![Dr Christine Staatz](/sites/default/files/profiles/800.jpeg)
Overview
Background
Christine graduated with a Bachelor of Pharmacy degree (honours class 1) from the University of Queensland in 1996.
She registered as a pharmacist in Australia in 1997 and in the United Kingdom in 2003 and has worked at the Redlands, Princess Alexandra and Wesley Hospitals in Brisbane and the Western Infirmary in Glasgow. In 2002 she was awarded a PhD from the University of Queensland, with a thesis focusing on improving usage of the immunosuppressant agent tacrolimus in solid organ transplant recipients.
In 2004 she was the recipient of a National Health and Medical Research Council (NHMRC) Neil Hamilton Fairley fellowship. This award enabled her to training overseas in the field of Pharmacometrics within the Department of Medicine and Therapeutics at the University of Glasgow (Scotland) and the Department of Pharmaceutical Biosciences at Uppsala University (Sweden).
On her return to Brisbane, Christine was the recipient of a Lions Medical Research Fellowship and was the chief investigator on a three year NHMRC Project Grant. She has also been a team member on an Amgen-Transplant Society of Australia and New Zealand Research Grant and a Cellcept Australia Research Grant. Over her research career Christine has attracted grants and awards totaling more than 2 million AUD from various funding agencies.
Research Interests
Christine has a wide range of interests in the fields of Quality Use of Medicine and Pharmacometrics. Her work to date has primarily been directed towards optimising usage of immunosuppressant drugs in solid organ transplant recipients and antibiotics in patients with life-threatening infections.
Christine has published over 75 peer reviewed papers and 90 conference abstracts on these topics. Her publications have been cited on more than 3200 occasions, with twelve cited more than 50 times.
Christine has successfully supervised to completion fourteen higher research degree students and enjoys helping students meet their career goals.
Christine’s current projects include:
- Individualising immunosuppressant therapy in autoimmune disease to improve patient outcomes
- Comparing the efficacy and safety of continuous versus intermittent administration of beta-lactams in critically ill patients
- Examining the relationship between immunosuppression and non-melanoma skin cancer in renal transplant recipients
- Improving individualisation of immunosuppressant therapy in adult kidney transplant recipients
- Improving gentamycin dosing in paediatric oncology patients
- Examining tobramycin monitoring in cystic fibrosis patients in Australia and the United Kingdom
- Investigating the relationship between prednisolone exposure and drug-related toxicity in paediatric and adult kidney transplant recipients
- Comparing different therapeutic drug monitoring methods for dosage adjustment of once daily intravenous tobramycin treatment in children with cystic fibrosis
Projects currently available for interested research higher degree students include:
- Dose optimisation of busulfan in paediatric bone marrow transplant recipients
- Investigating the relationship between immunosupressant exposure and drug-related toxicity in transplant recipients
- Examining Bayesian forecasting methods to predict immunosuppressant exposure
- Examining the international use of immunosuppressant and anti-rheumatic drugs
- Examining the influence of plasma exchange on immunosuppressant drug exposure
Christine invites potential honours and post-graduate students to contact her via email to discuss research opportunities.
Teaching interests
Co-ordinates:
- PHRM3052- Biological Fate of Drugs
Teaches in:
- PHRM3052- Biological Fate of Drugs
- PHRM3011- Quality Use of Medicines
Availability
- Dr Christine Staatz is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, The University of Queensland
- Bachelor (Honours) of Pharmacy, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Christine Staatz’s works on UQ eSpace
2024
Journal Article
Does Age Influence Immunosuppressant Drug Pharmacokinetics in Kidney Transplant Recipients?
