Dr Michael Nissen
Dr

Michael Nissen

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Background

Michael has over 30 years’ experience in clinical medicine (infectious diseases & paediatrics) and clinical laboratory microbiology with a particular interest in the epidemiology of vaccine preventable diseases and the diagnosis of infectious diseases in hospital, public health and industry settings. He recently took up the inaugural Director of Research at The Prince Charles Hospital in Brisbane.

He is a past Principal Medical Officer and Director of CoVID-19 Pharmacovigilance at the Therapeutic Goods Administration, Department of Health & Ageing, Australian Government (2021-2022), Director of Scientific Affairs & Public Health for GSK Vaccines in the Greater China Intercontinental region based in Singapore (2014-2020) and Director of Infectious Diseases at the Royal Children’s Hospital-Brisbane and a practising Clinical Microbiologist at the Royal Brisbane & Women’s Hospitals (2000-2014). Michael is a past full member of the Australian Technical Advisory Group for Immunisation from 2007 to 2013.

Prof. Nissen has 223 peer-reviewed medical publications and book chapters, a h- index of 64 with 13,321 citations of his work to date. His research interests include the epidemiology and prevention of vaccine preventable diseases and the rapid molecular diagnostic techniques of infectious diseases.

Availability

Dr Michael Nissen is:
Available for supervision

Fields of research

Clinical sciences Medical microbiology

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians
  • Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia

Research impacts

Founder & Co-Lead of Queensland Paediatric Infectious Diseases Laboratory & Associate Professor, University of Queensland Australia: 2003-2014

Research laboratory dedicated to viral discovery, translational adaption of molecular techniques for the diagnosis of infectious and rapid molecular diagnosis of respiratory viruses. Co-discoverer of WU virus. Lead approximately 40 Phase I-IV vaccine trials in attached clinical trials unit including meningococcal and staphylococcal candidates. Established experience in the maintenance and utility of large microbiology (virus and bacteria) and serum biobanks that lead to significant viral discoveries and clinical translation.

Co-discoverer of WU Virus: 2007

Gaynor AM, MD Nissen, DM Whiley, IM Mackay, SB Lambert, G Wu, DC Brennan, GA Storch, TP Sloots, D Wang (2007). Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathogens May 4; 3(5):e64 doi:10.1371/journal.ppat.0030064 (Citations: 846).

Director of Infectious Diseases, Royal Children’s Hospital-Brisbane, QLD AUSTRALIA: 2003-2014

Foundation and Inaugural Director of Clinical Infectious Diseases (Infection Management Prevention Service-IMPS) and Pre-Eminent Staff Specialist at largest children’s hospital in Queensland and State-based Children’s Health Service (CHS). Established Antimicrobial Stewardship (AMS) Committee at CHS and developed the “AntibioCard.” Also acted as Chair of the Infection Control Committee during this period and served as paediatric representative on State Health Medicines Advisory Committee (2000-2014).

Search Professor Michael Nissen’s works on UQ eSpace

198 works between 1984 and 2023
All (198) Journal Article (173) Book Chapter (5) Conference Publication (18) Other Outputs (2)

81 - 100 of 198 works

2011

Journal Article

Enhancing gonococcal antimicrobial resistance surveillance: a real-time PCR assay for detection of penicillinase-producing Neisseria gonorrhoeae by use of noncultured clinical samples

Goire, Namraj, Freeman, Kevin, Tapsall, John W., Lambert, Stephen B., Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2011). Enhancing gonococcal antimicrobial resistance surveillance: a real-time PCR assay for detection of penicillinase-producing Neisseria gonorrhoeae by use of noncultured clinical samples. Journal of clinical microbiology, 49 (2), 513-518. doi: 10.1128/JCM.02024-10

Enhancing gonococcal antimicrobial resistance surveillance: a real-time PCR assay for detection of penicillinase-producing Neisseria gonorrhoeae by use of noncultured clinical samples

2011

Journal Article

Usefulness of published PCR primers in detecting human rhinovirus infection

Faux, Cassandra E., Arden, Katherine E., Lambert, Stephen B., Nissen, Michael D., Nolan, Terry M., Chang, Anne B., Sloots, Theo P. and Mackay, Ian M. (2011). Usefulness of published PCR primers in detecting human rhinovirus infection. Emerging Infectious Diseases, 17 (2), 296-298. doi: 10.3201/eid1702.101123

Usefulness of published PCR primers in detecting human rhinovirus infection

2011

Conference Publication

The continuing decline: rotavirus in Queensland following the introduction of multivalent vaccine

Lambert, Stephen B., Peterson, K., Selvey, C., Sloots, Theodorus P., Nissen, Michael D. and Grimwood, Keith (2011). The continuing decline: rotavirus in Queensland following the introduction of multivalent vaccine. Public Health Association Communicable Disease Control Conference, Canberra, ACT, Australia, 4-6 April 2011.

