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2024 Journal Article Cyclic tachyplesin I kills proliferative, non-proliferative and drug-resistant melanoma cells without inducing resistanceBenfield, Aurélie H., Vernen, Felicitas, Young, Reuben S. E., Nadal-Bufí, Ferran, Lamb, Henry, Hammerlindl, Heinz, Craik, David J., Schaider, Helmut, Lawrence, Nicole, Blanksby, Stephen J. and Henriques, Sónia Troeira (2024). Cyclic tachyplesin I kills proliferative, non-proliferative and drug-resistant melanoma cells without inducing resistance. Pharmacological Research, 207 107298. doi: 10.1016/j.phrs.2024.107298 |
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2024 Journal Article Display technologies for expanding the pharmaceutical applications of cyclotidesXie, Jing, Kan, Meng‐Wei, de Veer, Simon J., Wang, Conan and Craik, David J. (2024). Display technologies for expanding the pharmaceutical applications of cyclotides. Israel Journal of Chemistry, 64 (8-9) e202400010. doi: 10.1002/ijch.202400010 |
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2024 Journal Article Conotoxins targeting voltage-gated sodium ion channelsPei, Shengrong, Wang, Nan, Mei, Zaoli, Zhangsun, Dongting, Craik, David J., McIntosh, J. Michael, Zhu, Xiaopeng and Luo, Sulan (2024). Conotoxins targeting voltage-gated sodium ion channels. Pharmacological Reviews, 76 (5), 828-845. doi: 10.1124/pharmrev.123.000923 |
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2024 Journal Article Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylationRehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 16 (9), 1565-1565. doi: 10.1038/s41557-024-01625-7 |
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2024 Journal Article Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptidesGilding, Edward K., Jackson, Mark A., Nguyen, Linh T. T., Hamilton, Brett R., Farquharson, Katherine A., Ho, Wing L., Yap, Kuok, Hogg, Carolyn J., Belov, Katherine and Craik, David J. (2024). Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptides. Nature Communications, 15 (1) 6565, 6565. doi: 10.1038/s41467-024-50742-x |
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2024 Journal Article Enhancing the intrinsic antiplasmodial activity and improving the stability and selectivity of a tunable peptide scaffold derived from human platelet factor 4Lawrence, Nicole, Handley, Thomas N. G., de Veer, Simon J., Harding, Maxim D., Andraszek, Alicja, Hall, Lachlan, Raven, Karoline D., Duffy, Sandra, Avery, Vicky M., Craik, David J., Malins, Lara R. and McMorran, Brendan J. (2024). Enhancing the intrinsic antiplasmodial activity and improving the stability and selectivity of a tunable peptide scaffold derived from human platelet factor 4. ACS Infectious Diseases, 10 (8), 2899-2912. doi: 10.1021/acsinfecdis.4c00276 |
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2024 Journal Article Topology in soft and biological matterTubiana, Luca, Alexander, Gareth P., Barbensi, Agnese, Buck, Dorothy, Cartwright, Julyan H.E., Chwastyk, Mateusz, Cieplak, Marek, Coluzza, Ivan, Čopar, Simon, Craik, David J., Di Stefano, Marco, Everaers, Ralf, Faísca, Patrícia F.N., Ferrari, Franco, Giacometti, Achille, Goundaroulis, Dimos, Haglund, Ellinor, Hou, Ya-Ming, Ilieva, Nevena, Jackson, Sophie E., Japaridze, Aleksandre, Kaplan, Noam, Klotz, Alexander R., Li, Hongbin, Likos, Christos N., Locatelli, Emanuele, López-León, Teresa, Machon, Thomas, Micheletti, Cristian ... Žumer, Slobodan (2024). Topology in soft and biological matter. Physics Reports, 1075, 1-137. doi: 10.1016/j.physrep.2024.04.002 |
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2024 Journal Article Structure and activity of reconstructed pseudo‐ancestral cyclotidesJiang, Zhihao, Huang, Yen-Hua, Kaas, Quentin, Craik, David J. and Wang, Conan K. (2024). Structure and activity of reconstructed pseudo‐ancestral cyclotides. ChemMedChem, 19 (14) e202400124, e202400124. doi: 10.1002/cmdc.202400124 |
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2024 Journal Article Aspartic acid mutagenesis of αO-Conotoxin GeXIVA isomers reveals arginine residues crucial for inhibition of the α9α10 nicotinic acetylcholine receptorLuo, An, He, Jie, Yu, Jinpeng, Wu, Yong, Harvey, Peta J., Kasheverov, Igor E., Kudryavtsev, Denis S., McIntosh, J. Michael, Tsetlin, Victor I., Craik, David J., Zhangsun, Dongting and Luo, Sulan (2024). Aspartic acid mutagenesis of αO-Conotoxin GeXIVA isomers reveals arginine residues crucial for inhibition of the α9α10 nicotinic acetylcholine receptor. International Journal of Biological Macromolecules, 271 (Part 1) 132472, 132472. doi: 10.1016/j.ijbiomac.2024.132472 |
