Dr Michael Nissen
Dr

Michael Nissen

Email: 

Background

Michael has over 30 years’ experience in clinical medicine (infectious diseases & paediatrics) and clinical laboratory microbiology with a particular interest in the epidemiology of vaccine preventable diseases and the diagnosis of infectious diseases in hospital, public health and industry settings. He recently took up the inaugural Director of Research at The Prince Charles Hospital in Brisbane.

He is a past Principal Medical Officer and Director of CoVID-19 Pharmacovigilance at the Therapeutic Goods Administration, Department of Health & Ageing, Australian Government (2021-2022), Director of Scientific Affairs & Public Health for GSK Vaccines in the Greater China Intercontinental region based in Singapore (2014-2020) and Director of Infectious Diseases at the Royal Children’s Hospital-Brisbane and a practising Clinical Microbiologist at the Royal Brisbane & Women’s Hospitals (2000-2014). Michael is a past full member of the Australian Technical Advisory Group for Immunisation from 2007 to 2013.

Prof. Nissen has 223 peer-reviewed medical publications and book chapters, a h- index of 64 with 13,321 citations of his work to date. His research interests include the epidemiology and prevention of vaccine preventable diseases and the rapid molecular diagnostic techniques of infectious diseases.

Availability

Dr Michael Nissen is:
Available for supervision

Fields of research

Clinical sciences Medical microbiology

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians
  • Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia

Research impacts

Founder & Co-Lead of Queensland Paediatric Infectious Diseases Laboratory & Associate Professor, University of Queensland Australia: 2003-2014

Research laboratory dedicated to viral discovery, translational adaption of molecular techniques for the diagnosis of infectious and rapid molecular diagnosis of respiratory viruses. Co-discoverer of WU virus. Lead approximately 40 Phase I-IV vaccine trials in attached clinical trials unit including meningococcal and staphylococcal candidates. Established experience in the maintenance and utility of large microbiology (virus and bacteria) and serum biobanks that lead to significant viral discoveries and clinical translation.

Co-discoverer of WU Virus: 2007

Gaynor AM, MD Nissen, DM Whiley, IM Mackay, SB Lambert, G Wu, DC Brennan, GA Storch, TP Sloots, D Wang (2007). Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathogens May 4; 3(5):e64 doi:10.1371/journal.ppat.0030064 (Citations: 846).

Director of Infectious Diseases, Royal Children’s Hospital-Brisbane, QLD AUSTRALIA: 2003-2014

Foundation and Inaugural Director of Clinical Infectious Diseases (Infection Management Prevention Service-IMPS) and Pre-Eminent Staff Specialist at largest children’s hospital in Queensland and State-based Children’s Health Service (CHS). Established Antimicrobial Stewardship (AMS) Committee at CHS and developed the “AntibioCard.” Also acted as Chair of the Infection Control Committee during this period and served as paediatric representative on State Health Medicines Advisory Committee (2000-2014).

Search Professor Michael Nissen’s works on UQ eSpace

198 works between 1984 and 2023
All (198) Journal Article (173) Book Chapter (5) Conference Publication (18) Other Outputs (2)

41 - 60 of 198 works

2013

Journal Article

Detection of novel polyomaviruses, TSPyV, HPyV6, HPyV7, HPyV9 and MWPyV in feces, urine, blood, respiratory swabs and cerebrospinal fluid

Rockett, Rebecca J., Sloots, Theo P., Bowes, Sharleen, O'Neill, Nicholas, Ye, Suifang, Robson, Jenny, Whiley, David M., Lambert, Stephen B., Wang, David, Nissen, Michael D. and Bialasiewicz, Seweryn (2013). Detection of novel polyomaviruses, TSPyV, HPyV6, HPyV7, HPyV9 and MWPyV in feces, urine, blood, respiratory swabs and cerebrospinal fluid. PLoS ONE, 8 (5) e62764, e62764.1-e62764.9. doi: 10.1371/journal.pone.0062764

Detection of novel polyomaviruses, TSPyV, HPyV6, HPyV7, HPyV9 and MWPyV in feces, urine, blood, respiratory swabs and cerebrospinal fluid

2013

Journal Article

High-throughput single-nucleotide polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic fibrosis patients using the Sequenom iPLEX platform

Syrmis, Melanie W., Moser, Ralf J., Kidd, Timothy J., Hunt, Priscilla, Ramsay, Kay A., Bell, Scott C., Wainwright, Claire E., Grimwood, Keith, Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2013). High-throughput single-nucleotide polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic fibrosis patients using the Sequenom iPLEX platform. Journal of Medical Microbiology, 62 (5), 734-740. doi: 10.1099/jmm.0.055905-0

