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Professor Denise Doolan
Professor

Denise Doolan

Email: 
Phone: 
+61 7 334 62159

Overview

Background

Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicine, and Director of the JCU Centre for Molecular Therapeutics, at James Cook University.

She is a molecular immunologist, working on the development of vaccines, diagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public health, with a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunity, antigen discovery, vaccine engineering, and biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.

She is a recognized world expert in malaria immunology, vaccinology, and omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.

Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recently, she has been elected as President of the International Society for Vaccines (2021-2023), and has been appointed to the Federal Government’s Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia’s medical research and innovation priorities.

Availability

Professor Denise Doolan is:
Available for supervision

Fields of research

Qualifications

  • Bachelor of Science, The University of Queensland
  • B Sc Hons (Biochemistry), The University of Queensland
  • M Phil (Life Sciences), Griffith University
  • PhD (Molecular Immunology), The University of Queensland

Works

Search Professor Denise Doolan’s works on UQ eSpace

224 works between 1987 and 2025

101 - 120 of 224 works

2013

Journal Article

Subcutaneous cholera toxin exposure induces potent CD103+ dermal dendritic cell activation and migration

Apte, Simon H., Redmond, Andrew M., Groves, Penny L., Schussek, Sophie, Pattinson, David J. and Doolan, Denise L. (2013). Subcutaneous cholera toxin exposure induces potent CD103+ dermal dendritic cell activation and migration. European Journal of Immunology, 43 (10), 2707-2717. doi: 10.1002/eji.201343475

Subcutaneous cholera toxin exposure induces potent CD103+ dermal dendritic cell activation and migration

2013

Journal Article

Highly sensitive quantitative real-time PCR for the detection of Plasmodium liver-stage parasite burden following low-dose sporozoite challenge

Schussek, Sophie, Groves, Penny L., Apte, Simon H. and Doolan, Denise L. (2013). Highly sensitive quantitative real-time PCR for the detection of Plasmodium liver-stage parasite burden following low-dose sporozoite challenge. PLoS One, 8 (10) e77811, e77811.1-e77811.10. doi: 10.1371/journal.pone.0077811

Highly sensitive quantitative real-time PCR for the detection of Plasmodium liver-stage parasite burden following low-dose sporozoite challenge

2013

Journal Article

Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model

Schussek, Sophie, Trieu, Angela, Apte, Simon H., Sidney, John, Sette, Alessandro and Doolan, Denise L. (2013). Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model. Infection and Immunity, 81 (10), 3586-3599. doi: 10.1128/IAI.00544-13

Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model

2013

Journal Article

A novel candidate vaccine for Cytauxzoonosis inferred from comparative apicomplexan genomics

Tarigo, Jaime L., Scholl, Elizabeth H., Bird, David McK, Brown, Corrie C., Cohn, Leah A., Dean, Gregg A., Levy, Michael G., Doolan, Denise L., Trieu, Angela, Nordone, Shila K., Felgner, Philip L., Vigil, Adam and Birkenheuer, Adam J. (2013). A novel candidate vaccine for Cytauxzoonosis inferred from comparative apicomplexan genomics. PLoS One, 8 (8) e71233, 1-9. doi: 10.1371/journal.pone.0071233

A novel candidate vaccine for Cytauxzoonosis inferred from comparative apicomplexan genomics

2013

Journal Article

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

Sedegah, Martha, Kim, Yohan, Ganeshan, Harini, Huang, Jun, Belmonte, Maria, Abot, Esteban, Banania, Jo Glenna, Farooq, Fouzia, McGrath, Shannon, Peters, Bjoern, Sette, Alessandro, Soisson, Lorraine, Diggs, Carter, Doolan, Denise L, Tamminga, Cindy, Villasante, Eileen, Hollingdale, Michael R and Richie, Thomas L. (2013). Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP). Malaria Journal, 12 (1) 185. doi: 10.1186/1475-2875-12-185

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

2013

Journal Article

DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity

Chuang, Ilin, Sedegah, Martha, Cicatelli, Susan, Spring, Michele, Polhemus, Mark, Tamminga, Cindy, Patterson, Noelle, Guerrero, Melanie, Bennett, Jason W, McGrath, Shannon, Ganeshan, Harini, Belmonte, Maria, Farooq, Fouzia, Abot, Esteban, Banania, Jo Glenna, Huang, Jun, Newcomer, Rhonda, Rein, Lisa, Litilit, Dianne, Richie, Nancy O, Wood, Chloe, Murphy, Jittawadee, Sauerwein, Robert, Hermsen, Cornelus C, McCoy, Andrea J, Kamau, Edwin, Cummings, James, Komisar, Jack, Sutamihardja, Awalludin ... Richie, Thomas L (2013). DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity. PLoS One, 8 (2) e55571, 1-15. doi: 10.1371/journal.pone.0055571

DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity

2012

Journal Article

Editorial

Doolan, Denise (2012). Editorial. International Journal for Parasitology: Parasites and Wildlife, 1, 1-1. doi: 10.1016/j.ijppaw.2012.07.001

Editorial

2012

Journal Article

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA

Richie, Thomas L, Charoenvit, Yupin, Wang, Ruobing, Epstein, Judith E, Hedstrom, Richard C, Kumar, Sanjai, Luke, Thomas C, Freilich, Daniel A, Aguiar, Joao C, Sacci, John B, Sedegah, Martha, Nosek, Ronald A, De La Vega, Patricia, Berzins, Mara P, Majam, Victoria F, Abot, Esteban N, Ganeshan, Harini, Richie, Nancy O, Banania, Jo Glenna, Baraceros, Maria Fe B, Geter, Tanya G, Mere, Robin, Bebris, Lolita, Limbach, Keith, Hickey, Bradley W, Lanar, David E, Ng, Jennifer, Shi, Meng, Hobart, Peter M ... Hoffman, Stephen L (2012). Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA. Human Vaccines and Immunotherapeutics, 8 (11), 1564-1584. doi: 10.4161/hv.22129

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA

2012

Conference Publication

Dissecting T cell or antibody immunodominance in a complex host-pathogen system

Proietti, Carla, Krause, Lutz, Roddick, Joanne, Trieu, Angela and Doolan, Denise L. (2012). Dissecting T cell or antibody immunodominance in a complex host-pathogen system. Challenges in Malaria Research, Basel, Switzerland, 10-12 October 2012. London, United Kingdom: BioMed Central. doi: 10.1186/1475-2875-11-s1-o23

Dissecting T cell or antibody immunodominance in a complex host-pathogen system

2012

Journal Article

Addressing the bottleneck at clinical testing of candidate malaria vaccines

Doolan, Denise L. and Apte, Simon H. (2012). Addressing the bottleneck at clinical testing of candidate malaria vaccines. Pathogens and Global Health, 106 (6). doi: 10.1179/2047772412Z.00000000081

Addressing the bottleneck at clinical testing of candidate malaria vaccines

2012

Journal Article

Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.

Apte, Simon H., Groves, Penny L., Skwarczynski, Mariusz, Fujita, Yoshio, Chang, Chenghung, Toth, Istvan and Doolan, Denise L. (2012). Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.. PLoS One, 7 (8 Article. No.e40928) e40928, e40928. doi: 10.1371/journal.pone.0040928

Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.

2012

Book Chapter

Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates

Loukas, Alex, Gaze, Soraya, Pearson, Mark, Doolan, Denise, Felgner, Philip, Diemert, David, Mcmanus, Donald P., Driguez, Patrick and Bethony, Jeffrey (2012). Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates. Parasitic Helminths: Targets, Screens, Drugs and Vaccines. (pp. 421-433) Wiley-VCH. doi: 10.1002/9783527652969.ch25

Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates

2012

Journal Article

Correction: Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses

Bruder, Joseph T., Semenova, Elena, Chen, Ping, Limbach, Keith, Patterson, Noelle B., Stefaniak, Maureen E., Konovalova, Svetlana, Thomas, Charlie, Hamilton, Melissa, King, C. Richter, Richie, Thomas L. and Doolan, Denise L. (2012). Correction: Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses. PLoS One, 7 (5). doi: 10.1371/annotation/c110beed-3cac-48db-9039-ba4498d5db50

Correction: Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses

2012

Journal Article

Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses

Bruder, Joseph T., Semenova, Elena, Chen, Ping, Limbach, Keith, Patterson, Noelle B., Stefaniak, Maureen E., Konovalova, Svetlana, Thomas, Charlie, Hamilton, Melissa, King, C. Richter, Richie, Thomas L. and Doolan, Denise L. (2012). Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses. PLoS One, 7 (4) e33920, 1-13. doi: 10.1371/journal.pone.0033920

Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses

2012

Journal Article

The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial

Guinovart, Caterina, Dobaño, Carlota, Bassat, Quique, Nhabomba, Augusto, Quintó, Llorenç, Manaca, Maria Nélia, Aguilar, Ruth, Rodríguez, Mauricio H, Barbosa, Arnoldo, Aponte, John J, Mayor, Alfredo G, Renom, Montse, Moraleda, Cinta, Roberts, David J, Schwarzer, Evelin, Le Souëf, Peter N, Schofield, Louis, Chitnis, Chetan E, Doolan, Denise L and Alonso, Pedro L (2012). The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial. PLoS One, 7 (3) e32362, 1-11. doi: 10.1371/journal.pone.0032362

