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Professor Roger Wepf
Professor

Roger Wepf

Email: 
Phone: 
+61 7 334 63966

Overview

Background

Professor Roger Wepf is the Director of the Centre for Microscopy and Microanalysis (CMM) and leads the UQ node of Microscopy Australia. His career spans decades at the forefront of high-resolution imaging in electron microscopy, structural biology, and advanced analytical workflows of material science, with previous leadership roles at ETH Zurich and in the EMBL Heidelberg Physical Instrumentation R&D group. At UQ, he has driven the development of multimodal and correlative microscopy approaches, integrating light microscopy, electron microscopy, X-ray fluorescence microscopy, imaging mass spectrometry and advanced data management. Professor Wepf has been instrumental in developing cryo sample preparation tools and correlative workflows that are now used globally and marketed by well-known suppliers in the electron microscopy field. He also established with NewSpec/Hitachi the Inspire outreach program in QLD, delivering a desktop SEM to local schools to train the next generation of curious scientific minds. He has played a key role in building NRICH’s capabilities for large-scale mineral, biological, and materials characterisation, combining state-of-the-art instrumentation with innovative workflows and data integration pipelines that adhere to FAIR/FAIR-CARE principles.

Professor Wepf’s research bridges academic and industry needs, from localisation of biomolecules at the nanoscale to the characterisation of beam- and environment-sensitive materials critical for quantum technologies, catalysis, and battery development. His leadership has fostered partnerships with global instrumentation companies and industry collaborators to co-develop new imaging hardware, detectors, and workflows. He is a founding member of two scientific journals, most recently Methods in Microscopy with De Gruyter, a community-focused open access journal advancing method development and dissemination in the microscopy field. He has also initiated strategic programs such as the Pitschi data repository and multimodal segmentation projects, enabling the Australian research community to manage, share, and analyse large datasets at scale. Professor Wepf’s commitment to mentoring and training ensures that the next generation of scientists are skilled in applying advanced microscopy to solve problems in energy, health, minerals, and materials science. He also established with NewSpec/ Hitachi the Inpsire outreach program in QLD delivering a desktop SEM to local schools to train next generation of curious scientific minds

Availability

Professor Roger Wepf is:
Available for supervision

Qualifications

  • Doctoral Diploma of Science (Advanced), Swiss Federal Institute of Technology ETH Zürich

Works

Search Professor Roger Wepf’s works on UQ eSpace

111 works between 1989 and 2025

61 - 80 of 111 works

2007

Journal Article

Nanoparticles - An efficient carrier for drug delivery into the hair follicles

Lademann, Juergen, Richter, Heike, Teichmann, Alexa, Otberg, Nina, Blume-Peytavi, Ulrike, Luengo, Javiana, Weiß, Barbara, Schaefer, Ulrich F., Lehr, Claus-Michael, Wepf, Roger and Sterry, Wolfram (2007). Nanoparticles - An efficient carrier for drug delivery into the hair follicles. European Journal of Pharmaceutics and Biopharmaceutics, 66 (2), 159-164. doi: 10.1016/j.ejpb.2006.10.019

Nanoparticles - An efficient carrier for drug delivery into the hair follicles

2007

Journal Article

Stratum corneum: Structure and morphology of a highly efficient barrier Stratum corneum: Struktur und morphologie einer hoch effizienten barriere

Wepf, Roger and Neubert, Reinhard H. H. (2007). Stratum corneum: Structure and morphology of a highly efficient barrier Stratum corneum: Struktur und morphologie einer hoch effizienten barriere. Pharmazeutische Zeitung, 152 (17), 14-21.

Stratum corneum: Structure and morphology of a highly efficient barrier Stratum corneum: Struktur und morphologie einer hoch effizienten barriere

2007

Journal Article

Pros and cons: cryo-electron microscopic evaluation of block faces versus cryo-sections from frozen-hydrated skin specimens prepared by different techniques

Richter, T., Biel, S. S., Sattler, M., Wenck, H., Wittern, K. P., Wiesendanger, R. and Wepf, R. (2007). Pros and cons: cryo-electron microscopic evaluation of block faces versus cryo-sections from frozen-hydrated skin specimens prepared by different techniques. Journal of Microscopy, 225 (2), 201-207. doi: 10.1111/j.1365-2818.2007.01732.x

Pros and cons: cryo-electron microscopic evaluation of block faces versus cryo-sections from frozen-hydrated skin specimens prepared by different techniques

2006

Conference Publication

Improved native tissue ultrastructure investigations by high pressure freezing and cryo-SEM

Kaech, A., Gross, H. and Wepf, R. (2006). Improved native tissue ultrastructure investigations by high pressure freezing and cryo-SEM. doi: 10.1017/S1431927606062908

