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2024 Journal Article Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptidesGilding, Edward K., Jackson, Mark A., Nguyen, Linh T. T., Hamilton, Brett R., Farquharson, Katherine A., Ho, Wing L., Yap, Kuok, Hogg, Carolyn J., Belov, Katherine and Craik, David J. (2024). Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptides. Nature Communications, 15 (1) 6565. doi: 10.1038/s41467-024-50742-x |
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2024 Journal Article Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applicationsFan, Xiwei, Sun, Antonia Rujia, Young, Reuben S. E., Afara, Isaac O., Hamilton, Brett R., Ong, Louis Jun Ye, Crawford, Ross and Prasadam, Indira (2024). Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications. Bone Research, 12 (1) 7, 7. doi: 10.1038/s41413-023-00304-6 |
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2023 Journal Article Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin familyAshwood, Lauren M., Elnahriry, Khaled A., Stewart, Zachary K., Shafee, Thomas, Naseem, Muhammad Umair, Szanto, Tibor G., van der Burg, Chloé A., Smith, Hayden L., Surm, Joachim M., Undheim, Eivind A. B., Madio, Bruno, Hamilton, Brett R., Guo, Shaodong, Wai, Dorothy C. C., Coyne, Victoria L., Phillips, Matthew J., Dudley, Kevin J., Hurwood, David A., Panyi, Gyorgy, King, Glenn F., Pavasovic, Ana, Norton, Raymond S. and Prentis, Peter J. (2023). Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family. BMC Biology, 21 (1) 121, 121. doi: 10.1186/s12915-023-01617-y |
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2023 Journal Article Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisationJia, Xinying, Chin, Yanni K.-Y., Zhang, Alan H., Crawford, Theo, Zhu, Yifei, Fletcher, Nicholas L., Zhou, Zihan, Hamilton, Brett R., Stroet, Martin, Thurecht, Kristofer J. and Mobli, Mehdi (2023). Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation. Communications Chemistry, 6 (1) 48, 1-10. doi: 10.1038/s42004-023-00841-5 |
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2023 Journal Article Spatial Distribution and Biochemical Characterization of Serine Peptidase Inhibitors in the Venom of the Brazilian Sea Anemone Anthopleura cascaia Using Mass Spectrometry Imagingda Silva, Daiane Laise, Valladão, Rodrigo, Beraldo-Neto, Emidio, Coelho, Guilherme Rabelo, Neto, Oscar Bento da Silva, Vigerelli, Hugo, Lopes, Adriana Rios, Hamilton, Brett R., Undheim, Eivind A. B., Sciani, Juliana Mozer and Pimenta, Daniel Carvalho (2023). Spatial Distribution and Biochemical Characterization of Serine Peptidase Inhibitors in the Venom of the Brazilian Sea Anemone Anthopleura cascaia Using Mass Spectrometry Imaging. Marine Drugs, 21 (9) 481, 1-20. doi: 10.3390/md21090481 |
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2023 Journal Article Visualization of the distribution of PFOS and PFHxS in concrete by DESI MSIVo, Phong H. N., Hamilton, Brett R., Wepf, Roger A., Key, Trent A., Nguyen, Thi Minh Hong, Thai, Phong K., Thomas, Kevin and Mueller, Jochen F. (2023). Visualization of the distribution of PFOS and PFHxS in concrete by DESI MSI. Environmental Science and Technology Letters, 10 (5), 446-451. doi: 10.1021/acs.estlett.3c00211 |
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2023 Journal Article Functional mass spectrometry imaging maps phospholipase-A2 enzyme activity during osteoarthritis progressionFan, Xiwei, Young, Reuben S E, Sun, Antonia Rujia, Hamilton, Brett R., Nedunchezhiyan, Udhaya, Crawford, Ross, Blanksby, Stephen J. and Prasadam, Indira (2023). Functional mass spectrometry imaging maps phospholipase-A2 enzyme activity during osteoarthritis progression. Theranostics, 13 (13), 4636-4649. doi: 10.7150/thno.86623 |
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2022 Journal Article Utilizing PET and MALDI imaging for discovery of a targeted probe for brain endocannabinoid α/β-hydrolase domain 6 (ABHD6)Mardon, Karine, Patel, Jayendra Z., Savinainen, Juha R., Stimson, Damion H. R., Oyagawa, Caitlin R. M., Grimsey, Natasha L., Migotto, Mary-anne, Njiru, Grace F. M., Hamilton, Brett R., Cowin, Gary, Yli-Kauhaluoma, Jari, Vanduffel, Wim, Blakey, Idriss, Bhalla, Rajiv, Cawthorne, Christopher, Celen, Sofie, Bormans, Guy, Thurecht, Kristofer J and Ahamed, Muneer (2022). Utilizing PET and MALDI imaging for discovery of a targeted probe for brain endocannabinoid α/β-hydrolase domain 6 (ABHD6). Journal of Medicinal Chemistry, 66 (1), 538-552. doi: 10.1021/acs.jmedchem.2c01485 |
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2022 Journal Article Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica feroxXie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218 |