Cossart, Amelia R., Isbel, Nicole M., Campbell, Scott B., McWhinney, Brett and Staatz, Christine E. (2024). Does Age Influence Immunosuppressant Drug Pharmacokinetics in Kidney Transplant Recipients?. European Journal of Drug Metabolism and Pharmacokinetics. doi: 10.1007/s13318-024-00914-3
2024
Journal Article
Preparedness of pharmacy students and preceptors for work integrated learning in an undergraduate Pharmacy program
Quach, Thien An, Staatz, Christine, Lee, Jane, Fejzic, Jasmina and Hardman, Caitlin (2024). Preparedness of pharmacy students and preceptors for work integrated learning in an undergraduate Pharmacy program. The Australian Pharmacy Students' Journal, 3 (2), 15-29. doi: 10.55136/apsj326
2024
Journal Article
Metformin for preventing the progression of chronic kidney disease
El-Damanawi, Ragada, Stanley, Isabelle Kitty, Staatz, Christine, Pascoe, Elaine M, Craig, Jonathan C, Johnson, David W, Mallett, Andrew J, Hawley, Carmel M, Milanzi, Elasma, Hiemstra, Thomas F and Viecelli, Andrea K (2024). Metformin for preventing the progression of chronic kidney disease. Cochrane Database of Systematic Reviews, 2024 (6) CD013414. doi: 10.1002/14651858.cd013414.pub2
2024
Journal Article
Efficacy and safety of fibroblast growth factor‐21 analogs for the treatment of metabolic dysfunction‐associated steatohepatitis: a systematic review and meta‐analysis
Jeong, Changhyeon, Han, Nayoung, Jeon, Nakyung, Rhee, Su‐jin, Staatz, Christine E., Kim, Min‐Soo and Baek, In‐hwan (2024). Efficacy and safety of fibroblast growth factor‐21 analogs for the treatment of metabolic dysfunction‐associated steatohepatitis: a systematic review and meta‐analysis. Clinical Pharmacology and Therapeutics, 116 (1), 72-81. doi: 10.1002/cpt.3278
2024
Journal Article
A secondary analysis of concurrent use of metformin and tolvaptan in ADPKD tolvaptan trials
Stanley, I. Kitty, Palma, Anton M., Viecelli, Andrea K., Johnson, David W., Hawley, Carmel M., Staatz, Christine E. and Mallett, Andrew J. (2024). A secondary analysis of concurrent use of metformin and tolvaptan in ADPKD tolvaptan trials. Journal of Nephrology. doi: 10.1007/s40620-024-01906-x
2024
Journal Article
A post hoc analysis of the CKD-FIX study analysing the association between metformin usage and eGFR decline
Stanley, Kitty, Mallett, Andrew J., Viecelli, Andrea K., Hawley, Carmel M., Staatz, Christine E., Johnson, David W. and Milanzi, Elasma (2024). A post hoc analysis of the CKD-FIX study analysing the association between metformin usage and eGFR decline. Kidney International Reports, 9 (5), 1525-1527. doi: 10.1016/j.ekir.2024.02.011
2024
Journal Article
Clinical safety and narcolepsy-like symptoms of dual orexin receptor antagonists in patients with insomnia: a systematic review and meta-analysis
Na, Hyun-jin, Jeon, Nakyung, Staatz, Christine E, Han, Nayoung and Baek, In-hwan (2024). Clinical safety and narcolepsy-like symptoms of dual orexin receptor antagonists in patients with insomnia: a systematic review and meta-analysis. SLEEP, 47 (2) zsad293, 1-11. doi: 10.1093/sleep/zsad293
2024
Conference Publication
Population pharmacokinetic modelling of intracellular tacrolimus in stable kidney transplanted patients.
Agergaard, K., Thiesson, H.C., Carstens, J., Kjellsson, M., Staatz, C.E., Järvinen, E., Nielsen, F., Christensen, H.D., Juhl-Sandberg, R., Brøsen, K., Stage, T.B. and Bergmann, T.K. (2024). Population pharmacokinetic modelling of intracellular tacrolimus in stable kidney transplanted patients.. Danish Society of Pharmacology., Odense, Denmark, 16 January 2024.
2024
Journal Article
The association between tacrolimus exposure and tremor, headache and insomnia in adult kidney transplant recipients: a systematic review
King, Catherine P., Cossart, Amelia R., Isbel, Nicole M., Campbell, Scott B. and Staatz, Christine E. (2024). The association between tacrolimus exposure and tremor, headache and insomnia in adult kidney transplant recipients: a systematic review. Transplantation Reviews, 38 (1) 100815, 1-12. doi: 10.1016/j.trre.2023.100815
2023
Journal Article
Effect on lipid profile and clinical outcomes of obeticholic acid for the treatment of primary biliary cholangitis and metabolic dysfunction-associated steatohepatitis: a systematic review and meta-analysis
Jang, Hyejung, Han, Nayoung, Staatz, Christine E., Kwak, Jae-Hwan and Baek, In-hwan (2023). Effect on lipid profile and clinical outcomes of obeticholic acid for the treatment of primary biliary cholangitis and metabolic dysfunction-associated steatohepatitis: a systematic review and meta-analysis. Clinics and Research in Hepatology and Gastroenterology, 47 (10) 102227, 102227. doi: 10.1016/j.clinre.2023.102227
2023
Conference Publication
Limited sampling strategies to estimate tacrolimus whole blood, total plasma, and free plasma exposure.