Improved native tissue ultrastructure investigations by high pressure freezing and cryo-SEM

2006

Conference Publication

Skin imaged by femtosecond laser irradition: A risk assessment for in vivo applications

Fischer, F., Volkmer, B., Puschmann, S., Greinert, R., Breitbart, W., Kiefer, J. and Wepf, R. (2006). Skin imaged by femtosecond laser irradition: A risk assessment for in vivo applications. doi: 10.1117/12.662600

Skin imaged by femtosecond laser irradition: A risk assessment for in vivo applications

2006

Conference Publication

Skin Pharmacology and Physiology: Editorial

Lademann, Jürgen, Wepf, Roger and Fluhr, Joachim (2006). Skin Pharmacology and Physiology: Editorial. doi: 10.1159/000091970

Skin Pharmacology and Physiology: Editorial

2006

Journal Article

Investigation of differences in follicular penetration of particle-and nonparticle-containing emulsions by laser scanning microscopy

Ossadnik, M., Richter, H., Teichmann, A., Koch, S., Schäfer, U., Wepf, R., Sterry, W. and Lademann, J. (2006). Investigation of differences in follicular penetration of particle-and nonparticle-containing emulsions by laser scanning microscopy. Laser Physics, 16 (5), 747-750. doi: 10.1134/S1054660X06050033

Investigation of differences in follicular penetration of particle-and nonparticle-containing emulsions by laser scanning microscopy

2006

Book Chapter

Confocal microscopy of skin in vitro and ex vivo

Biel, Stefan S., Wepf, Roger and Wessel, Sonja (2006). Confocal microscopy of skin in vitro and ex vivo. Bioengineering of the Skin: Skin Imaging and Analysis. (pp. 149-164) CRC Press.

Confocal microscopy of skin in vitro and ex vivo

2006

Book Chapter

Multimodal imaging of skin structures: Imagining imaging of the skin

Wepf, Roger, Richter, Tobias, Biel, Stefan S., Schlüter, Holger, Fischer, Frank, Wittern, Klaus-Peter and Hohenberg, Heinrich (2006). Multimodal imaging of skin structures: Imagining imaging of the skin. Bioengineering of the Skin: Skin Imaging and Analysis. (pp. 51-69) CRC Press.

Multimodal imaging of skin structures: Imagining imaging of the skin

2006

Journal Article

Structural investigations of human hairs by spectrally resolved ellipsometry

Chan, Danny, Schulz, Benjamin, Rübhausen, Michael, Wessel, Sonja and Wepf, Roger (2006). Structural investigations of human hairs by spectrally resolved ellipsometry. Journal of Biomedical Optics, 11 (1) 014029, 014029. doi: 10.1117/1.2162848

Structural investigations of human hairs by spectrally resolved ellipsometry

2005

Journal Article

Are sweat glands an alternate penetration pathway? Understanding the morphological complexity of the axillary sweat gland apparatus

Wilke, K., Wepf, R., Keil, F. J., Wittern, K. P., Wenck, H. and Biel, S. S. (2005). Are sweat glands an alternate penetration pathway? Understanding the morphological complexity of the axillary sweat gland apparatus. Skin Pharmacology and Physiology, 19 (1), 38-49. doi: 10.1159/000089142

Are sweat glands an alternate penetration pathway? Understanding the morphological complexity of the axillary sweat gland apparatus

2005

Journal Article

Noninvasive measurement of cell volume changes by negative staining

Droste, Miriam S., Biel, Stefan S., Terstegen, Lara, Wittern, Klaus-Peter, Wenck, Horst and Wepf, Roger (2005). Noninvasive measurement of cell volume changes by negative staining. Journal of Biomedical Optics, 10 (6) 064017, 064017. doi: 10.1117/1.2138011

Noninvasive measurement of cell volume changes by negative staining

2004

Conference Publication

Characterization of multiphoton laser scanning device optical parameters for image restoration

Fischer, Frank, König, K., Puschmann, S., Wepf, R., Riemann, L., Ulrich, V. and Fischer, P. (2004). Characterization of multiphoton laser scanning device optical parameters for image restoration. doi: 10.1117/12.545604

Characterization of multiphoton laser scanning device optical parameters for image restoration

2004

Journal Article

Dead but highly dynamic - The stratum corneum is divided into three hydration zones

Richter, T., Peuckert, C., Sattler, M., Koenig, K., Riemann, I., Hintze, U., Wittern, K. P., Wiesendanger, R. and Wepf, R. (2004). Dead but highly dynamic - The stratum corneum is divided into three hydration zones. Skin Pharmacology and Physiology, 17 (5), 246-257. doi: 10.1159/000080218