High-throughput single-nucleotide polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic fibrosis patients using the Sequenom iPLEX platform

2013

Journal Article

Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period

Mackay, Ian M., Lambert, Stephen B., Faux, Cassandra E., Arden, Katherine E., Nissen, Michael D., Sloots, Theo P. and Nolan, Terence M. (2013). Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period. Journal of Infectious Diseases, 207 (9), 1433-1441. doi: 10.1093/infdis/jis476

Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period

2013

Journal Article

Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial

Howard, Peter F., Mccaw, James M., Richmond, Peter C., Nissen, Michael, Sloots, Theo, Lambert, Stephen B., Lai, Michael, Greenberg, Michael, Nolan, Terry and Mcvernon, Jodie (2013). Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial. Influenza and other Respiratory Viruses, 7 (3), 330-339. doi: 10.1111/j.1750-2659.2012.00395.x

Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial

2013

Journal Article

A Randomized, Controlled, Phase 1/2 Trial of a Neisseria meningitidis Serogroup B Bivalent rLP2086 Vaccine in Healthy Children and Adolescents

Nissen, Michael D., Marshall, Helen S., Richmond, Peter C., Jiang, Qin, Harris, Shannon L., Jones, Thomas R., Jansen, Kathrin U. and Perez, John L. (2013). A Randomized, Controlled, Phase 1/2 Trial of a Neisseria meningitidis Serogroup B Bivalent rLP2086 Vaccine in Healthy Children and Adolescents. Pediatric Infectious Disease Journal, 32 (4), 364-371. doi: 10.1097/INF.0b013e31827b0d24

A Randomized, Controlled, Phase 1/2 Trial of a Neisseria meningitidis Serogroup B Bivalent rLP2086 Vaccine in Healthy Children and Adolescents

2013

Journal Article

Polymerase chain reaction-based screening for the ceftriaxone-resistant Neisseria gonorrhoeae F89 strain

Goire, N., Lahra, M. M., Ohnishi, M., Hogan, T., Liminios, A. E., Nissen, M. D., Sloots, T. P. and Whiley, D. M. (2013). Polymerase chain reaction-based screening for the ceftriaxone-resistant Neisseria gonorrhoeae F89 strain. Eurosurveillance, 18 (14), 18-23. doi: 10.2807/1560-7917.ES2013.18.14.20444

Polymerase chain reaction-based screening for the ceftriaxone-resistant Neisseria gonorrhoeae F89 strain

2013

Journal Article

A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults

Marshall, Helen S., Richmond, Peter C., Nissen, Michael D., Wouters, Ann, Baber, James, Jiang, Qin, Anderson, Annaliesa S., Jones, Thomas R., Harris, Shannon L., Jansen, Kathrin U. and Perez, John L. (2013). A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults. Vaccine, 31 (12), 1569-1575. doi: 10.1016/j.vaccine.2013.01.021

A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults

2013

Journal Article

Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness

Ferguson, Patricia E., Gilroy, Nicole M., Faux, Cassandra E., Mackay, Ian M., Sloots, Theo P., Nissen, Michael D., Dwyer, Dominic E. and Sorrell, Tania C. (2013). Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness. Journal of Clinical Virology, 56 (3), 255-259. doi: 10.1016/j.jcv.2012.11.010

Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness

2013

Journal Article

Further evidence that the IS481 target is suitable for real-time PCR detection of Bordetella pertussis

Cox, Hannah C., Jacob, Kevin, Whiley, David M., Bletchly, Cheryl, Nimmo, Graeme R., Nissen, Michael D. and Sloots, Theo P. (2013). Further evidence that the IS481 target is suitable for real-time PCR detection of Bordetella pertussis. Pathology, 45 (2), 202-203. doi: 10.1097/PAT.0b013e32835cc2d7

Further evidence that the IS481 target is suitable for real-time PCR detection of Bordetella pertussis

2013

Journal Article

Real-time PCR genotyping of Neisseria gonorrhoeae isolates using 14 informative single nucleotide polymorphisms on gonococcal housekeeping genes

Whiley, David M., Goire, Namraj, Rahimi, Frashta, Lahra, Monica M., Limnios, Athena E., Nissen, Michael D. and Sloots, Theo P. (2013). Real-time PCR genotyping of Neisseria gonorrhoeae isolates using 14 informative single nucleotide polymorphisms on gonococcal housekeeping genes. Journal of Antimicrobial Chemotherapy, 68 (2) dks381, 322-328. doi: 10.1093/jac/dks381

