
Overview
Background
Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicine, and Director of the JCU Centre for Molecular Therapeutics, at James Cook University.
She is a molecular immunologist, working on the development of vaccines, diagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public health, with a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunity, antigen discovery, vaccine engineering, and biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.
She is a recognized world expert in malaria immunology, vaccinology, and omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.
Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recently, she has been elected as President of the International Society for Vaccines (2021-2023), and has been appointed to the Federal Government’s Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia’s medical research and innovation priorities.
Availability
- Professor Denise Doolan is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- B Sc Hons (Biochemistry), The University of Queensland
- M Phil (Life Sciences), Griffith University
- PhD (Molecular Immunology), The University of Queensland
Works
Search Professor Denise Doolan’s works on UQ eSpace
2006
Journal Article
Vaxfectin™ enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccine
Sedegah, Martha, Rogers, William O., Belmonte, Arnel, Belmonte, Maria, Banania, Glenna, Patterson, Noelle, Ferrari, Marilyn, Kaslow, David C., Carucci, Daniel J., Richie, Thomas L. and Doolan, Denise L. (2006). Vaxfectin™ enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccine. Vaccine, 24 (11), 1921-1927. doi: 10.1016/j.vaccine.2005.10.041
2006
Journal Article
The US capitol bioterrorism anthrax exposures: Clinical epidemiological and immunological characteristics
Doolan, Denise L., Freilich, Daniel A., Brice, Gary T., Burgess, Timothy H., Berzins, Mara P., Bull, Robert L., Graber, Norma L., Dabbs, Jason L., Shatney, Lori L., Blazes, David L., Bebris, Lolita M., Malone, Maria F., Eisold, John F., Mateczun, Alfred J. and Martin, Gregory J. (2006). The US capitol bioterrorism anthrax exposures: Clinical epidemiological and immunological characteristics. Journal of Infectious Diseases, 195 (2), 174-184. doi: 10.1086/510312
2006
Journal Article
Immune response to pre-erythrocytic stages of malaria parasites
Doolan, D. L. and Martinez-Alier, N. (2006). Immune response to pre-erythrocytic stages of malaria parasites. Current Molecular Medicine, 6 (2), 169-185. doi: 10.2174/156652406776055249
2006
Journal Article
Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques
Sundaresh, S., Doolan, D. L., Hirst, S., Mu, Y., Unal, B., Davies, H., Felgner, P. and Baldi, P. (2006). Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques. Bioinformatics, 22 (14), 1760-1766. doi: 10.1093/bioinformatics/btl162
2004
Journal Article
A Small Peptide (CEL-1000) Derived from the ß-Chain of the Human Major Histocompatibility Complex Class II Molecule Induces Complete Protection against Malaria in an Antigen-Independent Manner
Charoenvit, Yupin, Brice, Gary T., Bacon, David, Majam, Victoria, Williams, Jackie, Abot, Esteban, Ganeshan, Harini, Sedegah, Martha, Doolan, Denise L., Carucci, Daniel J. and Zimmerman, Daniel H. (2004). A Small Peptide (CEL-1000) Derived from the ß-Chain of the Human Major Histocompatibility Complex Class II Molecule Induces Complete Protection against Malaria in an Antigen-Independent Manner. Antimicrobial agents and chemotherapy, 48 (7), 2455-2463. doi: 10.1128/AAC.48.7.2455-2463.2004
2004
Journal Article
Induction in Humans of CD8+ and CD4+ T Cell and Antibody Responses by Sequential Immunization with Malaria DNA and Recombinant Protein
Wang, Ruobing, Epstein, Judith, Charoenvit, Yupin, Baraceros, Fe Maria, Rahardjo, Nancy, Gay, Tanya, Banania, Jo-Glenna, Chattopadhyay, Rana, de la Vega, Patricia, Richie, Thomas L., Tornieporth, Nadia, Doolan, Denise L., Kester, Kent E., Heppner, D. Gray, Norman, Jon, Carucci, Daniel J., Cohen, Joe D. and Hoffman, Stephen L. (2004). Induction in Humans of CD8+ and CD4+ T Cell and Antibody Responses by Sequential Immunization with Malaria DNA and Recombinant Protein. Journal of immunology, 172 (9), 5561-5569. doi: 10.4049/jimmunol.172.9.5561
2003
