Overview
Background
Dr Ran Wang graduated with her PhD in 2015, and after undertaking a postdoc position in Scripps Research, USA returned to Australia in 2017. She is now a Senior Postdoctoral Researcher supported by the prestigious Bushell Postdoctoral Research Fellowship from the Gastroenterology Society of Australia. Dr Wang is interested to understand the nature of inflammation in gut and lung and investigate the local and systemic impacts of chronic gut inflammation. In addition to a growing track-record in the mucosal immunology field, she is also building an inter-disciplinary research profile in material science and nanotechnology for drug delivery and immune modulation. She is the Associate Editor of Frontier of Cellular and Infection Microbiology Journal since 2018.
Availability
- Dr Ran Wang is:
- Available for supervision
Fields of research
Qualifications
- Masters (Coursework) of Biotechnology, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Ran Wang’s works on UQ eSpace
2016
Conference Publication
971d Colonic microbiota can promote rapid improvement of murine colitis by thioguanine independently of T-lymphocytes and host metabolism
Oancea, Iulia, Das, Indrajit D., de Carcer, Daniel Aguirre, Schreiber, Veronika, Wang, Ran, Sheng, Yong, Movva, Ramya, Cuiv, Paraic O, Duley, John, Begun, Jakob and Florin, Timothy H. (2016). 971d Colonic microbiota can promote rapid improvement of murine colitis by thioguanine independently of T-lymphocytes and host metabolism. Digestive Disease Week 2016, San Diego, CA USA, 21-24 May 2016. Philadelphia, PA USA: Elsevier. doi: 10.1016/s0016-5085(16)30737-5
2016
Journal Article
Metabolism of murine TH17 cells: impact on cell fate and function
Wang, Ran and Solt, Laura A. (2016). Metabolism of murine TH17 cells: impact on cell fate and function. European Journal of Immunology, 46 (4), 807-816. doi: 10.1002/eji.201545788
2016
Conference Publication
Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis
Oancea, I., Das, I., de Carcer, D. Aguirre, Movva, R., Schreiber, V., Yang, Y., Proctor, M., Wang, R., Sheng, Y., Lobb, M., Cuiv, P. O., Duley, J. A., Begun, J. and Florin, T. H. J. (2016). Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis. 11th Congress of ECCO - European Crohn’s and Colitis Organisation, Amsterdam, Netherlands, 16-19 March 2016. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjw019.177
2016
Conference Publication
Unravelling a novel mechanism by which cytokines induce ER stress to halt viral protein synthesis in mucosal epithelial cells
Hasnain, S. Z., Taylor, S., Wang, R., Chen, A., Oancea, I, Das, I, Tong, H., Florin, T., Serisier, D., Coulson, B., Mcauley, J., Lourie, R., Phipps, S. and Mcguckin, M. (2016). Unravelling a novel mechanism by which cytokines induce ER stress to halt viral protein synthesis in mucosal epithelial cells. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200
2016
Conference Publication
MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target
Sheng, Yong H., He, Yaowu, Hasnain, Sumaira Z., Wang, Ran, Tong, Hui, Clarke, Daniel T., Lourie, Rohan, Oancea, Lulia, Wong, Kuanyau, Lumley, John W., Florin, Timothy H., Sutton, Philip, Hooper, John. D., Mcmillan, Nigel A. and Mcguckin, Michael A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target. AACR 107th Annual Meeting on Bioinformatics and Systems Biology, New Orleans, Los Angeles, 16-20 April 2016 . Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2016-3564
2015
Journal Article
Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model
Wang, Ran, Hasnain, Sumaira Z., Tong, Hui, Das, Indrajit, Che-Hao Chen, Alice, Oancea, Iulia, Proctor, Martina, Florin, Timothy H., Eri, Rajaraman D. and McGuckin, Michael A. (2015). Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model. Inflammatory Bowel Diseases, 21 (5), 973-984. doi: 10.1097/MIB.0000000000000353
2015
Other Outputs
Targeting IL-23/TH17 axis in suppressing intestinal inflammation
Wang, Ran (2015). Targeting IL-23/TH17 axis in suppressing intestinal inflammation. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2015.426
2015
Conference Publication
High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease
Gulhane, M., Murray, L., Wang, R., Tong, H., Mcguckin, M. and Hasnain, S. (2015). High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13094
2014
Journal Article
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress
Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonghua H., Ng, Choa Ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014). Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12), 1417-1426. doi: 10.1038/nm.3705
2014
Journal Article
Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice
Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014). Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 (7), 1755-1767. doi: 10.1002/art.38638
2014
Conference Publication
Direct Adverse Effects of IL-23 on Epithelial Cells Underline Greater Efficacy of Neutralizing IL-23 in Suppressing Murine Colitis
Wang, Ran, Hasnain, Sumaira Z., Tong, Hui, Lourie, Rohan, Florin, Timothy H. and McGuckin, Michael A. (2014). Direct Adverse Effects of IL-23 on Epithelial Cells Underline Greater Efficacy of Neutralizing IL-23 in Suppressing Murine Colitis. 55th Annual Meeting of the Society for Surgery of the Alimentary Tract (SSAT) / Digestive Disease Week (DDW), Chicago, Il, United States, May 03-06, 2014. Maryland Heights, MO, United States: W.B. Saunders Co.. doi: 10.1016/S0016-5085(14)62987-5
2013
Journal Article
MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli
Sheng, Y. H., Triyana, S., Wang, R., Das, I., Gerloff, K., Florin, T. H., Sutton, P. and McGuckin, M. A. (2013). MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunology, 6 (3), 557-568. doi: 10.1038/mi.2012.98
2011
Conference Publication
Immunoregulation of Human Myeloid Dendritic Cells and Monocytes by Vascular Endothelial Growth Factor
Sanchez, Washington Yamandu, Jr., Wang, Ran, Wilkinson, Andrew, Khalil, Dalia, Hart, Derek N. J., Catley, Laurence and Vuckovic, Slavica (2011). Immunoregulation of Human Myeloid Dendritic Cells and Monocytes by Vascular Endothelial Growth Factor. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego Ca, Dec 10-13, 2011.
Funding
Past funding
Supervision
Availability
- Dr Ran Wang is:
- Available for supervision
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Available projects
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Artificial cells for targeting immune activation associated cytokine storm
Immune activation is the key to combat bacteria and viral infections. However, in some cases, overactivated immune cells are not only killing the bacteria or virus, but also causing damage to our own body. Activated immune cells release large amount of immune mediators “cytokine” to attract other immune cells and causing more damage. To break the vicious cycle, this project aims to develop “artificial cells” that can “mop up” excess cytokines therefore dampen the overactivated immune response. The artificial cells are generated to mimic normal immune cell function using nanotechnology in combination of immunotechniques. The efficacy of the artificial cells in blocking immune overactivation will be assessed in vitro using immune activation assays as well as in vivo using humanised mouse models.
Supervision history
Completed supervision
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2022
Master Philosophy
Targeting Intestinal Epithelial Cell-Derived Interleukin-23 (p19) To Improve Intestinal Barrier Integrity in Inflammatory Bowel Disease
Associate Advisor
Other advisors: Associate Professor Jakob Begun
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2021
Doctor Philosophy
Exploring the gut-liver axis and immunity in paracetamol-induced toxicity
Associate Advisor
Other advisors: Associate Professor Jakob Begun
-
2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Media
Enquiries
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