Overview
Background
Professor Roger Wepf is the Director of the Centre for Microscopy and Microanalysis (CMM) and leads the UQ node of Microscopy Australia. His career spans decades at the forefront of high-resolution imaging in electron microscopy, structural biology, and advanced analytical workflows of material science, with previous leadership roles at ETH Zurich and in the EMBL Heidelberg Physical Instrumentation R&D group. At UQ, he has driven the development of multimodal and correlative microscopy approaches, integrating light microscopy, electron microscopy, X-ray fluorescence microscopy, imaging mass spectrometry and advanced data management. Professor Wepf has been instrumental in developing cryo sample preparation tools and correlative workflows that are now used globally and marketed by well-known suppliers in the electron microscopy field. He also established with NewSpec/Hitachi the Inspire outreach program in QLD, delivering a desktop SEM to local schools to train the next generation of curious scientific minds. He has played a key role in building NRICH’s capabilities for large-scale mineral, biological, and materials characterisation, combining state-of-the-art instrumentation with innovative workflows and data integration pipelines that adhere to FAIR/FAIR-CARE principles.
Professor Wepf’s research bridges academic and industry needs, from localisation of biomolecules at the nanoscale to the characterisation of beam- and environment-sensitive materials critical for quantum technologies, catalysis, and battery development. His leadership has fostered partnerships with global instrumentation companies and industry collaborators to co-develop new imaging hardware, detectors, and workflows. He is a founding member of two scientific journals, most recently Methods in Microscopy with De Gruyter, a community-focused open access journal advancing method development and dissemination in the microscopy field. He has also initiated strategic programs such as the Pitschi data repository and multimodal segmentation projects, enabling the Australian research community to manage, share, and analyse large datasets at scale. Professor Wepf’s commitment to mentoring and training ensures that the next generation of scientists are skilled in applying advanced microscopy to solve problems in energy, health, minerals, and materials science. He also established with NewSpec/ Hitachi the Inpsire outreach program in QLD delivering a desktop SEM to local schools to train next generation of curious scientific minds
Availability
- Professor Roger Wepf is:
- Available for supervision
Qualifications
- Doctoral Diploma of Science (Advanced), Swiss Federal Institute of Technology ETH Zürich
Works
Search Professor Roger Wepf’s works on UQ eSpace
2003
Conference Publication
Functional states in cellular nano-morphology: From life-like sampling to 3-D reconstruction and interpretation
Hohenberg, Heinz, Dimmeler, Eva and Wepf, Roger (2003). Functional states in cellular nano-morphology: From life-like sampling to 3-D reconstruction and interpretation.
2003
Conference Publication
TEM and Cryo-SEM of colloidal systems: A flexible combination of cryo-preparation techniques leads to optimal results
Wiesner, S., Biel, S. S., Wittern, K. P., Hintze, U., Wepf, R. and Beiersdorf, A. G. (2003). TEM and Cryo-SEM of colloidal systems: A flexible combination of cryo-preparation techniques leads to optimal results.
2003
Conference Publication
From tissue to cellular ultrastructure: Closing the gap between micro- and nanostructural imaging
Biel, Stefan S., Kawaschinski, K., Wittern, K. P., Hintze, U. and Wepf, R. (2003). From tissue to cellular ultrastructure: Closing the gap between micro- and nanostructural imaging. doi: 10.1046/j.1365-2818.2003.01227.x
2003
Conference Publication
No compromise in correlative microscopy: One sample, one preparation protocol for CLSM and TEM
Biel, S. S., Kawaschinski, K., Wittern, K. P., Hintze, U. and Wepf, R. (2003). No compromise in correlative microscopy: One sample, one preparation protocol for CLSM and TEM.
2003
Conference Publication
Cryopreparation of skin samples: A comparison between ultrathin cryosections and resin embedded sections of human skin
Wepf, Roger, Pfeiffer, Stephan, Richter, Tobias, Dunckelmann, Katja, Biel, Stefan and Wittern, K. P. (2003). Cryopreparation of skin samples: A comparison between ultrathin cryosections and resin embedded sections of human skin.
2003
Conference Publication
Frozen hydrated bloc-face investigation of tissue for Cryo SEM
Richter, T., Sattler, M., Wiesendanger, R., Wittern, K. P. and Wepf, R. (2003). Frozen hydrated bloc-face investigation of tissue for Cryo SEM.
