
Overview
Background
Professor Roger Wepf is the Director of the Centre for Microscopy and Microanalysis (CMM) and leads the UQ node of Microscopy Australia. His career spans decades at the forefront of high-resolution imaging in electron microscopy, structural biology, and advanced analytical workflows of material science, with previous leadership roles at ETH Zurich and in the EMBL Heidelberg Physical Instrumentation R&D group. At UQ, he has driven the development of multimodal and correlative microscopy approaches, integrating light microscopy, electron microscopy, X-ray fluorescence microscopy, imaging mass spectrometry and advanced data management. Professor Wepf has been instrumental in developing cryo sample preparation tools and correlative workflows that are now used globally and marketed by well-known suppliers in the electron microscopy field. He also established with NewSpec/Hitachi the Inspire outreach program in QLD, delivering a desktop SEM to local schools to train the next generation of curious scientific minds. He has played a key role in building NRICH’s capabilities for large-scale mineral, biological, and materials characterisation, combining state-of-the-art instrumentation with innovative workflows and data integration pipelines that adhere to FAIR/FAIR-CARE principles.
Professor Wepf’s research bridges academic and industry needs, from localisation of biomolecules at the nanoscale to the characterisation of beam- and environment-sensitive materials critical for quantum technologies, catalysis, and battery development. His leadership has fostered partnerships with global instrumentation companies and industry collaborators to co-develop new imaging hardware, detectors, and workflows. He is a founding member of two scientific journals, most recently Methods in Microscopy with De Gruyter, a community-focused open access journal advancing method development and dissemination in the microscopy field. He has also initiated strategic programs such as the Pitschi data repository and multimodal segmentation projects, enabling the Australian research community to manage, share, and analyse large datasets at scale. Professor Wepf’s commitment to mentoring and training ensures that the next generation of scientists are skilled in applying advanced microscopy to solve problems in energy, health, minerals, and materials science. He also established with NewSpec/ Hitachi the Inpsire outreach program in QLD delivering a desktop SEM to local schools to train next generation of curious scientific minds
Availability
- Professor Roger Wepf is:
- Available for supervision
Qualifications
- Doctoral Diploma of Science (Advanced), Swiss Federal Institute of Technology ETH Zürich
Works
Search Professor Roger Wepf’s works on UQ eSpace
2017
Journal Article
OMNY PIN-A versatile sample holder for tomographic measurements at room and cryogenic temperatures
Holler, M., Raabe, J., Wepf, R., Shahmoradian, S. H., Diaz, A., Sarafimov, B., Lachat, T., Walther, H. and Vitins, M. (2017). OMNY PIN-A versatile sample holder for tomographic measurements at room and cryogenic temperatures. Review of Scientific Instruments, 88 (11) 113701, 113701. doi: 10.1063/1.4996092
2017
Journal Article
Correlation of live-cell imaging with volume scanning electron microscopy
Lucas, Miriam S., Gunthert, Maja, Bittermann, Anne Greet, de Marco, Alex and Wepf, Roger (2017). Correlation of live-cell imaging with volume scanning electron microscopy. Methods in Cell Biology, 140, 123-148. doi: 10.1016/bs.mcb.2017.03.001
2017
Journal Article
Direct observation of individual hydrogen atoms at trapping sites in a ferritic steel
Chen, Y. -S., Haley, D., Gerstl, S. S. A., London, A. J., Sweeney, F., Wepf, R. A., Rainforth, W. M., Bagot, P. A. J. and Moody, M. P. (2017). Direct observation of individual hydrogen atoms at trapping sites in a ferritic steel. Science, 355 (6330), 1196-1199. doi: 10.1126/science.aal2418
