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2020

Journal Article

Inferring structural variant cancer cell fraction

Cmero, Marek, Yuan, Ke, Ong, Cheng Soon, Schröder, Jan, Adams, David J., Anur, Pavana, Beroukhim, Rameen, Boutros, Paul C., Bowtell, David D. L., Campbell, Peter J., Cao, Shaolong, Christie, Elizabeth L., Cun, Yupeng, Dawson, Kevin J., Demeulemeester, Jonas, Dentro, Stefan C., Deshwar, Amit G., Donmez, Nilgun, Drews, Ruben M., Eils, Roland, Fan, Yu, Fittall, Matthew W., Garsed, Dale W., Gerstung, Moritz, Getz, Gad, Gonzalez, Santiago, Ha, Gavin, Haase, Kerstin, Imielinski, Marcin ... von Mering, Christian (2020). Inferring structural variant cancer cell fraction. Nature Communications, 11 (1) 730. doi: 10.1038/s41467-020-14351-8

Inferring structural variant cancer cell fraction

2020

Journal Article

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Hudeček, Jan, Voorwerk, Leonie, van Seijen, Maartje, Nederlof, Iris, de Maaker, Michiel, van den Berg, Jose, van de Vijver, Koen K., Sikorska, Karolina, Adams, Sylvia, Demaria, Sandra, Viale, Giuseppe, Nielsen, Torsten O., Badve, Sunil S., Michiels, Stefan, Symmans, William Fraser, Sotiriou, Christos, Rimm, David L., Hewitt, Stephen M., Denkert, Carsten, Loibl, Sibylle, Loi, Sherene, Bartlett, John M. S., Pruneri, Giancarlo, Dillon, Deborah A., Cheang, Maggie C. U., Tutt, Andrew, Hall, Jacqueline A., Kos, Zuzana, Salgado, Roberto ... and International Immuno-Oncology Biomarker Working Group (2020). Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials. npj Breast Cancer, 6 (1) 15. doi: 10.1038/s41523-020-0155-1

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

2020

Journal Article

Lobular carcinoma in situ: diagnostic criteria and molecular correlates

Sokolova, Anna and Lakhani, Sunil R. (2020). Lobular carcinoma in situ: diagnostic criteria and molecular correlates. Modern Pathology, 34 (S1), 8-14. doi: 10.1038/s41379-020-00689-3

Lobular carcinoma in situ: diagnostic criteria and molecular correlates

2020

Journal Article

Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1

Kalaw, Emarene, Lim, Malcolm, Kutasovic, Jamie R., Sokolova, Anna, Taege, Lucinda, Johnstone, Kate, Bennett, James, Saunus, Jodi M., Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Bettington, Mark, Pathmanathan, Nirmala, Tse, Gary M., Papadimos, David, Pathmanathan, Rajadurai, Harris, Gavin, Yamaguchi, Rin, Tan, Puay Hoon, Fox, Stephen, O’Toole, Sandra A., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2020). Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1. British Journal of Cancer, 123 (11), 1665-1672. doi: 10.1038/s41416-020-01065-3

Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1

2020

Journal Article

Phenotypic drift in metastatic progression of breast cancer: a case report with histologically heterogeneous lesions that are clonally related

Kutasovic, Jamie R., McCart Reed, Amy E., Sokolova, Anna, Jayanthan, Janani, Da Silva, Leonard, Simpson, Peter T. and Lakhani, Sunil R. (2020). Phenotypic drift in metastatic progression of breast cancer: a case report with histologically heterogeneous lesions that are clonally related. Clinical Case Reports, 8 (12) ccr3.3257, 2725-2731. doi: 10.1002/ccr3.3257

Phenotypic drift in metastatic progression of breast cancer: a case report with histologically heterogeneous lesions that are clonally related

2020

Journal Article

The latest FADS: Functional analysis of GLDN patient variants and classification of GLDN-associated AMC as a type of viable fetal akinesia deformation sequence