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2022 Journal Article Physiological constraints dictate toxin spatial heterogeneity in snake venom glandsKazandjian, Taline D., Hamilton, Brett R., Robinson, Samuel D., Hall, Steven R., Bartlett, Keirah E., Rowley, Paul, Wilkinson, Mark C., Casewell, Nicholas R. and Undheim, Eivind A. B. (2022). Physiological constraints dictate toxin spatial heterogeneity in snake venom glands. BMC Biology, 20 (1) 148, 1-14. doi: 10.1186/s12915-022-01350-y |
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2022 Journal Article Evolution, expression patterns, and distribution of novel ribbon worm predatory and defensive toxinsVerdes, Aida, Taboada, Sergi, Hamilton, Brett R., Undheim, Eivind A. B., Sonoda, Gabriel G., Andrade, Sonia C. S., Morato, Esperanza, Marina, Ana Isabel, Cárdenas, César A. and Riesgo, Ana (2022). Evolution, expression patterns, and distribution of novel ribbon worm predatory and defensive toxins. Molecular Biology and Evolution, 39 (5) msac096, 1-16. doi: 10.1093/molbev/msac096 |
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2022 Journal Article The deterioration of calcified cartilage integrity reflects the severity of osteoarthritis—A structural, molecular, and biochemical analysisFan, Xiwei, Wu, Xiaoxin, Trevisan Franca De Lima, Lucas, Stehbens, Samantha, Punyadeera, Chamindie, Webb, Richard, Hamilton, Brett, Ayyapann, Vijay, McLauchlan, Connor, Crawford, Ross, Zheng, Minghao, Xiao, Yin and Prasadam, Indira (2022). The deterioration of calcified cartilage integrity reflects the severity of osteoarthritis—A structural, molecular, and biochemical analysis. FASEB Journal, 36 (2) e22142, 1-18. doi: 10.1096/fj.202101449R |
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2022 Journal Article Cryo-ultramicrotomy and mass spectrometry imaging analysis of nudibranch microstructuresHamilton, Brett R., Chan, Weili, Cheney, Karen L., Sullivan, Robert K. P., Floetenmeyer, Matthias, Garson, Mary J. and Wepf, Roger (2022). Cryo-ultramicrotomy and mass spectrometry imaging analysis of nudibranch microstructures. Journal of The American Society for Mass Spectrometry, 33 (3) jasms.1c00254, 1-6. doi: 10.1021/jasms.1c00254 |
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2021 Journal Article Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatusHimaya, S. W.A., Jin, Ai-Hua, Hamilton, Brett, Rai, Subash K., Alewood, Paul and Lewis, Richard J. (2021). Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus. Scientific Reports, 11 (1) 13282, 13282. doi: 10.1038/s41598-021-91919-4 |
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2021 Journal Article Venoms for all occasions: the functional toxin profiles of different anatomical regions in sea anemones are related to their ecological functionAshwood, Lauren M., Undheim, Eivind A. B., Madio, Bruno, Hamilton, Brett R., Daly, Marymegan, Hurwood, David A., King, Glenn F. and Prentis, Peter J. (2021). Venoms for all occasions: the functional toxin profiles of different anatomical regions in sea anemones are related to their ecological function. Molecular Ecology, 31 (3), 866-883. doi: 10.1111/mec.16286 |
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2021 Journal Article Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A. and Craik, David J. (2021). Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1. Medicine in Drug Discovery, 10 100087, 1-10. doi: 10.1016/j.medidd.2021.100087 |
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2020 Journal Article Neurotoxic peptides from the venom of the giant Australian stinging treeGilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828 |
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2020 Journal Article Deadly proteomes: a practical guide to proteotranscriptomics of animal venomsWalker, Andrew A., Robinson, Samuel D., Hamilton, Brett F., Undheim, Eivind A. B. and King, Glenn F. (2020). Deadly proteomes: a practical guide to proteotranscriptomics of animal venoms. Proteomics, 20 (17-18) 1900324, e1900324. doi: 10.1002/pmic.201900324 |
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2020 Journal Article Mapping enzyme activity on tissue by functional mass spectrometry imagingHamilton, Brett R., Marshall, David L., Casewell, Nicholas R., Harrison, Robert A., Blanksby, Stephen J. and Undheim, Eivind A. B. (2020). Mapping enzyme activity on tissue by functional mass spectrometry imaging. Angewandte Chemie-International Edition, 132 (10) ange.201911390, 3883-3886. doi: 10.1002/anie.201911390 |
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2020 Journal Article Mapping enzyme activity on tissue by functional mass spectrometry imagingHamilton, Brett R., Marshall, David L., Casewell, Nicholas R., Harrison, Robert A., Blanksby, Stephen J. and Undheim, Eivind A. B. (2020). Mapping enzyme activity on tissue by functional mass spectrometry imaging. Advanced Materials, 59 (10), 3883-3886. doi: 10.1002/ANGE.201911390 |