The continuing decline: rotavirus in Queensland following the introduction of multivalent vaccine

2011

Conference Publication

The changing epidemiology of rotavirus in Queensland, Australia, three years after the introduction of pentavalent rotavirus vaccine

Lambert, Stephen B., Peterson KV, Selvey CE, Sloots, Theodorus P., Nissen, Michael D. and Keith Grimwood (2011). The changing epidemiology of rotavirus in Queensland, Australia, three years after the introduction of pentavalent rotavirus vaccine. The 7th World Congress of the World Society of Pediatric Infectious Diseases, Melbourne , Australia, 16 - 19th, 2011.

The changing epidemiology of rotavirus in Queensland, Australia, three years after the introduction of pentavalent rotavirus vaccine

2011

Journal Article

Reduction in rotavirus associated acute gastroenteritis following introduction of rotavirus vaccine into Australia’s national childhood vaccine schedule

Buttery, Jim P., Lambert, Stephen B., Grimwood, Keith, Nissen, Michael D., Field, Emma J., Macartney, Kristine K., Akikusa, Jonathan D., Kelly, Julian J. and Kirkwood, Carl D. (2011). Reduction in rotavirus associated acute gastroenteritis following introduction of rotavirus vaccine into Australia’s national childhood vaccine schedule. Pediatric Infectious Diseases Journal, 30 (Supp. 1), S25-S29. doi: 10.1097/INF.0b013e3181fefdee

Reduction in rotavirus associated acute gastroenteritis following introduction of rotavirus vaccine into Australia’s national childhood vaccine schedule

2010

Journal Article

Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains

Whiley, David M., Jacobsson, Susanne, Tapsall, John W., Nissen, Michael D., Sloots, Theo P. and Unemo, Magnus (2010). Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains. Journal of Antimicrobial Chemotherapy, 65 (12) dkq377, 2543-2547. doi: 10.1093/jac/dkq377

Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains

2010

Journal Article

Evaluation of the cobas 4800 CT/NG test for detecting Chlamydia trachomatis and Neisseria gonorrhoeae

Rockett, Rebecca, Goire, Namraj, Limnios, Athena, Turra, Mark, Higgens, Geoffrey, Lambert, Stephen B., Bletchly, Cheryl, Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2010). Evaluation of the cobas 4800 CT/NG test for detecting Chlamydia trachomatis and Neisseria gonorrhoeae. Sexually Transmitted Infections, 86 (6), 470-473. doi: 10.1136/sti.2010.042812

Evaluation of the cobas 4800 CT/NG test for detecting Chlamydia trachomatis and Neisseria gonorrhoeae

2010

Journal Article

Reduced susceptibility to ceftriaxone in neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2

Whiley, David M., Goire, Namraj, Lambert, Stephen B., Ray, Sanghamitra, Limnios, E. Athena, Nissen, Michael D., Sloots, Theo P. and Tapsall, John W. (2010). Reduced susceptibility to ceftriaxone in neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2. Journal of Antimicrobial Chemotherapy, 65 (8) dkq187, 1615-1618. doi: 10.1093/jac/dkq187

Reduced susceptibility to ceftriaxone in neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2

2010

Journal Article

Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital

Arden, KE, Chang, AB, Lambert, SB, Nissen, MD, Sloots, TP and Mackay, IM (2010). Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital. Journal of Medical Virology, 82 (8), 1458-1461. doi: 10.1002/jmv.21819

Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital

2010

Journal Article

A simple approach for preparing real-time PCR positive reaction controls for rare or emerging viruses

Whiley, David M., Faux, Cassandra E., Bialasiewicz, Seweryn, Gould, Allan R., Lambert, Stephen B., Nissen, Michael D. and Sloots, Theo P. (2010). A simple approach for preparing real-time PCR positive reaction controls for rare or emerging viruses. Journal of Clinical Virology, 48 (3), 193-197. doi: 10.1016/j.jcv.2010.03.022

A simple approach for preparing real-time PCR positive reaction controls for rare or emerging viruses

2010

Journal Article

A phase 2, randomized, double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season

