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Professor Denise Doolan
Professor

Denise Doolan

Email: 
Phone: 
+61 7 334 62159

Overview

Background

Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicine, and Director of the JCU Centre for Molecular Therapeutics, at James Cook University.

She is a molecular immunologist, working on the development of vaccines, diagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public health, with a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunity, antigen discovery, vaccine engineering, and biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.

She is a recognized world expert in malaria immunology, vaccinology, and omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.

Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recently, she has been elected as President of the International Society for Vaccines (2021-2023), and has been appointed to the Federal Government’s Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia’s medical research and innovation priorities.

Availability

Professor Denise Doolan is:
Available for supervision

Fields of research

Qualifications

  • Bachelor of Science, The University of Queensland
  • B Sc Hons (Biochemistry), The University of Queensland
  • M Phil (Life Sciences), Griffith University
  • PhD (Molecular Immunology), The University of Queensland

Works

Search Professor Denise Doolan’s works on UQ eSpace

224 works between 1987 and 2025

121 - 140 of 224 works

2011

Journal Article

Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component

Tamminga, Cindy, Sedegah, Martha, Regis, David, Chuang, Ilin, Epstein, Judith E, Spring, Michele, Mendoza-Silveiras, Jose, McGrath, Shannon, Maiolatesi, Santina, Reyes, Sharina, Steinbeiss, Victoria, Fedders, Charlotte, Smith, Kathryn, House, Brent, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna J, Sayo, Renato, Farooq, Fouzia, Belmonte, Maria, Murphy, Jittawadee, Komisar, Jack, Williams, Jackie, Shi, Meng, Brambilla, Donald, Manohar, Nalini, Richie, Nancy O, Wood, Chloe ... Richie, Thomas L (2011). Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component. PLoS One, 6 (10) e25868, 1-20. doi: 10.1371/journal.pone.0025868

Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component

2011

Journal Article

High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood

Apte, Simon H., Groves, Penny L., Roddick, Joanne S., P da Hora, Vanusa and Doolan, Denise L. (2011). High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood. International Journal for Parasitology, 41 (12), 1285-94. doi: 10.1016/j.ijpara.2011.07.010

High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood

2011

Journal Article

Vaccinomics for the major blood feeding helminths of humans

Loukas, Alex, Gaze, Soraya, Mulvenna, Jason P., Gasser, Robin B, Brindley, Paul J., Doolan, Denise L., Bethony, Jeffrey M., Jones, Malcolm K., Gobert, Geoffrey N., Driguez, Patrick, McManus, Donald P. and Hotez, Peter J. (2011). Vaccinomics for the major blood feeding helminths of humans. OMICS: A Journal of Integrative Biology, 15 (9), 567-577. doi: 10.1089/omi.2010.0150

Vaccinomics for the major blood feeding helminths of humans

2011

Journal Article

Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens

Trieu, Angela, Kayala, Matthew A., Burk, Chad, Molina, Douglas M., Freilich, Daniel A., Richie, Thomas L., Baldi, Pierre, Felgner, Philip L. and Doolan, Denise L. (2011). Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens. Molecular and Cellular Proteomics, 10 (9) M111.007948, 1-15. doi: 10.1074/mcp.M111.007948

Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens

2011

Journal Article

Toward a surrogate marker of malaria exposure: Modeling longitudinal antibody measurements under outbreak conditions

Campo, Joseph J., Whitman, Timothy J., Freilich, Daniel, Burgess, Timothy H., Martin, Gregory J. and Doolan, Denise L. (2011). Toward a surrogate marker of malaria exposure: Modeling longitudinal antibody measurements under outbreak conditions. PLoS One, 6 (7) e21826, 1-6. doi: 10.1371/journal.pone.0021826

Toward a surrogate marker of malaria exposure: Modeling longitudinal antibody measurements under outbreak conditions

