![Dr Michael Nissen](/sites/default/files/profiles/6931.jpeg)
Overview
Background
Michael has over 30 years’ experience in clinical medicine (infectious diseases & paediatrics) and clinical laboratory microbiology with a particular interest in the epidemiology of vaccine preventable diseases and the diagnosis of infectious diseases in hospital, public health and industry settings. He recently took up the inaugural Director of Research at The Prince Charles Hospital in Brisbane.
He is a past Principal Medical Officer and Director of CoVID-19 Pharmacovigilance at the Therapeutic Goods Administration, Department of Health & Ageing, Australian Government (2021-2022), Director of Scientific Affairs & Public Health for GSK Vaccines in the Greater China Intercontinental region based in Singapore (2014-2020) and Director of Infectious Diseases at the Royal Children’s Hospital-Brisbane and a practising Clinical Microbiologist at the Royal Brisbane & Women’s Hospitals (2000-2014). Michael is a past full member of the Australian Technical Advisory Group for Immunisation from 2007 to 2013.
Prof. Nissen has 223 peer-reviewed medical publications and book chapters, a h- index of 64 with 13,321 citations of his work to date. His research interests include the epidemiology and prevention of vaccine preventable diseases and the rapid molecular diagnostic techniques of infectious diseases.
Availability
- Dr Michael Nissen is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Royal Australasian College of Physicians, Royal Australasian College of Physicians
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
Research impacts
Founder & Co-Lead of Queensland Paediatric Infectious Diseases Laboratory & Associate Professor, University of Queensland Australia: 2003-2014
Research laboratory dedicated to viral discovery, translational adaption of molecular techniques for the diagnosis of infectious and rapid molecular diagnosis of respiratory viruses. Co-discoverer of WU virus. Lead approximately 40 Phase I-IV vaccine trials in attached clinical trials unit including meningococcal and staphylococcal candidates. Established experience in the maintenance and utility of large microbiology (virus and bacteria) and serum biobanks that lead to significant viral discoveries and clinical translation.
Co-discoverer of WU Virus: 2007
Gaynor AM, MD Nissen, DM Whiley, IM Mackay, SB Lambert, G Wu, DC Brennan, GA Storch, TP Sloots, D Wang (2007). Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathogens May 4; 3(5):e64 doi:10.1371/journal.ppat.0030064 (Citations: 846).
Director of Infectious Diseases, Royal Children’s Hospital-Brisbane, QLD AUSTRALIA: 2003-2014
Foundation and Inaugural Director of Clinical Infectious Diseases (Infection Management Prevention Service-IMPS) and Pre-Eminent Staff Specialist at largest children’s hospital in Queensland and State-based Children’s Health Service (CHS). Established Antimicrobial Stewardship (AMS) Committee at CHS and developed the “AntibioCard.” Also acted as Chair of the Infection Control Committee during this period and served as paediatric representative on State Health Medicines Advisory Committee (2000-2014).