Fernandez, Pilar, Trenholme, Adrian, Abarca, Katia, Griffin, M. Pamela, Hultquist, Micki, Harris, Brian, Losonsky, Genevieve, Motavizumab Study Group, McCreanor, J., Nissen, M., Reynolds, G., Robertson, C., Wake, C., Lindemann, C., Mena, P., Novoa, J., Pena, V., Vivanco, G., Austin, N., Brown, J., Jackson, P. and Weston, P. (2010). A phase 2, randomized, double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season. BMC Pediatrics, 10 (1) 38, 38.1-38.12. doi: 10.1186/1471-2431-10-38

A phase 2, randomized, double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season

2010

Journal Article

Whole-genome characterization and genotyping of global WU polyomavirus strains

Bialasiewicz, Seweryn, Rockett, Rebecca, Whiley, David W., Abed, Yacine, Allander, Tobias, Binks, Michael, Boivin, Guy, Cheng, Allen C., Chung, Ju-Young, Ferguson, Patricia E., Gilroy, Nicole M., Leach, Amanda J., Lindau, Cecilia, Rossen, John W., Sorrell, Tania C., Nissen, Michael D. and Sloots, Theo P. (2010). Whole-genome characterization and genotyping of global WU polyomavirus strains. Journal of Virology, 84 (12), 6229-6234. doi: 10.1128/JVI.02658-09

Whole-genome characterization and genotyping of global WU polyomavirus strains

2010

Journal Article

Errantum : Early evidence for direct and indirect effects of the infant rotavirus vaccine program in Queensland (vol 191, pg 157, 2009)

Lambert, Stephen B., Faux, Cassandra E., Hall, Lisa, Birrell, Frances A., Peterson, Karen V, Selvey, Christine E., Sloots, Theo P., Nissen, Michael D and Grimwood, Keith (2010). Errantum : Early evidence for direct and indirect effects of the infant rotavirus vaccine program in Queensland (vol 191, pg 157, 2009). Medical Journal of Australia, 192 (9), 525-525.

Errantum : Early evidence for direct and indirect effects of the infant rotavirus vaccine program in Queensland (vol 191, pg 157, 2009)

2010

Journal Article

Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003

Arden, K. E., Faux, C. E., O'Neill, N. T., McErlean, P., Nitsche, A., Lambert, S. B., Nissen, M. D., Sloots, T. P. and Mackay, I. M. (2010). Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003. Journal of Clinical Virology, 47 (3), 219-223. doi: 10.1016/j.jcv.2010.01.001

Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003

2010

Journal Article

Immunologenicity of a monovalent 2009 influenza A(H1N1) vaccine in infants and children

Nolan, Terry, McVernon, Jodie, Skeljo, Maryanne, Richmond, Peter, Wadia, Ushma, Lambert, Stephen B., Nissen, Michael D., Marshall,Helen, Booy, Robert, Heron, Leon, Hartel, Gunter, Lai, Michael, Basser, Russell, Gittleson, Charmaine and Greenberg, Michael (2010). Immunologenicity of a monovalent 2009 influenza A(H1N1) vaccine in infants and children. JAMA: The Journal of the American Medical Association, 303 (1), 37-46. doi: 10.1001/jama.2009.1911

Immunologenicity of a monovalent 2009 influenza A(H1N1) vaccine in infants and children

2010

Book Chapter

Respiratory infections

Nissen, Michael D., Lambert, Stephen B., Whiley, David M. and Sloots, Theo P. (2010). Respiratory infections. PCR for clinical microbiology: an Australian and international perspective. (pp. 67-82) edited by Margret Schuller, Theo P. Sloots, Gregory S. James, Catriona L. Halliday and Ian W. J. Carter. Dordrecht, Netherlands : Springer. doi: 10.1007/978-90-481-9039-3_5

Respiratory infections

2010

Journal Article

Motavizumab for prophylaxis of Respiratory Syncytial Virus in high-risk children: A noninferiority trial

Carbonell-Estrany, Xavier, Simoes, Eric A. F., Dagan, Ron, Hall, Caroline B., Harris, Brian, Hultquist, Micki, Connor, Edward M., Losonsky, Genevieve A., Motavizumab Study Group and Nissen, Michael D. (2010). Motavizumab for prophylaxis of Respiratory Syncytial Virus in high-risk children: A noninferiority trial. Pediatrics, 125 (1), e35-e51. doi: 10.1542/peds.2008-1036

Motavizumab for prophylaxis of Respiratory Syncytial Virus in high-risk children: A noninferiority trial

2009

Journal Article

A novel duplex real-time reverse transcription PCR Assay for the detection of influenza A and the novel influenza A(H1N1)strain.

