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2022 Journal Article An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffoldCardoso, Marlon H., Chan, Lai Y., Cândido, Elizabete S., Buccini, Danieli F., Rezende, Samilla B., Torres, Marcelo D. T., Oshiro, Karen G. N., Silva, Ítala C., Gonçalves, Sónia, Lu, Timothy K., Santos, Nuno C., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2022). An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold. Chemical Science, 13 (32), 9410-9424. doi: 10.1039/d1sc06998e |
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2022 Journal Article ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activationYousuf, Arsalan, Wu, Xiaosa, Bony, Anuja R., Sadeghi, Mahsa, Huang, Yen-Hua, Craik, David J. and Adams, David J. (2022). ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of Neurochemistry, 160 (2), 154-171. doi: 10.1111/jnc.15535 |
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2021 Journal Article Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptidesTran, Hue N. T., Tran, Poanna, Deuis, Jennifer R., McMahon, Kirsten L., Yap, Kuok, Craik, David J., Vetter, Irina and Schroeder, Christina I. (2021). Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00452, 2407-2419. doi: 10.1021/acs.bioconjchem.1c00452 |
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2021 Journal Article Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotidesHuang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J., Collins, Brett M., Wang, Conan K. and Craik, David J. (2021). Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides. Molecules, 26 (18) 5554, 5554. doi: 10.3390/molecules26185554 |
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2021 Journal Article Interactions of globular and ribbon [γ4E]GID with α4β2 neuronal nicotinic acetylcholine receptorWu, Xiaosa, Craik, David J. and Kaas, Quentin (2021). Interactions of globular and ribbon [γ4E]GID with α4β2 neuronal nicotinic acetylcholine receptor. Marine Drugs, 19 (9) 482, 482. doi: 10.3390/md19090482 |
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2021 Journal Article How can we improve peptide drug discovery? Learning from the pastCraik, David J. and Kan, Meng-Wei (2021). How can we improve peptide drug discovery? Learning from the past. Expert Opinion on Drug Discovery, 16 (12), 1-4. doi: 10.1080/17460441.2021.1961740 |
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2021 Journal Article Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A. and Craik, David J. (2021). Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1. Medicine in Drug Discovery, 10 100087, 1-10. doi: 10.1016/j.medidd.2021.100087 |
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2021 Journal Article Converting peptides into drugs targeting intracellular protein–protein interactionsPhilippe, Grégoire J.B., Craik, David J. and Henriques, Sónia T. (2021). Converting peptides into drugs targeting intracellular protein–protein interactions. Drug Discovery Today, 26 (6), 1521-1531. doi: 10.1016/j.drudis.2021.01.022 |
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2021 Journal Article Engineered conotoxin differentially blocks and discriminates rat and human α7 nicotinic acetylcholine receptorsWang, Shuai, Zhu, Xiaopeng, Zhangsun, Manqi, Wu, Yong, Yu, Jinpeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2021). Engineered conotoxin differentially blocks and discriminates rat and human α7 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, 64 (9), 5620-5631. doi: 10.1021/acs.jmedchem.0c02079 |
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2021 Journal Article Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternusMuller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli-Kadri, Mônica C., Koehbach, Johannes and Craik, David (2021). Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus. Chembiochem , 22 (8) cbic.202000716, 1415-1423. doi: 10.1002/cbic.202000716 |
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2021 Journal Article Computational and functional mapping of human and rat α6β4 nicotinic acetylcholine receptors reveals species-specific ligand-binding motifsHone, Arik J., Kaas, Quentin, Kearns, Ireland, Hararah, Fuaad, Gajewiak, Joanna, Christensen, Sean, Craik, David J. and McIntosh, J. Michael (2021). Computational and functional mapping of human and rat α6β4 nicotinic acetylcholine receptors reveals species-specific ligand-binding motifs. Journal of Medicinal Chemistry, 64 (3), 1685-1700. doi: 10.1021/acs.jmedchem.0c01973 |