Mis, Emily K., Al-Ali, Samir, Ji, Weizhen, Spencer-Manzon, Michele, Konstantino, Monica, Khokha, Mustafa K., Jeffries, Lauren and Lakhani, Saquib A. (2020). The latest FADS: Functional analysis of GLDN patient variants and classification of GLDN-associated AMC as a type of viable fetal akinesia deformation sequence. American Journal of Medical Genetics Part A, 182 (10), 2291-2296. doi: 10.1002/ajmg.a.61783

The latest FADS: Functional analysis of GLDN patient variants and classification of GLDN-associated AMC as a type of viable fetal akinesia deformation sequence

2020

Journal Article

Using whole-genome sequencing data to derive the homologous recombination deficiency scores

de Luca, Xavier M., Newell, Felicity, Kazakoff, Stephen H., Hartel, Gunter, McCart Reed, Amy E., Holmes, Oliver, Xu, Qinying, Wood, Scott, Leonard, Conrad, Pearson, John V., Lakhani, Sunil R., Waddell, Nicola, Nones, Katia and Simpson, Peter T. (2020). Using whole-genome sequencing data to derive the homologous recombination deficiency scores. npj Breast Cancer, 6 (1) 33, 33. doi: 10.1038/s41523-020-0172-0

Using whole-genome sequencing data to derive the homologous recombination deficiency scores

2020

Journal Article

Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases

Kalita-de Croft, Priyakshi, Lim, Malcolm, Chittoory, Haarika, de Luca, Xavier M., Kutasovic, Jamie R., Day, Bryan W., Al-Ejeh, Fares, Simpson, Peter T., McCart Reed, Amy E., Lakhani, Sunil R. and Saunus, Jodi M. (2020). Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases. Therapeutic Advances in Medical Oncology, 12 1758835920946259, 175883592094625. doi: 10.1177/1758835920946259

Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases

2020

Journal Article

Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1

Teo, Wee S., Holliday, Holly, Karthikeyan, Nitheesh, Cazet, Aurélie S., Roden, Daniel L., Harvey, Kate, Konrad, Christina Valbirk, Murali, Reshma, Varghese, Binitha Anu, Thankamony, Archana P., Chan, Chia-Ling, McFarland, Andrea, Junankar, Simon, Ye, Sunny, Yang, Jessica, Nikolic, Iva, Shah, Jaynish S., Baker, Laura A., Millar, Ewan K. A., Naylor, Matthew J., Ormandy, Christopher J., Lakhani, Sunil R., Kaplan, Warren, Mellick, Albert S., O'Toole, Sandra A., Swarbrick, Alexander and Nair, Radhika (2020). Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1. Frontiers in Cell and Developmental Biology, 8 552, 552. doi: 10.3389/fcell.2020.00552

Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1

2020

Journal Article

Association of sperm-associated antigen 5 and treatment response in patients with estrogen receptor-positive breast cancer

Abdel-Fatah, Tarek M. A., Ball, Graham R., Thangavelu, Pulari U., Reid, Lynne E., McCart Reed, Amy E., Saunus, Jodi M., Duijf, Pascal H. G., Simpson, Peter T., Lakhani, Sunil R., Pongor, Lorinc, Gyorffy, Balázs, Moseley, Paul M., Green, Andrew R., Pockley, Alan G., Caldas, Carlos, Ellis, Ian O. and Chan, Stephen Y. T. (2020). Association of sperm-associated antigen 5 and treatment response in patients with estrogen receptor-positive breast cancer. JAMA Network Open, 3 (7) e209486, e209486. doi: 10.1001/jamanetworkopen.2020.9486

Association of sperm-associated antigen 5 and treatment response in patients with estrogen receptor-positive breast cancer