Works
Search Professor Michael Nissen’s works on UQ eSpace
2012
Journal Article
Co-circulation of four human Coronaviruses (HCoVs) in Queensland children with acute respiratory tract illnesses in 2004
Mackay, Ian M., Arden, Katherine E., Speicher, David J., O'Neil, Nicholas T., McErlean, Peter K., Greer, Ristan M., Nissen, Michael D. and Sloots, Theo P. (2012). Co-circulation of four human Coronaviruses (HCoVs) in Queensland children with acute respiratory tract illnesses in 2004. Viruses, 4 (4), 637-653. doi: 10.3390/v4040637
2012
Journal Article
Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone resistance: A real-time PCR assay for direct detection of the Neisseria gonorrhoeae H041 strain
Goire, Namraj, Ohnishi, Makoto, Limnios, Athena E., Lahra, Monica M., Lambert, Stephen B., Nimmo, Graeme R., Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2012). Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone resistance: A real-time PCR assay for direct detection of the Neisseria gonorrhoeae H041 strain. Journal of Antimicrobial Chemotherapy, 67 (4) dkr549, 902-905. doi: 10.1093/jac/dkr549
2012
Journal Article
The influence of target population on nonculture-based detection of markers of Neisseria gonorrhoeae antimicrobial resistance
Goire, Namraj, Freeman, Kevin, Lambert, Stephen B., Nimmo, Graeme R., Limnios, Athena E., Lahra, Monica M., Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2012). The influence of target population on nonculture-based detection of markers of Neisseria gonorrhoeae antimicrobial resistance. Sexual Health, 9 (5), 422-429. doi: 10.1071/SH12026
2012
Journal Article
A randomized trial to assess safety and immunogenicity of alternative formulations of a quadrivalent meningococcal (A, C, Y, and W-135) tetanus protein conjugate vaccine in toddlers
McVernon, Jodie, Nolan, Terry, Richmond, Peter, Reynolds, Graham, Nissen, Michael, Lambert, Stephen B., Marshall, Helen, Papa, Thomas and Rehm, Christine (2012). A randomized trial to assess safety and immunogenicity of alternative formulations of a quadrivalent meningococcal (A, C, Y, and W-135) tetanus protein conjugate vaccine in toddlers. Pediatric Infectious Disease Journal, 31 (1), e15-e23. doi: 10.1097/INF.0b013e31823e1e34
2012
Book Chapter
Protocol for the molecular detection of antibiotic resistance mechanisms in Neisseria gonorrhoeae
Goire, Namraj, Sloots, Theo P., Whiley, David M. and Nissen, Michael D. (2012). Protocol for the molecular detection of antibiotic resistance mechanisms in Neisseria gonorrhoeae. Diagnosis of sexually transmitted diseases. (pp. 319-328) edited by Colin R. MacKenzie and Birgit Henrich. Heidelberg, Germany: Springer. doi: 10.1007/978-1-61779-937-2_22
2011
Journal Article
Pilot study of influenza vaccine effectiveness in urban Australian children attending childcare
Yin, J. Kevin, Lahra, Monica M., Iskander, Mary, Lambert, Stephen B., Heron, Leon, Nissen, Michael D., Rost, Laura, Murphy, Jennifer, Sloots, Theo P. and Booy, Robert (2011). Pilot study of influenza vaccine effectiveness in urban Australian children attending childcare. Journal of Paediatrics and Child Health, 47 (12), 857-862. doi: 10.1111/j.1440-1754.2011.02098.x
2011
Journal Article
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
Khor, Chiea Chuen, Davila, Sonia, Breunis, Willemijn B., Lee, Yi-Ching, Shimizu, Chisato, Wright, Victoria J., Yeung, Rae S. M., Tan, Dennis E. K., Sim, Kar Seng, Wang, Jie Jin, Wong, Tien Yin, Pang, Junxiong, Mitchell, Paul, Cimaz, Rolando, Dahdah, Nagib, Cheung, Yiu-Fai, Huang, Guo-Ying, Yang, Wanling L, Park, In-Sook, Lee, Jong-Keuk, Wu, Jer-Yuarn, Levin, Michael, Burns, Jane C., Burgner, David, Kuijpers, Taco W., Hibberd, Martin L., Lau, Yu-Lung, Zhang, Jing, Ma, Xiao-Jing ... Blue Mountain Eye Study (2011). Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nature Genetics, 43 (12), 1241-1246. doi: 10.1038/ng.981
2011
Journal Article