Masoud, D., Cossart, A.R., Isbel, N.M., Campbell, S.B., McWhinney, B. and Staatz, C.E. (2023). Limited sampling strategies to estimate tacrolimus whole blood, total plasma, and free plasma exposure.. International Association of Therapeutic Drug Monitoring and Clinical Toxicology, Oslo, Norway, 24-27 September 2023.
2023
Conference Publication
Trimethoprim-sulfamethoxazole pharmacokinetic evaluation in adult kidney transplant recipients.
Scuderi, C.E., Parker, S.L., Jacks, M., John, G.T., McWhinney, B., Ungerer, J., Mallett, A.J., Healy, H.G., Roberts, J.A. and Staatz, C.E. (2023). Trimethoprim-sulfamethoxazole pharmacokinetic evaluation in adult kidney transplant recipients.. World Congress on Pharmacy and Pharmaceutical Sciences., Brisbane, QLD Australia, 24-28 September 2023.
2023
Conference Publication
Management of neonatal seizures by neonatologists and paediatric neurologists: A survey of practice in Australia and New Zealand.
Williams, A., Liley, H. and Staatz, C.E. (2023). Management of neonatal seizures by neonatologists and paediatric neurologists: A survey of practice in Australia and New Zealand.. European Society for Developmental, Perinatal and Paediatric Pharmacology, Prague, Czech Republic, 28-30 June 2023.
2023
Journal Article
Serum creatinine and tacrolimus assessment with VAMS finger-prick microsampling: a diagnostic test study
Scuderi, Carla E., Parker, Suzanne L., Jacks, Margaret, John, George T., McWhinney, Brett, Ungerer, Jacobus, Mallett, Andrew J., Healy, Helen G., Roberts, Jason A. and Staatz, Christine E. (2023). Serum creatinine and tacrolimus assessment with VAMS finger-prick microsampling: a diagnostic test study. Kidney Medicine, 5 (4) 100610, 100610. doi: 10.1016/j.xkme.2023.100610
2023
Journal Article
Fingerprick microsampling methods can replace venepuncture for simultaneous therapeutic drug monitoring of tacrolimus, mycophenolic acid, and prednisolone concentrations in adult kidney transplant patients
Scuderi, Carla, Parker, Suzanne, Jacks, Margaret, John, George T., McWhinney, Brett, Ungerer, Jacobus, Mallett, Andrew, Healy, Helen, Roberts, Jason and Staatz, Christine (2023). Fingerprick microsampling methods can replace venepuncture for simultaneous therapeutic drug monitoring of tacrolimus, mycophenolic acid, and prednisolone concentrations in adult kidney transplant patients. Therapeutic Drug Monitoring, 45 (1), 69-78. doi: 10.1097/FTD.0000000000001024
2023
Conference Publication
A post-hoc analysis of the CKD-FIX study analysing the association between metformin use and eGFR decline
Stanley, I., Viecelli, A., Johnson, D., Hawley, C., Mallett, A., Staatz, C. and Milanzi, E. (2023). A post-hoc analysis of the CKD-FIX study analysing the association between metformin use and eGFR decline. Australian and New Zealand Society of Nephrology Conference, Cairns, QLD, Australia, 22-24 October 2023. HOBOKEN: WILEY.
2023
Conference Publication
A Secondary Analysis of Concurrent use of Metformin and Tolvaptan in ADPKD Tolvaptan Trials
Stanley, I., Palma, A., Viecelli, A., Johnson. D., Hawley, C., Staatz, C. and Mallett, A. (2023). A Secondary Analysis of Concurrent use of Metformin and Tolvaptan in ADPKD Tolvaptan Trials. Asian Pacific Society of Dialysis Access (APSDA) Conference, Cairns, QLD Australia, 22-24th October 2023. HOBOKEN: WILEY.
