Dr Michael Nissen
Dr

Michael Nissen

Email: 

Background

Michael has over 30 years’ experience in clinical medicine (infectious diseases & paediatrics) and clinical laboratory microbiology with a particular interest in the epidemiology of vaccine preventable diseases and the diagnosis of infectious diseases in hospital, public health and industry settings. He recently took up the inaugural Director of Research at The Prince Charles Hospital in Brisbane.

He is a past Principal Medical Officer and Director of CoVID-19 Pharmacovigilance at the Therapeutic Goods Administration, Department of Health & Ageing, Australian Government (2021-2022), Director of Scientific Affairs & Public Health for GSK Vaccines in the Greater China Intercontinental region based in Singapore (2014-2020) and Director of Infectious Diseases at the Royal Children’s Hospital-Brisbane and a practising Clinical Microbiologist at the Royal Brisbane & Women’s Hospitals (2000-2014). Michael is a past full member of the Australian Technical Advisory Group for Immunisation from 2007 to 2013.

Prof. Nissen has 223 peer-reviewed medical publications and book chapters, a h- index of 64 with 13,321 citations of his work to date. His research interests include the epidemiology and prevention of vaccine preventable diseases and the rapid molecular diagnostic techniques of infectious diseases.

Availability

Dr Michael Nissen is:
Available for supervision

Fields of research

Clinical sciences Medical microbiology

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians
  • Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia

Research impacts

Founder & Co-Lead of Queensland Paediatric Infectious Diseases Laboratory & Associate Professor, University of Queensland Australia: 2003-2014

Research laboratory dedicated to viral discovery, translational adaption of molecular techniques for the diagnosis of infectious and rapid molecular diagnosis of respiratory viruses. Co-discoverer of WU virus. Lead approximately 40 Phase I-IV vaccine trials in attached clinical trials unit including meningococcal and staphylococcal candidates. Established experience in the maintenance and utility of large microbiology (virus and bacteria) and serum biobanks that lead to significant viral discoveries and clinical translation.

Co-discoverer of WU Virus: 2007

Gaynor AM, MD Nissen, DM Whiley, IM Mackay, SB Lambert, G Wu, DC Brennan, GA Storch, TP Sloots, D Wang (2007). Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathogens May 4; 3(5):e64 doi:10.1371/journal.ppat.0030064 (Citations: 846).

Director of Infectious Diseases, Royal Children’s Hospital-Brisbane, QLD AUSTRALIA: 2003-2014

Foundation and Inaugural Director of Clinical Infectious Diseases (Infection Management Prevention Service-IMPS) and Pre-Eminent Staff Specialist at largest children’s hospital in Queensland and State-based Children’s Health Service (CHS). Established Antimicrobial Stewardship (AMS) Committee at CHS and developed the “AntibioCard.” Also acted as Chair of the Infection Control Committee during this period and served as paediatric representative on State Health Medicines Advisory Committee (2000-2014).

Search Professor Michael Nissen’s works on UQ eSpace

198 works between 1984 and 2023
All (198) Journal Article (173) Book Chapter (5) Conference Publication (18) Other Outputs (2)

21 - 40 of 198 works

2016

Journal Article

Prospective clinical trial of hepatitis B vaccination in adults with and without type-2 diabetes mellitus

Van Der Meeren, Olivier, Peterson, James T., Dionne, Marc, Beasley, Richard, Ebeling, Peter R., Ferguson, Murdo, Nissen, Michael D., Rheault, Paul, Simpson, Richard W., De Ridder, Marc, Crasta, Priya D., Miller, Jacqueline M. and Trofa, Andrew F. (2016). Prospective clinical trial of hepatitis B vaccination in adults with and without type-2 diabetes mellitus. Human Vaccines and Immunotherapeutics, 12 (8), 2197-2203. doi: 10.1080/21645515.2016.1164362

Prospective clinical trial of hepatitis B vaccination in adults with and without type-2 diabetes mellitus

2015

Journal Article

Immune responses to a recombinant, four-component, meningococcal serogroup B vaccine (4CMenB) in adolescents: A phase III, randomized, multicentre, lot-to-lot consistency study

Perrett, Kirsten P., McVernon, Jodie, Richmond, Peter C., Marshall, Helen, Nissen, Michael, August, Allison, Percell, Sandra, Toneatto, Daniela and Nolan, Terry (2015). Immune responses to a recombinant, four-component, meningococcal serogroup B vaccine (4CMenB) in adolescents: A phase III, randomized, multicentre, lot-to-lot consistency study. Vaccine, 33 (39), 5217-5224. doi: 10.1016/j.vaccine.2015.06.103