Comparison of a multiplexed MassARRAY system with real-time allele-specific PCR technology for genotyping of methicillin-resistant Staphylococcus aureus
Syrmis, M. W., Moser, R. J., Whiley, D. M., Vaska, V., Coombs, G. W., Nissen, M. D., Sloots, T. P. and Nimmo, G. R. (2011). Comparison of a multiplexed MassARRAY system with real-time allele-specific PCR technology for genotyping of methicillin-resistant Staphylococcus aureus. Clinical Microbiology and Infection, 17 (12), 1804-1810. doi: 10.1111/j.1469-0691.2011.03521.x
2011
Journal Article
Community-associated Methicillin-resistant Staphylococcus aureus causing orbital cellulitis in Australian children
Vaska, Vikram L., Grimwood, Keith, Gole, Glen A., Nimmo, Graeme R., Paterson, David L. and Nissen, Michael D. (2011). Community-associated Methicillin-resistant Staphylococcus aureus causing orbital cellulitis in Australian children. Pediatric Infectious Disease Journal, 30 (11), 1003-1006. doi: 10.1097/INF.0b013e318224fda5
2011
Journal Article
Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients
Ferguson, P. E., Gilroy, N. M., Sloots, T. P., Nissen, M. D., Dwyer, D. E. and Sorrell, T. C. (2011). Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients. Transplant Infectious Disease, 13 (5), 448-455. doi: 10.1111/j.1399-3062.2011.00631.x
2011
Journal Article
Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia
Tozer, S.J., Lambert, S.B., Sloots, T.P. and Nissen, M.D. (2011). Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia. European Journal of Clinical Microbiology and Infectious Diseases, 30 (10), 1287-1293. doi: 10.1007/s10096-011-1225-y
2011
Journal Article
Rapid single-nucleotide polymorphism-based identification of clonal Pseudomonas aeruginosa isolates from patients with cystic fibrosis by the use of real-time PCR and high-resolution melting curve analysis
Anuj, S. N., Whiley, D. M., Kidd, T. J., Ramsay, K. A., Bell, S. C., Syrmis, M. W., Grimwood, K., Wainwright, C. E., Nissen, M. D. and Sloots, T. P. (2011). Rapid single-nucleotide polymorphism-based identification of clonal Pseudomonas aeruginosa isolates from patients with cystic fibrosis by the use of real-time PCR and high-resolution melting curve analysis. Clinical Microbiology and Infection, 17 (9), 1403-1408. doi: 10.1111/j.1469-0691.2010.03439.x
2011
Journal Article
Successful application of a simple transport method for the conduct of respiratory virus surveillance in remote Indigenous communities in Australia
O'Grady, Kerry-Ann F., Torzillo, Paul J., Rockett, Rebecca J., Whiley, David M., Nissen, Michael D., Sloots, Theo P. and Lambert, Stephen B. (2011). Successful application of a simple transport method for the conduct of respiratory virus surveillance in remote Indigenous communities in Australia. Tropical Medicine and International Health, 16 (6), 766-772. doi: 10.1111/j.1365-3156.2011.02757.x
2011
Journal Article
Viral-bacterial co-infection in Australian Indigenous children with acute otitis media
Binks, Michael J., Cheng, Allen C., Smith-Vaughan, Heidi, Sloots, Theo, Nissen, Michael, Whiley, David, McDonnell, Joseph and Leach, Amanda J. (2011). Viral-bacterial co-infection in Australian Indigenous children with acute otitis media. BMC Infectious Diseases, 11 (161) 161, 1-8. doi: 10.1186/1471-2334-11-161
2011
Journal Article
False-negative results using Neisseria gonorrhoeae porA pseudogene PCR - a clinical gonococcal isolate with an N. meningitidis porA sequence, Australia, March 2011
Whiley, D.M., Limnios, A., Moon, N.J., Gehrig, N., Goire, N., Hogan, T., Lam, A., Jacob, K., Lambert, S.B., Nissen, M.D. and Sloots, T.P. (2011). False-negative results using Neisseria gonorrhoeae porA pseudogene PCR - a clinical gonococcal isolate with an N. meningitidis porA sequence, Australia, March 2011. Eurosurveillance, 16 (21), 5-8. doi: 10.2807/ese.16.21.19874-en
2011
Journal Article
Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is spread internationally by genetically distinct gonococcal populations
