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2016 Conference Publication Targeting the NLRP3 inflammasome is a viable option for the treatment of pathogenic influenza virus infectionTate, M., Ong, J., Dowling, J., Robertson, A., Cooper, M. and Mansell, A. (2016). Targeting the NLRP3 inflammasome is a viable option for the treatment of pathogenic influenza virus infection. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL. |
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2016 Conference Publication Human monocytes engage an alternative inflammasome pathwayGaidt, M., Ebert, T., Chauhan, D., Schmidt, T., Schmid-Burgk, J., Rapino, F., Robertson, A., Cooper, M., Graf, T. and Hornung, (2016). Human monocytes engage an alternative inflammasome pathway. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL. |
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2016 Conference Publication Delayed inhibition of the NLRP3 inflammasome during pathogenic influenza A virus infection in mice reduces disease severity and prolongs survivalTate, M., Pinar, A., Dowling, J., McAuley, J., Robertson, A., Cooper, M. and Mansell, A. (2016). Delayed inhibition of the NLRP3 inflammasome during pathogenic influenza A virus infection in mice reduces disease severity and prolongs survival. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL. |
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2016 Conference Publication NLRP3 inflammasome-mediated, IL-1β-dependent inflammatory responses drive severe, steroid-resistant asthmaKim, R., Pinkerton, J., Essilfie, A. -T, Robertson, A., Baines, K., Mayall, J., Starkey, M., Wark, P., Gibson, P., O'neill, L., Cooper, M., Horvat, J. and Hansbro, P. (2016). NLRP3 inflammasome-mediated, IL-1β-dependent inflammatory responses drive severe, steroid-resistant asthma. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL. |
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2016 Conference Publication Autocrine NLRP3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+T cellsArbore, G., West, E., Robertson, A., Klos, A., Rheinheimer, C., Dutow, P., Woodruff, T., O'Neill, L., Coll, R., Sher, A., Leonard, W., Koehl, J., Monk, P., Cooper, M., Arno, M., Afzali, B., Lachmann, H., Cope, A., Mayer-Barber, K. and Kemper, C. (2016). Autocrine NLRP3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+T cells. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL. |
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2016 Journal Article IL-1beta is an innate immune sensor of microbial proteolysisLaRock, Christopher N., Todd, Jordan, LaRock, Doris L., Olson, Joshua, O’Donoghue, Anthony J., Robertson, Avril A. B., Cooper, Matthew A., Hoffman, Hal M. and Nizet, Victor (2016). IL-1beta is an innate immune sensor of microbial proteolysis. Science Immunology, 1 (2) eaah3539, eaah3539-eaah3539. doi: 10.1126/sciimmunol.aah3539 |
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2016 Journal Article The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarctionvan Hout, Gerardus P. J., Bosch, Lena, Ellenbroek, Guilielmus H. J. M., de Haan, Judith J., van Solinge, Wouter W., Cooper, Matthew A., Arslan, Fatih, de Jager, Saskia C. A., Robertson, Avril A. B., Pasterkamp, Gerard and Hoefer, Imo E. (2016). The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. European Heart Journal, 38 (11), 1-10. doi: 10.1093/eurheartj/ehw247 |
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2016 Journal Article T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsArbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210 |
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2016 Journal Article Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibitionTate, Michelle D., Ong, James D. H., Dowling, Jennifer K., McAuley, Julie L., Robertson, Avril B., Latz, Eicke, Drummond, Grant R., Cooper, Matthew A., Hertzog, Paul J. and Mansell, Ashley (2016). Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition. Scientific Reports, 6 (1) 27912, 27912. doi: 10.1038/srep27912 |
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2016 Journal Article The endoplasmic reticulum-mitochondrion tether ERMES orchestrates fungal immune evasion, illuminating inflammasome responses to hyphal signalsTucey, Timothy M., Verma-Guar, Jiyoti, Nguyen, Julie, Hewitt, Victoria L., Lo, Tricia L., Shingu-Vazquez, Miguel, Robertson, Avril A. B., Hill, James R., Pettolino, Filomena A., Beddoe, Travis, Cooper, Matthew A., Naderer, Thomas and Traven, Ana (2016). The endoplasmic reticulum-mitochondrion tether ERMES orchestrates fungal immune evasion, illuminating inflammasome responses to hyphal signals. mSphere, 1 (3) e00074-16, 1-18. doi: 10.1128/mSphere.00074-16 |
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2016 Journal Article Human monocytes engage an alternative inflammasome pathwayGaidt, Moritz M., Ebert, Thomas S., Chauhan, Dhruv, Schmidt, Tobias, Schmid-Burgk, Jonathan L., Rapino, Francesca, Robertson, Avril A. B., Cooper, Matthew A., Graf, Thomas and Hornung, Veit (2016). Human monocytes engage an alternative inflammasome pathway. Immunity, 44 (4), 833-846. doi: 10.1016/j.immuni.2016.01.012 |