Real-time PCR genotyping of Neisseria gonorrhoeae isolates using 14 informative single nucleotide polymorphisms on gonococcal housekeeping genes

2013

Journal Article

Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in Hib-primed toddlers

Booy R., Richmond P., Nolan T., McVernon J., Marshall H., Nissen M., Reynolds G., Ziegler J.B., Stoney T., Heron L., Lambert S., Mesaros N., Peddiraju K. and Miller J.M. (2013). Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in Hib-primed toddlers. Pediatric Infectious Disease Journal, 32 (2), 169-174. doi: 10.1097/INF.0b013e3182787bff

Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in Hib-primed toddlers

2013

Journal Article

Direct urine polymerase chain reaction for chlamydia and gonorrhoea: a simple means of bringing high-throughput rapid testing to remote settings?

Rahimi, Frashta, Goire, Namraj, Guy, Rebecca, Kaldor, John M., Ward, James, Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2013). Direct urine polymerase chain reaction for chlamydia and gonorrhoea: a simple means of bringing high-throughput rapid testing to remote settings?. Sexual Health, 10 (4), 299-304. doi: 10.1071/SH12108

Direct urine polymerase chain reaction for chlamydia and gonorrhoea: a simple means of bringing high-throughput rapid testing to remote settings?

2012

Journal Article

Household transmission of respiratory viruses - assessment of viral, individual and household characteristics in a population study of healthy Australian adults

McCaw, James M., Howard, Peter F., Richmond, Peter C., Nissen, Michael, Sloots, Theo, Lambert, Stephen B., Lai, Michael, Greenberg, Michael, Nolan, Terry and McVernon, Jodie (2012). Household transmission of respiratory viruses - assessment of viral, individual and household characteristics in a population study of healthy Australian adults. BMC Infectious Diseases, 12 (1) 345, 345.1-345.10. doi: 10.1186/1471-2334-12-345

Household transmission of respiratory viruses - assessment of viral, individual and household characteristics in a population study of healthy Australian adults

2012

Journal Article

Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study

Lambert, Stephen Bernard, Ware, Robert S., Cook, Anne L., Maguire, Frances A., Whiley, David M,, Bialasiewicz, Seweryn, Mackay, Ian M, Wang, David, Sloots, Theo P., Nissen, Michael D. and Grimwood, Keith (2012). Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study. BMJ Open, 2 (6) e002134, e002134.1-e002134.7. doi: 10.1136/bmjopen-2012-002134

Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study

2012

Journal Article

Safety and immunogenicity of a meningococcal B bivalent rLP2086 vaccine in healthy toddlers aged 18-36 Months: a phase 1 randomized-controlled clinical trial

Marshall, Helen S., Richmond, Peter C., Nissen, Michael D., Jiang, Qin, Anderson, Annaliesa S., Jansen, Kathrin U., Reynolds, Graham, Ziegler, John B., Harris, Shannon L., Jones, Thomas R. and Perez, John L. (2012). Safety and immunogenicity of a meningococcal B bivalent rLP2086 vaccine in healthy toddlers aged 18-36 Months: a phase 1 randomized-controlled clinical trial. Pediatric Infectious Disease Journal, 31 (10), 1061-1068. doi: 10.1097/INF.0b013e31826327e4

Safety and immunogenicity of a meningococcal B bivalent rLP2086 vaccine in healthy toddlers aged 18-36 Months: a phase 1 randomized-controlled clinical trial

2012

Journal Article

A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults: results of a randomised, controlled, dose-escalation phase-1 trial

Richmond, P. C., Nissen, M. D., Marshall, H. S., Lambert, S. B., Roberton, D., Gruber, W. C., Jones, T. R. and Arora, A. (2012). A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults: results of a randomised, controlled, dose-escalation phase-1 trial. Vaccine, 30 (43), 6163-6174. doi: 10.1016/j.vaccine.2012.07.065

A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults: results of a randomised, controlled, dose-escalation phase-1 trial

2012

Journal Article

The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting

Whiley, David M., Goire, Namraj, Lahra, Monica M., Donovan, Basil, Limnios, Athena E., Nissen, Michael D. and Sloots, Theo P. (2012). The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting. Journal of Antimicrobial Chemotherapy, 67 (9) dks188, 2059-2061. doi: 10.1093/jac/dks188

The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting

2012

Journal Article

Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of r

Bryant, Kristina A., McVernon, Jodie, Marchant, Colin D., Nolan, Terry, Marshall, Gary S., Richmond, Peter, Marshall, Helen, Nissen, Michael, Lambert, Stephen B., Aris, Emmanuel, Mesaros, Narcisa and Miller, Jacqueline M. (2012). Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of r. Human Vaccines and Immunotherapeutics, 8 (8), 1036-1041. doi: 10.4161/hv.20357

Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of r

2012

Journal Article

Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: A randomised, single-blind, placebo-controlled, phase 2 trial

Richmond, Peter C., Marshall, Helen S., Nissen, Michael D., Jiang, Qin, Jansen, Kathrin U., Garces-Sanchez, Maria, Martinon-Torres, Federico, Beeslaar, Johannes, Szenborn, Leszek, Wysocki, Jacek, Eiden, Joseph, Harris, Shannon L., Jones, Thomas R. and Perez, John L. (2012). Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: A randomised, single-blind, placebo-controlled, phase 2 trial. Lancet Infectious Diseases, 12 (8), 597-607. doi: 10.1016/S1473-3099(12)70087-7

Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: A randomised, single-blind, placebo-controlled, phase 2 trial

2012

Journal Article

Improved detection of genetic markers of antimicrobial resistance by hybridization probe-based melting curve analysis using primers to mask proximal mutations: Examples include the influenza H275Y substitution

Whiley, David M., Jacob, Kevin, Nakos, Jennifer, Bletchly, Cheryl, Nimmo, Graeme R., Nissen, Michael D. and Sloots, Theo P. (2012). Improved detection of genetic markers of antimicrobial resistance by hybridization probe-based melting curve analysis using primers to mask proximal mutations: Examples include the influenza H275Y substitution. Journal of Antimicrobial Chemotherapy, 67 (6) dks040, 1375-1379. doi: 10.1093/jac/dks040

Improved detection of genetic markers of antimicrobial resistance by hybridization probe-based melting curve analysis using primers to mask proximal mutations: Examples include the influenza H275Y substitution

Past funding

  • 2013 - 2016
    Q fever: How common is it and how can we best prevent it? Research to inform Q fever vaccine policy in Australia and Internationally. (NHMRC project grant administered by University of Sydney)
    University of Sydney
    Open grant
  • 2010 - 2016
    Molecular microbiology and epidemiology of respiratory infections in children
    Royal Children's Hospital Foundation
    Open grant
  • 2010 - 2011
    Development of a novel assay for the detection of clonal P.aeruginosa in persons with CF
    Australian Cystic Fibrosis Research Trust
    Open grant
  • 2010 - 2014
    Burden of respiratory infection in the first 2 years of life: a birth cohort study of emerging respiratory pathogens
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    Characterisation of novel picornavirus-like viruses identified from patients with acute respiratory infections
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    Clinical impact of clonal Pseudomonas aeruginosa in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    The clinical and epidemiological characterisation of a newly discovered human polyonmavirus, WU (WU Virus Research)
    Royal Children's Hospital Foundation
    Open grant
  • 2006
    Identification of Virulence Markers in the Respiratory Syncytial Virus Genome
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2006
    Characterisation and Epidemiology of Emerging Pathogens in Paediatrics
    ANZ Executors and Trustees' Company Ltd
    Open grant
  • 2005 - 2010
    Research support for paediatric infectious diseases
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2010
    Epidemiology and Control of Q Fever in Children
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2010
    How Children and adults with cystic fibrosis get lung infections with Pseudomonas aeruginosa
    Royal Children's Hospital Foundation
    Open grant
  • 2004 - 2010
    (i) Detection of mucoid P. aeruginosa antigens and antibodies in CF (ii) Molecular epidemiology of respiratory syncytial virus infections and the immune response in Australian children
    Royal Children's Hospital Foundation
    Open grant
  • 2003
    Macquarie Bank Asthma Research Fellowship for 2003
    Royal Australasian College of Physicians
    Open grant
  • 2003 - 2008
    The clinical significance of human metapneumovirus infections in Australian children
    Royal Children's Hospital Foundation
    Open grant
  • 2002
    Molecular epidemiology of respiratory syncitial virus in Australia
    UQ Early Career Researcher
    Open grant
  • 2001
    Establishment of a Malarial & Molecular Research Program at the RCH, Brisbane
    Royal Children's Hospital Foundation
    Open grant
  • 2001
    Real-time diagnosis of respiratory tract infections in children
    Royal Children's Hospital Foundation
    Open grant
  • 2000 - 2001
    Establishment of a Paediatric and Molecular Infectious Diseases Research Program at the Royal Children's Hospital, Brisbane
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000
    Competitive Research Equipment Grant
    Royal Children's Hospital Foundation
    Open grant

Availability

Dr Michael Nissen is:
Available for supervision

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Supervision history

Completed supervision

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