The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial

2012

Journal Article

Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children

Quelhas, Diana, Puyol, Laura, Quintó, Llorenç, Nhampossa, Tacilta, Serra-Casas, Elisa, Macete, Eusébio, Aide, Pedro, Sanz, Sergi, Aponte, John J, Doolan, Denise L, Alonso, Pedro L, Menéndez, Clara and Dobaño, Carlota (2012). Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children. BMC Immunology, 13 (1) 5, 1-18. doi: 10.1186/1471-2172-13-5

Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children

2011

Journal Article

Editorial

Doolan, Denise L. and Spithill, Terry (2011). Editorial. International Journal for Parasitology: Drugs and Drug Resistance, 1 (1), 1-1. doi: 10.1016/j.ijpddr.2011.09.001

Editorial

2011

Journal Article

Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale

Cardoso, Fernanda C., Roddick, Joanne S., Groves, Penny and Doolan, Denise L. (2011). Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale. Plos One, 6 (11) e27666, e27666.1-e27666.14. doi: 10.1371/journal.pone.0027666

Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale

2011

Journal Article

The stability and complexity of antibody responses to the major surface antigen of plasmodium falciparum are associated with age in a malaria endemic area

Barry, Alyssa E., Trieu, Angela, Fowkes, Freya J. I., Pablo, Jozelyn, Kalantari-Dehaghi, Matthew, Jasinskas, Algis, Tan, Xiaolin, Kayala, Matthew A., Tavul, Livingstone, Siba, Peter M., Day, Karen P., Baldi, Pierre, Felgner, Philip L. and Doolan, Denise L. (2011). The stability and complexity of antibody responses to the major surface antigen of plasmodium falciparum are associated with age in a malaria endemic area. Molecular and Cellular Proteomics, 10 (11) M111.008326, 1-12. doi: 10.1074/mcp.M111.008326

The stability and complexity of antibody responses to the major surface antigen of plasmodium falciparum are associated with age in a malaria endemic area

2011

Journal Article

Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults

Sedegah, Martha, Tamminga, Cindy, McGrath, Shannon, House, Brent, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna J, Sayo, Renato, Farooq, Fouzia, Belmonte, Maria, Manohar, Nalini, Richie, Nancy O, Wood, Chloe, Long, Carole A, Regis, David, Williams, Francis T, Shi, Meng, Chuang, Ilin, Spring, Michele, Epstein, Judith E, Mendoza-Silveiras, Jose, Limbach, Keith, Patterson, Noelle B, Bruder, Joseph T, Doolan, Denise L, King, C Richter, Soisson, Lorraine, Diggs, Carter ... Richie, Thomas L (2011). Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults. PLoS One, 6 (10) e24586, 1-22. doi: 10.1371/journal.pone.0024586

Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults

Funding

Current funding

  • 2026 - 2030
    Next-generation therapeutics for malaria designed using systems-based approaches
    NHMRC Investigator Grants
    Open grant
  • 2025 - 2026
    An mRNA T-cell Vaccine Against Malaria
    UQ - Sanofi Translational Science Hub Partnership Scheme
    Open grant
  • 2025 - 2026
    A Facility for Accelerated Microbial Phenotyping in Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2024 - 2026
    Development of a multi-antigen T-cell malaria vaccine (NFMRI grant administered by James Cook University)
    James Cook University
    Open grant
  • 2024 - 2026
    Effective Multiple Sclerosis diagnosis based on EBV proteome screening
    MS Research Australia Project Grant
    Open grant
  • 2023 - 2026
    Human-informed data-driven development of next-generation T cell vaccine against malaria
    United States National Institutes of Health
    Open grant

Past funding

  • 2013 - 2017
    Tropical disease - immunity, pathogenesis and vaccine development: global translation (NHMRC Program Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2012 - 2014
    ResTeach Funding 2012 0.1 FTE School of Medicine/School of Chemisty and Molecular Biosciences
    UQ ResTeach
    Open grant

Supervision

Availability

Professor Denise Doolan is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Understanding the link between EBV and Multiple Sclerosis

    Principal Advisor

  • Doctor Philosophy

    Systems immunology and multi-omics approaches to understand protective immunity to human malaria

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Utilising high throughout spatial Transcriptomics to personlise treatment approaches for endometriosis patients

    Associate Advisor

    Other advisors: Dr Quan Nguyen, Associate Professor Akwasi Amoako, Dr Brett McKinnon

Completed supervision

Media

Enquiries

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