![Dr Nemat Khan](/sites/default/files/profiles/12108.png)
Overview
Availability
- Dr Nemat Khan is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy of Pharmacology, The University of Queensland
Research interests
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Multiple sclerosis
To investigate the therapeutic efficacy, pharmacokinetics, and toxicity profile of novel drug treatments using the Experimental Autoimmune Encephalomyelitis (EAE) mouse model, Cuprizone mouse model, and in-vitro models. To delineate the pathological role of Acid-sensing ion channels (ASICs) in triggering MS disease using preclinical and clinical samples. To delineate the pathological role of NLRP3 inflammasome activation in Secondary-progressive MS (SP-MS) disease using preclinical and clinical samples.
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Sepsis and Acute Lung Injury
To understand the role of various inflammatory pathways in sepsis and SIRS using mouse models of Caecal Ligation and Puncture (CLP), Lipopolysaccharide (LPS), and acute lung injury mouse models. To investigate the pathophysiology of sepsis-related vascular permeability and cardiac dysfunction
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Ischemia-Reperfusion Injury
Preclinical translational studies of novel drug treatments in mouse models of: - Gut ischemia-reperfusion mouse model - Liver ischemia-reperfusion injury mouse model - Myocardial ischemia-reperfusion injury - Renal ischemia-reperfusion injury mouse model
Works
Search Professor Nemat Khan’s works on UQ eSpace
2024
Journal Article
Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction
Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793
2024
Journal Article
Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis
Khan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Irwin, Adam (RSG member), Phillips, Natalie (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768
2024
Journal Article
Transient binocular vision loss and pain insensitivity in Klippel–Feil syndrome: a case report
Ullah, Zeeshan, Zafar, Ayesha, Ishaq, Hira, Umar, Zainab, Khan, Amir, Badar, Yaseen, Din, Nizamud, Khan, Muhammad Fawad, McCombe, Pamela and Khan, Nemat (2024). Transient binocular vision loss and pain insensitivity in Klippel–Feil syndrome: a case report. Journal of Medical Case Reports, 18 (1) 137, 137. doi: 10.1186/s13256-024-04374-w
2024
Book Chapter
Targeting acid-sensing ion channels in disease
Senescall, Victor, Budusan, Elena, Knezic, Adriana, Waqar, Maleeha, Butcher, Neville, Khan, Nemat, McCarthy, Claudia, Widopp, Robert, Karatt-Vellat, Aneesh and Rash, Lachlan D. (2024). Targeting acid-sensing ion channels in disease. Ion channels as targets in drug discovery. (pp. 303-355) edited by Gary Stephens and Edward Stevens. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-031-52197-3_10
2023
Journal Article
Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo
Althobity, Abdullah A., Khan, Nemat, Sandrock, Cheyenne J., Woodruff, Trent M, Cowin, Gary J., Brereton, Ian M. and Kurniawan, Nyoman D. (2023). Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo. NMR in Biomedicine, 36 (10) e4964, e4964. doi: 10.1002/nbm.4964
2022
Journal Article
Carbohydrate polymer-based targeted pharmaceutical formulations for colorectal cancer: systematic review of the literature
Farhaj, Samia, Agbotui, Theodora L., Nirwan, Jorabar Singh, Mahmood, Qaisar, Yousaf, Abid Mehmood, Hussain, Talib, Shahzad, Yasser, Khan, Nemat, Conway, Barbara R. and Ghori, Muhammad Usman (2022). Carbohydrate polymer-based targeted pharmaceutical formulations for colorectal cancer: systematic review of the literature. Polysaccharides, 3 (4), 692-714. doi: 10.3390/polysaccharides3040040
2022
Journal Article
Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain
Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic and Medicinal Chemistry, 69 116889, 1-10. doi: 10.1016/j.bmc.2022.116889
2022
Journal Article
β-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping
Bouchery, Tiffany, Volpe, Beatrice, Doolan, Rory, Coakley, Gillian, Moyat, Mati, Esser-von Bieren, Julia, Wickramasinghe, Lakshanie C, Hibbs, Margaret L, Sotillo, Javier, Camberis, Mali, Le Gros, Graham, Khan, Nemat, Williams, David and Harris, Nicola L (2022). β-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping. Immunology and Cell Biology, 100 (4), 223-234. doi: 10.1111/imcb.12536
2021
Journal Article
Post-COVID opsoclonus myoclonus syndrome: a case report from Pakistan
Ishaq, Hira, Durrani, Talha, Umar, Zainab, Khan, Nemat, McCombe, Pamela and Ul Haq, Mian Ayaz (2021). Post-COVID opsoclonus myoclonus syndrome: a case report from Pakistan. Frontiers in Neurology, 12 672524, 672524. doi: 10.3389/fneur.2021.672524