2011

Journal Article

Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults

Dodoo, Daniel, Hollingdale, Michael R., Anum, Dorothy, Koram, Kwadwo A., Gyan, Ben, Akanmori, Bartholomew D., Ocran, Josephine, Adu-Amankwah, Susan, Geneshan, Harini, Abot, Esteban, Legano, Jennylyn, Banania, Glenna, Sayo, Renato, Brambilla, Donald, Kumar, Sanjai, Doolan, Denise L., Rogers, William O., Epstein, Judith, Richie, Thomas L. and Sedegah, Martha (2011). Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults. Malaria Journal, 10 (1) 168. doi: 10.1186/1475-2875-10-168

Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults

2011

Journal Article

Harnessing immune responses against Plasmodium for rational vaccine design

Douradinha, Bruno and Doolan, Denise L. (2011). Harnessing immune responses against Plasmodium for rational vaccine design. Trends in Parasitology, 27 (6), 274-283. doi: 10.1016/j.pt.2011.01.002

Harnessing immune responses against Plasmodium for rational vaccine design

2011

Journal Article

Non-toxic derivatives of LT as potent adjuvants

da Hora, Vanusa P., Conceição, Fabricio R., Dellagostin, Odir A. and Doolan, Denise L. (2011). Non-toxic derivatives of LT as potent adjuvants. Vaccine, 29 (8), 1538-1544. doi: 10.1016/j.vaccine.2010.11.091

Non-toxic derivatives of LT as potent adjuvants

2011

Journal Article

Plasmodium immunomics

Doolan, Denise L. (2011). Plasmodium immunomics. International Journal for Parasitology, 41 (1), 3-20. doi: 10.1016/j.ijpara.2010.08.002

Plasmodium immunomics

2010

Journal Article

Malaria vaccine design: Immunological Considerations

Good, Michael F. and Doolan, Denise L. (2010). Malaria vaccine design: Immunological Considerations. Immunity, 33 (4), 555-566. doi: 10.1016/j.immuni.2010.10.005

Malaria vaccine design: Immunological Considerations

2010

Journal Article

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

Sedegah, Martha, Kim, Yohan, Peters, Bjoern, McGrath, Shannon, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna, Belmonte, Maria, Sayo, Renato, Farooq, Fouzia, Doolan, Denise L., Regis, David, Tamminga, Cindy, Chuang, Ilin, Bruder, Joseph T., King, C. Richter, Ockenhouse, Christian F., Faber, Bart, Remarque, Edmond, Hollingdale, Michael R., Richie, Thomas L. and Sette, Alessandro (2010). Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein. Malaria Journal, 9 (1) 241. doi: 10.1186/1475-2875-9-241

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

2010

Journal Article

The Australasian contribution to malaria vaccine development

Redmond, A. M. and Doolan, D. L. (2010). The Australasian contribution to malaria vaccine development. Parasite Immunology, 32 (8), 607-622. doi: 10.1111/j.1365-3024.2010.01229.x

The Australasian contribution to malaria vaccine development

2010

Journal Article

IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response

Apte, Simon H, Groves, Penny, Olver, Stuart, Baz, Adriana, Doolan, Denise L, Kelso, Anne and Kienzle, Norbert (2010). IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response. Journal of Immunology, 185 (2), 998-1004. doi: 10.4049/jimmunol.0903372

IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response

2010

Journal Article

Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

Bruder, Joseph T., Stefaniak, Maureen E., Patterson, Noelle B., Chen, Ping, Konovalova, Svetlana, Limbach, Keith, Campo, Joseph J., Ettyreddy, Damodar, Li, Sheng, Dubovsky, Filip, Richie, Thomas L., King, C. Richter, Long, Carole A. and Doolan, Denise L. (2010). Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth. Vaccine, 28 (18), 3201-3210. doi: 10.1016/j.vaccine.2010.02.024

Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

2010

Journal Article

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

Crompton, Peter D., Kayala, Matthew A., Traore, Boubacar, Kayentao, Kassoum, Ongoiba, Aissata, Weiss, Greta E., Molina, Douglas M., Burk, Chad R., Waisberg, Michael, Jasinskas, Algis, Tan, Xiaolin, Doumbo, Safiatou, Doumtabe, Didier, Kone, Younoussou, Narum, David L., Liang, Xiaowu, Doumbo, Ogobara K., Miller, Louis H., Doolan, Denise L., Baldi, Pierre, Felgner, Philip L. and Pierce, Susan K. (2010). A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proceedings of the National Academy of Sciences of the United States of America, 107 (15), 6958-6963. doi: 10.1073/pnas.1001323107

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

2010

Journal Article

Vaxfectin® enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses

Sedegah, Martha, Rogers, William O., Belmonte, Maria, Belmonte, Arnel, Banania, Glenna, Patterson, Noelle B., Rusalov, Denis, Ferrari, Marilyn, Richie, Thomas L. and Doolan, Denise L. (2010). Vaxfectin® enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses. Vaccine, 28 (17), 3055-3065. doi: 10.1016/j.vaccine.2009.10.044

Vaxfectin® enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses

2010

Conference Publication

Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses

Cardoso, F. C., Groves, P., Roddick, J. and Doolan, D. L. (2010). Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses. XII International Conference for Parasitology, Melbourme, Australia, 15-20 August 2010.

Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses

2010

Journal Article

Special issue on malaria vaccine development

Doolan, Denise L. (2010). Special issue on malaria vaccine development. Human Vaccines, 6 (1). doi: 10.4161/hv.6.1.10703

Special issue on malaria vaccine development

2010

Conference Publication

Proteome-wide screening of antigens targeted by cell mediated immune responses

Cardoso, F. C., Trieu, A., Groves, P. and Doolan, D. L. (2010). Proteome-wide screening of antigens targeted by cell mediated immune responses. 14th International Congress of Immunology, Kobe, Japan, 22-27 August 2010.

Proteome-wide screening of antigens targeted by cell mediated immune responses

2010

Conference Publication

Development and immunoscreening of an immunomics protein microarray to investigate schistosomiasis

Driguez, Patrick, Ellis, Magda, McWilliarn, Hamish, Trieu, Angela, Gaze, Soraya, Jones, Malcolm K., Gobert, Geoff, Loukas, Alex, Doolan, Denise L., Felgner, Philip L. and McManus, Donald P. (2010). Development and immunoscreening of an immunomics protein microarray to investigate schistosomiasis. 59th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, GA, United States, 3-7 November, 2010. Deerfield, IL, United States : American Society of Tropical Medicine and Hygiene .

Development and immunoscreening of an immunomics protein microarray to investigate schistosomiasis

Funding

Current funding

  • 2026 - 2030
    Next-generation therapeutics for malaria designed using systems-based approaches
    NHMRC Investigator Grants
    Open grant
  • 2025 - 2026
    An mRNA T-cell Vaccine Against Malaria
    UQ - Sanofi Translational Science Hub Partnership Scheme
    Open grant
  • 2025 - 2026
    A Facility for Accelerated Microbial Phenotyping in Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2024 - 2026
    Development of a multi-antigen T-cell malaria vaccine (NFMRI grant administered by James Cook University)
    James Cook University
    Open grant
  • 2024 - 2026
    Effective Multiple Sclerosis diagnosis based on EBV proteome screening
    MS Research Australia Project Grant
    Open grant

Past funding

  • 2023 - 2025
    Human-informed data-driven development of next-generation T cell vaccine against malaria
    United States National Institutes of Health
    Open grant
  • 2013 - 2017
    Tropical disease - immunity, pathogenesis and vaccine development: global translation (NHMRC Program Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2012 - 2014
    ResTeach Funding 2012 0.1 FTE School of Medicine/School of Chemisty and Molecular Biosciences
    UQ ResTeach
    Open grant

Supervision

Availability

Professor Denise Doolan is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Systems immunology and multi-omics approaches to understand protective immunity to human malaria

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Understanding the link between EBV and Multiple Sclerosis

    Principal Advisor

  • Doctor Philosophy

    Utilising high throughout spatial Transcriptomics to personlise treatment approaches for endometriosis patients

    Associate Advisor

    Other advisors: Dr Quan Nguyen, Associate Professor Akwasi Amoako, Dr Brett McKinnon

Completed supervision

Media

Enquiries

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