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2019 Journal Article Retrograde regulation by the viral protein kinase epigenetically sustains the Epstein-Barr virus latency-to-lytic switch to augment virus productionLi, Xiaofan, Kozlov, Sergei V., El-Guindy, Ayman and Bhaduri-McIntosh, Sumita (2019). Retrograde regulation by the viral protein kinase epigenetically sustains the Epstein-Barr virus latency-to-lytic switch to augment virus production. Journal of Virology, 93 (17). doi: 10.1128/JVI.00572-19 |
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2019 Journal Article A Roberts syndrome individual with differential genotoxin sensitivity and a DNA damage response defectMcKay, Michael J., Craig, Jeffery, Kalitsis, Paul, Kozlov, Sergei, Verschoor, Sandra, Chen, Phillip, Lobachevsky, Pavel, Vasireddy, Raja, Yan, Yuqian, Ryan, Jacinta, McGillivray, George, Savarirayan, Ravi, Lavin, Martin F., Ramsay, Robert G. and Xu, Huiling (2019). A Roberts syndrome individual with differential genotoxin sensitivity and a DNA damage response defect. International Journal of Radiation Oncology Biology Physics, 103 (5), 1194-1202. doi: 10.1016/j.ijrobp.2018.11.047 |
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2016 Journal Article Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damageQuek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C. Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Journal of Leukocyte Biology, 101 (4), 927-947. doi: 10.1189/jlb.4VMA0716-316R |
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2016 Journal Article A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotypeQuek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Human Molecular Genetics, 26 (1), 109-123. doi: 10.1093/hmg/ddw371 |
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2015 Journal Article ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptorLavin, Martin F., Kozlov, Sergei, Gatei, Magtouf and Kijas, Amanda W. (2015). ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor. Biomolecules, 5 (4) A31, 2877-2902. doi: 10.3390/biom5042877 |
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2015 Journal Article ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screenKozlov, Sergei V., Waardenberg, Ashley J., Engholm-Keller, Kasper, Arthur, Jonathan W., Graham, Mark E. and Lavin, Martin (2015). ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen. Molecular and Cellular Proteomics, 15 (3), 1032-1047. doi: 10.1074/mcp.M115.055723 |
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2014 Journal Article Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cellsLim, Yi Chieh, Roberts, Tara L., Day, Bryan W., Stringer, Brett W., Kozlov, Sergei, Fazry, Shazrul, Bruce, Zara C., Ensbey, Kathleen S., Walker, David G., Boyd, Andrew W. and Lavin, Martin F. (2014). Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells. Molecular Oncology, 8 (8), 1603-1615. doi: 10.1016/j.molonc.2014.06.012 |
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2013 Journal Article A patient-derived olfactory stem cell disease model for ataxia-telangiectasiaStewart, Romal, Kozlov, Sergei, Matigian, Nicholas, Wali, Gautam, Gatei, Magtouf, Sutharsan, Ratneswary, Bellette, Bernadette, Kijas, Amanda Wraith, Cochrane, Julie, Coulthard, Mark, Perry, Chris, Sinclair, Kate, Mackay-Sim, Alan and Lavin, Martin F. (2013). A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Human Molecular Genetics, 22 (12), 2495-2509. doi: 10.1093/hmg/ddt101 |
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2012 Journal Article A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cellsLim, Yi Chieh, Roberts, Tara L., Day, Bryan W., Harding, Angus, Kozlov, Sergei, Kijas, Amanda W., Ensbey, Kathleen S., Walker, David G. and Lavin, Martin F. (2012). A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells. Molecular Cancer Therapeutics, 11 (9), 1863-1872. doi: 10.1158/1535-7163.MCT-11-1044 |
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2012 Journal Article Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular PhenotypeNayler, Sam, Gatei, Magtouf, Kozlov, Sergei, Gatti, Richard, Mar, Jessica C., Wells, Christine A., Lavin, Martin and Wolvetang, Ernst (2012). Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype. Stem Cells Translational Medicine, 1 (7), 523-535. doi: 10.5966/sctm.2012-0024 |
