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2019 Journal Article NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activityMarín-Aguilar, Fabiola, Castejón-Vega, Beatriz, Alcocer-Gómez, Elísabet, Lendines-Cordero, Debora, Cooper, Matthew A., de la Cruz, Patricia, Andújar-Pulido, Eloísa, Pérez-Alegre, Mónica, Muntané, Jordi, Pérez-Pulido, Antonio J., Ryffel, Bernhard, Robertson, Avril A. B., Ruiz-Cabello, Jesús, Bullón, Pedro and Cordero, Mario D (2019). NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activity. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 75 (8), 1457-1464. doi: 10.1093/gerona/glz239 |
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2019 Journal Article Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with OsteomyelitisGreene, Elizabeth, Flees, Joshua, Dhamad, Ahmed, Alrubaye, Adnan, Hennigan, Stephen, Pleimann, Jason, Smeltzer, Mark, Murray, Sue, Kugel, Jennifer, Goodrich, James, Robertson, Avril, Wideman, Robert, Rhoads, Douglas and Dridi, Sami (2019). Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis. American Journal of Pathology, 189 (10), 2077-2089. doi: 10.1016/j.ajpath.2019.06.013 |
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2019 Journal Article MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibitionColl, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7 |
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2019 Journal Article Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytesSkinner, Oliver P., Jurczyluk, Julie, Baker, Paul J., Masters, Seth L., Rios Wilks, Alicia G., Clearwater, Misaki S., Robertson, Avril A. B., Schroder, Kate, Mehr, Sam, Munoz, Marcia A. and Rogers, Michael J. (2019). Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes. Journal of Allergy and Clinical Immunology, 143 (6), 2315-2317.e3. doi: 10.1016/j.jaci.2019.02.013 |
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2019 Journal Article Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertensionKrishnan, Shalini M, Ling, Yeong H, Huuskes, Brooke M, Ferens, Dorota M, Saini, Narbada, Chan, Christopher T, Diep, Henry, Kett, Michelle M, Samuel, Chrishan S, Kemp-Harper, Barbara K, Robertson, Avril A B, Cooper, Matthew A, Peter, Karlheinz, Latz, Eicke, Mansell, Ashley S, Sobey, Christopher G, Drummond, Grant R and Vinh, Antony (2019). Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension. Cardiovascular Research, 115 (4), 776-787. doi: 10.1093/cvr/cvy252 |
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2019 Journal Article A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasomeMathur, Anukriti, Feng, Shouya, Hayward, Jenni A., Ngo, Chinh, Fox, Daniel, Atmosukarto, Ines I., Price, Jason D., Schauer, Kristina, Märtlbauer, Erwin, Robertson, Avril A. B., Burgio, Gaetan, Fox, Edward M., Leppla, Stephen H., Kaakoush, Nadeem O. and Man, Si Ming (2019). A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome. Nature Microbiology, 4 (2), 362-374. doi: 10.1038/s41564-018-0318-0 |
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2019 Conference Publication Inhibition of NLRP3 does not protect against photo-oxidative damage-induced retinal degenerationWooff, Yvette, Fernando, Nilisha, Wong, Josephine, Dietrich, Catherine, Aggio-Bruce, Riemke, Chu-Tan, Joshua Aaron, Doyle, Sarah, Robertson, Avril, Man, Si Ming and Natoli, Riccardo Carlo (2019). Inhibition of NLRP3 does not protect against photo-oxidative damage-induced retinal degeneration. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, Canada, 28 April - 2 May 2019. Rockville, MD, United States: Association for Research in Vision and Ophthalmology. |
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2019 Journal Article Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophagesThygesen, Sara J., Takizawa, Karli E., Robertson, Avril A. B., Sester, David P. and Stacey, Katryn J. (2019). Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. Immunology and cell biology, 97 (1), 17-28. doi: 10.1111/imcb.12193 |
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2019 Conference Publication IL-5/IL-13 drive NLRP3 inflammasome-mediated, steroid-resistant AHR in a model of obesity-associated asthmaPinkerton, James, Kim, Richard, Brown, Alexandra, Rae, Brittany, Mayall, Jemma, Ali, Md. Khadem, Starkey, Malcolm, Robertson, Avril, Wood, Lisa, Cooper, Matthew, O'Neill, Luke, Hansbro, Philip and Horvat, Jay (2019). IL-5/IL-13 drive NLRP3 inflammasome-mediated, steroid-resistant AHR in a model of obesity-associated asthma. European Respiratory Society (ERS) International Congress, Madrid, Spain, 28 September-2 October 2019. Lausanne, Switzerland: European Respiratory Society. doi: 10.1183/13993003.congress-2019.pa3345 |
