Dr Michael Nissen
Dr

Michael Nissen

Email: 

Background

Michael has over 30 years’ experience in clinical medicine (infectious diseases & paediatrics) and clinical laboratory microbiology with a particular interest in the epidemiology of vaccine preventable diseases and the diagnosis of infectious diseases in hospital, public health and industry settings. He recently took up the inaugural Director of Research at The Prince Charles Hospital in Brisbane.

He is a past Principal Medical Officer and Director of CoVID-19 Pharmacovigilance at the Therapeutic Goods Administration, Department of Health & Ageing, Australian Government (2021-2022), Director of Scientific Affairs & Public Health for GSK Vaccines in the Greater China Intercontinental region based in Singapore (2014-2020) and Director of Infectious Diseases at the Royal Children’s Hospital-Brisbane and a practising Clinical Microbiologist at the Royal Brisbane & Women’s Hospitals (2000-2014). Michael is a past full member of the Australian Technical Advisory Group for Immunisation from 2007 to 2013.

Prof. Nissen has 223 peer-reviewed medical publications and book chapters, a h- index of 64 with 13,321 citations of his work to date. His research interests include the epidemiology and prevention of vaccine preventable diseases and the rapid molecular diagnostic techniques of infectious diseases.

Availability

Dr Michael Nissen is:
Available for supervision

Fields of research

Clinical sciences Medical microbiology

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians
  • Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia

Research impacts

Founder & Co-Lead of Queensland Paediatric Infectious Diseases Laboratory & Associate Professor, University of Queensland Australia: 2003-2014

Research laboratory dedicated to viral discovery, translational adaption of molecular techniques for the diagnosis of infectious and rapid molecular diagnosis of respiratory viruses. Co-discoverer of WU virus. Lead approximately 40 Phase I-IV vaccine trials in attached clinical trials unit including meningococcal and staphylococcal candidates. Established experience in the maintenance and utility of large microbiology (virus and bacteria) and serum biobanks that lead to significant viral discoveries and clinical translation.

Co-discoverer of WU Virus: 2007

Gaynor AM, MD Nissen, DM Whiley, IM Mackay, SB Lambert, G Wu, DC Brennan, GA Storch, TP Sloots, D Wang (2007). Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathogens May 4; 3(5):e64 doi:10.1371/journal.ppat.0030064 (Citations: 846).

Director of Infectious Diseases, Royal Children’s Hospital-Brisbane, QLD AUSTRALIA: 2003-2014

Foundation and Inaugural Director of Clinical Infectious Diseases (Infection Management Prevention Service-IMPS) and Pre-Eminent Staff Specialist at largest children’s hospital in Queensland and State-based Children’s Health Service (CHS). Established Antimicrobial Stewardship (AMS) Committee at CHS and developed the “AntibioCard.” Also acted as Chair of the Infection Control Committee during this period and served as paediatric representative on State Health Medicines Advisory Committee (2000-2014).

Search Professor Michael Nissen’s works on UQ eSpace

198 works between 1984 and 2023
All (198) Journal Article (173) Book Chapter (5) Conference Publication (18) Other Outputs (2)

61 - 80 of 198 works

2012

Journal Article

Co-circulation of four human Coronaviruses (HCoVs) in Queensland children with acute respiratory tract illnesses in 2004

Mackay, Ian M., Arden, Katherine E., Speicher, David J., O'Neil, Nicholas T., McErlean, Peter K., Greer, Ristan M., Nissen, Michael D. and Sloots, Theo P. (2012). Co-circulation of four human Coronaviruses (HCoVs) in Queensland children with acute respiratory tract illnesses in 2004. Viruses, 4 (4), 637-653. doi: 10.3390/v4040637

Co-circulation of four human Coronaviruses (HCoVs) in Queensland children with acute respiratory tract illnesses in 2004

2012

Journal Article

Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone resistance: A real-time PCR assay for direct detection of the Neisseria gonorrhoeae H041 strain

Goire, Namraj, Ohnishi, Makoto, Limnios, Athena E., Lahra, Monica M., Lambert, Stephen B., Nimmo, Graeme R., Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2012). Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone resistance: A real-time PCR assay for direct detection of the Neisseria gonorrhoeae H041 strain. Journal of Antimicrobial Chemotherapy, 67 (4) dkr549, 902-905. doi: 10.1093/jac/dkr549

Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone resistance: A real-time PCR assay for direct detection of the Neisseria gonorrhoeae H041 strain

2012

Journal Article

The influence of target population on nonculture-based detection of markers of Neisseria gonorrhoeae antimicrobial resistance