Immune responses to a recombinant, four-component, meningococcal serogroup B vaccine (4CMenB) in adolescents: A phase III, randomized, multicentre, lot-to-lot consistency study

2015

Journal Article

Specific rolling circle amplification of low-copy human polyomaviruses BKV, HPyV6, HPyV7, TSPyV, and STLPyV

Rockett, Rebecca, Barraclough K.A., Isbel, Nicole M., Dudley, Kevin J., Nissen, Michael D., Sloots, Theo P. and Bialasiewicz, Seweryn (2015). Specific rolling circle amplification of low-copy human polyomaviruses BKV, HPyV6, HPyV7, TSPyV, and STLPyV. Journal of Virological Methods, 215-216, 17-21. doi: 10.1016/j.jviromet.2015.02.004

Specific rolling circle amplification of low-copy human polyomaviruses BKV, HPyV6, HPyV7, TSPyV, and STLPyV

2015

Journal Article

Deep sequence characterisation of a divergent HPIV-4a from an adult with prolonged influenza-like illness

Arden, Katherine E., Beatson, Scott A., Lambert, Stephen B., Wang, Claire W. T., McVernon, Jodie, Nissen, Michael D., Nolan, Terry, Sloots, Theo P. and Mackay, Ian M. (2015). Deep sequence characterisation of a divergent HPIV-4a from an adult with prolonged influenza-like illness. Virology Reports, 5, 19-28. doi: 10.1016/j.virep.2015.02.001

Deep sequence characterisation of a divergent HPIV-4a from an adult with prolonged influenza-like illness

2015

Journal Article

Acquisition of human polyomaviruses in the first 18 months of life

Rockett, Rebecca J., Bialasiewicz, Seweryn, Mhango, Lebogang, Gaydon, Jane, Holding, Rebecca, Whiley, David M., Lambert, Stephen B., Ware, Robert S., Nissen, Michael D., Grimwood, Keith and Sloots, Theo P. (2015). Acquisition of human polyomaviruses in the first 18 months of life. Emerging Infectious Diseases, 21 (2), 365-367. doi: 10.3201/eid2102.141429

Acquisition of human polyomaviruses in the first 18 months of life

2014

Journal Article

Enhancing influenza diagnostics to catch a shifting target

Whiley, David M., Mackay, Ian M., Nimmo, Graeme R., Sloots, Theo P. and Nissen, Michael D. (2014). Enhancing influenza diagnostics to catch a shifting target. Lancet Infectious Diseases, 14 (10), 923-923. doi: 10.1016/S1473-3099(14)70916-8

Enhancing influenza diagnostics to catch a shifting target

2014

Journal Article

High-throughput informative single nucleotide polymorphism-based typing of Neisseria gonorrhoeae using the Sequenom MassARRAY iPLEX platform

Trembizki, Ella, Smith, Helen, Lahra, Monica M., Chen, Marcus, Donovan, Basil, Fairley, Christopher K., Guy, Rebecca, Kaldor, John, Regan, David, Ward, James, Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2014). High-throughput informative single nucleotide polymorphism-based typing of Neisseria gonorrhoeae using the Sequenom MassARRAY iPLEX platform. Journal of Antimicrobial Chemotherapy, 69 (6), 1526-1532. doi: 10.1093/jac/dkt544

High-throughput informative single nucleotide polymorphism-based typing of Neisseria gonorrhoeae using the Sequenom MassARRAY iPLEX platform

2014

Journal Article

Detection of a divergent Parainfluenza 4 virus in an adult patient with influenza like illness using next-generation sequencing

Bialasiewicz, Seweryn, McVernon, Jodie, Nolan, Terry, Lambert, Stephen B., Zhao, Guoyan, Wang, David, Nissen, Michael D. and Sloots, Theo P. (2014). Detection of a divergent Parainfluenza 4 virus in an adult patient with influenza like illness using next-generation sequencing. BMC Infectious Diseases, 14 (1) 275, 275.1-275.5. doi: 10.1186/1471-2334-14-275

Detection of a divergent Parainfluenza 4 virus in an adult patient with influenza like illness using next-generation sequencing

2014

Journal Article

A comparison of two informative SNP-based strategies for typing Pseudomonas aeruginosa isolates from patients with cystic fibrosis

Syrmis, Melanie W., Kidd, Timothy J., Moser, Ralf J., Ramsay, Kay A., Gibson, Kristen M., Anuj, Snehal, Bell, Scott C., Wainwright, Claire E., Grimwood, Keith, Nissen, Michael, Sloots, Theo P. and Whiley, David M. (2014). A comparison of two informative SNP-based strategies for typing Pseudomonas aeruginosa isolates from patients with cystic fibrosis. BMC Infectious Diseases, 14 (1) 307, 307.1-307.8. doi: 10.1186/1471-2334-14-307