2016
Journal Article
A versatile high-vacuum cryo-transfer system for cryo-microscopy and analytics
Tacke, Sebastian, Krzyzanek, Vladislav, Nüsse, Harald, Wepf, Roger Albert, Klingauf, Jürgen and Reichelt, Rudolf (2016). A versatile high-vacuum cryo-transfer system for cryo-microscopy and analytics. Biophysical Journal, 110 (4), 758-765. doi: 10.1016/j.bpj.2016.01.024
2016
Journal Article
Errata to Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography [J. Struct. Biol. 192, (2015), 461-469] Doi:/10.1016/j.jsb.2015.12.003
Diaz, Ana, Malkova, Barbora, Holler, Mirko, Guizar-Sicairos, Manuel, Lima, Enju, Panneels, Valerie, Pigino, Gaia, Bittermann, Anne Greet, Wettstein, Larissa, Tomizaki, Takashi, Bunk, Oliver, Schertler, Gebhard, Ishikawa, Takashi, Wepf, Roger and Menzel, Andreas (2016). Errata to Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography [J. Struct. Biol. 192, (2015), 461-469] Doi:/10.1016/j.jsb.2015.12.003. Journal of Structural Biology, 193 (1), 83-83. doi: 10.1016/j.jsb.2015.12.003
2015
Journal Article
Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography
Diaz, Ana, Malkova, Barbora, Holler, Mirko, Guizar-Sicairos, Manuel, Lima, Enju, Panneels, Valerie, Pigino, Gaia, Bittermann, Anne Greet, Wettstein, Larissa, Tomizaki, Takashi, Bunk, Oliver, Schertler, Gebhard, Ishikawa, Takashi, Wepf, Roger and Menzel, Andreas (2015). Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography. Journal of Structural Biology, 192 (3), 461-469. doi: 10.1016/j.jsb.2015.10.008
2015
Journal Article
The ultrastructure of fibronectin fibers pulled from a protein monolayer at the air-liquid interface and the mechanism of the sheet-to-fiber transition
Mitsi, Maria, Handschin, Stephan, Gerber, Isabel, Schwartländer, Ruth, Klotzsch, Enrico, Wepf, Roger and Vogel, Viola (2015). The ultrastructure of fibronectin fibers pulled from a protein monolayer at the air-liquid interface and the mechanism of the sheet-to-fiber transition. Biomaterials, 36, 66-79. doi: 10.1016/j.biomaterials.2014.08.012
2014
Journal Article
Macromolecular 3D SEM reconstruction strategies: signal to noise ratio and resolution
Woodward, J. D. and Wepf, R. A. (2014). Macromolecular 3D SEM reconstruction strategies: signal to noise ratio and resolution. Ultramicroscopy, 144, 43-49. doi: 10.1016/j.ultramic.2014.04.009
2014
Book Chapter
Correlative 3D imaging: CLSM and FIB-SEM tomography using high-pressure frozen, freeze-substituted biological samples
Lucas, Miriam S., Guenthert, Maja, Gasser, Philippe, Lucas, Falk and Wepf, Roger (2014). Correlative 3D imaging: CLSM and FIB-SEM tomography using high-pressure frozen, freeze-substituted biological samples. Electron microscopy: methods and protocols. (pp. 593-616) edited by John Kuo. Totowa, NJ, USA: Humana Press. doi: 10.1007/978-1-62703-776-1_26
2013
Journal Article
Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage
Schaer, C. A., Deuel, J. W., Bittermann, A. G., Rubio, I. G., Schoedon, G., Spahn, D. R., Wepf, R. A., Vallelian, F. and Schaer, D. J. (2013). Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage. Cell Death and Differentiation, 20 (11), 1569-1579. doi: 10.1038/cdd.2013.113
2013
Journal Article
Phase-contrast imaging in aberration-corrected scanning transmission electron microscopy
Krumeich, F., Müller, E. and Wepf, R. A. (2013). Phase-contrast imaging in aberration-corrected scanning transmission electron microscopy. Micron, 49, 1-14. doi: 10.1016/j.micron.2013.03.006
2013
Journal Article
Three-dimensional pore structure and ion conductivity of porous ceramic diaphragms
