Overview
Availability
- Dr Nemat Khan is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy of Pharmacology, The University of Queensland
Research interests
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Multiple sclerosis
To investigate the therapeutic efficacy, pharmacokinetics, and toxicity profile of novel drug treatments using the Experimental Autoimmune Encephalomyelitis (EAE) mouse model, Cuprizone mouse model, and in-vitro models. To delineate the pathological role of Acid-sensing ion channels (ASICs) in triggering MS disease using preclinical and clinical samples. To delineate the pathological role of NLRP3 inflammasome activation in Secondary-progressive MS (SP-MS) disease using preclinical and clinical samples.
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Sepsis and Acute Lung Injury
To understand the role of various inflammatory pathways in sepsis and SIRS using mouse models of Caecal Ligation and Puncture (CLP), Lipopolysaccharide (LPS), and acute lung injury mouse models. To investigate the pathophysiology of sepsis-related vascular permeability and cardiac dysfunction
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Ischemia-Reperfusion Injury
Preclinical translational studies of novel drug treatments in mouse models of: - Gut ischemia-reperfusion mouse model - Liver ischemia-reperfusion injury mouse model - Myocardial ischemia-reperfusion injury - Renal ischemia-reperfusion injury mouse model
Works
Search Professor Nemat Khan’s works on UQ eSpace
2015
Journal Article
Neurotrophins and neuropathic pain: role in pathobiology
Khan, Nemat and Smith, Maree T. (2015). Neurotrophins and neuropathic pain: role in pathobiology. Molecules, 20 (6), 10657-10688. doi: 10.3390/molecules200610657
2015
Journal Article
Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord
Khan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015). Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord. Pharmacology Research and Perspectives, 3 (3) e00137, 1-16. doi: 10.1002/prp2.137
2015
Other Outputs
Cellular and molecular insights into multiple sclerosis-induced neuropathic pain
Khan, Nematullah (2015). Cellular and molecular insights into multiple sclerosis-induced neuropathic pain. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/uql.2015.387
2014
Journal Article
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods
Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014). Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126, 13-27. doi: 10.1016/j.pbb.2014.09.003
2013
Journal Article
Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models
Khan, Nemat and Smith, Maree T. (2013). Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 (1), 1-22. doi: 10.1007/s10787-013-0195-3
2012
Journal Article
Molecular simulations of bergenin as a new urease inhibitor
Arfan, Mohammad, Amin, Hazrat, Khan, Inamullah, Shah, Muhammad Raza, Shah, Hamidullah, Khan, Amir Zada, Halimi, Syed Muhammad Ashhad, Khan, Nematullah, Kaleem, Waqar Ahmad, Qayum, Mughal, Shahidullah, Adnan and Khan, Muhammad Azam (2012). Molecular simulations of bergenin as a new urease inhibitor. Medicinal Chemistry Research, 21 (9), 2454-2457. doi: 10.1007/s00044-011-9762-6
2012
Journal Article
Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.
Qayum, Mughal, Nisar, Muhammad, Shah, Muhammad Raza, Adhikari, Achyut, Kaleem, Waqar Ahmad, Khan, Inamullah, Khan, Nematullah, Gul, Farah, Khan, Ihsan Ali, Zia-ul-Haq, M. and Khan, Abad (2012). Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.. Phytotherapy Research, 26 (4), 552-556. doi: 10.1002/ptr.3574
2012
Journal Article
Discovery and molecular docking of quinolyl-thienyl chalcones as anti-angiogenic agents targeting VEGFR-2 tyrosine kinase
Rizvi, Syed Umar Farooq, Siddiqui, Hamid Latif, Nisar, Muhammad, Khan, Nematullah and Khan, Inamullah (2012). Discovery and molecular docking of quinolyl-thienyl chalcones as anti-angiogenic agents targeting VEGFR-2 tyrosine kinase. Bioorganic and Medicinal Chemistry Letters, 22 (2), 942-944. doi: 10.1016/j.bmcl.2011.12.017
2011
Journal Article
Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc.