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2021 Journal Article In planta discovery and chemical synthesis of bracelet cystine knot peptides from Rinorea bengalensisDang, Tien T., Chan, Lai Y., Tombling, Benjamin J., Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2021). In planta discovery and chemical synthesis of bracelet cystine knot peptides from Rinorea bengalensis. Journal of Natural Products, 84 (2), 395-407. doi: 10.1021/acs.jnatprod.0c01065 |
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2021 Journal Article Cyclotides from Brazilian Palicourea sessilis and their effects on human lymphocytesPinto, Meri Emili F., Chan, Lai Yue, Koehbach, Johannes, Devi, Seema, Gründemann, Carsten, Gruber, Christian W., Gomes, Mario, Bolzani, Vanderlan S., Cilli, Eduardo Maffud and Craik, David J. (2021). Cyclotides from Brazilian Palicourea sessilis and their effects on human lymphocytes. Journal of Natural Products, 84 (1) acs.jnatprod.0c01069, 81-90. doi: 10.1021/acs.jnatprod.0c01069 |
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2021 Journal Article Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cellsBenfield, Aurélie H., Defaus, Sira, Lawrence, Nicole, Chaousis, Stephanie, Condon, Nicholas, Cheneval, Olivier, Huang, Yen-Hua, Chan, Lai Yue, Andreu, David, Craik, David J. and Henriques, Sónia Troeira (2021). Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells. Biochimica et Biophysica Acta - Biomembranes, 1863 (1) 183480, 183480. doi: 10.1016/j.bbamem.2020.183480 |
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2021 Journal Article Small cyclic sodium channel inhibitorsPeigneur, Steve, da Costa Oliveira, Cristina, de Sousa Fonseca, Flávia Cristina, McMahon, Kirsten L., Mueller, Alexander, Cheneval, Olivier, Cristina Nogueira Freitas, Ana, Starobova, Hana, Dimitri Gama Duarte, Igor, Craik, David J., Vetter, Irina, de Lima, Maria Elena, Schroeder, Christina I. and Tytgat, Jan (2021). Small cyclic sodium channel inhibitors. Biochemical Pharmacology, 183 114291, 114291. doi: 10.1016/j.bcp.2020.114291 |
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2020 Journal Article Improved asparaginyl‐ligase‐catalyzed transpeptidation via selective nucleophile quenchingRehm, Fabian B. H., Tyler, Tristan J., Yap, Kuok, Durek, Thomas and Craik, David J. (2020). Improved asparaginyl‐ligase‐catalyzed transpeptidation via selective nucleophile quenching. Angewandte Chemie, 133 (8) ange.202013584, 4050-4054. doi: 10.1002/ange.202013584 |
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2020 Journal Article Evaluation of the in vivo aphrodisiac activity of a cyclotide extract from Hybanthus enneaspermusDu, Qingdan, Huang, Yen-Hua, Bajpai, Abhishek, Frosig- Jorgensen, Majbrit, Zhao, Guangzu and Craik, David J. (2020). Evaluation of the in vivo aphrodisiac activity of a cyclotide extract from Hybanthus enneaspermus. Journal of Natural Products, 83 (12), 3736-3743. doi: 10.1021/acs.jnatprod.0c01045 |
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2020 Journal Article Make it or break it: plant AEPs on stage in biotechnologyJackson, Mark A., Nguyen, Linh T. T., Gilding, Edward K., Durek, Thomas and Craik, David J. (2020). Make it or break it: plant AEPs on stage in biotechnology. Biotechnology Advances, 45 107651, 107651. doi: 10.1016/j.biotechadv.2020.107651 |
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2020 Journal Article Sunflower trypsin inhibitor-1 (SFTI-1): sowing seeds in the fields of chemistry and biologyde Veer, Simon J., White, Andrew M. and Craik, David (2020). Sunflower trypsin inhibitor-1 (SFTI-1): sowing seeds in the fields of chemistry and biology. Angewandte Chemie (International Edition), 59 (15), 2-24. doi: 10.1002/anie.202006919 |
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2020 Journal Article Der Sonnenblumen‐Trypsin‐Inhibitor 1 (SFTI‐1) in der Chemie und BiologieVeer, Simon J., White, Andrew M. and Craik, David J. (2020). Der Sonnenblumen‐Trypsin‐Inhibitor 1 (SFTI‐1) in der Chemie und Biologie. Angewandte Chemie, 133 (15), 8128-8151. doi: 10.1002/ange.202006919 |