2003
Conference Publication
A cryogenic scanning force microscope for the characterization of frozen biological samples
Müller, J. H., Schwarz, U. D., Wepf, R. and Wiesendanger, R. (2003). A cryogenic scanning force microscope for the characterization of frozen biological samples. doi: 10.1007/s00339-002-1971-x
2002
Conference Publication
Distribution of sunscreens on skin
Schulz, Jens, Hohenberg, H., Pflücker, F., Gärtner, E., Will, T., Pfeiffer, S., Wepf, R., Wendel, V., Gers-Barlag, H. and Wittern, K. P. (2002). Distribution of sunscreens on skin. doi: 10.1016/S0169-409X(02)00120-5
2002
Journal Article
Erratum: Hydration dynamics of human fingernails: An ellipsometric study (Physical Review E (2002) 65 (061913))
Schulz, B., Chan, D., Bäckström, J., Rübhausen, M., Wittern, K. P., Wessel, S., Wepf, R. and Williams, S. (2002). Erratum: Hydration dynamics of human fingernails: An ellipsometric study (Physical Review E (2002) 65 (061913)). Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 66 (2) 029901. doi: 10.1103/PhysRevE.66.029901
2002
Journal Article
Hydration dynamics of human fingernails: An ellipsometric study
Schulz, B., Chan, D., Bäckström, J., Rübhausen, M., Wittern, K. P., Wessel, S., Wepf, R. and Williams, S. (2002). Hydration dynamics of human fingernails: An ellipsometric study. Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, 65 (6) doi: 10.1103/PhysRevE.65.061913
2001
Journal Article
The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide
Pflücker, F., Wendel, Volker, Hohenberg, H., Gärtner, E., Will, T., Pfeiffer, S., Wepf, R. and Gers-Barlag, H. (2001). The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. Skin Pharmacology and Applied Skin Physiology, 14 (SUPPL. 1), 92-97. doi: 10.1159/000056396
2001
Journal Article
Investigation of the swelling of human skin cells in liquid media by tapping mode scanning force microscopy
Richter, T., Müller, J. H., Schwarz, U. D., Wepf, R. and Wiesendanger, R. (2001). Investigation of the swelling of human skin cells in liquid media by tapping mode scanning force microscopy. Applied Physics A: Materials Science and Processing, 72 (7), S125-S128. doi: 10.1007/s003390100750
2001
Journal Article
Structure and assembly of intracellular mature vaccinia virus: isolated-particle analysis
Griffiths, G., Wepf, R., Wendt, T., Krijnse Locker, J. K., Cyrklaff, M. and Roos, N. (2001). Structure and assembly of intracellular mature vaccinia virus: isolated-particle analysis. Journal of Virology, 75 (22), 11034-11055. doi: 10.1128/JVI.75.22.11034-11055.2001
2001
Journal Article
Mouse anti-ceramide antiserum: A specific tool for the detection of endogenous ceramide
Vielhaber, Gabriele, Brade, Lore, Lindner, Buko, Pfeiffer, Stephan, Wepf, Roger, Hintze, Ulrich, Wittern, Klaus-Peter and Brade, Helmut (2001). Mouse anti-ceramide antiserum: A specific tool for the detection of endogenous ceramide. Glycobiology, 11 (6), 451-457. doi: 10.1093/glycob/11.6.451
2001
Journal Article
Localization of ceramide and glucosylceramide in human epidermis by immunogold electron microscopy
Vielhaber, Gabriele, Pfeiffer, Stephan, Brade, Lore, Lindner, Buko, Goldmann, Torsten, Vollmer, Ekkehard, Hintze, Ulrich, Wittern, Klaus-Peter and Wepf, Roger (2001). Localization of ceramide and glucosylceramide in human epidermis by immunogold electron microscopy. Journal of Investigative Dermatology, 117 (5), 1126-1136. doi: 10.1046/j.0022-202X.2001.01527.x
2000
Journal Article
Penetration pathways of fluorescent dyes in human hair fibres investigated by scanning near-field optical microscopy
Kelch, A., Wessel, S., Will, T., Hintze, U., Wepf, R. and Wiesendanger, R. (2000). Penetration pathways of fluorescent dyes in human hair fibres investigated by scanning near-field optical microscopy. Journal of Microscopy, 200 (3), 179-186. doi: 10.1046/j.1365-2818.2000.00756.x
2000
Journal Article
Entry of the two infectious forms of vaccinia virus at the plasma membane is signaling-dependent for the IMV but not the EEV
Locker, Jacomine Krijnse, Kuehn, Annett, Schleich, Sibylle, Rutter, Gaby, Hohenberg, Heinrich, Wepf, Roger and Griffiths, Gareth (2000). Entry of the two infectious forms of vaccinia virus at the plasma membane is signaling-dependent for the IMV but not the EEV. Molecular Biology of the Cell, 11 (7), 2497-2511. doi: 10.1091/mbc.11.7.2497
2000
Journal Article
High-pressure freezing provides new information on human epidermis: Simultaneous protein antigen and lamellar lipid structure preservation. Study on human epidermis by cryoimmobilization
Pfeiffer, Stephan, Vielhaber, Gabriele, Vietzke, Jens-Peter, Wittern, Klaus-Peter, Hintze, Ulrich and Wepf, Roger (2000). High-pressure freezing provides new information on human epidermis: Simultaneous protein antigen and lamellar lipid structure preservation. Study on human epidermis by cryoimmobilization. Journal of Investigative Dermatology, 114 (5), 1030-1038. doi: 10.1046/j.1523-1747.2000.00966.x
1999
Journal Article
The outermost stratum corneum layer is an effective barrier against dermal uptake of topically applied micronized titanium dioxide
Pflücker, F., Hohenberg, H., Hölzle, E., Will, T., Pfeiffer, S., Wepf, R., Diembeck, W., Wenck, H. and Gers-Barlag, H. (1999). The outermost stratum corneum layer is an effective barrier against dermal uptake of topically applied micronized titanium dioxide. International Journal of Cosmetic Science, 21 (6), 399-411. doi: 10.1023/A:1005450606035
1999
Journal Article
Quantification of total calcium in terminal cisternae of skinned muscle fibers by imaging electron energy-loss spectroscopy
Stegmann, Heiko, Wepf, Roger, Schröder, Rasmus R. and Fink, Rainer H.A. (1999). Quantification of total calcium in terminal cisternae of skinned muscle fibers by imaging electron energy-loss spectroscopy. Journal of Muscle Research and Cell Motility, 20 (5-6), 505-515. doi: 10.1023/A:1005522912044
Funding
Current funding
Supervision
Availability
- Professor Roger Wepf is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of topical delivery system (TDS): Role of intrinsic and extrinsic factors on performance
Associate Advisor
Other advisors: Associate Professor Yousuf Mohammed
Media
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