
Overview
Background
Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicine, and Director of the JCU Centre for Molecular Therapeutics, at James Cook University.
She is a molecular immunologist, working on the development of vaccines, diagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public health, with a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunity, antigen discovery, vaccine engineering, and biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.
She is a recognized world expert in malaria immunology, vaccinology, and omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.
Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recently, she has been elected as President of the International Society for Vaccines (2021-2023), and has been appointed to the Federal Government’s Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia’s medical research and innovation priorities.
Availability
- Professor Denise Doolan is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- B Sc Hons (Biochemistry), The University of Queensland
- M Phil (Life Sciences), Griffith University
- PhD (Molecular Immunology), The University of Queensland
Works
Search Professor Denise Doolan’s works on UQ eSpace
2010
Journal Article
Schistosomiasis vaccine discovery using immunomics
Driguez, P, Doolan, DL, Loukas, A, Felgner, PL and McManus, DP (2010). Schistosomiasis vaccine discovery using immunomics. Parasites and Vectors, 3 (1) 4, 4 - 1-4 - 5. doi: 10.1186/1756-3305-3-4
2010
Conference Publication
Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses
Cardoso, F. C., Groves, P., Roddick, J. and Doolan, D. L. (2010). Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses. XII International Conference for Parasitology, Melbourme, Australia, 15-20 August 2010.
2009
Journal Article
Sterile protection ,against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: Comparison of heterologous prime boost strategies
Jiang, George, Shi, Meng, Conteh, Solomon, Richie, Nancy, Banania, Glenna, Geneshan, Harini, Valencia, Anais, Singh, Priti, Aguiar, Joao, Limbach, Keith, Kamrud, Kurt I., Rayner, Jonathan, Smith, Jonathan, Bruder, Joseph T., King, C. Richter, Tsuboi, Takafumi, Takeo, Satoru, Endo, Yaeta, Doolan, Denise L., Richie, Thomas L. and Weiss, Walter R. (2009). Sterile protection ,against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: Comparison of heterologous prime boost strategies. PloS one, 4 (8) e6559, e6559 -1-e6559 -12. doi: 10.1371/journal.pone.0006559
2009
Journal Article
Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
Woodberry, Tonia, Pinzon-Charry, Alberto, Piera, Kim A., Panpisutchai, Yawalak, Engwerda, Christian R., Doolan, Denise L., Salwati, Ervi, Kenangalem, Enny, Tjitra, Emiliana, Price, Ric N., Good, Michael F. and Anstey, Nicholas M. (2009). Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria. Malaria Journal, 8 (1) 122, 122.1-122.10. doi: 10.1186/1475-2875-8-122
2009
Journal Article
Plasmodium: Mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity
Dobañoa, Carlota, Sedegah, Martha, Rogers, William O., Kumar, Sanjai, Zheng, Hong, Hoffman, Stephen L. and Doolan, Denise (2009). Plasmodium: Mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity. Experimental Parasitology, 122 (2), 112-123. doi: 10.1016/j.exppara.2009.02.010
2009
Journal Article
Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues
Vaughan, K., Blythe, M., Greenbaum, J., Zhang, Q., Peters, B., Doolan, D.L. and Sette, A. (2009). Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues. Parasite Immunology, 31 (2), 78-97. doi: 10.1111/j.1365-3024.2008.01077.x
2009
Journal Article
Acquired immunity to malaria
Doolan, Denise L., Dobano, Carlota and Baird, J. Kevin (2009). Acquired immunity to malaria. Clinical Microbiology Reviews, 22 (1), 13-26. doi: 10.1128/CMR.00025-08
2008
Journal Article
Profiling humoral immune responses to P. falciparum infection with protein microarrays
Doolan, Denise L., Mu, Yunxiang, Una, Berkay, Sundaresh, Suman, Hirst, Siddiqua, Valdez, Conrad and et al. (2008). Profiling humoral immune responses to P. falciparum infection with protein microarrays. Proteomics, 8 (22), 4680-4694. doi: 10.1002/pmic.200800194
2008
Journal Article
The path of discovery
Doolan, Denise L. (2008). The path of discovery. Human Vaccines, 4 (5), 324-327. doi: 10.4161/hv.4.5.6707
2008
Journal Article
Alphavirus replicon particles are highly immunogenic in the murine malaria model by homologous or heterologous immunization
Dobano, C., Weiss, W. R., Kamrud, K. I., Chulay, J. D., Smith, J., Carucci, D. J. and Doolan, D. L. (2008). Alphavirus replicon particles are highly immunogenic in the murine malaria model by homologous or heterologous immunization. The Open Vaccine Journal, 1, 27-37.