2023
Conference Publication
Examining different methods to assess busulfan exposure in paediatric stem cell transplant recipients.
Thompson, M., Staatz, C.E., Fraser, C.J., Mitchell, R., Ramachandran, S., Teague, L., O’Brien, T.A., McWhinney, B., Stacey, S., Hennig, S. and Lawson, R. (2023). Examining different methods to assess busulfan exposure in paediatric stem cell transplant recipients.. ASCEPT-APSA, Sydney, NSW, Australia, 20-23 November 2023.
2022
Conference Publication
Tacrolimus, mycophenolate and prednisolone concentration monitoring using microsampling instead of venepuncture in kidney transplant patients
Scuderi, C. E., Parker, S. L., Jacks, M., John, G. T., McWhinney, B., Ungerer, J., Mallett, A. J., Healy, H. G., Roberts, J. A. and Staatz, C. E. (2022). Tacrolimus, mycophenolate and prednisolone concentration monitoring using microsampling instead of venepuncture in kidney transplant patients. Society of Hospital Pharmacists of Australia, Brisbane, QLD, Australia, 1-3 December 2022.
2022
Conference Publication
Examining preparedness of hospital pharmacy preceptors for work integrated learning (WIL) placements
Hardman, C., Quach, T. A., Staatz, C. E., Fejzic, J. and Lee, J. (2022). Examining preparedness of hospital pharmacy preceptors for work integrated learning (WIL) placements. Society of Hospital Pharmacists of Australia, Brisbane, QLD Australia, 1-3 December 2022.
Funding
Supervision
Availability
- Dr Christine Staatz is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Exploring free plasma tacrolimus and mycophenolic acid measurements and defining a therapeutic target range for therapeutic drug monitoring
Principal Advisor
Other advisors: Dr Meng-Wong Taing
-
Doctor Philosophy
Improving patient centred outcomes in kidney transplant recipients
Principal Advisor
Other advisors: Dr Andrew Mallett
-
Doctor Philosophy
The IMPEDE-PKD Clinical Trial - Investigating the repurposing of metformin in ADPKD
Associate Advisor
Other advisors: Professor David Johnson, Professor Carmel Hawley, Dr Andrew Mallett, Associate Professor Andrea Viecelli
-
Doctor Philosophy
To investigate the pharmacotherapy management of the bariatric surgery patient and the impact of the pharmacist in the multidisciplinary team
Associate Advisor
Other advisors: Dr Karen Whitfield
Completed supervision
-
2023
Doctor Philosophy
Pharmacokinetics and Pharmacodynamics of Intravenous Busulfan in Children: Once daily administration
Principal Advisor
-
2022
Doctor Philosophy
Optimising immunosuppressant medicines in elderly kidney transplant recipients
Principal Advisor
Other advisors: Associate Professor Neil Cottrell
-
2021
Doctor Philosophy
Evaluating Prediction Methods for Estimating Tacrolimus, Mycophenolate and Prednisolone Exposure Following Adult Kidney Transplantation
Principal Advisor
Other advisors: Emeritus Professor Sue Tett
-
2016
Doctor Philosophy
Individualising immunosuppressant therapy in autoimmune disease to improve patient outcomes
Principal Advisor
Other advisors: Emeritus Professor Sue Tett
-
2016
Doctor Philosophy
Optimizing beta-lactam antibiotic dosing in critically ill patients: Prolonged infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Professor Jeffrey Lipman, Professor Jason Roberts
-
2012
Doctor Philosophy
Pharmacokinetic, Pharmacogenetic and Pharmacodynamic Monitoring of Immunosuppressive Therapy in Adult Kidney Transplant Recipients
Associate Advisor
-
2018
Doctor Philosophy
Optimising gentamicin therapy in paediatric oncology patients
Joint Principal Advisor
-
2017
Doctor Philosophy
The impact of increasing patient weight on the dosing of high-dose methotrexate chemotherapy in aggressive non-Hodgkin lymphoma
Joint Principal Advisor
Media
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