Journal Article
Utilization of genomic sequence information to develop malaria vaccines
Doolan, D. L., Aguiar, J. C., Weiss, W. R., Sette, A., Felgner, P. L., Regis, D. P., Quinones-Casas, P., Yates, J. R. III, Blair, P. L., Richie, T. L., Hoffman, S. L. and Carucci, D. J. (2003). Utilization of genomic sequence information to develop malaria vaccines. Journal of experimental biology, 206 (21), 3789-3802. doi: 10.1242/jeb.00615
2003
Journal Article
Identification of plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
Doolan, Denise, Southwood, S., Freilich, D. A., Sidney, J., Graber, N. L., Shatney, L., Bebris, L., Florens, L., Dobano, C., Witney, A.A., Apella, E., Hoffman, S. L., Yates, J. R. 3rd, Carucci, D. J. and Sette, A. (2003). Identification of plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proceedings of the National Academy of Sciences of the United States of America, 100 (17), 9952-9957. doi: 10.1073/pnas.1633254100
2003
Conference Publication
Third meeting on Novel Adjuvants Currently in or Close to Clinical Testing World Health Organization - Organisation Mondiale de la Santé, Fondation Mérieux, Annecy, France, 7-9 January 2002
Engers, Howard, Kieny, Marie Paule, Malhotra, Pawan, Pink, J. Richard, Davies, Gwyn, Kensil, Charlotte Read, Jeannin, Pascale, Aubry, Jean-Pierre, Goetsch, Liliane, Delneste, Yves, Bonnefoy, Jean-Yves, Revets, Hilde, De Baetselier, Patrick, Steward, Michael, Fritchley, Sarah J., Bright, Jeremy R., Oldroyd, Rodney G., Affleck, Louise J., Ross, Ted M., Holder, Anthony A., Smith, Richard A.G., Kenney, Richard, Glenn, Gregory, Czerkinsky, Cecil, Del Giudice, Giuseppe, Zurbriggen, Rinaldo, Glück, Reinhard, Drane, Debbie, Pearse, Martin ... Sedegah, M. (2003). Third meeting on Novel Adjuvants Currently in or Close to Clinical Testing World Health Organization - Organisation Mondiale de la Santé, Fondation Mérieux, Annecy, France, 7-9 January 2002. Elsevier BV. doi: 10.1016/S0264-410X(03)00164-6
2002
Journal Article
Optimal induction of antigen-specific CD8+ T cell responses requires bystander cell participation
Brice, Gary T., Graber, Norma L., Carucci, Daniel J. and Doolan, Denise L. (2002). Optimal induction of antigen-specific CD8+ T cell responses requires bystander cell participation. Journal of leukocyte biology, 72 (6), 1164-1171. doi: 10.1189/jlb.72.6.1164
2002
Journal Article
Erratum: Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice (Infection and Immunity (2001) 69:3 (1643-1649))
Gramzinski, Robert A., Doolan, Denise L., Sedegah, Martha, Davis, Heather L., Krieg, Arthur M. and Hoffman, Stephen L. (2002). Erratum: Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice (Infection and Immunity (2001) 69:3 (1643-1649)). Infection and Immunity, 70 (9). doi: 10.1128/IAI.70.9.5338.2002
2002
Journal Article
Persistence of Protective Immunity to Malaria Induced by DNA Priming and Poxvirus Boosting: Characterization of Effector and Memory CD8+-T-Cell Populations
Sedegah, Martha, Brice, Gary T., Rogers, William O., Doolan, Denise L., Charoenvit, Yupin, Jones, Trevor R., Majam, Victoria F., Belmonte, Arnel, Lu, Minh, Belmonte, Maria, Carucci, Daniel J. and Hoffman, Stephen L. (2002). Persistence of Protective Immunity to Malaria Induced by DNA Priming and Poxvirus Boosting: Characterization of Effector and Memory CD8+-T-Cell Populations. Infection and immunity, 70 (7), 3493-3499. doi: 10.1128/IAI.70.7.3493-3499.2002
2002
Journal Article
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites
Hoffman, Stephen L., Goh, Lucy M. L., Luke, Thomas C., Schneider, Imogene, Le, Thong P., Doolan, Denise L., Sacci, John, De la Vega, Patricia, Dowler, Megan, Paul, Chris, Gordon, Daniel M., Stoute, Jose A., Preston Church, L. W., Sedegah, Martha, Gray Heppner, D., Ripley Ballou, W. and Richie, Thomas L. (2002). Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. Journal of Infectious Diseases, 185 (8), 1155-1164. doi: 10.1086/339409
2002
Journal Article
A simple method for delivery and antigen presentation of a malaria protein in human dendritic cells (Application Note)
Doolan, Denise L. and Graber, Norma L. (2002). A simple method for delivery and antigen presentation of a malaria protein in human dendritic cells (Application Note). Delivery, 22, 6-7.
