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2018 Journal Article The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infectionAlhallaf, Rafid, Agha, Zainab, Miller, Catherine M., Robertson, Avril A. B., Sotillo, Javier, Croese, John, Cooper, Matthew A., Masters, Seth L., Kupz, Andreas, Smith, Nicholas C., Loukas, Alex and Giacomin, Paul R. (2018). The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection. Cell Reports, 23 (4), 1085-1098. doi: 10.1016/j.celrep.2018.03.097 |
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2018 Journal Article Fishing for drug targets: a focus on diazirine photoaffinity probe synthesisHill, James R. and Robertson, Avril A. B. (2018). Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis. Journal of Medicinal Chemistry, 61 (16) acs.jmedchem.7b01561, 6945-6963. doi: 10.1021/acs.jmedchem.7b01561 |
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2018 Journal Article Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950Salla, Manohar, Butler, Mark S., Massey, Nicholas L., Reid, Janet C., Cooper, Matthew A. and Robertson, Avril A. B. (2018). Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950. Bioorganic and Medicinal Chemistry Letters, 28 (4), 793-795. doi: 10.1016/j.bmcl.2017.12.054 |
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2018 Journal Article Evidence against a role for NLRP3-driven islet inflammation in db/db miceKammoun, H. L., Allen, T. L., Henstridge, D. C., Barre, S., Coll, R. C., Lancaster, G. I., Cron, L., Reibe, S., Chan, J. Y., Bensellam, M., Laybutt, D. R., Butler, M. S., Robertson, A. A. B., O'Neill, L. A., Cooper, M. A. and Febbraio, M. A. (2018). Evidence against a role for NLRP3-driven islet inflammation in db/db mice. Molecular Metabolism, 10, 66-73. doi: 10.1016/j.molmet.2018.02.001 |
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2018 Book Chapter Inhibiting inflammasomes with small moleculesRobertson, Avril A. B. (2018). Inhibiting inflammasomes with small molecules. Inflammasomes: clinical and therapeutic implications. (pp. 343-400) edited by Mario D. Cordero and Elísabet Alcocer-Gómez. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-89390-7_15 |
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2018 Journal Article Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitisChen, Alice C. -H., Tran, Hai B., Xi, Yang, Yerkovich, Stephanie T., Baines, Katherine J., Pizzutto, Susan J., Carroll, Melanie, Robertson, Avril A. B., Cooper, Matthew A., Schroder, Kate, Simpson, Jodie L., Gibson, Peter G., Hodge, Greg, Masters, Ian B., Buntain, Helen M., Petsky, Helen L., Prime, Samantha J., Chang, Anne B., Hodge, Sandra and Upham, John W. (2018). Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis. ERJ Open Research, 4 (1) 00130-2017, 00130-2017. doi: 10.1183/23120541.00130-2017 |
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2017 Other Outputs Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesisFrancois, Mathias, Zuegg, Johannes, Overman, Jeroen, Mamidyala, Sreeman Kumar, Salim, Angela Aguslyarti, Fontaine, Frank Roger, Cooper, Matthew Allister, Capon, Robert John and Robertson, Avril Alexis Barbara (2017). Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesis. WO2018112545. |
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2017 Journal Article An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomesGrinstein, Lev, Luksch, Hella, Schulze, Felix, Robertson, Avril A. B., Cooper, Matthew A., Rösen-Wolff, Angela and Winkler, Stefan (2017). An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes. Clinical Immunology, 191, 100-109. doi: 10.1016/j.clim.2017.11.011 |
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2017 Journal Article Antimicrobial octapeptin C4 analogues active against Cryptococcus speciesChitty, Jessica L., Butler, Mark S., Suboh, Azzah, Edwards, David J., Cooper, Matthew A., Fraser, James A. and Robertson, Avril A. B. (2017). Antimicrobial octapeptin C4 analogues active against Cryptococcus species. Antimicrobial agents and chemotherapy, 62 (2) e00986-17, 1-10. doi: 10.1128/AAC.00986-17 |
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2017 Journal Article Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammationChen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4 |
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2017 Other Outputs Sulfonylureas and related compounds and use of the sameO'Neill, Luke , Coll, Rebecca , Cooper, Matt , Robertson, Avril , Schroder, Kate , Macleod, Angus Murray and Miller, David John (2017). Sulfonylureas and related compounds and use of the same. WO2017140778. |
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2017 Journal Article Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitorsHill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017). Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 (17), 1449-1457. doi: 10.1002/cmdc.201700270 |
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2017 Journal Article Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthmaKim, Richard Y., Pinkerton, James W., Essilfie, Ama T., Robertson, Avril A. B., Baines, Katherine J., Brown, Alexandra C., Mayall, Jemma R., Ali, M. Khadem, Starkey, Malcolm R., Hansbro, Nicole G., Hirota, Jeremy A., Wood, Lisa G. , Simpson, Jodie L., Knight, Darryl A., Wark, Peter A., Gibson, Peter G., O'Neill, Luke A. J., Cooper, Matthew A., Horvat, Jay C. and Hansbro, Philip M. (2017). Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma. American Journal of Respiratory and Critical Care Medicine, 196 (3), 283-297. doi: 10.1164/rccm.201609-1830OC |
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2017 Journal Article Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug designChitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994 |
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2017 Journal Article NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy inductionPavillard, Luis E., Cañadas-Lozano, Diego, Alcocer-Gómez, Elísabet, Marín-Aguilar, Fabiola, Pereira, Sheila, Robertson, Avril A. B., Muntané, Jordi, Ryffel, Bernhard, Cooper, Matthew A., Quiles, José L., Bullón, Pedro, Ruiz-Cabello, Jesús and Cordero, Mario D. (2017). NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget, 8 (59), 99740-99756. doi: 10.18632/oncotarget.20763 |
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2017 Journal Article Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasomeNeudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A. B., Cooper, Matthew A., Furuta, Glenn T., Dinarello, Charles A., O'Neill, Luke A., Eltzschig, Holger K., Masters, Seth L. and McNamee, Eoin N. (2017). Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. Journal of Experimental Medicine, 214 (6), 1737-1752. doi: 10.1084/jem.20160462 |
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2017 Journal Article Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stressDinh, Quynh Nhu, Drummond, Grant R., Kemp-Harper, Barbara K., Diep, Henry, De Silva, T. Michael, Kim, Hyun Ah, Vinh, Antony, Robertson, Avril A. B., Cooper, Matthew A., Mansell, Ashley, Chrissobolis, Sophocles and Sobey, Christopher G. (2017). Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress. Aging, 9 (6), 1595-1606. doi: 10.18632/aging.101255 |
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2017 Other Outputs Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.O'Neill, Luke , Coll, Rebecca , Robertson, Avril , Cooper, Matthew , Schroder, Kate , Macleod, Angus Murray and Miller, David John (2017). Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.. WO2018215818. |
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2017 Other Outputs Novel compounds and usesO'Neill, L. A., Coll, R. C., Cooper, M. A., Robertson, A. A. B., Schroder, K., MacLeod, A. M. and Miller, D. J. (2017). Novel compounds and uses. PCT/IB2017/053059. |
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2017 Journal Article NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in miceMridha, Auvro R., Wree, Alexander, Robertson, Avril A. B., Yeh, Matthew M., Johnson, Casey D., Van Rooyen, Derrick M., Haczeyni, Fahrettin, Teoh, Narci C. -H., Savard, Christopher, Ioannou, George N., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., Feldstein, Ariel E. and Farrell, Geoffrey C. (2017). NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, 66 (5), 1037-1046. doi: 10.1016/j.jhep.2017.01.022 |