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2024 Journal Article Design, synthesis, and structure–activity relationships of novel peptide derivatives of the severe acute respiratory syndrome-coronavirus-2 spike-protein that potently inhibit nicotinic acetylcholine receptorsHone, Arik J., Santiago, Ulises, Harvey, Peta J., Tekarli, Bassel, Gajewiak, Joanna, Craik, David J., Camacho, Carlos J. and McIntosh, J. Michael (2024). Design, synthesis, and structure–activity relationships of novel peptide derivatives of the severe acute respiratory syndrome-coronavirus-2 spike-protein that potently inhibit nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, 67 (11), 9587-9598. doi: 10.1021/acs.jmedchem.4c00735 |
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2024 Journal Article Repurposing a plant peptide cyclase for targeted lysine acylationRehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024 (9), 1-1. doi: 10.1038/s41557-024-01520-1 |
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2024 Journal Article Isolation and characterization of insecticidal cyclotides from Viola communisKhatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and characterization of insecticidal cyclotides from Viola communis. Journal of Natural Products, 88 (1), 24-35. doi: 10.1021/acs.jnatprod.4c00168 |
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2024 Journal Article Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systemsMorin, Marie, Jönsson, Mathias, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2024). Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systems. PLOS Biology, 22 (5) e3002620, e3002620. doi: 10.1371/journal.pbio.3002620 |
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2024 Journal Article Chemical synthesis of grafted cyclotides using a “plug and play” approachKoehbach, Johannes, Muratspahić, Edin, Ahmed, Zakaria M., White, Andrew M., Tomašević, Nataša, Durek, Thomas, Clark, Richard J., Gruber, Christian W. and Craik, David J. (2024). Chemical synthesis of grafted cyclotides using a “plug and play” approach. RSC Chemical Biology, 5 (6), 567-571. doi: 10.1039/d4cb00008k |
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2024 Journal Article Proximity labelling confirms the involvement of papain-like cysteine proteases and chaperones in cyclotide biosynthesisLee, Meng-Han, Jackson, Mark A., Rehm, Fabian B. H., Barkauskas, Deborah S., Ho, Wing L., Yap, Kuok, Craik, David J. and Gilding, Edward K. (2024). Proximity labelling confirms the involvement of papain-like cysteine proteases and chaperones in cyclotide biosynthesis. Plant Molecular Biology Reporter, 42 (3), 611-623. doi: 10.1007/s11105-024-01462-5 |
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2024 Journal Article Nucleation of a key beta-turn promotes cyclotide oxidative foldingTian, Sixin, de Veer, Simon J., Durek, Thomas, Wang, Conan K. and Craik, David J. (2024). Nucleation of a key beta-turn promotes cyclotide oxidative folding. Journal of Biological Chemistry, 300 (4) 107125, 107125. doi: 10.1016/j.jbc.2024.107125 |
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2024 Journal Article Tertiary amide bond formation by an engineered asparaginyl ligasede Veer, Simon J., Zhou, Yan, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2024). Tertiary amide bond formation by an engineered asparaginyl ligase. Chemical Science, 15 (14) 06352, 5248-5255. doi: 10.1039/d3sc06352f |
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2024 Journal Article Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1Huang, Yen-Hua, Jiang, Zhihao, Du, Qingdan, Yap, Kuok, Bigot, Aurélien, Kaas, Quentin, Wang, Conan K. and Craik, David J. (2024). Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. Journal of Biological Chemistry, 300 (3) 105682. doi: 10.1016/j.jbc.2024.105682 |
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2024 Journal Article Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptidesOshiro, Karen G. N., Freitas, Carlos D. P., Rezende, Samilla B., Orozco, Raquel M. Q., Chan, Lai Y., Lawrence, Nicole, Lião, Luciano M., Macedo, Maria L. R., Craik, David J., Cardoso, Marlon H. and Franco, Octávio L. (2024). Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptides. The FEBS Journal, 291 (5), 865-883. doi: 10.1111/febs.17010 |
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2024 Journal Article Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipidsRoseli, Ras Baizureen, Huang, Yen-Hua, Henriques, Sónia Troeira, Kaas, Quentin and Craik, David J. (2024). Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1866 (3) 184268, 1-13. doi: 10.1016/j.bbamem.2023.184268 |