2002
Journal Article
Nucleic acid vaccines against malaria
Doolan, Denise L. and Hoffman, Stephen L. (2002). Nucleic acid vaccines against malaria. Chemical Immunology, 80, 308-321. doi: 10.1159/000058851
2002
Book Chapter
DNA vaccination
Hedstrom, Richard C. and Doolan, Denise L. (2002). DNA vaccination. Malaria methods and protocols. (pp. 347-59) edited by Denise L. Doolan. New York, NY, United States: Humana Press. doi: 10.1385/1-59259-271-6:347
2002
Book Chapter
Assessing antigen-specific CD8+ CTL responses in humans
Doolan, Denise L. (2002). Assessing antigen-specific CD8+ CTL responses in humans. Malaria Methods and Protocols. (pp. 445-456) edited by Denise L. Doolan. New York, NY, United States: Humana Press. doi: 10.1385/1-59259-271-6:445
2001
Journal Article
Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy
Witney, Adam A., Doolan, Denise L., Anthony, Robert M., Weiss, Walter R., Hoffman, Stephen L. and Carucci, Daniel J. (2001). Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy. Molecular and Biochemical Parasitology, 118 (2), 233-245. doi: 10.1016/S0166-6851(01)00372-3
2001
Journal Article
Foreword--MBP thematic issue on genomics
Doolan, D. L., Coppel, R. L. and Waters, A. P. (2001). Foreword--MBP thematic issue on genomics. Molecular and Biochemical Parasitology, 118 (2), 127-8. doi: 10.1016/s0166-6851(01)00389-9
2001
Journal Article
Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-γ production and IFN-γ-secreting cells
Brice, G. T., Graber, N. L., Hoffman, S. L. and Doolan, D. L. (2001). Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-γ production and IFN-γ-secreting cells. Journal of Immunological Methods, 257 (1-2), 55-69. doi: 10.1016/s0022-1759(01)00446-x
Funding
Current funding
Past funding
Supervision
Availability
- Professor Denise Doolan is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Systems immunology and multi-omics approaches to understand protective immunity to human malaria
Principal Advisor
Other advisors: Dr Quan Nguyen
-
Doctor Philosophy
Understanding the link between EBV and Multiple Sclerosis
Principal Advisor
-
Doctor Philosophy
Utilising high throughout spatial Transcriptomics to personlise treatment approaches for endometriosis patients
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Akwasi Amoako, Dr Brett McKinnon
Completed supervision
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2025
Doctor Philosophy
Understanding the Molecular Basis of Immune Heterogeneity using Systems Immunology
Principal Advisor
-
2018
Doctor Philosophy
Characterization of cross-reactive immune responses in the context of a complex host-pathogen system.
Principal Advisor
-
2015
Doctor Philosophy
Molecular profiling of cellular immune responses to Plasmodium spp. blood-stage infection in humans using systems immunology
Principal Advisor
-
2014
Doctor Philosophy
Evaluation of novel DNA vaccine delivery strategies targeting dendritic cells: mechanisms of action, immunogenicity and protective efficacy
Principal Advisor
-
2014
Doctor Philosophy
Evaluation of novel antigens identified in genome-wide screening approaches for next-generation malaria vaccines
Principal Advisor
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2013
Doctor Philosophy
Design and use of a schistosome protein microarray to investigate Asian schistosomiasis
Associate Advisor
Other advisors: Professor Malcolm Jones
Media
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