2021
Journal Article
Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods. Clinical and Experimental Pharmacology and Physiology, 48 (1) 1440-1681.13402, 96-106. doi: 10.1111/1440-1681.13402
2020
Journal Article
Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease
Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363
2019
Journal Article
J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. Biomedicine and Pharmacotherapy, 117 109056, 109056. doi: 10.1016/j.biopha.2019.109056
2018
Journal Article
The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain
Shenoy, Priyank A., Kuo, Andy, Khan, Nemat, Gorham, Louise, Nicholson, Janet, Corradini, Laura, Vetter, Irina and Smith, Maree T. (2018). The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain. Frontiers in Pharmacology, 9 (MAY) 495, 495. doi: 10.3389/fphar.2018.00495
2017
Journal Article
Attenuation of the Infiltration of Angiotensin II Expressing CD3(+) T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia - A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT(2)) Receptor Antagonist
Khan, Nemat, Muralidharan, Arjun and Smith, Maree T. (2017). Attenuation of the Infiltration of Angiotensin II Expressing CD3(+) T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia - A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT(2)) Receptor Antagonist. Frontiers in Molecular Neuroscience, 10 389, 389. doi: 10.3389/fnmol.2017.00389
2017
Journal Article
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain
Khan, Nemat, Kuo, Andy, Brockman, David A, Cooper, Matthew A and Smith, Maree T (2017). Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain. Inflammopharmacology, 26 (1), 77-86. doi: 10.1007/s10787-017-0401-9
2015
Journal Article
Neurotrophins and neuropathic pain: role in pathobiology
Khan, Nemat and Smith, Maree T. (2015). Neurotrophins and neuropathic pain: role in pathobiology. Molecules, 20 (6), 10657-10688. doi: 10.3390/molecules200610657
2015
Journal Article
Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord
Khan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015). Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord. Pharmacology Research and Perspectives, 3 (3) e00137, 1-16. doi: 10.1002/prp2.137
2015
Other Outputs
Cellular and molecular insights into multiple sclerosis-induced neuropathic pain
Khan, Nematullah (2015). Cellular and molecular insights into multiple sclerosis-induced neuropathic pain. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/uql.2015.387
2014
Journal Article
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods
Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014). Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126, 13-27. doi: 10.1016/j.pbb.2014.09.003
2013
Journal Article
Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models
Khan, Nemat and Smith, Maree T. (2013). Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 (1), 1-22. doi: 10.1007/s10787-013-0195-3
Funding
Current funding
Past funding
Supervision
Availability
- Dr Nemat Khan is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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To study pathobiological mechanisms and develop novel drug treatments for Multiple Sclerosis (MS)
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To study pathobiological mechanisms and develop novel drug treatments for sepsis and acute lung injury
Supervision history
Current supervision
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Doctor Philosophy
Charaterisation of ion channels as pattern recognition receptors for acidosis and potential anti-inflammatory targets.
Associate Advisor
Other advisors: Dr Neville Butcher, Dr Lachlan Rash
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Doctor Philosophy
Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.
Associate Advisor
Other advisors: Dr Neville Butcher, Dr Lachlan Rash
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Doctor Philosophy
Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Dr Neville Butcher, Dr Lachlan Rash
Completed supervision
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2023
Doctor Philosophy
Multimodal MRI to monitor disease and treatment in a chronic-progressive EAE mouse model of multiple sclerosis
Associate Advisor
Other advisors: Dr Gary Cowin, Dr Nyoman Kurniawan
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2019
Doctor Philosophy
Insight into the Pathobiology of Breast Cancer Induced Bone Pain in a Rat Model
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
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