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2021 Journal Article Enzymatic C-terminal protein engineering with aminesRehm, Fabian B. H., Tyler, Tristan J., Yap, Kuok, de Veer, Simon J., Craik, David J. and Durek, Thomas (2021). Enzymatic C-terminal protein engineering with amines. Journal of the American Chemical Society, 143 (46) jacs.1c08976, 19498-19504. doi: 10.1021/jacs.1c08976 |
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2021 Journal Article Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapyYin, Huawu, Zhou, Xiuman, Huang, Yen-Hua, King, Gordon J., Collins, Brett M., Gao, Yanfeng, Craik, David J. and Wang, Conan K. (2021). Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy. Journal of the American Chemical Society, 143 (44) jacs.1c08132, 18536-18547. doi: 10.1021/jacs.1c08132 |
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2021 Journal Article An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffoldLiu, Wenyu, de Veer, Simon J., Huang, Yen-Hua, Sengoku, Toru, Okada, Chikako, Ogata, Kazuhiro, Zdenek, Christina N., Fry, Bryan G., Swedberg, Joakim E., Passioura, Toby, Craik, David J. and Suga, Hiroaki (2021). An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold. Journal of the American Chemical Society, 143 (44) jacs.1c07574, 18481-18489. doi: 10.1021/jacs.1c07574 |
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2021 Journal Article Importance of the cyclic cystine knot structural motif for immunosuppressive effects of cyclotidesHellinger, Roland, Muratspahić, Edin, Devi, Seema, Koehbach, Johannes, Vasileva, Mina, Harvey, Peta J., Craik, David J., Gründemann, Carsten and Gruber, Christian W. (2021). Importance of the cyclic cystine knot structural motif for immunosuppressive effects of cyclotides. ACS Chemical Biology, 16 (11) acschembio.1c00524, 2373-2386. doi: 10.1021/acschembio.1c00524 |
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2021 Journal Article The emerging landscape of peptide-based inhibitors of PCSK9Tombling, Benjamin J., Zhang, Yuhui, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2021). The emerging landscape of peptide-based inhibitors of PCSK9. Atherosclerosis, 330, 52-60. doi: 10.1016/j.atherosclerosis.2021.06.903 |
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2021 Journal Article Melanocortin 1 receptor agonists based on a bivalent, bicyclic peptide frameworkDurek, Thomas, Kaas, Quentin, White, Andrew M., Weidmann, Joachim, Fuaad, Abdullah Ahmad, Cheneval, Olivier, Schroeder, Christina I., de Veer, Simon J., Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Plowright, Alleyn T. and Craik, David J. (2021). Melanocortin 1 receptor agonists based on a bivalent, bicyclic peptide framework. Journal of Medicinal Chemistry, 64 (14) acs.jmedchem.1c00095, 9906-9915. doi: 10.1021/acs.jmedchem.1c00095 |
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2021 Journal Article Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal painMuratspahić, Edin, Tomašević, Nataša, Koehbach, Johannes, Duerrauer, Leopold, Hadžić, Seid, Castro, Joel, Schober, Gudrun, Sideromenos, Spyridon, Clark, Richard J., Brierley, Stuart M., Craik, David J. and Gruber, Christian W. (2021). Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00158, 9042-9055. doi: 10.1021/acs.jmedchem.1c00158 |
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2021 Journal Article An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitorsYin, Huawu, Huang, Yen-Hua, Best, Sarah A., Sutherland, Kate D., Craik, David J. and Wang, Conan K. (2021). An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors. ACS Chemical Biology, 16 (7) acschembio.1c00388, 1276-1287. doi: 10.1021/acschembio.1c00388 |
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2021 Journal Article Asparaginyl ligases: new enzymes for the protein engineer's toolboxRehm, Fabian B. H., Tyler, Tristan J., Xie, Jing, Yap, Kuok, Durek, Thomas and Craik, David J. (2021). Asparaginyl ligases: new enzymes for the protein engineer's toolbox. ChemBioChem, 22 (12), 2079-2086. doi: 10.1002/cbic.202100071 |
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2021 Journal Article Comparison of a short linear antimicrobial peptide with its disulfide-cyclized and cyclotide-grafted variants against clinically relevant pathogensKoehbach, Johannes, Gani, Jurnorain, Hilpert, Kai and Craik, David J. (2021). Comparison of a short linear antimicrobial peptide with its disulfide-cyclized and cyclotide-grafted variants against clinically relevant pathogens. Microorganisms, 9 (6) 1249, 1249. doi: 10.3390/microorganisms9061249 |