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2011 Journal Article ATM protein kinase: The linchpin of cellular defenses to stressBhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin and Khanna, Kum Kum (2011). ATM protein kinase: The linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences, 68 (18), 2977-3006. doi: 10.1007/s00018-011-0683-9 |
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2011 Journal Article Autophosphorylation and ATM activation: Additional sites add to the complexityKozlov, Sergei V., Graham, Mark E., Jakob, Burkhard, Tobias, Frank, Kijas, Amanda W., Tanuji, Marcel, Chen, Philip, Robinson, Phillip J., Taucher-Scholz, Gisela, Suzuki, Keiji, So, Sairai, Chen, David and Lavin, Martin F. (2011). Autophosphorylation and ATM activation: Additional sites add to the complexity. The Journal of Biological Chemistry, 286 (11), 9107-9119. doi: 10.1074/jbc.M110.204065 |
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2010 Journal Article Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesisJurado, Sabine, Smyth, Ian, van Denderen, Bryce, Tenis, Nora, Hammet, Andrew, Hewitt, Kimberly, Ng, Jane-Lee, McNees, Carolyn J., Kozlov, Sergei V., Oka, Hayato, Kobayashi, Masahiko, Conlan, Lindus A., Cole, Timothy J., Yamamoto, Ken-ichi, Taniguchi, Yoshihito, Takeda, Shunichi, Lavin, Martin F. and Heierhorst, Jörg (2010). Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genetics, 6 (10) e1001170, e1001170-1-e1001170-13. doi: 10.1371/journal.pgen.1001170 |
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2010 Journal Article ATM activation by oxidative stressGuo, Zhi, Kozlov, Sergei, Lavin, Martin F., Person, Maria D. and Paull, Tanya T. (2010). ATM activation by oxidative stress. Science, 330 (6003), 517-521. doi: 10.1126/science.1192912 |
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2010 Journal Article Low levels of ATM in breast cancer patients with clinical radiosensitivityFang, Zhiming, Kozlov, Sergei, McKay, Michael J., Woods, Rick, Birrell, Geoff, Sprung, Carl N., Murrell, Dédée F., Wangoo, Kiran, Teng, Linda, Lavin, Martin F., Kearsley, John H., Graham, Peter H. and Clarke, Raymond A. (2010). Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integrity, 1 (1) 9, 9-1-9-9. doi: 10.1186/2041-9414-1-9 |
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2010 Journal Article Leveraging cell cycle analysis in anticancer drug discovery to identify novel plasmodial drug targetsKozlov, Sergei, Waters, Norman C. and Chavchich, Marina (2010). Leveraging cell cycle analysis in anticancer drug discovery to identify novel plasmodial drug targets. Infectious Disorders - Drug Targets, 10 (3), 165-190. |
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2009 Journal Article Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated proteinFang Z. M., Tse R. V., Marjoniemi V. M., Koslov, S., Lavin, M. F., Chen, H., Kearsley, J. H., Graham, P. H. and Clarke, R. A. (2009). Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein. Journal of Medical Imaging and Radiation Oncology, 53 (2), 234-239. doi: 10.1111/j.1754-9485.2009.02053.x |
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2008 Journal Article Low dose ionizing radiation responses and knockdown of ATM kinase activity in glioma stem cellsLim, Yi Chieh, Roberts, Tara, Harding, Angus, Day, Bryan, Kozlov, Sergei, Walker, David and Lavin, Martin (2008). Low dose ionizing radiation responses and knockdown of ATM kinase activity in glioma stem cells. Acta Medica Nagasakiensia, 53 (Suppl.), 37-43. doi: 10.11343/amn.53.S37 |
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2007 Journal Article ATM activation and DNA damage responseLavin, MF and Kozlov, S (2007). ATM activation and DNA damage response. Cell Cycle, 6 (8), 931-942. doi: 10.4161/cc.6.8.4180 |
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2007 Journal Article Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly (ADP-ribose) dependent pathway in the early response to DNA-damaging agentsHaince, J. F., Kozlov, S., Dawson, V. L., Dawson, T. M., Hendzel, M. J., Lavin, M. F. and Poirier, G. G. (2007). Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly (ADP-ribose) dependent pathway in the early response to DNA-damaging agents. Journal of Biological Chemistry, 282 (22), 16441-16453. doi: 10.1074/jbc.M608406200 |