Wiedenmann, Daniel, Keller, Lukas, Holzer, Lorenz, Stojadinović, Jelena, Münch, Beat, Suarez, Laura, Fumey, Benjamin, Hagendorfer, Harald, Brönnimann, Rolf, Modregger, Peter, Gorbar, Michal, Vogt, Ulrich F., Züttel, Andreas, Mantia, Fabio La, Wepf, Roger and Grobéty, Bernard (2013). Three-dimensional pore structure and ion conductivity of porous ceramic diaphragms. AIChE Journal, 59 (5), 1446-1457. doi: 10.1002/aic.14094
2013
Journal Article
Simultaneous correlative scanning electron and high-NA fluorescence microscopy
Liv, Nalan, Zonnevylle, A. Christiaan, Narvaez, Angela C., Effting, Andries P. J., Voorneveld, Philip W., Lucas, Miriam S., Hardwick, James C., Wepf, Roger A., Kruit, Pieter and Hoogenboom, Jacob P. (2013). Simultaneous correlative scanning electron and high-NA fluorescence microscopy. PLoS ONE, 8 (2) e55707, e55707. doi: 10.1371/journal.pone.0055707
2013
Journal Article
Freezing continuous-flow self-Assembly in a microfluidic device: toward imaging of liposome formation
Jahn, Andreas, Lucas, Falk, Wepf, Roger A. and Dittrich, Petra S. (2013). Freezing continuous-flow self-Assembly in a microfluidic device: toward imaging of liposome formation. Langmuir, 29 (5), 1717-1723. doi: 10.1021/la303675g
2012
Journal Article
The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility
Seuring, Carolin, Greenwald, Jason, Wasmer, Christian, Wepf, Roger, Saupe, Sven J., Meier, Beat H. and Riek, Roland (2012). The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility. PLoS Biology, 10 (12) e1001451, e1001451. doi: 10.1371/journal.pbio.1001451
2012
Journal Article
The structure of dodecagonal (Ta,V) 1.6Te imaged by phase-contrast scanning transmission electron microscopy
Krumeich, F., Müller, E., Wepf, R. A., Conrad, M., Reich, C., Harbrecht, B. and Nesper, R. (2012). The structure of dodecagonal (Ta,V) 1.6Te imaged by phase-contrast scanning transmission electron microscopy. Journal of Solid State Chemistry, 194, 106-112. doi: 10.1016/j.jssc.2012.04.050
2012
Journal Article
The stratum corneum: New insights into the morphological and molecular structures
Schröter, Annett, Engelbrecht, Tanja, Wepf, Roger Albert and Neubert, Reinhard H.H. (2012). The stratum corneum: New insights into the morphological and molecular structures. PZ Prisma, 19 (3), 163-170.
2012
Journal Article
Bridging microscopes: 3D correlative light and scanning electron microscopy of complex biological structures
Lucas, Miriam S., Günthert, Maja, Gasser, Philippe, Lucas, Falk and Wepf, Roger (2012). Bridging microscopes: 3D correlative light and scanning electron microscopy of complex biological structures. Methods in Cell Biology, 111, 325-356. doi: 10.1016/B978-0-12-416026-2.00017-0
2011
Journal Article
Phase tomography from x-ray coherent diffractive imaging projections
Guizar-Sicairos, Manuel, Diaz, Ana, Holler, Mirko, Lucas, Miriam S., Menzel, Andreas, Wepf, Roger A. and Bunk, Oliver (2011). Phase tomography from x-ray coherent diffractive imaging projections. Optics Express, 19 (22), 21345-21357. doi: 10.1364/OE.19.021345
2011
Journal Article
Height and width of adsorbed dendronized polymers: electron and atomic force microscopy of homologous series
Zhang, Baozhong, Wepf, Roger, Kröger, Martin, Halperin, Avraham and Schlüter, A. Dieter (2011). Height and width of adsorbed dendronized polymers: electron and atomic force microscopy of homologous series. Macromolecules, 44 (17), 6785-6792. doi: 10.1021/ma2014707
Funding
Current funding
Supervision
Availability
- Professor Roger Wepf is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Development of topical delivery system (TDS): Role of intrinsic and extrinsic factors on performance
Associate Advisor
Other advisors: Associate Professor Yousuf Mohammed
Media
Enquiries
For media enquiries about Professor Roger Wepf's areas of expertise, story ideas and help finding experts, contact our Media team: