
Overview
Background
Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicine, and Director of the JCU Centre for Molecular Therapeutics, at James Cook University.
She is a molecular immunologist, working on the development of vaccines, diagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public health, with a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunity, antigen discovery, vaccine engineering, and biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.
She is a recognized world expert in malaria immunology, vaccinology, and omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.
Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recently, she has been elected as President of the International Society for Vaccines (2021-2023), and has been appointed to the Federal Government’s Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia’s medical research and innovation priorities.
Availability
- Professor Denise Doolan is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- B Sc Hons (Biochemistry), The University of Queensland
- M Phil (Life Sciences), Griffith University
- PhD (Molecular Immunology), The University of Queensland
Works
Search Professor Denise Doolan’s works on UQ eSpace
2011
Journal Article
Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component
Tamminga, Cindy, Sedegah, Martha, Regis, David, Chuang, Ilin, Epstein, Judith E, Spring, Michele, Mendoza-Silveiras, Jose, McGrath, Shannon, Maiolatesi, Santina, Reyes, Sharina, Steinbeiss, Victoria, Fedders, Charlotte, Smith, Kathryn, House, Brent, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna J, Sayo, Renato, Farooq, Fouzia, Belmonte, Maria, Murphy, Jittawadee, Komisar, Jack, Williams, Jackie, Shi, Meng, Brambilla, Donald, Manohar, Nalini, Richie, Nancy O, Wood, Chloe ... Richie, Thomas L (2011). Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component. PLoS One, 6 (10) e25868, 1-20. doi: 10.1371/journal.pone.0025868
2011
Journal Article
High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood
Apte, Simon H., Groves, Penny L., Roddick, Joanne S., P da Hora, Vanusa and Doolan, Denise L. (2011). High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood. International Journal for Parasitology, 41 (12), 1285-94. doi: 10.1016/j.ijpara.2011.07.010
2011
Journal Article
Vaccinomics for the major blood feeding helminths of humans
Loukas, Alex, Gaze, Soraya, Mulvenna, Jason P., Gasser, Robin B, Brindley, Paul J., Doolan, Denise L., Bethony, Jeffrey M., Jones, Malcolm K., Gobert, Geoffrey N., Driguez, Patrick, McManus, Donald P. and Hotez, Peter J. (2011). Vaccinomics for the major blood feeding helminths of humans. OMICS: A Journal of Integrative Biology, 15 (9), 567-577. doi: 10.1089/omi.2010.0150
2011
Journal Article
Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens
Trieu, Angela, Kayala, Matthew A., Burk, Chad, Molina, Douglas M., Freilich, Daniel A., Richie, Thomas L., Baldi, Pierre, Felgner, Philip L. and Doolan, Denise L. (2011). Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens. Molecular and Cellular Proteomics, 10 (9) M111.007948, 1-15. doi: 10.1074/mcp.M111.007948
2011
Journal Article
Toward a surrogate marker of malaria exposure: Modeling longitudinal antibody measurements under outbreak conditions
Campo, Joseph J., Whitman, Timothy J., Freilich, Daniel, Burgess, Timothy H., Martin, Gregory J. and Doolan, Denise L. (2011). Toward a surrogate marker of malaria exposure: Modeling longitudinal antibody measurements under outbreak conditions. PLoS One, 6 (7) e21826, 1-6. doi: 10.1371/journal.pone.0021826
2011
Journal Article
Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults
Dodoo, Daniel, Hollingdale, Michael R., Anum, Dorothy, Koram, Kwadwo A., Gyan, Ben, Akanmori, Bartholomew D., Ocran, Josephine, Adu-Amankwah, Susan, Geneshan, Harini, Abot, Esteban, Legano, Jennylyn, Banania, Glenna, Sayo, Renato, Brambilla, Donald, Kumar, Sanjai, Doolan, Denise L., Rogers, William O., Epstein, Judith, Richie, Thomas L. and Sedegah, Martha (2011). Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults. Malaria Journal, 10 (1) 168. doi: 10.1186/1475-2875-10-168
2011
Journal Article
Harnessing immune responses against Plasmodium for rational vaccine design
Douradinha, Bruno and Doolan, Denise L. (2011). Harnessing immune responses against Plasmodium for rational vaccine design. Trends in Parasitology, 27 (6), 274-283. doi: 10.1016/j.pt.2011.01.002
2011
Journal Article
Non-toxic derivatives of LT as potent adjuvants
da Hora, Vanusa P., Conceição, Fabricio R., Dellagostin, Odir A. and Doolan, Denise L. (2011). Non-toxic derivatives of LT as potent adjuvants. Vaccine, 29 (8), 1538-1544. doi: 10.1016/j.vaccine.2010.11.091
2011
Journal Article
Plasmodium immunomics
Doolan, Denise L. (2011). Plasmodium immunomics. International Journal for Parasitology, 41 (1), 3-20. doi: 10.1016/j.ijpara.2010.08.002
2010
Journal Article
Malaria vaccine design: Immunological Considerations
Good, Michael F. and Doolan, Denise L. (2010). Malaria vaccine design: Immunological Considerations. Immunity, 33 (4), 555-566. doi: 10.1016/j.immuni.2010.10.005
2010
Journal Article
Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
Sedegah, Martha, Kim, Yohan, Peters, Bjoern, McGrath, Shannon, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna, Belmonte, Maria, Sayo, Renato, Farooq, Fouzia, Doolan, Denise L., Regis, David, Tamminga, Cindy, Chuang, Ilin, Bruder, Joseph T., King, C. Richter, Ockenhouse, Christian F., Faber, Bart, Remarque, Edmond, Hollingdale, Michael R., Richie, Thomas L. and Sette, Alessandro (2010). Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein. Malaria Journal, 9 (1) 241. doi: 10.1186/1475-2875-9-241
