Overview
Background
Professor Roger Wepf is the Director of the Centre for Microscopy and Microanalysis (CMM) and leads the UQ node of Microscopy Australia. His career spans decades at the forefront of high-resolution imaging in electron microscopy, structural biology, and advanced analytical workflows of material science, with previous leadership roles at ETH Zurich and in the EMBL Heidelberg Physical Instrumentation R&D group. At UQ, he has driven the development of multimodal and correlative microscopy approaches, integrating light microscopy, electron microscopy, X-ray fluorescence microscopy, imaging mass spectrometry and advanced data management. Professor Wepf has been instrumental in developing cryo sample preparation tools and correlative workflows that are now used globally and marketed by well-known suppliers in the electron microscopy field. He also established with NewSpec/Hitachi the Inspire outreach program in QLD, delivering a desktop SEM to local schools to train the next generation of curious scientific minds. He has played a key role in building NRICH’s capabilities for large-scale mineral, biological, and materials characterisation, combining state-of-the-art instrumentation with innovative workflows and data integration pipelines that adhere to FAIR/FAIR-CARE principles.
Professor Wepf’s research bridges academic and industry needs, from localisation of biomolecules at the nanoscale to the characterisation of beam- and environment-sensitive materials critical for quantum technologies, catalysis, and battery development. His leadership has fostered partnerships with global instrumentation companies and industry collaborators to co-develop new imaging hardware, detectors, and workflows. He is a founding member of two scientific journals, most recently Methods in Microscopy with De Gruyter, a community-focused open access journal advancing method development and dissemination in the microscopy field. He has also initiated strategic programs such as the Pitschi data repository and multimodal segmentation projects, enabling the Australian research community to manage, share, and analyse large datasets at scale. Professor Wepf’s commitment to mentoring and training ensures that the next generation of scientists are skilled in applying advanced microscopy to solve problems in energy, health, minerals, and materials science. He also established with NewSpec/ Hitachi the Inpsire outreach program in QLD delivering a desktop SEM to local schools to train next generation of curious scientific minds
Availability
- Professor Roger Wepf is:
- Available for supervision
Qualifications
- Doctoral Diploma of Science (Advanced), Swiss Federal Institute of Technology ETH Zürich
Works
Search Professor Roger Wepf’s works on UQ eSpace
2007
Journal Article
Nanoparticles - An efficient carrier for drug delivery into the hair follicles
Lademann, Juergen, Richter, Heike, Teichmann, Alexa, Otberg, Nina, Blume-Peytavi, Ulrike, Luengo, Javiana, Weiß, Barbara, Schaefer, Ulrich F., Lehr, Claus-Michael, Wepf, Roger and Sterry, Wolfram (2007). Nanoparticles - An efficient carrier for drug delivery into the hair follicles. European Journal of Pharmaceutics and Biopharmaceutics, 66 (2), 159-164. doi: 10.1016/j.ejpb.2006.10.019
2007
Journal Article
Stratum corneum: Structure and morphology of a highly efficient barrier Stratum corneum: Struktur und morphologie einer hoch effizienten barriere
Wepf, Roger and Neubert, Reinhard H. H. (2007). Stratum corneum: Structure and morphology of a highly efficient barrier Stratum corneum: Struktur und morphologie einer hoch effizienten barriere. Pharmazeutische Zeitung, 152 (17), 14-21.
2007
Journal Article
Pros and cons: cryo-electron microscopic evaluation of block faces versus cryo-sections from frozen-hydrated skin specimens prepared by different techniques
Richter, T., Biel, S. S., Sattler, M., Wenck, H., Wittern, K. P., Wiesendanger, R. and Wepf, R. (2007). Pros and cons: cryo-electron microscopic evaluation of block faces versus cryo-sections from frozen-hydrated skin specimens prepared by different techniques. Journal of Microscopy, 225 (2), 201-207. doi: 10.1111/j.1365-2818.2007.01732.x
2006
Conference Publication
Improved native tissue ultrastructure investigations by high pressure freezing and cryo-SEM
Kaech, A., Gross, H. and Wepf, R. (2006). Improved native tissue ultrastructure investigations by high pressure freezing and cryo-SEM. doi: 10.1017/S1431927606062908
2006
Conference Publication
Skin imaged by femtosecond laser irradition: A risk assessment for in vivo applications
Fischer, F., Volkmer, B., Puschmann, S., Greinert, R., Breitbart, W., Kiefer, J. and Wepf, R. (2006). Skin imaged by femtosecond laser irradition: A risk assessment for in vivo applications. doi: 10.1117/12.662600
2006
Conference Publication
Skin Pharmacology and Physiology: Editorial
Lademann, Jürgen, Wepf, Roger and Fluhr, Joachim (2006). Skin Pharmacology and Physiology: Editorial. doi: 10.1159/000091970
2006
Journal Article
Investigation of differences in follicular penetration of particle-and nonparticle-containing emulsions by laser scanning microscopy
Ossadnik, M., Richter, H., Teichmann, A., Koch, S., Schäfer, U., Wepf, R., Sterry, W. and Lademann, J. (2006). Investigation of differences in follicular penetration of particle-and nonparticle-containing emulsions by laser scanning microscopy. Laser Physics, 16 (5), 747-750. doi: 10.1134/S1054660X06050033
2006
Book Chapter
Confocal microscopy of skin in vitro and ex vivo
Biel, Stefan S., Wepf, Roger and Wessel, Sonja (2006). Confocal microscopy of skin in vitro and ex vivo. Bioengineering of the Skin: Skin Imaging and Analysis. (pp. 149-164) CRC Press.