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2021 Journal Article Cyclic peptides as T-type calcium channel blockers: characterization and molecular mapping of the binding siteDepuydt, Anne-Sophie, Rihon, Jérôme, Cheneval, Olivier, Vanmeert, Michiel, Schroeder, Christina I., Craik, David J., Lescrinier, Eveline, Peigneur, Steve and Tytgat, Jan (2021). Cyclic peptides as T-type calcium channel blockers: characterization and molecular mapping of the binding site. ACS Pharmacology and Translational Science, 4 (4) acsptsci.1c00079, 1379-1389. doi: 10.1021/acsptsci.1c00079 |
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2021 Journal Article Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9)Tombling, Benjamin J., Lammi, Carmen, Bollati, Carlotta, Anoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). ChemBioChem, 22 (12) cbic.202100103, 1-8. doi: 10.1002/cbic.202100103 |
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2021 Journal Article Tuning the anti-angiogenic effect of the P15 peptide using cyclic trypsin inhibitor scaffoldsChan, Lai Yue, Du, Junqiao and Craik, David J. (2021). Tuning the anti-angiogenic effect of the P15 peptide using cyclic trypsin inhibitor scaffolds. ACS Chemical Biology, 16 (5), 829-837. doi: 10.1021/acschembio.0c00907 |
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2021 Journal Article Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic ActivityNadal-Bufi, Ferran, Mason, Jody M., Chan, Lai Yue, Craik, David J., Kaas, Quentin and Troeira Henriques, Sónia (2021). Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity. Journal of Medicinal Chemistry, 64 (7) acs.jmedchem.0c01898, 3767-3779. doi: 10.1021/acs.jmedchem.0c01898 |
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2021 Journal Article Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitorTombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Gilding, Edward K., Grazioso, Giovanni, Craik, David J. and Wang, Conan K. (2021). Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01766, 2523-2533. doi: 10.1021/acs.jmedchem.0c01766 |
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2021 Journal Article Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidasesYap, Kuok, Du, Junqiao, Rehm, Fabian B. H., Tang, Shyn Ric, Zhou, Yan, Xie, Jing, Wang, Conan K., de Veer, Simon J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2021). Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols, 16 (3), 1-23. doi: 10.1038/s41596-020-00483-0 |
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2021 Journal Article Angler peptides: macrocyclic conjugates inhibit p53:MDM2/X interactions and activate apoptosis in cancer cellsPhilippe, Grégoire J.-B., Mittermeier, Anna, Lawrence, Nicole, Huang, Yen-Hua, Condon, Nicholas D., Loewer, Alexander, Craik, David J. and Henriques, Sónia T. (2021). Angler peptides: macrocyclic conjugates inhibit p53:MDM2/X interactions and activate apoptosis in cancer cells. ACS Chemical Biology, 16 (2) acschembio.0c00988, 414-428. doi: 10.1021/acschembio.0c00988 |
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2021 Journal Article Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9)Tombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Li, Jianqiang, Arnoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9). ACS Chemical Biology, 16 (2) acschembio.0c00991, 429-439. doi: 10.1021/acschembio.0c00991 |
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2021 Journal Article Linking molecular evolution to molecular graftingWang, Conan K. and Craik, David J. (2021). Linking molecular evolution to molecular grafting. Journal of Biological Chemistry, 296 100425, 1-11. doi: 10.1016/j.jbc.2021.100425 |
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2020 Journal Article Cyclotide structures revealed by NMR, with a little help from X-ray crystallographyHandley, Thomas N. G., Harvey, Peta J., Wang, Conan K., Lawrence, Nicole and Craik, David (2020). Cyclotide structures revealed by NMR, with a little help from X-ray crystallography. Chembiochem, 21 (24) cbic.202000315, 3463-3475. doi: 10.1002/cbic.202000315 |
