![Dr Michael Nissen](/sites/default/files/profiles/6931.jpeg)
Overview
Background
Michael has over 30 years’ experience in clinical medicine (infectious diseases & paediatrics) and clinical laboratory microbiology with a particular interest in the epidemiology of vaccine preventable diseases and the diagnosis of infectious diseases in hospital, public health and industry settings. He recently took up the inaugural Director of Research at The Prince Charles Hospital in Brisbane.
He is a past Principal Medical Officer and Director of CoVID-19 Pharmacovigilance at the Therapeutic Goods Administration, Department of Health & Ageing, Australian Government (2021-2022), Director of Scientific Affairs & Public Health for GSK Vaccines in the Greater China Intercontinental region based in Singapore (2014-2020) and Director of Infectious Diseases at the Royal Children’s Hospital-Brisbane and a practising Clinical Microbiologist at the Royal Brisbane & Women’s Hospitals (2000-2014). Michael is a past full member of the Australian Technical Advisory Group for Immunisation from 2007 to 2013.
Prof. Nissen has 223 peer-reviewed medical publications and book chapters, a h- index of 64 with 13,321 citations of his work to date. His research interests include the epidemiology and prevention of vaccine preventable diseases and the rapid molecular diagnostic techniques of infectious diseases.
Availability
- Dr Michael Nissen is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Royal Australasian College of Physicians, Royal Australasian College of Physicians
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
Research impacts
Founder & Co-Lead of Queensland Paediatric Infectious Diseases Laboratory & Associate Professor, University of Queensland Australia: 2003-2014
Research laboratory dedicated to viral discovery, translational adaption of molecular techniques for the diagnosis of infectious and rapid molecular diagnosis of respiratory viruses. Co-discoverer of WU virus. Lead approximately 40 Phase I-IV vaccine trials in attached clinical trials unit including meningococcal and staphylococcal candidates. Established experience in the maintenance and utility of large microbiology (virus and bacteria) and serum biobanks that lead to significant viral discoveries and clinical translation.
Co-discoverer of WU Virus: 2007
Gaynor AM, MD Nissen, DM Whiley, IM Mackay, SB Lambert, G Wu, DC Brennan, GA Storch, TP Sloots, D Wang (2007). Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathogens May 4; 3(5):e64 doi:10.1371/journal.ppat.0030064 (Citations: 846).
Director of Infectious Diseases, Royal Children’s Hospital-Brisbane, QLD AUSTRALIA: 2003-2014
Foundation and Inaugural Director of Clinical Infectious Diseases (Infection Management Prevention Service-IMPS) and Pre-Eminent Staff Specialist at largest children’s hospital in Queensland and State-based Children’s Health Service (CHS). Established Antimicrobial Stewardship (AMS) Committee at CHS and developed the “AntibioCard.” Also acted as Chair of the Infection Control Committee during this period and served as paediatric representative on State Health Medicines Advisory Committee (2000-2014).