2006
Book Chapter
Multimodal imaging of skin structures: Imagining imaging of the skin
Wepf, Roger, Richter, Tobias, Biel, Stefan S., Schlüter, Holger, Fischer, Frank, Wittern, Klaus-Peter and Hohenberg, Heinrich (2006). Multimodal imaging of skin structures: Imagining imaging of the skin. Bioengineering of the Skin: Skin Imaging and Analysis. (pp. 51-69) CRC Press.
2006
Journal Article
Structural investigations of human hairs by spectrally resolved ellipsometry
Chan, Danny, Schulz, Benjamin, Rübhausen, Michael, Wessel, Sonja and Wepf, Roger (2006). Structural investigations of human hairs by spectrally resolved ellipsometry. Journal of Biomedical Optics, 11 (1) 014029, 014029. doi: 10.1117/1.2162848
2005
Journal Article
Are sweat glands an alternate penetration pathway? Understanding the morphological complexity of the axillary sweat gland apparatus
Wilke, K., Wepf, R., Keil, F. J., Wittern, K. P., Wenck, H. and Biel, S. S. (2005). Are sweat glands an alternate penetration pathway? Understanding the morphological complexity of the axillary sweat gland apparatus. Skin Pharmacology and Physiology, 19 (1), 38-49. doi: 10.1159/000089142
2005
Journal Article
Noninvasive measurement of cell volume changes by negative staining
Droste, Miriam S., Biel, Stefan S., Terstegen, Lara, Wittern, Klaus-Peter, Wenck, Horst and Wepf, Roger (2005). Noninvasive measurement of cell volume changes by negative staining. Journal of Biomedical Optics, 10 (6) 064017, 064017. doi: 10.1117/1.2138011
2004
Conference Publication
Characterization of multiphoton laser scanning device optical parameters for image restoration
Fischer, Frank, König, K., Puschmann, S., Wepf, R., Riemann, L., Ulrich, V. and Fischer, P. (2004). Characterization of multiphoton laser scanning device optical parameters for image restoration. doi: 10.1117/12.545604
2004
Journal Article
Dead but highly dynamic - The stratum corneum is divided into three hydration zones
Richter, T., Peuckert, C., Sattler, M., Koenig, K., Riemann, I., Hintze, U., Wittern, K. P., Wiesendanger, R. and Wepf, R. (2004). Dead but highly dynamic - The stratum corneum is divided into three hydration zones. Skin Pharmacology and Physiology, 17 (5), 246-257. doi: 10.1159/000080218
2004
Conference Publication
Improvements for HR- and Cryo-SEM by the VCT 100 high-vacuum cryo transfer system and SEM cooling stage
Wepf, R., Richter, T., Sattler, M. and Kaech, A. (2004). Improvements for HR- and Cryo-SEM by the VCT 100 high-vacuum cryo transfer system and SEM cooling stage. doi: 10.1017/S1431927604887713
2004
Journal Article
Sealing the live part of the skin: The integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis
Schlüter, Holger, Wepf, Roger, Moll, Ingrid and Franke, Werner W. (2004). Sealing the live part of the skin: The integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis. European Journal of Cell Biology, 83 (11-12), 655-665. doi: 10.1078/0171-9335-00434
2003
Conference Publication
Combining histological and ultrastructural description of high-pressure frozen skin samples by correlative CLSM and TEM
Biel, S. S., Kawaschinski, K., Wittern, K. P., Hintze, U. and Wepf, R. (2003). Combining histological and ultrastructural description of high-pressure frozen skin samples by correlative CLSM and TEM.
2003
Conference Publication
Topographic measurements of real structures in reflection Confocal Laser Scanning Microscope (CLSM)
Wessel, S., Pagel, S., Ritter, M., Hohenberg, H. and Wepf, R. (2003). Topographic measurements of real structures in reflection Confocal Laser Scanning Microscope (CLSM).
2003
Conference Publication
Functional states in cellular nano-morphology: From life-like sampling to 3-D reconstruction and interpretation
Hohenberg, Heinz, Dimmeler, Eva and Wepf, Roger (2003). Functional states in cellular nano-morphology: From life-like sampling to 3-D reconstruction and interpretation.
2003
Conference Publication
TEM and Cryo-SEM of colloidal systems: A flexible combination of cryo-preparation techniques leads to optimal results
Wiesner, S., Biel, S. S., Wittern, K. P., Hintze, U., Wepf, R. and Beiersdorf, A. G. (2003). TEM and Cryo-SEM of colloidal systems: A flexible combination of cryo-preparation techniques leads to optimal results.
Funding
Current funding
Supervision
Availability
- Professor Roger Wepf is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of topical delivery system (TDS): Role of intrinsic and extrinsic factors on performance
Associate Advisor
Other advisors: Associate Professor Yousuf Mohammed
Media
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