A comparison of two informative SNP-based strategies for typing Pseudomonas aeruginosa isolates from patients with cystic fibrosis

2014

Journal Article

Epidemiology of respiratory viral infections in children enrolled in a study of influenza vaccine effectiveness

Dierig, Alexa, Heron, Leon G., Lambert, Stephen B., Yin, Jiehui Kevin, Leask, Julie, Chow, Maria Yui Kwan, Sloots, Theo P., Nissen, Michael D., Ridda, Iman and Booy, Robert (2014). Epidemiology of respiratory viral infections in children enrolled in a study of influenza vaccine effectiveness. Influenza and other Respiratory Viruses, 8 (3), 293-301. doi: 10.1111/irv.12229

Epidemiology of respiratory viral infections in children enrolled in a study of influenza vaccine effectiveness

2014

Journal Article

Potential Animal and Environmental Sources of Q Fever Infection for Humans in Queensland

Tozer, S.J., Lambert, S.B., Strong, C.L., Field, H.E., Sloots, T.P. and Nissen, M.D. (2014). Potential Animal and Environmental Sources of Q Fever Infection for Humans in Queensland. Zoonoses and Public Health, 61 (2), 105-112. doi: 10.1111/zph.12051

Potential Animal and Environmental Sources of Q Fever Infection for Humans in Queensland

2014

Journal Article

Nasal swab samples and real-time polymerase chain reaction assays in community-based, longitudinal studies of respiratory viruses: the importance of sample integrity and quality control

Alsaleh, Asma N., Whiley, David M., Bialasiewicz, Seweryn, Lambert, Stephen B., Ware, Robert S., Nissen, Michael D., Sloots, Theo P. and Grimwood, Keith (2014). Nasal swab samples and real-time polymerase chain reaction assays in community-based, longitudinal studies of respiratory viruses: the importance of sample integrity and quality control. BMC Infectious Diseases, 14 (1) 15, 15. doi: 10.1186/1471-2334-14-15

Nasal swab samples and real-time polymerase chain reaction assays in community-based, longitudinal studies of respiratory viruses: the importance of sample integrity and quality control

2014

Journal Article

Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Goire, Namraj, Lahra, Monica M., Chen, Marcus, Donovan, Basil, Fairley, Christopher K., Guy, Rebecca, Kaldor, John, Regan, David, Ward, James, Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2014). Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance. Nature Reviews Microbiology, 12 (3), 223-229. doi: 10.1038/nrmicro3217

Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

2014

Journal Article

Screening for H7N9 influenza A by matrix gene-based real-time reverse-transcription PCR

Hackett, H., Bialasiewicz, S., Jacob, K., Bletchly, C., Harrower, B., Nimmo, G.R., Nissen, M.D., Sloots, T.P. and Whiley, D.M. (2014). Screening for H7N9 influenza A by matrix gene-based real-time reverse-transcription PCR. Journal of Virological Methods, 195, 123-125. doi: 10.1016/j.jviromet.2013.10.016

Screening for H7N9 influenza A by matrix gene-based real-time reverse-transcription PCR

2014

Journal Article

PCR to diagnose infectious disease

Sloots, T.P. and Nissen, M.D. (2014). PCR to diagnose infectious disease. European Pharmaceutical Review, 19 (3), 68-74.

PCR to diagnose infectious disease

2014

Journal Article

A national quality assurance survey of Neisseria gonorrhoeae testing

Trembizki, E., Lahra, M., Stevens, K., Freeman, K., Hogan, T., Hogg, G., Lawrence, A., Limnios, A., Pearson, J., Smith, H., Nissen, M., Sloots, T. and Whiley, D.M. (2014). A national quality assurance survey of Neisseria gonorrhoeae testing. Journal of Medical Microbiology, 63 (PART 1), 45-49. doi: 10.1099/jmm.0.065094-0

A national quality assurance survey of Neisseria gonorrhoeae testing

2014

Journal Article

Immunogenicity and safety of a CRM-conjugated meningococcal ACWY vaccine administered concomitantly with routine vaccines starting at 2 months of age

Nolan, T.M., Nissen, M.D., Naz, A., Shepard, J., Bedell, L., Hohenboken, M., Odrljin, T. and Dull, P.M. (2014). Immunogenicity and safety of a CRM-conjugated meningococcal ACWY vaccine administered concomitantly with routine vaccines starting at 2 months of age. Human Vaccines and Immunotherapeutics, 10 (2), 280-289. doi: 10.4161/hv.27051

Immunogenicity and safety of a CRM-conjugated meningococcal ACWY vaccine administered concomitantly with routine vaccines starting at 2 months of age