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2016 Conference Publication Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cellsWest, Erin E., Arbore, Giuseppina, Robertson, Avril A.B., Klos, Andreas, Woodruff, Trent M., O’Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Köhl, Jörg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cells. Immunology 2016™ Meeting, Seattle, WA United States, 13 - 17 May 2016. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.196.supp.58.6 |
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2016 Journal Article Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.Schaale, K., Peters, K. M., Murthy, A. M., Fritzsche, A. K., Phan, M.-D., Totsika, M., Robertson, A. A. B., Nichols, K. B., Cooper, M. A., Stacey, K. J., Ulett, G. C., Schroder, K., Schembri, M. A. and Sweet, M. J. (2016). Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.. Mucosal Immunology, 9 (1), 124-136. doi: 10.1038/mi.2015.44 |
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2016 Conference Publication Nlrp3 Inflammasome-Mediated, Il-1 beta-Dependent Inflammatory Responses Drive Severe, Steroid-Insensitive AsthmaKim, R. Y., Pinkerton, J. W., Essilfie, A. -T., Robertson, A. A., Baines, K. J., Mayall, J. R., Starkey, M. R., Wark, P. A., Gibson, P. G., O'Neill, L. A., Cooper, M. A., Horvat, J. C. and Hansbro, P. M. (2016). Nlrp3 Inflammasome-Mediated, Il-1 beta-Dependent Inflammatory Responses Drive Severe, Steroid-Insensitive Asthma. International Conference of the American Thoracic Society (ATS), San Francisco, California, 13-18 May 2016 . New York, NY, United States: American Thoracic Society. |
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2016 Conference Publication Evidence against a role for NLRP3-driven inflammation in the db/db mouse model of type 2 diabetesKammoun, H. L., Allen, T. L., Henstridge, D. C., Barre, S., Coll, R. C., Butler, M. S., Roberston, A. A. B., O'Neill, L. A., Murphy, A. J., Cooper, M. A. and Febbraio, M. A. (2016). Evidence against a role for NLRP3-driven inflammation in the db/db mouse model of type 2 diabetes. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/eji.201670200 |
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2016 Conference Publication Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4(+) T cellsWest, Erin E., Arbore, Giuseppina, Robertson, Avril A. B., Klos, Andreas, Woodruff, Trent M., O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Joerg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4(+) T cells. Annual Meeting of the American Association of Immunologists (AAI), Seattle, WA, United States, 13-17 May 2016. Bethesda, MD, United States: American Association of Immunologists. |
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2016 Conference Publication Role of inflammation, vasoconstriction and oxidative stress in the enhanced pressor response to angiotensin II in aged miceDinh, Q. N., Drummond, G. R., Kemp-Harper, B. K., Diep, H., Robertson, A. A. B., Cooper, M. A., Sobey, C. G. and Chrissobolis, S. (2016). Role of inflammation, vasoconstriction and oxidative stress in the enhanced pressor response to angiotensin II in aged mice. 37th Annual Scientific Meeting of The High Blood Pressure Research Council Of Australia, Melbourne, VIC, Australia, 2-4 December 2015. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1161/HYP.0000000000000042 |
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2016 Conference Publication The NLRP3 inflammasome negatively regulates type 2 immunity to gastrointestinal helminth infectionAlhallaf, R., Agha, Z., Miller, C. M., Robertson, A. A., Dent, L. A., Cooper, M. A., Masters, S. L., Smith, N. C., Loukas, A. and Giacomin, P. R. (2016). The NLRP3 inflammasome negatively regulates type 2 immunity to gastrointestinal helminth infection. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/eji.201670200 |
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2016 Conference Publication NLRP3 inflammasome-mediated, IL-1 beta-dependent inflammatory responses drive severe, steroid-insensitive asthmaKim, R., Pinkerton, J., Essilfie, A., Robertson, A., Baines, K., Mayall, J., Starkey, M., Wark, P., Gibson, P., O'Neill, L., Cooper, M., Horvat, J. and Hansbro, P. (2016). NLRP3 inflammasome-mediated, IL-1 beta-dependent inflammatory responses drive severe, steroid-insensitive asthma. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA, Australia, 1–6 April 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12754_11 |
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2015 Journal Article NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B, Tanzer, Marco J., Monteleone, Mercedes, Robertson, Avril A.B., Cooper, Matthew A., Alvarez-Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate and Masters, Seth L. (2015). NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology, 45 (10), 2918-2926. doi: 10.1002/eji.201545655 |
