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2025

Journal Article

pH of Microenvironment Directly Modulates the Phenotype and Function of Cancer-Associated Fibroblasts

Li, Ying, He, Chao, Shen, Ai Ning, Wang, Yu, Xu, Zhi Ping, Zhang, Lingxiao and Wang, Ran (2025). pH of Microenvironment Directly Modulates the Phenotype and Function of Cancer-Associated Fibroblasts. ACS Omega, 10 (4), 3937-3943. doi: 10.1021/acsomega.4c09716

pH of Microenvironment Directly Modulates the Phenotype and Function of Cancer-Associated Fibroblasts

2024

Journal Article

Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death

Sharma, Astha, Yan, Jiachen, Siwakoti, Prakrit, Saeed, Ayad, Agarwal, Vipul, Xu, Zhi Ping, Wang, Ran and Kumeria, Tushar (2024). Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death. Nano TransMed, 3 100053. doi: 10.1016/j.ntm.2024.100053

Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death

2024

Journal Article

Next-generation aluminum adjuvants: immunomodulatory layered double hydroxides NanoAlum reengineered from first-line drugs

Su, Zhenwei, Boucetta, Hamza, Shao, Jiahui, Huang, Jinling, Wang, Ran, Shen, Aining, He, Wei, Xu, Zhi Ping and Zhang, Lingxiao (2024). Next-generation aluminum adjuvants: immunomodulatory layered double hydroxides NanoAlum reengineered from first-line drugs. Acta Pharmaceutica Sinica B, 14 (11), 4665-4682. doi: 10.1016/j.apsb.2024.09.012

Next-generation aluminum adjuvants: immunomodulatory layered double hydroxides NanoAlum reengineered from first-line drugs

2024

Journal Article

Genome-wide assessment of shared genetic landscape of idiopathic pulmonary fibrosis and its comorbidities

Yang, Yuanhao, Sheng, Yong H., Carreira, Patricia, Wang, Tong, Zhao, Huiying and Wang, Ran (2024). Genome-wide assessment of shared genetic landscape of idiopathic pulmonary fibrosis and its comorbidities. Human Genetics, 143 (9-10), 1223-1239. doi: 10.1007/s00439-024-02696-9

Genome-wide assessment of shared genetic landscape of idiopathic pulmonary fibrosis and its comorbidities

2024

Journal Article

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis

Sajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 1-13. doi: 10.1038/s41467-024-48317-x

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis

2024

Journal Article

Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease

Kumarapperuma, Hirushi, Wang, Ran, Little, Peter J and Kamato, Danielle (2024). Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease. Trends in Cardiovascular Medicine, 34 (3), 203-211. doi: 10.1016/j.tcm.2023.01.002

Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease

2023

Journal Article

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells

Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells

2023

Journal Article

GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection

Foo, Cheng Xiang, Bartlett, Stacey, Chew, Keng Yih, Ngo, Minh Dao, Bielefeldt-Ohmann, Helle, Jayakody Arachchige, Buddhika, Matthews, Benjamin, Reed, Sarah, Wang, Ran, Smith, Christian, Sweet, Matthew J., Burr, Lucy, Bisht, Kavita, Shatunova, Svetlana, Sinclair, Jane E., Parry, Rhys, Yang, Yuanhao, Lévesque, Jean-Pierre, Khromykh, Alexander, Rosenkilde, Mette Marie, Short, Kirsty R. and Ronacher, Katharina (2023). GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection. European Respiratory Journal, 61 (3) 2201306, 1-15. doi: 10.1183/13993003.01306-2022

GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection

2022

Journal Article

IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis

Moniruzzaman, Md., Wong, Kuan Yau, Wang, Ran, Symon, Hamish, Mueller, Alexandra, Rahman, M. Arifur and Hasnain, Sumaira Z. (2022). IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis. International Journal of Molecular Sciences, 24 (1) 174, 174. doi: 10.3390/ijms24010174

IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis

2022

Journal Article

MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis

Sheng, Yong H., Davies, Julie M., Wang, Ran, Wong, Kuan Yau, Giri, Rabina, Yang, Yuanhao, Begun, Jakob, Florin, Timothy H., Hasnain, Sumaira Z. and McGuckin, Michael A. (2022). MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis. Cellular and Molecular Gastroenterology and Hepatology, 14 (4), 789-811. doi: 10.1016/j.jcmgh.2022.06.010

MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis

2022

Journal Article

A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells

Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C-H, Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Martin, Megan L., Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Zia (2022). A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells. SSRN Electronic Journal. doi: 10.2139/ssrn.4185134

A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells

2021

Journal Article

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders

Wang, Ran, Campbell, Sean, Amir, Mohammed, Mosure, Sarah A., Bassette, Molly A., Eliason, Amber, Sundrud, Mark S., Kamenecka, Theodore M. and Solt, Laura A. (2021). Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders. Nature Communications, 12 (1) 76, 1-18. doi: 10.1038/s41467-020-20385-9

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders

2021

Journal Article

Nanocarriers for oral delivery of biologics: small carriers for big payloads

Cao, Yuxue, Rewatkar, Prarthana, Wang, Ran, Hasnain, Sumaira Z., Popat, Amirali and Kumeria, Tushar (2021). Nanocarriers for oral delivery of biologics: small carriers for big payloads. Trends in Pharmacological Sciences, 42 (11), 957-972. doi: 10.1016/j.tips.2021.08.005

Nanocarriers for oral delivery of biologics: small carriers for big payloads

2021

Journal Article

Gut microbiota shape the inflammatory response in mice with an epithelial defect

Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720

Gut microbiota shape the inflammatory response in mice with an epithelial defect

2020

Journal Article

Editorial: the response of mucosal epithelial cells to infections

Wang, Ran and Proud, David (2020). Editorial: the response of mucosal epithelial cells to infections. Frontiers in Cellular and Infection Microbiology, 10 602312, 602312. doi: 10.3389/fcimb.2020.602312

Editorial: the response of mucosal epithelial cells to infections

2020

Journal Article

Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis

Pujara, Naisarg, Wong, Kuan Yau, Qu, Zhi, Wang, Ran, Moniruzzaman, Md., Rewatkar, Prarthana, Kumeria, Tushar, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2020). Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, 18 (2) acs.molpharmaceut.0c00048, 627-640. doi: 10.1021/acs.molpharmaceut.0c00048

Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis

2019

Journal Article

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

2019

Journal Article

Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway

Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468

Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway

2018

Journal Article

REV-ERBα regulates T(H)17 cell development and autoimmunity

Amir, Mohammed, Chaudhari, Sweena, Wang, Ran, Campbell, Sean, Mosure, Sarah A., Chopp, Laura B., Lu, Qun, Shang, Jinsai, Pelletier, Oliver B., He, Yuanjun, Doebelin, Christelle, Cameron, Michael D., Kojetin, Douglas J., Kamenecka, Theodore M. and Solt, Laura A. (2018). REV-ERBα regulates T(H)17 cell development and autoimmunity. Cell Reports, 25 (13), 3733-+. doi: 10.1016/j.celrep.2018.11.101

REV-ERBα regulates T(H)17 cell development and autoimmunity

2018

Journal Article

Immune regulation of the unfolded protein response at the mucosal barrier in viral infection

Wang, Ran, Moniruzzaman, Md., Shuffle, Eric, Lourie, Rohan and Hasnain, Sumaira Z. (2018). Immune regulation of the unfolded protein response at the mucosal barrier in viral infection. Clinical & Translational Immunology, 7 (4) e1014, e1014. doi: 10.1002/cti2.1014

Immune regulation of the unfolded protein response at the mucosal barrier in viral infection