Goire, Namraj, Freeman, Kevin, Lambert, Stephen B., Nimmo, Graeme R., Limnios, Athena E., Lahra, Monica M., Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2012). The influence of target population on nonculture-based detection of markers of Neisseria gonorrhoeae antimicrobial resistance. Sexual Health, 9 (5), 422-429. doi: 10.1071/SH12026

The influence of target population on nonculture-based detection of markers of Neisseria gonorrhoeae antimicrobial resistance

2012

Journal Article

A randomized trial to assess safety and immunogenicity of alternative formulations of a quadrivalent meningococcal (A, C, Y, and W-135) tetanus protein conjugate vaccine in toddlers

McVernon, Jodie, Nolan, Terry, Richmond, Peter, Reynolds, Graham, Nissen, Michael, Lambert, Stephen B., Marshall, Helen, Papa, Thomas and Rehm, Christine (2012). A randomized trial to assess safety and immunogenicity of alternative formulations of a quadrivalent meningococcal (A, C, Y, and W-135) tetanus protein conjugate vaccine in toddlers. Pediatric Infectious Disease Journal, 31 (1), e15-e23. doi: 10.1097/INF.0b013e31823e1e34

A randomized trial to assess safety and immunogenicity of alternative formulations of a quadrivalent meningococcal (A, C, Y, and W-135) tetanus protein conjugate vaccine in toddlers

2012

Book Chapter

Protocol for the molecular detection of antibiotic resistance mechanisms in Neisseria gonorrhoeae

Goire, Namraj, Sloots, Theo P., Whiley, David M. and Nissen, Michael D. (2012). Protocol for the molecular detection of antibiotic resistance mechanisms in Neisseria gonorrhoeae. Diagnosis of sexually transmitted diseases. (pp. 319-328) edited by Colin R. MacKenzie and Birgit Henrich. Heidelberg, Germany: Springer. doi: 10.1007/978-1-61779-937-2_22

Protocol for the molecular detection of antibiotic resistance mechanisms in Neisseria gonorrhoeae

2011

Journal Article

Pilot study of influenza vaccine effectiveness in urban Australian children attending childcare

Yin, J. Kevin, Lahra, Monica M., Iskander, Mary, Lambert, Stephen B., Heron, Leon, Nissen, Michael D., Rost, Laura, Murphy, Jennifer, Sloots, Theo P. and Booy, Robert (2011). Pilot study of influenza vaccine effectiveness in urban Australian children attending childcare. Journal of Paediatrics and Child Health, 47 (12), 857-862. doi: 10.1111/j.1440-1754.2011.02098.x

Pilot study of influenza vaccine effectiveness in urban Australian children attending childcare

2011

Journal Article

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

Khor, Chiea Chuen, Davila, Sonia, Breunis, Willemijn B., Lee, Yi-Ching, Shimizu, Chisato, Wright, Victoria J., Yeung, Rae S. M., Tan, Dennis E. K., Sim, Kar Seng, Wang, Jie Jin, Wong, Tien Yin, Pang, Junxiong, Mitchell, Paul, Cimaz, Rolando, Dahdah, Nagib, Cheung, Yiu-Fai, Huang, Guo-Ying, Yang, Wanling L, Park, In-Sook, Lee, Jong-Keuk, Wu, Jer-Yuarn, Levin, Michael, Burns, Jane C., Burgner, David, Kuijpers, Taco W., Hibberd, Martin L., Lau, Yu-Lung, Zhang, Jing, Ma, Xiao-Jing ... Blue Mountain Eye Study (2011). Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nature Genetics, 43 (12), 1241-1246. doi: 10.1038/ng.981

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

2011

Journal Article

Comparison of a multiplexed MassARRAY system with real-time allele-specific PCR technology for genotyping of methicillin-resistant Staphylococcus aureus

Syrmis, M. W., Moser, R. J., Whiley, D. M., Vaska, V., Coombs, G. W., Nissen, M. D., Sloots, T. P. and Nimmo, G. R. (2011). Comparison of a multiplexed MassARRAY system with real-time allele-specific PCR technology for genotyping of methicillin-resistant Staphylococcus aureus. Clinical Microbiology and Infection, 17 (12), 1804-1810. doi: 10.1111/j.1469-0691.2011.03521.x

Comparison of a multiplexed MassARRAY system with real-time allele-specific PCR technology for genotyping of methicillin-resistant Staphylococcus aureus

2011

Journal Article

Community-associated Methicillin-resistant Staphylococcus aureus causing orbital cellulitis in Australian children