2008
Journal Article
Transcriptionally active PCR for antigen identification and vaccine development: In vitro genome-wide screening and in vivo immunogenicity
Regis, David P., Dobaño, Carlota, Quiñones-Olson, Paola, Liang, Xiaowu, Graber, Norma L., Stefaniak, Maureen E., Campo, Joseph J., Carucci, Daniel J., Roth, David A., He, Huaping, Felgner, Philip L. and Doolan, Denise L. (2008). Transcriptionally active PCR for antigen identification and vaccine development: In vitro genome-wide screening and in vivo immunogenicity. Molecular and Biochemical Parasitology, 158 (1), 32-45. doi: 10.1016/j.molbiopara.2007.11.009
2007
Journal Article
Status of malaria vaccine R&D in 2007
Doolan, Denise L. and Stewart, V. Ann (2007). Status of malaria vaccine R&D in 2007. Expert Review of Vaccines, 6 (6), 903-905. doi: 10.1586/14760584.6.6.903
2007
Journal Article
Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization
Jiang, George, Charoenvit, Yupin, Moreno, Alberto, Baraceros, Maria F., Banania, Glenna, Richie, Nancy, Abot, Steve, Ganeshan, Harini, Fallarme, Victoria, Patterson, Noelle B., Geall, Andrew, Weiss, Walter R., Strobert, Elizabeth, Caro-Aquilar, Ivette, Lanar, David E., Saul, Allan, Martin, Laura B., Gowda, Kalpana, Morrissette, Craig R., Kaslow, David C., Carucci, Daniel J., Galinski, Mary R. and Doolan, Denise L. (2007). Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization. Malaria Journal, 6 (1) 135, 135-152. doi: 10.1186/1475-2875-6-135
2007
Journal Article
Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines
Brice, Gary T., Dobano, Carlota, Sedegah, Martha, Stefaniak, Maureen, Graber, Norma L., Campo, Joseph J., Carucci, Daniel J. and Doolan, Denise L. (2007). Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines. Microbes and Infection, 9 (12-13), 1439-1446. doi: 10.1016/j.micinf.2007.07.009
2007
Journal Article
Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation
Dobano, Carlota, Widera, Georg, Rabussay, Dietmar and Doolan, Denise L. (2007). Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation. Vaccine, 25 (36), 6635-6645. doi: 10.1016/j.vaccine.2007.06.036
2007
Journal Article
Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines
Dobañoa, Carlota, Rogersa, William O., Gowdaa , Kalpana and Doolana, Denise L. (2007). Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines. Immunology Letters, 111 (2), 92-102. doi: 10.1016/j.imlet.2007.05.007
2007
Journal Article
Viral vectors for malaria vaccine development
Li, Shengqiang, Locke, Emily, Bruder, Joseph, Clarke, David, Doolan, Denise L., Havenga, Menzo J. E., Hill, Adrian V. S., Liljestrom, Peter, Monath, Thomas P., Naimi, Hussein Y., Ockenhouse, Christian, Tang, De-chu C., Van Kampen, Kent R., Viret, Jean-Francois, Zavala, Fidel and Dubovsky, Filip (2007). Viral vectors for malaria vaccine development. Vaccine, 25 (14), 2567-2574. doi: 10.1016/j.vaccine.2006.07.035
2007
Journal Article
Mutating the Anchor Residues Associated with MHC Binding Inhibits and Deviates CD8+ T cell Mediated Protective Immunity Against Malaria
Dobano, C., McTague, A., Sette, A., Hoffman, S. L., Rogers, W. O. and Doolan, D. L. (2007). Mutating the Anchor Residues Associated with MHC Binding Inhibits and Deviates CD8+ T cell Mediated Protective Immunity Against Malaria. Molecular Immunology, 44 (9), 2235-2248. doi: 10.1016/j.molimm.2006.11.003
2007
Journal Article
Malaria's journey through the lymph node
Good, Michael F. and Doolan, Denise L. (2007). Malaria's journey through the lymph node. Nature Medicine, 13 (9), 1023-1024. doi: 10.1038/nm0907-1015
2007
Journal Article
Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17 kDa
Dobano, C. and Doolan, D.L. (2007). Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17 kDa. Molecular Immunology, 44 (11), 3037-3048. doi: 10.1016/j.molimm.2007.01.001
Funding
Current funding
Past funding
Supervision
Availability
- Professor Denise Doolan is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Systems immunology and multi-omics approaches to understand protective immunity to human malaria
Principal Advisor
Other advisors: Dr Quan Nguyen
-
Doctor Philosophy
Understanding the link between EBV and Multiple Sclerosis
Principal Advisor
-
Doctor Philosophy
Utilising high throughout spatial Transcriptomics to personlise treatment approaches for endometriosis patients
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Akwasi Amoako, Dr Brett McKinnon
Completed supervision
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2025
Doctor Philosophy
Understanding the Molecular Basis of Immune Heterogeneity using Systems Immunology
Principal Advisor
-
2018
Doctor Philosophy
Characterization of cross-reactive immune responses in the context of a complex host-pathogen system.
Principal Advisor
-
2015
Doctor Philosophy
Molecular profiling of cellular immune responses to Plasmodium spp. blood-stage infection in humans using systems immunology
Principal Advisor
-
2014
Doctor Philosophy
Evaluation of novel DNA vaccine delivery strategies targeting dendritic cells: mechanisms of action, immunogenicity and protective efficacy
Principal Advisor
-
2014
Doctor Philosophy
Evaluation of novel antigens identified in genome-wide screening approaches for next-generation malaria vaccines
Principal Advisor
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2013
Doctor Philosophy
Design and use of a schistosome protein microarray to investigate Asian schistosomiasis
Associate Advisor
Other advisors: Professor Malcolm Jones
Media
Enquiries
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