Overview
Background
Dr Ran Wang graduated with her PhD in 2015, and after undertaking a postdoc position in Scripps Research, USA returned to Australia in 2017. She is now a Senior Postdoctoral Researcher supported by the prestigious Bushell Postdoctoral Research Fellowship from the Gastroenterology Society of Australia. Dr Wang is interested to understand the nature of inflammation in gut and lung and investigate the local and systemic impacts of chronic gut inflammation. In addition to a growing track-record in the mucosal immunology field, she is also building an inter-disciplinary research profile in material science and nanotechnology for drug delivery and immune modulation. She is the Associate Editor of Frontier of Cellular and Infection Microbiology Journal since 2018.
Availability
- Dr Ran Wang is:
- Available for supervision
Fields of research
Qualifications
- Masters (Coursework) of Biotechnology, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Ran Wang’s works on UQ eSpace
2022
Journal Article
A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C-H, Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Martin, Megan L., Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Zia (2022). A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells. SSRN Electronic Journal. doi: 10.2139/ssrn.4185134
2021
Journal Article
Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders
Wang, Ran, Campbell, Sean, Amir, Mohammed, Mosure, Sarah A., Bassette, Molly A., Eliason, Amber, Sundrud, Mark S., Kamenecka, Theodore M. and Solt, Laura A. (2021). Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders. Nature Communications, 12 (1) 76, 1-18. doi: 10.1038/s41467-020-20385-9
2021
Journal Article
Nanocarriers for oral delivery of biologics: small carriers for big payloads
Cao, Yuxue, Rewatkar, Prarthana, Wang, Ran, Hasnain, Sumaira Z., Popat, Amirali and Kumeria, Tushar (2021). Nanocarriers for oral delivery of biologics: small carriers for big payloads. Trends in Pharmacological Sciences, 42 (11), 957-972. doi: 10.1016/j.tips.2021.08.005
2021
Journal Article
Gut microbiota shape the inflammatory response in mice with an epithelial defect
Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1) 1887720, 1-18. doi: 10.1080/19490976.2021.1887720
2020
Journal Article
Editorial: the response of mucosal epithelial cells to infections
Wang, Ran and Proud, David (2020). Editorial: the response of mucosal epithelial cells to infections. Frontiers in Cellular and Infection Microbiology, 10 602312, 602312. doi: 10.3389/fcimb.2020.602312
2020
Journal Article
Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis
Pujara, Naisarg, Wong, Kuan Yau, Qu, Zhi, Wang, Ran, Moniruzzaman, Md., Rewatkar, Prarthana, Kumeria, Tushar, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2020). Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, 18 (2) acs.molpharmaceut.0c00048, 627-640. doi: 10.1021/acs.molpharmaceut.0c00048
2020
Conference Publication
Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection
Hasnain, S., Wang, R., Taylor, S., Wong, K. Y., Moniruzzaman, M., Upham, J., Spann, K., Mcguckin, M. A., Burr, L. and Phipps, S. (2020). Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777
2020
Conference Publication
Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections
Wang, R., Moniruzzaman, M., Wang, K., Upham, J. W., McGuckin, M., Phipps, S. and Hasnain, S. Z. (2020). Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections. International Conference of the American-Thoracic-Society (ATS), Online, 10 November 2020. New York, NY, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6530
2019
Journal Article
MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity
Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y
2019
Journal Article
Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway
Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468
2019
Conference Publication
Genetic and pharmacological modulation of RORα regulates TH17-driven inflammatory disorders
Solt, Laura A., Wang, Ran, Amir, Mohammed, Chaudhari, Sweena, Campbell, Sean, Bassette, Molly B., Eliason, Amber, Sundrud, Mark S. and Kamenecka, Theodore (2019). Genetic and pharmacological modulation of RORα regulates TH17-driven inflammatory disorders. Immunology 2019™ Meeting, San Diego, CA United States, 9-13 May 2019. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.202.supp.68.11
2019
Conference Publication
Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity
Moniruzzaman, M., Wang, R., Wong, K., Tong, H., McGuckin, M. and Hasnain, S. (2019). Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity. Congress of ECCO, Copenhagen, Denmark, 6-9 March 2019. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjy222.044
2019
Conference Publication
A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection
Wang, R., Taylor, S., Moniruzzaman, M., Wong, K., Upham, J., Spann, K., McGuckin, M., Phipps, S. and Hasnain, S. (2019). A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection. 17th International Congress of Immunology (IUIS), Beijing, People's Republic of China, 9-23 October 2019. Weinheim, Germany: Wiley.