Works
Search Professor Michael Nissen’s works on UQ eSpace
2013
Journal Article
Detection of novel polyomaviruses, TSPyV, HPyV6, HPyV7, HPyV9 and MWPyV in feces, urine, blood, respiratory swabs and cerebrospinal fluid
Rockett, Rebecca J., Sloots, Theo P., Bowes, Sharleen, O'Neill, Nicholas, Ye, Suifang, Robson, Jenny, Whiley, David M., Lambert, Stephen B., Wang, David, Nissen, Michael D. and Bialasiewicz, Seweryn (2013). Detection of novel polyomaviruses, TSPyV, HPyV6, HPyV7, HPyV9 and MWPyV in feces, urine, blood, respiratory swabs and cerebrospinal fluid. PLoS ONE, 8 (5) e62764, e62764.1-e62764.9. doi: 10.1371/journal.pone.0062764
2013
Journal Article
High-throughput single-nucleotide polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic fibrosis patients using the Sequenom iPLEX platform
Syrmis, Melanie W., Moser, Ralf J., Kidd, Timothy J., Hunt, Priscilla, Ramsay, Kay A., Bell, Scott C., Wainwright, Claire E., Grimwood, Keith, Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2013). High-throughput single-nucleotide polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic fibrosis patients using the Sequenom iPLEX platform. Journal of Medical Microbiology, 62 (5), 734-740. doi: 10.1099/jmm.0.055905-0
2013
Journal Article
Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period
Mackay, Ian M., Lambert, Stephen B., Faux, Cassandra E., Arden, Katherine E., Nissen, Michael D., Sloots, Theo P. and Nolan, Terence M. (2013). Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period. Journal of Infectious Diseases, 207 (9), 1433-1441. doi: 10.1093/infdis/jis476
2013
Journal Article
Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial
Howard, Peter F., Mccaw, James M., Richmond, Peter C., Nissen, Michael, Sloots, Theo, Lambert, Stephen B., Lai, Michael, Greenberg, Michael, Nolan, Terry and Mcvernon, Jodie (2013). Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial. Influenza and other Respiratory Viruses, 7 (3), 330-339. doi: 10.1111/j.1750-2659.2012.00395.x
2013
Journal Article
A Randomized, Controlled, Phase 1/2 Trial of a Neisseria meningitidis Serogroup B Bivalent rLP2086 Vaccine in Healthy Children and Adolescents
Nissen, Michael D., Marshall, Helen S., Richmond, Peter C., Jiang, Qin, Harris, Shannon L., Jones, Thomas R., Jansen, Kathrin U. and Perez, John L. (2013). A Randomized, Controlled, Phase 1/2 Trial of a Neisseria meningitidis Serogroup B Bivalent rLP2086 Vaccine in Healthy Children and Adolescents. Pediatric Infectious Disease Journal, 32 (4), 364-371. doi: 10.1097/INF.0b013e31827b0d24
2013
Journal Article
Polymerase chain reaction-based screening for the ceftriaxone-resistant Neisseria gonorrhoeae F89 strain
Goire, N., Lahra, M. M., Ohnishi, M., Hogan, T., Liminios, A. E., Nissen, M. D., Sloots, T. P. and Whiley, D. M. (2013). Polymerase chain reaction-based screening for the ceftriaxone-resistant Neisseria gonorrhoeae F89 strain. Eurosurveillance, 18 (14), 18-23. doi: 10.2807/1560-7917.ES2013.18.14.20444
2013
Journal Article
A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults
Marshall, Helen S., Richmond, Peter C., Nissen, Michael D., Wouters, Ann, Baber, James, Jiang, Qin, Anderson, Annaliesa S., Jones, Thomas R., Harris, Shannon L., Jansen, Kathrin U. and Perez, John L. (2013). A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults. Vaccine, 31 (12), 1569-1575. doi: 10.1016/j.vaccine.2013.01.021
2013
Journal Article
Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness
Ferguson, Patricia E., Gilroy, Nicole M., Faux, Cassandra E., Mackay, Ian M., Sloots, Theo P., Nissen, Michael D., Dwyer, Dominic E. and Sorrell, Tania C. (2013). Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness. Journal of Clinical Virology, 56 (3), 255-259. doi: 10.1016/j.jcv.2012.11.010
2013
Journal Article
Further evidence that the IS481 target is suitable for real-time PCR detection of Bordetella pertussis
Cox, Hannah C., Jacob, Kevin, Whiley, David M., Bletchly, Cheryl, Nimmo, Graeme R., Nissen, Michael D. and Sloots, Theo P. (2013). Further evidence that the IS481 target is suitable for real-time PCR detection of Bordetella pertussis. Pathology, 45 (2), 202-203. doi: 10.1097/PAT.0b013e32835cc2d7
2013
Journal Article
Real-time PCR genotyping of Neisseria gonorrhoeae isolates using 14 informative single nucleotide polymorphisms on gonococcal housekeeping genes
Whiley, David M., Goire, Namraj, Rahimi, Frashta, Lahra, Monica M., Limnios, Athena E., Nissen, Michael D. and Sloots, Theo P. (2013). Real-time PCR genotyping of Neisseria gonorrhoeae isolates using 14 informative single nucleotide polymorphisms on gonococcal housekeeping genes. Journal of Antimicrobial Chemotherapy, 68 (2) dks381, 322-328. doi: 10.1093/jac/dks381
2013
Journal Article
Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in Hib-primed toddlers
Booy R., Richmond P., Nolan T., McVernon J., Marshall H., Nissen M., Reynolds G., Ziegler J.B., Stoney T., Heron L., Lambert S., Mesaros N., Peddiraju K. and Miller J.M. (2013). Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in Hib-primed toddlers. Pediatric Infectious Disease Journal, 32 (2), 169-174. doi: 10.1097/INF.0b013e3182787bff
2013
Journal Article
Direct urine polymerase chain reaction for chlamydia and gonorrhoea: a simple means of bringing high-throughput rapid testing to remote settings?