Rockett, Rebecca J., Bialasiewicz, Seweryn, Whiley, David M., Bletchly, Cheryl, Faux, Cassandra E., Lambert, Stephen B., Nimmo, Graeme R., Nissen, Michael D. and Sloots, Theodorus P. (2009). A novel duplex real-time reverse transcription PCR Assay for the detection of influenza A and the novel influenza A(H1N1)strain.. Viruses, 1 (3), 1204-1208. doi: 10.3390/v1031204

A novel duplex real-time reverse transcription PCR Assay for the detection of influenza A and the novel influenza A(H1N1)strain.

2009

Journal Article

Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis.

Wainwright, C. E., France, M. W., O'Rourke, P., Anuj, S., Kidd, T. J., Nissen, M. D., Sloots, T. P., Coulter, C., Ristovski, Z., Hargreaves, M., Rose, B. R., Harbour, C., Bell, SC and Fennelly, KP (2009). Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis.. Thorax, 64 (11), 926-931. doi: 10.1136/thx.2008.112466

Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis.

2009

Journal Article

Simple, rapid, and inexpensive detection of Neisseria gonorrhoeae resistance mechanisms using heat-denatured isolates and SYBR green-based real-time PCR.

Kugelman, Gayle, Tapsall, John W., Goire, Namraj, Syrmis, Melanie, Limnios, Athena, Lambert, Stephen B., Nissen, Michael D., Sloots, Theo P. and Whiley, David M. (2009). Simple, rapid, and inexpensive detection of Neisseria gonorrhoeae resistance mechanisms using heat-denatured isolates and SYBR green-based real-time PCR.. Antimicrobial Agents & Chemotherapy, 53 (10), 4211-4216. doi: 10.1128/AAC.00385-09

Simple, rapid, and inexpensive detection of Neisseria gonorrhoeae resistance mechanisms using heat-denatured isolates and SYBR green-based real-time PCR.

Past funding

  • 2013 - 2016
    Q fever: How common is it and how can we best prevent it? Research to inform Q fever vaccine policy in Australia and Internationally. (NHMRC project grant administered by University of Sydney)
    University of Sydney
    Open grant
  • 2010 - 2016
    Molecular microbiology and epidemiology of respiratory infections in children
    Royal Children's Hospital Foundation
    Open grant
  • 2010 - 2011
    Development of a novel assay for the detection of clonal P.aeruginosa in persons with CF
    Australian Cystic Fibrosis Research Trust
    Open grant
  • 2010 - 2014
    Burden of respiratory infection in the first 2 years of life: a birth cohort study of emerging respiratory pathogens
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    Characterisation of novel picornavirus-like viruses identified from patients with acute respiratory infections
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    Clinical impact of clonal Pseudomonas aeruginosa in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2007 - 2010
    The clinical and epidemiological characterisation of a newly discovered human polyonmavirus, WU (WU Virus Research)
    Royal Children's Hospital Foundation
    Open grant
  • 2006
    Identification of Virulence Markers in the Respiratory Syncytial Virus Genome
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2006
    Characterisation and Epidemiology of Emerging Pathogens in Paediatrics
    ANZ Executors and Trustees' Company Ltd
    Open grant
  • 2005 - 2010
    Research support for paediatric infectious diseases
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2010
    Epidemiology and Control of Q Fever in Children
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2010
    How Children and adults with cystic fibrosis get lung infections with Pseudomonas aeruginosa
    Royal Children's Hospital Foundation
    Open grant
  • 2004 - 2010
    (i) Detection of mucoid P. aeruginosa antigens and antibodies in CF (ii) Molecular epidemiology of respiratory syncytial virus infections and the immune response in Australian children
    Royal Children's Hospital Foundation
    Open grant
  • 2003
    Macquarie Bank Asthma Research Fellowship for 2003
    Royal Australasian College of Physicians
    Open grant
  • 2003 - 2008
    The clinical significance of human metapneumovirus infections in Australian children
    Royal Children's Hospital Foundation
    Open grant
  • 2002
    Molecular epidemiology of respiratory syncitial virus in Australia
    UQ Early Career Researcher
    Open grant
  • 2001
    Establishment of a Malarial & Molecular Research Program at the RCH, Brisbane
    Royal Children's Hospital Foundation
    Open grant
  • 2001
    Real-time diagnosis of respiratory tract infections in children
    Royal Children's Hospital Foundation
    Open grant
  • 2000 - 2001
    Establishment of a Paediatric and Molecular Infectious Diseases Research Program at the Royal Children's Hospital, Brisbane
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000
    Competitive Research Equipment Grant
    Royal Children's Hospital Foundation
    Open grant

Availability

Dr Michael Nissen is:
Available for supervision

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Supervision history

Completed supervision

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