2020

Journal Article

Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer

Baker, Laura A., Holliday, Holly, Roden, Daniel, Krisp, Christoph, Wu, Sunny Z., Junankar, Simon, Serandour, Aurelien A., Mohammed, Hisham, Nair, Radhika, Sankaranarayanan, Geetha, Law, Andrew M. K., McFarland, Andrea, Simpson, Peter T., Lakhani, Sunil, Dodson, Eoin, Selinger, Christina, Anderson, Lyndal, Samimi, Goli, Hacker, Neville F., Lim, Elgene, Ormandy, Christopher J., Naylor, Matthew J., Simpson, Kaylene, Nikolic, Iva, O'Toole, Sandra, Kaplan, Warren, Cowley, Mark J., Carroll, Jason S., Molloy, Mark and Swarbrick, Alexander (2020). Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer. Breast Cancer Research , 22 (1) 63, 63. doi: 10.1186/s13058-020-01306-6

Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer

2020

Journal Article

Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

Zhang, Lin, Yao, Jun, Wei, Yongkun, Zhou, Zhifen, Li, Ping, Qu, Jingkun, Badu-Nkansah, Akosua, Yuan, Xiangliang, Huang, Yu-Wen, Fukumura, Kazutaka, Mao, Xizeng, Chang, Wei-Chao, Saunus, Jodi, Lakhani, Sunil, Huse, Jason T., Hung, Mien-Chie and Yu, Dihua (2020). Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases. Science Translational Medicine, 12 (545) eaaz5387, eaaz5387. doi: 10.1126/scitranslmed.aaz5387

Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

2020

Journal Article

Digital spatial profiling application in breast cancer: a user’s perspective

McCart Reed, Amy E., Bennett, James, Kutasovic, Jamie R., Kalaw, Emarene, Ferguson, Kaltin, Yeong, Joe, Simpson, Peter T. and Lakhani, Sunil R. (2020). Digital spatial profiling application in breast cancer: a user’s perspective. Virchows Archiv, 477 (6), 885-890. doi: 10.1007/s00428-020-02821-9

Digital spatial profiling application in breast cancer: a user’s perspective

2020

Journal Article

Novel compound heterozygous variants in NHLRC2 in a patient with FINCA syndrome

Brodsky, Nina N., Boyarchuk, Oksana, Kovalchuk, Tetyana, Hariyan, Tetyana, Rice, Andrew, Ji, Weizhen, Khokha, Mustafa, Lakhani, Saquib and Lucas, Carrie L. (2020). Novel compound heterozygous variants in NHLRC2 in a patient with FINCA syndrome. Journal of Human Genetics, 65 (10), 911-915. doi: 10.1038/s10038-020-0776-0

Novel compound heterozygous variants in NHLRC2 in a patient with FINCA syndrome

2020

Journal Article

Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer

Adwal, Alaknanda, Kalita-de Croft, Priyakshi, Shakya, Reshma, Lim, Malcolm, Kalaw, Emarene, Taege, Lucinda D., McCart Reed, Amy E., Lakhani, Sunil R., Callen, David F. and Saunus, Jodi M. (2020). Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer. Life Science Alliance, 3 (7) e201900562, 1-12. doi: 10.26508/lsa.201900562

Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer

2020

Journal Article

Report on computational assessment of tumor infiltrating lymphocytes from the International Immuno-Oncology Biomarker Working Group

Amgad, Mohamed, Stovgaard, Elisabeth Specht, Balslev, Eva, Thagaard, Jeppe, Chen, Weijie, Dudgeon, Sarah, Sharma, Ashish, Kerner, Jennifer K., Denkert, Carsten, Yuan, Yinyin, AbdulJabbar, Khalid, Wienert, Stephan, Savas, Peter, Voorwerk, Leonie, Beck, Andrew H., Madabhushi, Anant, Hartman, Johan, Sebastian, Manu M., Horlings, Hugo M., Hudeček, Jan, Ciompi, Francesco, Moore, David A., Singh, Rajendra, Roblin, Elvire, Balancin, Marcelo Luiz, Mathieu, Marie-Christine, Lennerz, Jochen K., Kirtani, Pawan, Chen, I-Chun ... International Immuno-Oncology Biomarker Working Group (2020). Report on computational assessment of tumor infiltrating lymphocytes from the International Immuno-Oncology Biomarker Working Group. NPJ Breast Cancer, 6 (1) 16, 16. doi: 10.1038/s41523-020-0154-2