2013

Journal Article

High-throughput molecular typing of microbes using the Sequenom Massarray platform

Whiley, David, Trembizki, Ella, Syrmis, Melanie, Nakos, Jenny, Bletchly, Cheryl, Nissen, Michael, Nimmo, Graeme and Sloots, Theo P. (2013). High-throughput molecular typing of microbes using the Sequenom Massarray platform. Microbiology Australia, 34 (4), 175-177. doi: 10.1071/MA13058

High-throughput molecular typing of microbes using the Sequenom Massarray platform

2013

Journal Article

Safety and tolerability of a 2009 trivalent inactivated split-virion influenza vaccine in infants, children and adolescents

Lambert, Stephen B., Chuk, Lai-man R., Nissen, Michael D., Nolan, Terry M., McVernon, Jodie, Booy, Robert, Heron, Leon, Richmond, Peter C., Walls, Tony, Marshall, Helen S., Reynolds, Graham J., Hartel, Gunter F., Hu, Wilson and Lai, Michael H. (2013). Safety and tolerability of a 2009 trivalent inactivated split-virion influenza vaccine in infants, children and adolescents. Influenza and other Respiratory Viruses, 7 (5), 676-685. doi: 10.1111/irv.12107

Safety and tolerability of a 2009 trivalent inactivated split-virion influenza vaccine in infants, children and adolescents

2013

Journal Article

Bordetella holmesii and pertussis diagnosis: authors' reply

Cox, Hannah C., Jacob, Kevin, Whiley, David M., Bletchly, Cheryl, Nimmo, Graeme R., Nissen, Michael D. and Sloots, Theo P. (2013). Bordetella holmesii and pertussis diagnosis: authors' reply. Pathology, 45 (5), 532-532. doi: 10.1097/PAT.0b013e3283639c0d

Bordetella holmesii and pertussis diagnosis: authors' reply

Past funding

  • 2013 - 2016
    Q fever: How common is it and how can we best prevent it? Research to inform Q fever vaccine policy in Australia and Internationally. (NHMRC project grant administered by University of Sydney)
    University of Sydney
    Open grant
  • 2010 - 2016
    Molecular microbiology and epidemiology of respiratory infections in children
    Royal Children's Hospital Foundation
    Open grant
  • 2010 - 2011
    Development of a novel assay for the detection of clonal P.aeruginosa in persons with CF
    Australian Cystic Fibrosis Research Trust
    Open grant
  • 2010 - 2014
    Burden of respiratory infection in the first 2 years of life: a birth cohort study of emerging respiratory pathogens
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    Characterisation of novel picornavirus-like viruses identified from patients with acute respiratory infections
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    Clinical impact of clonal Pseudomonas aeruginosa in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    The clinical and epidemiological characterisation of a newly discovered human polyonmavirus, WU (WU Virus Research)
    Royal Children's Hospital Foundation
    Open grant
  • 2006
    Identification of Virulence Markers in the Respiratory Syncytial Virus Genome
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2006
    Characterisation and Epidemiology of Emerging Pathogens in Paediatrics
    ANZ Executors and Trustees' Company Ltd
    Open grant
  • 2005 - 2010
    Research support for paediatric infectious diseases
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2010
    Epidemiology and Control of Q Fever in Children
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2010
    How Children and adults with cystic fibrosis get lung infections with Pseudomonas aeruginosa
    Royal Children's Hospital Foundation
    Open grant
  • 2004 - 2010
    (i) Detection of mucoid P. aeruginosa antigens and antibodies in CF (ii) Molecular epidemiology of respiratory syncytial virus infections and the immune response in Australian children
    Royal Children's Hospital Foundation
    Open grant
  • 2003
    Macquarie Bank Asthma Research Fellowship for 2003
    Royal Australasian College of Physicians
    Open grant
  • 2003 - 2008
    The clinical significance of human metapneumovirus infections in Australian children
    Royal Children's Hospital Foundation
    Open grant
  • 2002
    Molecular epidemiology of respiratory syncitial virus in Australia
    UQ Early Career Researcher
    Open grant
  • 2001
    Establishment of a Malarial & Molecular Research Program at the RCH, Brisbane
    Royal Children's Hospital Foundation
    Open grant
  • 2001
    Real-time diagnosis of respiratory tract infections in children
    Royal Children's Hospital Foundation
    Open grant
  • 2000 - 2001
    Establishment of a Paediatric and Molecular Infectious Diseases Research Program at the Royal Children's Hospital, Brisbane
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000
    Competitive Research Equipment Grant
    Royal Children's Hospital Foundation
    Open grant

Availability

Dr Michael Nissen is:
Available for supervision

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Supervision history

Completed supervision

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