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2019 Journal Article Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During InfectionChitty, Jessica L., Edwards, David J., Robertson, Avril A. B., Butler, Mark S., Duley, John A., Cooper, Matthew A. and Fraser, James A. (2019). Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection. Mycopathologia, 184 (2), 273-281. doi: 10.1007/s11046-018-0315-0 |
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2018 Journal Article Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signallingSchofield, Zoe V., Croker, Daniel, Robertson, Avril A. B., Massey, Nicholas L., Donovan, Chantal, Tee, Ernest, Edwards, David, Woodruff, Trent M., Halai, Reena, Hansbro, Philip M. and Cooper, Matthew A. (2018). Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling. Scientific Reports, 8 (1) 17819, 17819. doi: 10.1038/s41598-018-36242-1 |
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2018 Journal Article The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese miceLee, James S., Robertson, Avril A. B., Cooper, Matthew A. and Khosrotehrani, Kiarash (2018). The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice. International Journal of Molecular Sciences, 19 (11) 3289, 3289. doi: 10.3390/ijms19113289 |
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2018 Journal Article Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceGordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066 |
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2018 Journal Article Chick embryo: a preclinical model for understanding ischemia-reperfusion mechanismFauzia, Eram, Barbhuyan, Tarun Kumar, Shrivastava, Amit Kumar, Kumar, Manish, Garg, Paarth, Khan, Mohsin Ali, Robertson, Avril A. B. and Raza, Syed Shadab (2018). Chick embryo: a preclinical model for understanding ischemia-reperfusion mechanism. Frontiers in Pharmacology, 9 (SEP) 1034, 1034. doi: 10.3389/fphar.2018.01034 |
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2018 Journal Article Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profilesKummari, Lalith K., Butler, Mark S., Furlong, Emily, Blundell, Ross, Nouwens, Amanda, Silva, Alberto B., Kappler, Ulrike, Fraser, James A., Kobe, Bostjan, Cooper, Matthew A. and Robertson, Avril A.B. (2018). Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorganic and Medicinal Chemistry, 26 (20), 5408-5419. doi: 10.1016/j.bmc.2018.09.004 |
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2018 Journal Article MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis micePerera, Agampodi Promoda, Fernando, Ruchira, Shinde, Tanvi, Gundamaraju, Rohit, Southam, Benjamin, Sohal, Sukhwinder Singh, Robertson, Avril A. B., Schroder, Kate, Kunde, Dale and Eri, Rajaraman (2018). MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Scientific Reports, 8 (1) 8618, 8618. doi: 10.1038/s41598-018-26775-w |
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2018 Journal Article Abstract 317: Inflammasome Inhibitor MCC950 Prevents the Development of Sporadic Thoracic and Abdominal Aortic Aneurysms and Dissections in MiceRen, Pingping, Appel, Richard, Zhang, Lin, Luo, Wei, Zhang, Chen, Wang, Yidan, Guo, Jiao, Robertson, Avril A. B., Cooper, Matthew A., Coselli, Joseph S., Shen, Ying H. and LeMaire, Scott A. (2018). Abstract 317: Inflammasome Inhibitor MCC950 Prevents the Development of Sporadic Thoracic and Abdominal Aortic Aneurysms and Dissections in Mice. Arteriosclerosis Thrombosis and Vascular Biology, 38 (Suppl_1). doi: 10.1161/atvb.38.suppl_1.317 |
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2018 Journal Article The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infectionAlhallaf, Rafid, Agha, Zainab, Miller, Catherine M., Robertson, Avril A. B., Sotillo, Javier, Croese, John, Cooper, Matthew A., Masters, Seth L., Kupz, Andreas, Smith, Nicholas C., Loukas, Alex and Giacomin, Paul R. (2018). The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection. Cell Reports, 23 (4), 1085-1098. doi: 10.1016/j.celrep.2018.03.097 |
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2018 Journal Article Fishing for drug targets: a focus on diazirine photoaffinity probe synthesisHill, James R. and Robertson, Avril A. B. (2018). Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis. Journal of Medicinal Chemistry, 61 (16) acs.jmedchem.7b01561, 6945-6963. doi: 10.1021/acs.jmedchem.7b01561 |
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2018 Journal Article Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950Salla, Manohar, Butler, Mark S., Massey, Nicholas L., Reid, Janet C., Cooper, Matthew A. and Robertson, Avril A. B. (2018). Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950. Bioorganic and Medicinal Chemistry Letters, 28 (4), 793-795. doi: 10.1016/j.bmcl.2017.12.054 |