Vaska, Vikram L., Grimwood, Keith, Gole, Glen A., Nimmo, Graeme R., Paterson, David L. and Nissen, Michael D. (2011). Community-associated Methicillin-resistant Staphylococcus aureus causing orbital cellulitis in Australian children. Pediatric Infectious Disease Journal, 30 (11), 1003-1006. doi: 10.1097/INF.0b013e318224fda5

Community-associated Methicillin-resistant Staphylococcus aureus causing orbital cellulitis in Australian children

2011

Journal Article

Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients

Ferguson, P. E., Gilroy, N. M., Sloots, T. P., Nissen, M. D., Dwyer, D. E. and Sorrell, T. C. (2011). Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients. Transplant Infectious Disease, 13 (5), 448-455. doi: 10.1111/j.1399-3062.2011.00631.x

Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients

2011

Journal Article

Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia

Tozer, S.J., Lambert, S.B., Sloots, T.P. and Nissen, M.D. (2011). Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia. European Journal of Clinical Microbiology and Infectious Diseases, 30 (10), 1287-1293. doi: 10.1007/s10096-011-1225-y

Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia

2011

Journal Article

Rapid single-nucleotide polymorphism-based identification of clonal Pseudomonas aeruginosa isolates from patients with cystic fibrosis by the use of real-time PCR and high-resolution melting curve analysis

Anuj, S. N., Whiley, D. M., Kidd, T. J., Ramsay, K. A., Bell, S. C., Syrmis, M. W., Grimwood, K., Wainwright, C. E., Nissen, M. D. and Sloots, T. P. (2011). Rapid single-nucleotide polymorphism-based identification of clonal Pseudomonas aeruginosa isolates from patients with cystic fibrosis by the use of real-time PCR and high-resolution melting curve analysis. Clinical Microbiology and Infection, 17 (9), 1403-1408. doi: 10.1111/j.1469-0691.2010.03439.x

Rapid single-nucleotide polymorphism-based identification of clonal Pseudomonas aeruginosa isolates from patients with cystic fibrosis by the use of real-time PCR and high-resolution melting curve analysis

2011

Journal Article

Successful application of a simple transport method for the conduct of respiratory virus surveillance in remote Indigenous communities in Australia

O'Grady, Kerry-Ann F., Torzillo, Paul J., Rockett, Rebecca J., Whiley, David M., Nissen, Michael D., Sloots, Theo P. and Lambert, Stephen B. (2011). Successful application of a simple transport method for the conduct of respiratory virus surveillance in remote Indigenous communities in Australia. Tropical Medicine and International Health, 16 (6), 766-772. doi: 10.1111/j.1365-3156.2011.02757.x

Successful application of a simple transport method for the conduct of respiratory virus surveillance in remote Indigenous communities in Australia

2011

Journal Article

Viral-bacterial co-infection in Australian Indigenous children with acute otitis media

Binks, Michael J., Cheng, Allen C., Smith-Vaughan, Heidi, Sloots, Theo, Nissen, Michael, Whiley, David, McDonnell, Joseph and Leach, Amanda J. (2011). Viral-bacterial co-infection in Australian Indigenous children with acute otitis media. BMC Infectious Diseases, 11 (161) 161, 1-8. doi: 10.1186/1471-2334-11-161

Viral-bacterial co-infection in Australian Indigenous children with acute otitis media

2011

Journal Article

False-negative results using Neisseria gonorrhoeae porA pseudogene PCR - a clinical gonococcal isolate with an N. meningitidis porA sequence, Australia, March 2011

Whiley, D.M., Limnios, A., Moon, N.J., Gehrig, N., Goire, N., Hogan, T., Lam, A., Jacob, K., Lambert, S.B., Nissen, M.D. and Sloots, T.P. (2011). False-negative results using Neisseria gonorrhoeae porA pseudogene PCR - a clinical gonococcal isolate with an N. meningitidis porA sequence, Australia, March 2011. Eurosurveillance, 16 (21), 5-8. doi: 10.2807/ese.16.21.19874-en

False-negative results using Neisseria gonorrhoeae porA pseudogene PCR - a clinical gonococcal isolate with an N. meningitidis porA sequence, Australia, March 2011

2011

Journal Article

Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is spread internationally by genetically distinct gonococcal populations

Whiley, David M., Goire, Namraj, Lambert, Stephen B., Nissen, Michael D., Sloots, Theo P. and Tapsall, John W. (2011). Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is spread internationally by genetically distinct gonococcal populations. Journal of Antimicrobial Chemotherapy, 66 (5) dkr052, 1186-1187. doi: 10.1093/jac/dkr052

Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is spread internationally by genetically distinct gonococcal populations

2011

Journal Article

Congenital and neonatal varicella: Impact of the national varicella vaccination programme in Australia

