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Professor Denise Doolan
Professor

Denise Doolan

Email: 
Phone: 
+61 7 334 62159

Overview

Background

Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicine, and Director of the JCU Centre for Molecular Therapeutics, at James Cook University.

She is a molecular immunologist, working on the development of vaccines, diagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public health, with a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunity, antigen discovery, vaccine engineering, and biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.

She is a recognized world expert in malaria immunology, vaccinology, and omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.

Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recently, she has been elected as President of the International Society for Vaccines (2021-2023), and has been appointed to the Federal Government’s Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia’s medical research and innovation priorities.

Availability

Professor Denise Doolan is:
Available for supervision

Fields of research

Qualifications

  • Bachelor of Science, The University of Queensland
  • B Sc Hons (Biochemistry), The University of Queensland
  • M Phil (Life Sciences), Griffith University
  • PhD (Molecular Immunology), The University of Queensland

Works

Search Professor Denise Doolan’s works on UQ eSpace

224 works between 1987 and 2025

141 - 160 of 224 works

2010

Journal Article

Schistosomiasis vaccine discovery using immunomics

Driguez, P, Doolan, DL, Loukas, A, Felgner, PL and McManus, DP (2010). Schistosomiasis vaccine discovery using immunomics. Parasites and Vectors, 3 (1) 4, 4 - 1-4 - 5. doi: 10.1186/1756-3305-3-4

Schistosomiasis vaccine discovery using immunomics

2010

Conference Publication

Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses

Cardoso, F. C., Groves, P., Roddick, J. and Doolan, D. L. (2010). Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses. XII International Conference for Parasitology, Melbourme, Australia, 15-20 August 2010.

Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses

2009

Journal Article

Sterile protection ,against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: Comparison of heterologous prime boost strategies

Jiang, George, Shi, Meng, Conteh, Solomon, Richie, Nancy, Banania, Glenna, Geneshan, Harini, Valencia, Anais, Singh, Priti, Aguiar, Joao, Limbach, Keith, Kamrud, Kurt I., Rayner, Jonathan, Smith, Jonathan, Bruder, Joseph T., King, C. Richter, Tsuboi, Takafumi, Takeo, Satoru, Endo, Yaeta, Doolan, Denise L., Richie, Thomas L. and Weiss, Walter R. (2009). Sterile protection ,against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: Comparison of heterologous prime boost strategies. PloS one, 4 (8) e6559, e6559 -1-e6559 -12. doi: 10.1371/journal.pone.0006559

Sterile protection ,against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: Comparison of heterologous prime boost strategies

2009

Journal Article

Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria

Woodberry, Tonia, Pinzon-Charry, Alberto, Piera, Kim A., Panpisutchai, Yawalak, Engwerda, Christian R., Doolan, Denise L., Salwati, Ervi, Kenangalem, Enny, Tjitra, Emiliana, Price, Ric N., Good, Michael F. and Anstey, Nicholas M. (2009). Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria. Malaria Journal, 8 (1) 122, 122.1-122.10. doi: 10.1186/1475-2875-8-122

Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria

2009

Journal Article

Plasmodium: Mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity

Dobañoa, Carlota, Sedegah, Martha, Rogers, William O., Kumar, Sanjai, Zheng, Hong, Hoffman, Stephen L. and Doolan, Denise (2009). Plasmodium: Mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity. Experimental Parasitology, 122 (2), 112-123. doi: 10.1016/j.exppara.2009.02.010

Plasmodium: Mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity

2009

Journal Article

Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues

Vaughan, K., Blythe, M., Greenbaum, J., Zhang, Q., Peters, B., Doolan, D.L. and Sette, A. (2009). Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues. Parasite Immunology, 31 (2), 78-97. doi: 10.1111/j.1365-3024.2008.01077.x

Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues

2009

Journal Article

Acquired immunity to malaria

Doolan, Denise L., Dobano, Carlota and Baird, J. Kevin (2009). Acquired immunity to malaria. Clinical Microbiology Reviews, 22 (1), 13-26. doi: 10.1128/CMR.00025-08

