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Associate Professor Adam Walker
Associate Professor

Adam Walker

Email: 

Overview

Background

Dr Adam Walker received his BSc(Hons) in Biochemistry from the University of Tasmania, and PhD in Neuroscience from the Florey Institute of Neuroscience and Mental Health at the University of Melbourne, focused on understanding the molecular mechanisms of motor neuron disease (MND). He undertook a postdoctoral fellowship with Professor Virginia Lee at the Center for Neurodegenerative Disease Research, University of Pennsylvania (2011-2015), developing new transgenic TDP-43 mouse models of disease. Dr Walker was previously an NHMRC CJ Martin Overseas Biomedical Research Fellow and was awarded an NHMRC RD Wright Career Development Fellowship (2018-2022), to continue his research on neurodegenerative diseases. His research has been supported by fellowships and project grants from the Australian National Health and Medical Research Council, the Australian National Foundation for Medical Research and Innovation, Dementia Australia, Motor Neuron Disease Research Institute of Australia, MonSTaR Foundation and the Cure for MND Foundation.

Availability

Associate Professor Adam Walker is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Melbourne

Research interests

  • Motor neuron disease (MND)/amyotrophic lateral sclerosis (ALS)

    Molecular mechanisms of disease and pre-clinical studies in model systems.

Funding

Current funding

  • 2024 - 2027
    Preclinical development of complement C5a receptor 2 modulators for motor neuron disease
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2024 - 2027
    Upstream Protein Clearance Pathway Activators for MND Treatment
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2024 - 2026
    Elucidating the role of UNC13A risk variants in sporadic frontotemporal dementia
    Dementia Australia Research Foundation
    Open grant
  • 2024 - 2025
    Exploring the therapeutic potential of a key chaperone against TDP-43 proteinopathy in MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2024 - 2027
    Oligodendrocytes and TDP-43 pathology in MND
    Cure for MND Foundation - Discovery Research Grants
    Open grant
  • 2023 - 2027
    Australian Preclinical Research ALS (APRALS) Network: a roadmap for effective translation of therapeutics for sporadic MND (MNDRA and FightMND grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Clearing TDP-43 pathology for MND therapy
    Cure for MND Foundation - Bill Guest Mid-Career Fellowship
    Open grant
  • 2022 - 2025
    Exploiting the neuroprotective effects of the gut microbiome for the treatment of spinocerebellar ataxia-3 and related neurodegenerative diseases (NHMRC Ideas Grant administered by Macquarie Uni).
    Macquarie University
    Open grant
  • 2021 - 2026
    Understanding the dynamics of TDP-43 aggregation in FTE using advanced imaging tools
    Dementia Australia Research Foundation
    Open grant
  • 2020 - 2025
    From the nucleus to the powerhouse: investigating how TDP-43-mitochondrial interactions wreak havoc in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant

Past funding

  • 2024 - 2025
    Synaptic mechanisms of non-motor dysfunction in MND
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2025
    A Collaborative Multivariable Approach to Prevent Network Dysfunction in ALS (University of Tasmania administered MNDRA grant)
    University of Tasmania
    Open grant
  • 2023 - 2024
    Identifying proteins controlling post-translational modification of TDP-43
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023
    High-resolution imaging of protein clumps in frontotemporal dementia and motor neuron disease
    Brain Foundation Research Grant
    Open grant
  • 2022 - 2025
    New viral-mediated TDP-43 mouse models of MND
    Cure for MND Foundation - Impact Grants
    Open grant
  • 2022 - 2024
    The Glymphatic System: Novel Biomarker of Disease Severity and Therapeutic Target (FightMND Impact Grant administered by Monash University)
    Monash University
    Open grant
  • 2022 - 2025
    NIBR Global Scholars Program Scholars Agreement
    UniQuest Pty Ltd
    Open grant
  • 2021 - 2022
    Defining the involvement of ubiquilin-2 in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2021
    Is the brain's waste clearance system impaired in Motor Neurone Disease (Bethlehem Griffiths Research Foundation Grant led by Monash University)
    Monash University
    Open grant
  • 2020 - 2024
    Preclinical development of centrally active complement C3a receptor modulators as disease-modifying drugs for motor neuron disease
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2020 - 2023
    Development of a TDP43-targeting gene therapy (FightMND Drug Development Grant administered by Macquarie University)
    Macquarie University
    Open grant
  • 2020 - 2021
    New mouse models of TDP-43 pathology
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2020
    Using viruses to target TDP-43 pathology for pre-clinical studies of neurodegenerative disease
    UQ Early Career Researcher
    Open grant
  • 2019 - 2020
    Genome-wide CRISPR screens to reveal regulators of TDP-43 aggregation and toxicity in motor neuron disease and frontotemporal dementia
    Brain Foundation Research Gift
    Open grant
  • 2019 - 2022
    Rapid flow cytometry screen for identifying novel ALS drug leads (CDMRP Grant administered by University of Wollongong)
    University of Wollongong
    Open grant
  • 2019 - 2021
    Targeting the nucleo-cytoplasmic transport machinery in sporadic and familial ALS (MNDRIA Grant led by Macquarie University)
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2020
    Pre-Clinical evaluation of novel therapies for clearance of TDP-43 in amyotrophic lateral sclerosis (NFMRI grant administered by Macquarie University)
    Macquarie University
    Open grant
  • 2018 - 2022
    Neurodegenerative disease pathology, mechanisms, models and treatments
    NHMRC Career Development Fellowship
    Open grant
  • 2018 - 2020
    Understanding the early disease mechanisms of motor neuron disease and frontotemporal dementia
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Calpeptin, and related candidates, for the treatment of Machado Joseph Disease (NHMRC Project Grant led by Macquarie University)
    Macquarie University
    Open grant

Supervision

Availability

Associate Professor Adam Walker is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Associate Professor Adam Walker directly for media enquiries about:

  • Frontotemporal dementia
  • Motor Neuron Disease
  • Neurodegenerative disease mechanisms
  • Pre-clinical disease research
  • TDP-43

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au