Report on computational assessment of tumor infiltrating lymphocytes from the International Immuno-Oncology Biomarker Working Group

2020

Journal Article

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Kos, Zuzana, Roblin, Elvire, Kim, Rim S., Michiels, Stefan, Gallas, Brandon D., Chen, Weijie, van de Vijver, Koen K., Goel, Shom, Adams, Sylvia, Demaria, Sandra, Viale, Giuseppe, Nielsen, Torsten O., Badve, Sunil S., Symmans, W. Fraser, Sotiriou, Christos, Rimm, David L., Hewitt, Stephen, Denkert, Carsten, Loibl, Sibylle, Luen, Stephen J., Bartlett, John M. S., Savas, Peter, Pruneri, Giancarlo, Dillon, Deborah A., Cheang, Maggie Chon U., Tutt, Andrew, Hall, Jacqueline A., Kok, Marleen, Horlings, Hugo M. ... International Immuno-Oncology Biomarker Working Group (2020). Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer. NPJ Breast Cancer, 6 (1) 17, 17. doi: 10.1038/s41523-020-0156-0

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

2020

Journal Article

Estrogen and progesterone receptor testing in breast cancer: American society of clinical oncology/college of American pathologists guideline update

Allison, Kimberly H., Hammond, M. Elizabeth H., Dowsett, Mitchell, McKernin, Shannon E., Carey, Lisa A., Fitzgibbons, Patrick L., Hayes, Daniel F., Lakhani, Sunil R., Chavez-MacGregor, Mariana, Perlmutter, Jane, Perou, Charles M., Regan, Meredith M., Rimm, David L., Symmans, W. Fraser, Torlakovic, Emina E., Varella, Leticia, Viale, Giuseppe, Weisberg, Tracey F., McShane, Lisa M. and Wolff, Antonio C. (2020). Estrogen and progesterone receptor testing in breast cancer: American society of clinical oncology/college of American pathologists guideline update. Archives of Pathology and Laboratory Medicine, 144 (5), 545-563. doi: 10.5858/arpa.2019-0904-SA

Estrogen and progesterone receptor testing in breast cancer: American society of clinical oncology/college of American pathologists guideline update

2020

Journal Article

Estrogen and progesterone receptor testing in breast cancer: ASCO/CAP guideline update

Allison, Kimberly H., Hammond, M. Elizabeth H., Dowsett, Mitchell, McKernin, Shannon E., Carey, Lisa A., Fitzgibbons, Patrick L., Hayes, Daniel F., Lakhani, Sunil R., Chavez-MacGregor, Mariana, Perlmutter, Jane, Perou, Charles M., Regan, Meredith M., Rimm, David L., Symmans, W. Fraser, Torlakovic, Emina E., Varella, Leticia, Viale, Giuseppe, Weisberg, Tracey F., McShane, Lisa M. and Wolff, Antonio C. (2020). Estrogen and progesterone receptor testing in breast cancer: ASCO/CAP guideline update. Journal of Clinical Oncology, 38 (12), 1346-1366. doi: 10.1200/JCO.19.02309

Estrogen and progesterone receptor testing in breast cancer: ASCO/CAP guideline update

2020

Journal Article

American registry of pathology expert opinions: The spectrum of lobular carcinoma in situ: Diagnostic features and clinical implications

Schnitt, Stuart J., Brogi, Edi, Chen, Yunn-Yi, King, Tari A. and Lakhani, Sunil R. (2020). American registry of pathology expert opinions: The spectrum of lobular carcinoma in situ: Diagnostic features and clinical implications. Annals of Diagnostic Pathology, 45 151481, 151481. doi: 10.1016/j.anndiagpath.2020.151481

American registry of pathology expert opinions: The spectrum of lobular carcinoma in situ: Diagnostic features and clinical implications