Dead but highly dynamic - The stratum corneum is divided into three hydration zones

2004

Conference Publication

Improvements for HR- and Cryo-SEM by the VCT 100 high-vacuum cryo transfer system and SEM cooling stage

Wepf, R., Richter, T., Sattler, M. and Kaech, A. (2004). Improvements for HR- and Cryo-SEM by the VCT 100 high-vacuum cryo transfer system and SEM cooling stage. doi: 10.1017/S1431927604887713

Improvements for HR- and Cryo-SEM by the VCT 100 high-vacuum cryo transfer system and SEM cooling stage

2004

Journal Article

Sealing the live part of the skin: The integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis

Schlüter, Holger, Wepf, Roger, Moll, Ingrid and Franke, Werner W. (2004). Sealing the live part of the skin: The integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis. European Journal of Cell Biology, 83 (11-12), 655-665. doi: 10.1078/0171-9335-00434

Sealing the live part of the skin: The integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis

2003

Conference Publication

Combining histological and ultrastructural description of high-pressure frozen skin samples by correlative CLSM and TEM

Biel, S. S., Kawaschinski, K., Wittern, K. P., Hintze, U. and Wepf, R. (2003). Combining histological and ultrastructural description of high-pressure frozen skin samples by correlative CLSM and TEM.

Combining histological and ultrastructural description of high-pressure frozen skin samples by correlative CLSM and TEM

2003

Conference Publication

Topographic measurements of real structures in reflection Confocal Laser Scanning Microscope (CLSM)

Wessel, S., Pagel, S., Ritter, M., Hohenberg, H. and Wepf, R. (2003). Topographic measurements of real structures in reflection Confocal Laser Scanning Microscope (CLSM).

Topographic measurements of real structures in reflection Confocal Laser Scanning Microscope (CLSM)

2003

Conference Publication

Functional states in cellular nano-morphology: From life-like sampling to 3-D reconstruction and interpretation

Hohenberg, Heinz, Dimmeler, Eva and Wepf, Roger (2003). Functional states in cellular nano-morphology: From life-like sampling to 3-D reconstruction and interpretation.

Functional states in cellular nano-morphology: From life-like sampling to 3-D reconstruction and interpretation

2003

Conference Publication

TEM and Cryo-SEM of colloidal systems: A flexible combination of cryo-preparation techniques leads to optimal results

Wiesner, S., Biel, S. S., Wittern, K. P., Hintze, U., Wepf, R. and Beiersdorf, A. G. (2003). TEM and Cryo-SEM of colloidal systems: A flexible combination of cryo-preparation techniques leads to optimal results.

TEM and Cryo-SEM of colloidal systems: A flexible combination of cryo-preparation techniques leads to optimal results

Funding

Current funding

  • 2024 - 2027
    Structure-guided optimisation of light-driven microalgae cell factories
    ARC Discovery Projects
    Open grant
  • 2023 - 2028
    Microscopy Australia - Australian Microscopy and Microanalysis Research Facility (AMMRF) - NCRIS22 (administered by the University of Sydney)
    University of Sydney
    Open grant

Past funding

  • 2024 - 2025
    Advanced Surface Characterisation for Minerals (RTCM Trailblazer project administered by Curtain University)
    Curtin University
    Open grant
  • 2023 - 2024
    Nanocrystal Electron Diffraction Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2021 - 2023
    A customised triple-beam microscope for precise fabricating/characterising
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2020 - 2024
    CMM Queensland Government NCRIS Co-investment Support 2019-2023 (RICF)
    University of Sydney
    Open grant
  • 2019 - 2020
    A correlative cryo-microscopy suite (ARC LIEF project administered by USYD)
    University of Sydney
    Open grant
  • 2019
    Imaging Mass Spectrometry at Higher Mass Resolution
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2018 - 2020
    The Characterisation Data Enhanced Virtual Laboratory (ANDS NCRIS administered by Monash University)
    Monash University
    Open grant
  • 2018 - 2019
    Automated high resolution & high contrast cryoTEM for 3D structural biology
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2018 - 2019
    Advanced micro-X-ray Fluorescence facility for biological, medical, materials science and geochemistry
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Cryoelectron Microscopy Platform for Cellular Structural Biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Data storage infrastructure
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2013 - 2024
    Australian Microscopy and Microanalysis Research Facility (AMMRF) - NCRIS 2013/2015/2016-17/2017-19/2019-22 (administered by the University of Sydney)
    University of Sydney
    Open grant

Supervision

Availability

Professor Roger Wepf is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Development of topical delivery system (TDS): Role of intrinsic and extrinsic factors on performance

    Associate Advisor

    Other advisors: Associate Professor Yousuf Mohammed

Media

Enquiries

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communications@uq.edu.au