Khan, Inamullah, Nisar, Muhammad, Shah, Muhammad Raza, Shah, Hamidullah, Gilani, Syed Naeemuddin, Gul, Farah, Abdullah, Syed Muhammad, Ismail, Mohammad, Khan, Nematullah, Kaleem, Waqar Ahmad, Qayum, Mughal, Khan, Haroon, Obaidullah, Samiullah and Ullah, Majeed (2011). Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc.. Fitoterapia, 82 (7), 1003-1007. doi: 10.1016/j.fitote.2011.06.003
2011
Journal Article
Molecular simulations probing Kushecarpin A as a new lipoxygenase inhibitor
Nisar, Muhammad, Kaleem, Wagar Ahmad, Khan, Inamullah, Adhikari, Achyut, Khan, Nematullah, Shah, Muhammad Raza, Khan, Ihsan Ali, Qayum, Mughal, Samiullah, Ismail, Muhammad and Aman, Akhter (2011). Molecular simulations probing Kushecarpin A as a new lipoxygenase inhibitor. Fitoterapia, 82 (7), 1008-1011. doi: 10.1016/j.fitote.2011.06.002
2011
Journal Article
Antimicrobial activities of Conyzolide and Conyzoflavone from Conyza canadensis
Shakirullah, Mohammad, Ahmad, Hanif, Shah, Muhammad Raza, Ahmad, Imtiaz, Ishaq, Muhammad, Khan, Nematullah, Badshah, Amir and Khan, Inamullah (2011). Antimicrobial activities of Conyzolide and Conyzoflavone from Conyza canadensis. Journal of Enzyme Inhibition and Medicinal Chemistry, 26 (4), 468-471. doi: 10.3109/14756366.2010.528413
2010
Journal Article
Structural insights to investigate Conypododiol as a dual cholinesterase inhibitor from Asparagus adscendens
Khan, Inamullah, Nisar, Muhammad, Khan, Nematullah, Saeed, Muhammad, Nadeem, Said, Fazal-ur-Rehman, Ali, Farooq, Karim, Nasiara, Kaleem, Waqar Ahmad, Qayum, Mughal, Ahmad, Hanif and Khan, Ihsan Ali (2010). Structural insights to investigate Conypododiol as a dual cholinesterase inhibitor from Asparagus adscendens. Fitoterapia, 81 (8), 1020-1025. doi: 10.1016/j.fitote.2010.06.022
2010
Journal Article
Analgesic and anti-inflammatory activities of 11-O-galloylbergenin
Arfan, Mohammad, Amin, Hazrat, Khan, Nematullah, Khan, Inamullah, Saeed, Muhammad, Khan, Muhammad Azim and Fazal-ur-Rehman (2010). Analgesic and anti-inflammatory activities of 11-O-galloylbergenin. Journal of Ethnopharmacology, 131 (2), 502-504. doi: 10.1016/j.jep.2010.06.040
2009
Journal Article
Adulterant profile of illicit street heroin and reduction of its precipitated physical dependence withdrawal syndrome by extracts of st john's wort (hypericum perforatum)
Subhan, Fazal, Khan, Nematullah and Sewell, Robert D. E. (2009). Adulterant profile of illicit street heroin and reduction of its precipitated physical dependence withdrawal syndrome by extracts of st john's wort (hypericum perforatum). Phytotherapy Research, 23 (4), 564-571. doi: 10.1002/ptr.2692
Funding
Current funding
Past funding
Supervision
Availability
- Dr Nemat Khan is:
- Available for supervision
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Available projects
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To study pathobiological mechanisms and develop novel drug treatments for Multiple Sclerosis (MS)
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To study pathobiological mechanisms and develop novel drug treatments for sepsis and acute lung injury
Supervision history
Current supervision
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Doctor Philosophy
Charaterisation of ion channels as pattern recognition receptors for acidosis and potential anti-inflammatory targets.
Associate Advisor
Other advisors: Dr Neville Butcher, Dr Lachlan Rash
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Doctor Philosophy
Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Dr Neville Butcher, Dr Lachlan Rash
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Doctor Philosophy
Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.
Associate Advisor
Other advisors: Dr Neville Butcher, Dr Lachlan Rash
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Doctor Philosophy
Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.
Associate Advisor
Other advisors: Dr Neville Butcher, Dr Lachlan Rash
Completed supervision
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2023
Doctor Philosophy
Multimodal MRI to monitor disease and treatment in a chronic-progressive EAE mouse model of multiple sclerosis
Associate Advisor
Other advisors: Dr Gary Cowin, Dr Nyoman Kurniawan
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2019
Doctor Philosophy
Insight into the Pathobiology of Breast Cancer Induced Bone Pain in a Rat Model
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
Enquiries
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