Acquired immunity to malaria

2008

Journal Article

Profiling humoral immune responses to P. falciparum infection with protein microarrays

Doolan, Denise L., Mu, Yunxiang, Una, Berkay, Sundaresh, Suman, Hirst, Siddiqua, Valdez, Conrad and et al. (2008). Profiling humoral immune responses to P. falciparum infection with protein microarrays. Proteomics, 8 (22), 4680-4694. doi: 10.1002/pmic.200800194

Profiling humoral immune responses to P. falciparum infection with protein microarrays

2008

Journal Article

The path of discovery

Doolan, Denise L. (2008). The path of discovery. Human Vaccines, 4 (5), 324-327. doi: 10.4161/hv.4.5.6707

The path of discovery

2008

Journal Article

Alphavirus replicon particles are highly immunogenic in the murine malaria model by homologous or heterologous immunization

Dobano, C., Weiss, W. R., Kamrud, K. I., Chulay, J. D., Smith, J., Carucci, D. J. and Doolan, D. L. (2008). Alphavirus replicon particles are highly immunogenic in the murine malaria model by homologous or heterologous immunization. The Open Vaccine Journal, 1, 27-37.

Alphavirus replicon particles are highly immunogenic in the murine malaria model by homologous or heterologous immunization

2008

Journal Article

Transcriptionally active PCR for antigen identification and vaccine development: In vitro genome-wide screening and in vivo immunogenicity

Regis, David P., Dobaño, Carlota, Quiñones-Olson, Paola, Liang, Xiaowu, Graber, Norma L., Stefaniak, Maureen E., Campo, Joseph J., Carucci, Daniel J., Roth, David A., He, Huaping, Felgner, Philip L. and Doolan, Denise L. (2008). Transcriptionally active PCR for antigen identification and vaccine development: In vitro genome-wide screening and in vivo immunogenicity. Molecular and Biochemical Parasitology, 158 (1), 32-45. doi: 10.1016/j.molbiopara.2007.11.009

Transcriptionally active PCR for antigen identification and vaccine development: In vitro genome-wide screening and in vivo immunogenicity

2007

Journal Article

Status of malaria vaccine R&D in 2007

Doolan, Denise L. and Stewart, V. Ann (2007). Status of malaria vaccine R&D in 2007. Expert Review of Vaccines, 6 (6), 903-905. doi: 10.1586/14760584.6.6.903

Status of malaria vaccine R&D in 2007

2007

Journal Article

Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization

Jiang, George, Charoenvit, Yupin, Moreno, Alberto, Baraceros, Maria F., Banania, Glenna, Richie, Nancy, Abot, Steve, Ganeshan, Harini, Fallarme, Victoria, Patterson, Noelle B., Geall, Andrew, Weiss, Walter R., Strobert, Elizabeth, Caro-Aquilar, Ivette, Lanar, David E., Saul, Allan, Martin, Laura B., Gowda, Kalpana, Morrissette, Craig R., Kaslow, David C., Carucci, Daniel J., Galinski, Mary R. and Doolan, Denise L. (2007). Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization. Malaria Journal, 6 (1) 135, 135-152. doi: 10.1186/1475-2875-6-135

Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization

2007

Journal Article

Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines

Brice, Gary T., Dobano, Carlota, Sedegah, Martha, Stefaniak, Maureen, Graber, Norma L., Campo, Joseph J., Carucci, Daniel J. and Doolan, Denise L. (2007). Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines. Microbes and Infection, 9 (12-13), 1439-1446. doi: 10.1016/j.micinf.2007.07.009

Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines

2007

Journal Article

Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation

Dobano, Carlota, Widera, Georg, Rabussay, Dietmar and Doolan, Denise L. (2007). Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation. Vaccine, 25 (36), 6635-6645. doi: 10.1016/j.vaccine.2007.06.036

Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation

2007

Journal Article

Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines

Dobañoa, Carlota, Rogersa, William O., Gowdaa , Kalpana and Doolana, Denise L. (2007). Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines. Immunology Letters, 111 (2), 92-102. doi: 10.1016/j.imlet.2007.05.007

Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines

2007

Journal Article

Viral vectors for malaria vaccine development

Li, Shengqiang, Locke, Emily, Bruder, Joseph, Clarke, David, Doolan, Denise L., Havenga, Menzo J. E., Hill, Adrian V. S., Liljestrom, Peter, Monath, Thomas P., Naimi, Hussein Y., Ockenhouse, Christian, Tang, De-chu C., Van Kampen, Kent R., Viret, Jean-Francois, Zavala, Fidel and Dubovsky, Filip (2007). Viral vectors for malaria vaccine development. Vaccine, 25 (14), 2567-2574. doi: 10.1016/j.vaccine.2006.07.035

Viral vectors for malaria vaccine development

2007

Journal Article

Mutating the Anchor Residues Associated with MHC Binding Inhibits and Deviates CD8+ T cell Mediated Protective Immunity Against Malaria

Dobano, C., McTague, A., Sette, A., Hoffman, S. L., Rogers, W. O. and Doolan, D. L. (2007). Mutating the Anchor Residues Associated with MHC Binding Inhibits and Deviates CD8+ T cell Mediated Protective Immunity Against Malaria. Molecular Immunology, 44 (9), 2235-2248. doi: 10.1016/j.molimm.2006.11.003

Mutating the Anchor Residues Associated with MHC Binding Inhibits and Deviates CD8+ T cell Mediated Protective Immunity Against Malaria

2007

Journal Article

Malaria's journey through the lymph node

Good, Michael F. and Doolan, Denise L. (2007). Malaria's journey through the lymph node. Nature Medicine, 13 (9), 1023-1024. doi: 10.1038/nm0907-1015

Malaria's journey through the lymph node

2007

Journal Article

Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17 kDa

Dobano, C. and Doolan, D.L. (2007). Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17 kDa. Molecular Immunology, 44 (11), 3037-3048. doi: 10.1016/j.molimm.2007.01.001

Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17 kDa

Funding

Current funding

  • 2026 - 2030
    Next-generation therapeutics for malaria designed using systems-based approaches
    NHMRC Investigator Grants
    Open grant
  • 2025 - 2026
    An mRNA T-cell Vaccine Against Malaria
    UQ - Sanofi Translational Science Hub Partnership Scheme
    Open grant
  • 2025 - 2026
    A Facility for Accelerated Microbial Phenotyping in Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2024 - 2026
    Development of a multi-antigen T-cell malaria vaccine (NFMRI grant administered by James Cook University)
    James Cook University
    Open grant
  • 2024 - 2026
    Effective Multiple Sclerosis diagnosis based on EBV proteome screening
    MS Research Australia Project Grant
    Open grant

Past funding

  • 2023 - 2025
    Human-informed data-driven development of next-generation T cell vaccine against malaria
    United States National Institutes of Health
    Open grant
  • 2013 - 2017
    Tropical disease - immunity, pathogenesis and vaccine development: global translation (NHMRC Program Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2012 - 2014
    ResTeach Funding 2012 0.1 FTE School of Medicine/School of Chemisty and Molecular Biosciences
    UQ ResTeach
    Open grant

Supervision

Availability

Professor Denise Doolan is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Systems immunology and multi-omics approaches to understand protective immunity to human malaria

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Understanding the link between EBV and Multiple Sclerosis

    Principal Advisor

  • Doctor Philosophy

    Utilising high throughout spatial Transcriptomics to personlise treatment approaches for endometriosis patients

    Associate Advisor

    Other advisors: Dr Quan Nguyen, Associate Professor Akwasi Amoako, Dr Brett McKinnon

Completed supervision

Media

Enquiries

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