.151849 |
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2020 Journal Article Non-canonical Caspase-1 signaling drives RIP2-dependent and TNF-α-mediated inflammation in vivoReinke, Sören, Linge, Mary, Diebner, Hans H., Luksch, Hella, Glage, Silke, Gocht, Anne, Robertson, Avril A.B., Cooper, Matthew A., Hofmann, Sigrun R., Naumann, Ronald, Sarov, Mihail, Behrendt, Rayk, Roers, Axel, Pessler, Frank, Roesler, Joachim, Rösen-Wolff, Angela and Winkler, Stefan (2020). Non-canonical Caspase-1 signaling drives RIP2-dependent and TNF-α-mediated inflammation in vivo. Cell Reports, 30 (8), 2501-2511. doi: 10.1016/j.celrep.2020.01.090 |
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2020 Journal Article Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degenerationWooff, Yvette, Fernando, Nilisha, Wong, Josephine H. C., Dietrich, Catherine, Aggio-Bruce, Riemke, Chu-Tan, Joshua A., Robertson, Avril A. B., Doyle, Sarah L., Man, Si Ming and Natoli, Riccardo (2020). Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration. Scientific Reports, 10 (1) 2263, 2263. doi: 10.1038/s41598-020-58849-z |
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2020 Journal Article Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasomeFox, Daniel, Mathur, Anukriti, Xue, Yansong, Liu, Yunqi, Tan, Wei Hong, Feng, Shouya, Pandey, Abhimanu, Ngo, Chinh, Hayward, Jenni A., Atmosukarto, Ines I., Price, Jason D., Johnson, Matthew D., Jessberger, Nadja, Robertson, Avril A. B., Burgio, Gaetan, Tscharke, David C., Fox, Edward M., Leyton, Denisse L., Kaakoush, Nadeem O., Märtlbauer, Erwin, Leppla, Stephen H. and Man, Si Ming (2020). Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome. Nature Communications, 11 (1) 760, 760. doi: 10.1038/s41467-020-14534-3 |
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2020 Journal Article The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsDeora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728 |
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2020 Conference Publication Targeting the NLRP3 inflammasome as a novel approach to treat pulmonary hypertensionScott, T. E., Ung, V., Baliga, R. S., Robertson, A. A. B., Nold-Petry, C. A., Nold, M. F., Drummond, G. R., Hobbs, A. J. and Kemp-Harper, B. K. (2020). Targeting the NLRP3 inflammasome as a novel approach to treat pulmonary hypertension. International Conference of the American Thoracic Society, Electr Network, 2020. New York, NY, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3830 |
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2019 Journal Article Inflammasome-independent role for NLRP3 in controlling innate antihelminth immunity and tissue repair in the lungChenery, Alistair L., Alhallaf, Rafid, Agha, Zainab, Ajendra, Jesuthas, Parkinson, James E., Cooper, Martha M., Chan, Brian H. K., Eichenberger, Ramon M., Dent, Lindsay A., Robertson, Avril A. B., Kupz, Andreas, Brough, David, Loukas, Alex, Sutherland, Tara E., Allen, Judith E. and Giacomin, Paul R. (2019). Inflammasome-independent role for NLRP3 in controlling innate antihelminth immunity and tissue repair in the lung. Journal of Immunology, 203 (10), 2724-2734. doi: 10.4049/jimmunol.1900640 |