Whiley, David M., Goire, Namraj, Lambert, Stephen B., Nissen, Michael D., Sloots, Theo P. and Tapsall, John W. (2011). Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is spread internationally by genetically distinct gonococcal populations. Journal of Antimicrobial Chemotherapy, 66 (5) dkr052, 1186-1187. doi: 10.1093/jac/dkr052
2011
Journal Article
Congenital and neonatal varicella: Impact of the national varicella vaccination programme in Australia
Khandaker, Gulam, Marshall, Helen, Peadon, Elizabeth, Zurynski, Yvonne, Burgner, David, Buttery, Jim, Gold, Michael, Nissen, Michael, Elliott, Elizabeth J., Burgess, Margaret and Booy, Robert (2011). Congenital and neonatal varicella: Impact of the national varicella vaccination programme in Australia. Archives of Disease in Childhood, 96 (5), 453-456. doi: 10.1136/adc.2010.206037
2011
Journal Article
Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age
Booy, Robert, Richmond, Peter, Nolan, Terry, McVernon, Jodie, Marshall, Helen, Nissen, Michael, Reynolds, Graham, Ziegler, John B., Heron, Leon, Lambert, Stephen, Caubet, Magalie, Mesaros, Narcisa and Boutriau, Dominique (2011). Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age. Pediatric Infectious Disease Journal, 30 (4), 340-342. doi: 10.1097/INF.0b013e31820013d2
2011
Journal Article
Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy
Dang, Xin, Bialasiewicz, Seweryn, Nissen, Michael D., Sloots, Theo P., Koralnik, Igor J. and Tan, Chen S. (2011). Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. PLoS One, 6 (3) e16736, e16736.1-e16736.5. doi: 10.1371/journal.pone.0016736
2011
Journal Article
A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers
Rockett, Rebecca J., Tozer, Sarah J., Peatey, Chris, Bialasiewicz, Seweryn, Whiley, David M., Nissen, Michael D., Trenholme, Katharine, Mc Carthy, James S. and Sloots, Theo P. (2011). A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers. Malaria Journal, 10 (48) 48, 48-1-48-6. doi: 10.1186/1475-2875-10-48
Funding
Supervision
Availability
- Dr Michael Nissen is:
- Available for supervision
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Supervision history
Completed supervision
-
2013
Doctor Philosophy
Molecular Characterisation and Detection of Gonococcal Antimicrobial Resistance.
Principal Advisor
Other advisors: Associate Professor David Whiley
-
2010
Doctor Philosophy
Clinical and virological characteristics of human metapneumovirus
Principal Advisor
-
2005
Doctor Philosophy
RESPIRATORY DISEASES IN PATIENTS WITH CYSTIC FIBROSIS: ROLE AND PATHOGENESIS OF PSEUDOMONAS AERUGINOSA INFECTION
Principal Advisor
-
2003
Doctor Philosophy
REAL-TIME DETECTION, DIFFERENTIATION AND QUANTITATION OF CLINICALLY RELEVANT VIRUSES
Principal Advisor
-
2010
Doctor Philosophy
Characterisation of Newly Discovered Human Polyomaviruses WU and KI
Joint Principal Advisor
-
2016
Doctor Philosophy
A nationwide study of Neisseria gonorrhoeae antimicrobial resistance; towards molecular AMR surveillance
Associate Advisor
Other advisors: Associate Professor David Whiley
-
2015
Doctor Philosophy
Epidemiology, Diagnosis and Prevention of Q fever in Queensland.
Associate Advisor
-
2015
Doctor Philosophy
Characterising the Pathogenesis and Biology of Newly Described Human Polyomaviruses
Associate Advisor
Other advisors: Associate Professor David Whiley, Dr Seweryn Bialasiewicz
-
2013
Doctor Philosophy
Detection, Identification and Genotyping of Pseudomonas aeruginosa strains isolated from environmental and clinical samples.
Associate Advisor
Other advisors: Associate Professor David Whiley
-
2011
Doctor Philosophy
Ribozymes as Antivirals for Respiratory Syncytial Virus
Associate Advisor
Other advisors: Professor Paul Young
-
2008
Doctor Philosophy
Factors Affecting Nucleic Acid Amplification Tests for Neisseria Gonorrhoeae
Associate Advisor
Media
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