Rahimi, Frashta, Goire, Namraj, Guy, Rebecca, Kaldor, John M., Ward, James, Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2013). Direct urine polymerase chain reaction for chlamydia and gonorrhoea: a simple means of bringing high-throughput rapid testing to remote settings?. Sexual Health, 10 (4), 299-304. doi: 10.1071/SH12108
2012
Journal Article
Household transmission of respiratory viruses - assessment of viral, individual and household characteristics in a population study of healthy Australian adults
McCaw, James M., Howard, Peter F., Richmond, Peter C., Nissen, Michael, Sloots, Theo, Lambert, Stephen B., Lai, Michael, Greenberg, Michael, Nolan, Terry and McVernon, Jodie (2012). Household transmission of respiratory viruses - assessment of viral, individual and household characteristics in a population study of healthy Australian adults. BMC Infectious Diseases, 12 (1) 345, 345.1-345.10. doi: 10.1186/1471-2334-12-345
2012
Journal Article
Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
Lambert, Stephen Bernard, Ware, Robert S., Cook, Anne L., Maguire, Frances A., Whiley, David M,, Bialasiewicz, Seweryn, Mackay, Ian M, Wang, David, Sloots, Theo P., Nissen, Michael D. and Grimwood, Keith (2012). Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study. BMJ Open, 2 (6) e002134, e002134.1-e002134.7. doi: 10.1136/bmjopen-2012-002134
2012
Journal Article
Safety and immunogenicity of a meningococcal B bivalent rLP2086 vaccine in healthy toddlers aged 18-36 Months: a phase 1 randomized-controlled clinical trial
Marshall, Helen S., Richmond, Peter C., Nissen, Michael D., Jiang, Qin, Anderson, Annaliesa S., Jansen, Kathrin U., Reynolds, Graham, Ziegler, John B., Harris, Shannon L., Jones, Thomas R. and Perez, John L. (2012). Safety and immunogenicity of a meningococcal B bivalent rLP2086 vaccine in healthy toddlers aged 18-36 Months: a phase 1 randomized-controlled clinical trial. Pediatric Infectious Disease Journal, 31 (10), 1061-1068. doi: 10.1097/INF.0b013e31826327e4
2012
Journal Article
A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults: results of a randomised, controlled, dose-escalation phase-1 trial
Richmond, P. C., Nissen, M. D., Marshall, H. S., Lambert, S. B., Roberton, D., Gruber, W. C., Jones, T. R. and Arora, A. (2012). A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults: results of a randomised, controlled, dose-escalation phase-1 trial. Vaccine, 30 (43), 6163-6174. doi: 10.1016/j.vaccine.2012.07.065
2012
Journal Article
The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting
Whiley, David M., Goire, Namraj, Lahra, Monica M., Donovan, Basil, Limnios, Athena E., Nissen, Michael D. and Sloots, Theo P. (2012). The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting. Journal of Antimicrobial Chemotherapy, 67 (9) dks188, 2059-2061. doi: 10.1093/jac/dks188
2012
Journal Article
Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of r
Bryant, Kristina A., McVernon, Jodie, Marchant, Colin D., Nolan, Terry, Marshall, Gary S., Richmond, Peter, Marshall, Helen, Nissen, Michael, Lambert, Stephen B., Aris, Emmanuel, Mesaros, Narcisa and Miller, Jacqueline M. (2012). Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of r. Human Vaccines and Immunotherapeutics, 8 (8), 1036-1041. doi: 10.4161/hv.20357
2012
Journal Article
Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: A randomised, single-blind, placebo-controlled, phase 2 trial
Richmond, Peter C., Marshall, Helen S., Nissen, Michael D., Jiang, Qin, Jansen, Kathrin U., Garces-Sanchez, Maria, Martinon-Torres, Federico, Beeslaar, Johannes, Szenborn, Leszek, Wysocki, Jacek, Eiden, Joseph, Harris, Shannon L., Jones, Thomas R. and Perez, John L. (2012). Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: A randomised, single-blind, placebo-controlled, phase 2 trial. Lancet Infectious Diseases, 12 (8), 597-607. doi: 10.1016/S1473-3099(12)70087-7
2012
Journal Article
Improved detection of genetic markers of antimicrobial resistance by hybridization probe-based melting curve analysis using primers to mask proximal mutations: Examples include the influenza H275Y substitution
Whiley, David M., Jacob, Kevin, Nakos, Jennifer, Bletchly, Cheryl, Nimmo, Graeme R., Nissen, Michael D. and Sloots, Theo P. (2012). Improved detection of genetic markers of antimicrobial resistance by hybridization probe-based melting curve analysis using primers to mask proximal mutations: Examples include the influenza H275Y substitution. Journal of Antimicrobial Chemotherapy, 67 (6) dks040, 1375-1379. doi: 10.1093/jac/dks040
Funding
Supervision
Availability
- Dr Michael Nissen is:
- Available for supervision
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Supervision history
Completed supervision
-
2013
Doctor Philosophy
Molecular Characterisation and Detection of Gonococcal Antimicrobial Resistance.
Principal Advisor
Other advisors: Associate Professor David Whiley
-
2010
Doctor Philosophy
Clinical and virological characteristics of human metapneumovirus
Principal Advisor
-
2005
Doctor Philosophy
RESPIRATORY DISEASES IN PATIENTS WITH CYSTIC FIBROSIS: ROLE AND PATHOGENESIS OF PSEUDOMONAS AERUGINOSA INFECTION
Principal Advisor
-
2003
Doctor Philosophy
REAL-TIME DETECTION, DIFFERENTIATION AND QUANTITATION OF CLINICALLY RELEVANT VIRUSES
Principal Advisor
-
2010
Doctor Philosophy
Characterisation of Newly Discovered Human Polyomaviruses WU and KI
Joint Principal Advisor
-
2016
Doctor Philosophy
A nationwide study of Neisseria gonorrhoeae antimicrobial resistance; towards molecular AMR surveillance
Associate Advisor
Other advisors: Associate Professor David Whiley
-
2015
Doctor Philosophy
Epidemiology, Diagnosis and Prevention of Q fever in Queensland.
Associate Advisor
-
2015
Doctor Philosophy
Characterising the Pathogenesis and Biology of Newly Described Human Polyomaviruses
Associate Advisor
Other advisors: Associate Professor David Whiley, Dr Seweryn Bialasiewicz
-
2013
Doctor Philosophy
Detection, Identification and Genotyping of Pseudomonas aeruginosa strains isolated from environmental and clinical samples.
Associate Advisor
Other advisors: Associate Professor David Whiley
-
2011
Doctor Philosophy
Ribozymes as Antivirals for Respiratory Syncytial Virus
Associate Advisor
Other advisors: Professor Paul Young
-
2008
Doctor Philosophy
Factors Affecting Nucleic Acid Amplification Tests for Neisseria Gonorrhoeae
Associate Advisor
Media
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