Khandaker, Gulam, Marshall, Helen, Peadon, Elizabeth, Zurynski, Yvonne, Burgner, David, Buttery, Jim, Gold, Michael, Nissen, Michael, Elliott, Elizabeth J., Burgess, Margaret and Booy, Robert (2011). Congenital and neonatal varicella: Impact of the national varicella vaccination programme in Australia. Archives of Disease in Childhood, 96 (5), 453-456. doi: 10.1136/adc.2010.206037

Congenital and neonatal varicella: Impact of the national varicella vaccination programme in Australia

2011

Journal Article

Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age

Booy, Robert, Richmond, Peter, Nolan, Terry, McVernon, Jodie, Marshall, Helen, Nissen, Michael, Reynolds, Graham, Ziegler, John B., Heron, Leon, Lambert, Stephen, Caubet, Magalie, Mesaros, Narcisa and Boutriau, Dominique (2011). Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age. Pediatric Infectious Disease Journal, 30 (4), 340-342. doi: 10.1097/INF.0b013e31820013d2

Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age

2011

Journal Article

Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy

Dang, Xin, Bialasiewicz, Seweryn, Nissen, Michael D., Sloots, Theo P., Koralnik, Igor J. and Tan, Chen S. (2011). Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. PLoS One, 6 (3) e16736, e16736.1-e16736.5. doi: 10.1371/journal.pone.0016736

Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy

2011

Journal Article

A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers

Rockett, Rebecca J., Tozer, Sarah J., Peatey, Chris, Bialasiewicz, Seweryn, Whiley, David M., Nissen, Michael D., Trenholme, Katharine, Mc Carthy, James S. and Sloots, Theo P. (2011). A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers. Malaria Journal, 10 (48) 48, 48-1-48-6. doi: 10.1186/1475-2875-10-48

A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers

Past funding

  • 2013 - 2016
    Q fever: How common is it and how can we best prevent it? Research to inform Q fever vaccine policy in Australia and Internationally. (NHMRC project grant administered by University of Sydney)
    University of Sydney
    Open grant
  • 2010 - 2016
    Molecular microbiology and epidemiology of respiratory infections in children
    Royal Children's Hospital Foundation
    Open grant
  • 2010 - 2011
    Development of a novel assay for the detection of clonal P.aeruginosa in persons with CF
    Australian Cystic Fibrosis Research Trust
    Open grant
  • 2010 - 2014
    Burden of respiratory infection in the first 2 years of life: a birth cohort study of emerging respiratory pathogens
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    Characterisation of novel picornavirus-like viruses identified from patients with acute respiratory infections
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    Clinical impact of clonal Pseudomonas aeruginosa in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    The clinical and epidemiological characterisation of a newly discovered human polyonmavirus, WU (WU Virus Research)
    Royal Children's Hospital Foundation
    Open grant
  • 2006
    Identification of Virulence Markers in the Respiratory Syncytial Virus Genome
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2006
    Characterisation and Epidemiology of Emerging Pathogens in Paediatrics
    ANZ Executors and Trustees' Company Ltd
    Open grant
  • 2005 - 2010
    Research support for paediatric infectious diseases
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2010
    Epidemiology and Control of Q Fever in Children
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2010
    How Children and adults with cystic fibrosis get lung infections with Pseudomonas aeruginosa
    Royal Children's Hospital Foundation
    Open grant
  • 2004 - 2010
    (i) Detection of mucoid P. aeruginosa antigens and antibodies in CF (ii) Molecular epidemiology of respiratory syncytial virus infections and the immune response in Australian children
    Royal Children's Hospital Foundation
    Open grant
  • 2003
    Macquarie Bank Asthma Research Fellowship for 2003
    Royal Australasian College of Physicians
    Open grant
  • 2003 - 2008
    The clinical significance of human metapneumovirus infections in Australian children
    Royal Children's Hospital Foundation
    Open grant
  • 2002
    Molecular epidemiology of respiratory syncitial virus in Australia
    UQ Early Career Researcher
    Open grant
  • 2001
    Establishment of a Malarial & Molecular Research Program at the RCH, Brisbane
    Royal Children's Hospital Foundation
    Open grant
  • 2001
    Real-time diagnosis of respiratory tract infections in children
    Royal Children's Hospital Foundation
    Open grant
  • 2000 - 2001
    Establishment of a Paediatric and Molecular Infectious Diseases Research Program at the Royal Children's Hospital, Brisbane
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000
    Competitive Research Equipment Grant
    Royal Children's Hospital Foundation
    Open grant

Availability

Dr Michael Nissen is:
Available for supervision

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Supervision history

Completed supervision

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