2018
Journal Article
REV-ERBα regulates T(H)17 cell development and autoimmunity
Amir, Mohammed, Chaudhari, Sweena, Wang, Ran, Campbell, Sean, Mosure, Sarah A., Chopp, Laura B., Lu, Qun, Shang, Jinsai, Pelletier, Oliver B., He, Yuanjun, Doebelin, Christelle, Cameron, Michael D., Kojetin, Douglas J., Kamenecka, Theodore M. and Solt, Laura A. (2018). REV-ERBα regulates T(H)17 cell development and autoimmunity. Cell Reports, 25 (13), 3733-+. doi: 10.1016/j.celrep.2018.11.101
2018
Conference Publication
Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation
Wang, R., Giri, R., Moniruzzaman, M., Tong, H., Wong, K. Y., Begun, J., McGuckin, M. A. and Hasnain, S. Z. (2018). Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
2018
Conference Publication
Interleukin-22: A potential therapy to control intestinal inflammation
Moniruzzaman, M., Wang, R., Wong, K. Y., Tong, H., McGuckin, M. A. and Hasnain, S. Z. (2018). Interleukin-22: A potential therapy to control intestinal inflammation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
2018
Conference Publication
Ubiquitin Ligase MARCH8 attenuates Graft versus Host Disease via Regulation of Gut Epithelial Cell Surface MHC II Expression
Lineburg, Katie E., Le Texier, Laetitia, Melino, Michelle, Wang, Ran, Clouston, Andrew, Blazar, Bruce R., McGuckin, Michael A., Villadangos, Jose A., Mintern, Justine D. and MacDonald, Kelli P. A. (2018). Ubiquitin Ligase MARCH8 attenuates Graft versus Host Disease via Regulation of Gut Epithelial Cell Surface MHC II Expression. 27th International Congress of the Transplantation-Society (TTS), Madrid, Spain, 30 June-5 July 2018. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/01.tp.0000543013.84163.3a
2018
Conference Publication
The REV-ERBs: Negative Regulators of Th17 Cell Development and Autoimmunity
Amir, Mohammed, Chaudhari, Sweena M., Wang, Ran, Campbell, Sean, Kamenecka, Theodore M. and Solt, Laura A. (2018). The REV-ERBs: Negative Regulators of Th17 Cell Development and Autoimmunity. Immunology 2018™ Meeting, Austin, TX United States, 4-8 May 2018. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.200.supp.163.10
2018
Conference Publication
A non-redundant role for RORα in TH17 cell development and TH17-driven inflammatory disorders
Solt, Laura A., Wang, Ran, Amir, Mohammed, Chaudhari, Sweena M., Campbell, Sean, Bassette, Molly A. and Kamenecka, Theodore M. (2018). A non-redundant role for RORα in TH17 cell development and TH17-driven inflammatory disorders. Immunology 2018™ Meeting, Austin, TX United States, 4-8 May 2018. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.200.supp.121.3
2018
Journal Article
Immune regulation of the unfolded protein response at the mucosal barrier in viral infection
Wang, Ran, Moniruzzaman, Md., Shuffle, Eric, Lourie, Rohan and Hasnain, Sumaira Z. (2018). Immune regulation of the unfolded protein response at the mucosal barrier in viral infection. Clinical & Translational Immunology, 7 (4) e1014, e1014. doi: 10.1002/cti2.1014
Funding
Current funding
Past funding
Supervision
Availability
- Dr Ran Wang is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
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Artificial cells for targeting immune activation associated cytokine storm
Immune activation is the key to combat bacteria and viral infections. However, in some cases, overactivated immune cells are not only killing the bacteria or virus, but also causing damage to our own body. Activated immune cells release large amount of immune mediators “cytokine” to attract other immune cells and causing more damage. To break the vicious cycle, this project aims to develop “artificial cells” that can “mop up” excess cytokines therefore dampen the overactivated immune response. The artificial cells are generated to mimic normal immune cell function using nanotechnology in combination of immunotechniques. The efficacy of the artificial cells in blocking immune overactivation will be assessed in vitro using immune activation assays as well as in vivo using humanised mouse models.
Supervision history
Completed supervision
-
2022
Master Philosophy
Targeting Intestinal Epithelial Cell-Derived Interleukin-23 (p19) To Improve Intestinal Barrier Integrity in Inflammatory Bowel Disease
Associate Advisor
Other advisors: Associate Professor Jakob Begun, Honorary Professor Sumaira Hasnain
-
2021
Doctor Philosophy
Exploring the gut-liver axis and immunity in paracetamol-induced toxicity
Associate Advisor
Other advisors: Associate Professor Jakob Begun
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Honorary Professor Michael McGuckin, Honorary Professor Sumaira Hasnain
Media
Enquiries
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