2010
Journal Article
The Australasian contribution to malaria vaccine development
Redmond, A. M. and Doolan, D. L. (2010). The Australasian contribution to malaria vaccine development. Parasite Immunology, 32 (8), 607-622. doi: 10.1111/j.1365-3024.2010.01229.x
2010
Journal Article
IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response
Apte, Simon H, Groves, Penny, Olver, Stuart, Baz, Adriana, Doolan, Denise L, Kelso, Anne and Kienzle, Norbert (2010). IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response. Journal of Immunology, 185 (2), 998-1004. doi: 10.4049/jimmunol.0903372
2010
Journal Article
Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth
Bruder, Joseph T., Stefaniak, Maureen E., Patterson, Noelle B., Chen, Ping, Konovalova, Svetlana, Limbach, Keith, Campo, Joseph J., Ettyreddy, Damodar, Li, Sheng, Dubovsky, Filip, Richie, Thomas L., King, C. Richter, Long, Carole A. and Doolan, Denise L. (2010). Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth. Vaccine, 28 (18), 3201-3210. doi: 10.1016/j.vaccine.2010.02.024
2010
Journal Article
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray
Crompton, Peter D., Kayala, Matthew A., Traore, Boubacar, Kayentao, Kassoum, Ongoiba, Aissata, Weiss, Greta E., Molina, Douglas M., Burk, Chad R., Waisberg, Michael, Jasinskas, Algis, Tan, Xiaolin, Doumbo, Safiatou, Doumtabe, Didier, Kone, Younoussou, Narum, David L., Liang, Xiaowu, Doumbo, Ogobara K., Miller, Louis H., Doolan, Denise L., Baldi, Pierre, Felgner, Philip L. and Pierce, Susan K. (2010). A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proceedings of the National Academy of Sciences of the United States of America, 107 (15), 6958-6963. doi: 10.1073/pnas.1001323107
2010
Journal Article
Vaxfectin® enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses
Sedegah, Martha, Rogers, William O., Belmonte, Maria, Belmonte, Arnel, Banania, Glenna, Patterson, Noelle B., Rusalov, Denis, Ferrari, Marilyn, Richie, Thomas L. and Doolan, Denise L. (2010). Vaxfectin® enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses. Vaccine, 28 (17), 3055-3065. doi: 10.1016/j.vaccine.2009.10.044
2010
Conference Publication
Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses
Cardoso, F. C., Groves, P., Roddick, J. and Doolan, D. L. (2010). Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses. XII International Conference for Parasitology, Melbourme, Australia, 15-20 August 2010.
2010
Journal Article
Special issue on malaria vaccine development
Doolan, Denise L. (2010). Special issue on malaria vaccine development. Human Vaccines, 6 (1). doi: 10.4161/hv.6.1.10703
2010
Conference Publication
Proteome-wide screening of antigens targeted by cell mediated immune responses
Cardoso, F. C., Trieu, A., Groves, P. and Doolan, D. L. (2010). Proteome-wide screening of antigens targeted by cell mediated immune responses. 14th International Congress of Immunology, Kobe, Japan, 22-27 August 2010.
2010
Conference Publication
Development and immunoscreening of an immunomics protein microarray to investigate schistosomiasis
Driguez, Patrick, Ellis, Magda, McWilliarn, Hamish, Trieu, Angela, Gaze, Soraya, Jones, Malcolm K., Gobert, Geoff, Loukas, Alex, Doolan, Denise L., Felgner, Philip L. and McManus, Donald P. (2010). Development and immunoscreening of an immunomics protein microarray to investigate schistosomiasis. 59th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, GA, United States, 3-7 November, 2010. Deerfield, IL, United States : American Society of Tropical Medicine and Hygiene .
Funding
Current funding
Past funding
Supervision
Availability
- Professor Denise Doolan is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Systems immunology and multi-omics approaches to understand protective immunity to human malaria
Principal Advisor
Other advisors: Dr Quan Nguyen
-
Doctor Philosophy
Understanding the link between EBV and Multiple Sclerosis
Principal Advisor
-
Doctor Philosophy
Utilising high throughout spatial Transcriptomics to personlise treatment approaches for endometriosis patients
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Akwasi Amoako, Dr Brett McKinnon
Completed supervision
-
2025
Doctor Philosophy
Understanding the Molecular Basis of Immune Heterogeneity using Systems Immunology
Principal Advisor
-
2018
Doctor Philosophy
Characterization of cross-reactive immune responses in the context of a complex host-pathogen system.
Principal Advisor
-
2015
Doctor Philosophy
Molecular profiling of cellular immune responses to Plasmodium spp. blood-stage infection in humans using systems immunology
Principal Advisor
-
2014
Doctor Philosophy
Evaluation of novel DNA vaccine delivery strategies targeting dendritic cells: mechanisms of action, immunogenicity and protective efficacy
Principal Advisor
-
2014
Doctor Philosophy
Evaluation of novel antigens identified in genome-wide screening approaches for next-generation malaria vaccines
Principal Advisor
-
2013
Doctor Philosophy
Design and use of a schistosome protein microarray to investigate Asian schistosomiasis
Associate Advisor
Other advisors: Professor Malcolm Jones
Media
Enquiries
For media enquiries about Professor Denise Doolan's areas of expertise, story ideas and help finding experts, contact our Media team: