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2011 Journal Article Mice lacking phosphatase PP2A subunit PR61/B′δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3βLouis, Justin V., Martens, Ellen, Borghgraef, Peter, Lambrecht, Caroline, Sents, Ward, Longin, Sari, Zwaenepoel, Karen, Pijnenborg, Robert, Landrieu, Isabelle, Lippens, Guy, Ledermann, Birgit, Gotz, Jürgen, Van Leuven, Fred, Goris, Jozef and Janssens, Veerle (2011). Mice lacking phosphatase PP2A subunit PR61/B′δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β. Proceedings of the National Academy of Sciences of the United States of America, 108 (17), 6957-6962. doi: 10.1073/pnas.1018777108 |
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2011 Journal Article ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant miceLiu, Xin, Dobbie, Michael, Tunningley, Rob, Whittle, Belinda, Zhang, Yafei, Ittner, Lars M. and Gotz, Jurgen (2011). ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice. Journal of Biomedicine and Biotechnology, 2011 (1) 130947, 130947.1-130947.11. doi: 10.1155/2011/130947 |
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2011 Journal Article Brief update on different roles of tau in neurodegenerationIttner, Arne, Ke, Yazi D., van Eersel, Janet, Gladbach, Amadeus, Gotz, Jurgen and Ittner, Lars M. (2011). Brief update on different roles of tau in neurodegeneration. IUBMB Life, 63 (7), 495-502. doi: 10.1002/iub.467 |
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2011 Journal Article Reduced secretagogin expression in the hippocampus of P301L tau transgenic miceAttems, Johannes, Ittner, Arne, Jellinger, Kurt, Nitsch, Roger M., Maj, Magdalena, Wagner, Ludwig, Gotz, Jurgen and Heikenwalder, Mathias (2011). Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of Neural Transmission, 118 (5), 737-745. doi: 10.1007/s00702-011-0626-5 |
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2011 Journal Article Amyloid-β and tau - A toxic pas de deux in Alzheimer's diseaseIttner, Lars M. and Gotz, Jürgen (2011). Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease. Nature Reviews Neuroscience, 12 (2), 67-72. doi: 10.1038/nrn2967 |
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2011 Journal Article Modes of Aβ toxicity in Alzheimer's diseaseGotz, Jurgen, Eckert, Anne, Matamales, Miriam, Ittner, Lars M. and Liu, Xin (2011). Modes of Aβ toxicity in Alzheimer's disease. Cellular and Molecular Life Sciences, 68 (20), 3359-3375. doi: 10.1007/s00018-011-0750-2 |
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2011 Journal Article Invertebrate and vertebrate models of tauopathiesGoetz, Juergen, Ittner, Lars M., Goetz, Naeman N., Lam, Hong and Nicholas, Hannah R. (2011). Invertebrate and vertebrate models of tauopathies. Animal Models for Neurodegenerative Disease (6), 69-85. doi: 10.1039/9781849732758 |
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2011 Journal Article Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylationHundelt, M., Fath, T., Selle, K., Oesterwind, K., Jordan, J., Schultz, C., Götz, J., von Engelhardt, J., Monyer, H., Lewejohann, L., Sachser, N., Bakota, L. and Brandt, R. (2011). Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiology of Aging, 32 (6), 991-1006. doi: 10.1016/j.neurobiolaging.2009.06.007 |
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2010 Journal Article Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathyKohler, C., Bista, P., Gotz, J. and Schroder, H. (2010). Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain Research, 1347, 111-124. doi: 10.1016/j.brainres.2010.05.076 |
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2010 Journal Article Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease modelsvan Eersel, Janet, Ke, Yazi D., Liu, Xin, Delerue, Fabien, Kril, Jillian J., Gotz, Jürgen and Ittner, Lars M. (2010). Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences of the United States of America, 107 (31), 13888-13893. doi: 10.1073/pnas.1009038107 |
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2010 Journal Article Neuronal microrna deregulation in response to Alzheimer's disease amyloid-βSchonrock, Nicole, Ke, Yazi D., Humphreys, David, Staufenbiel, Matthias, Ittner, Lars M., Preiss, Thomas and Gotz, Jurgen (2010). Neuronal microrna deregulation in response to Alzheimer's disease amyloid-β. PLoS ONE, 5 (6) e11070, e11070.1-e11070.11. doi: 10.1371/journal.pone.0011070 |
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2010 Journal Article Convergence of amyloid-β and tau pathologies on mitochondria in vivoEckert, Anne, Schulz, Kathrin L., Rhein, Virginie and Gotz, Jürgen (2010). Convergence of amyloid-β and tau pathologies on mitochondria in vivo. Molecular Neurobiology, 41 (2-3), 107-114. doi: 10.1007/s12035-010-8109-5 |
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2010 Journal Article Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse modelsIttner, Lars M., Ke, Yazi D., Delerue, Fabien, Bi, Mian, Gladbach, Amadeus, van Eersel, Janet, Wolfing, Heidrun, Chieng, Billy C., Christie, MacDonald J., Napier, Ian A., Eckert, Anne, Staufenbiel, Matthias, Hardeman, Edna and Gotz, Jurgen (2010). Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell, 142 (3), 387-397. doi: 10.1016/j.cell.2010.06.036 |
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2010 Journal Article Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteinsKrupka, Niklas, Strappe, Padraig, Gotz, Jürgen and Ittner, Lars M. (2010). Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid, 63 (3), 155-160. doi: 10.1016/j.plasmid.2010.01.002 |
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2010 Journal Article Animal models reveal role for tau phosphorylation in human diseaseGotz, Jurgen, Gladbach, Amadeus, Pennanen, Luis, van Eersel, Janet, Schild, Andreas, David, Della and Ittner, Lars M. (2010). Animal models reveal role for tau phosphorylation in human disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1802 (10), 860-871. doi: 10.1016/j.bbadis.2009.09.008 |
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2010 Journal Article Parkinson's disease: insights from non-traditional model organismsPienaar, Ilse S., Gotz, Jürgen and Feany, Mel B. (2010). Parkinson's disease: insights from non-traditional model organisms. Progress in Neurobiology, 92 (4), 558-571. doi: 10.1016/j.pneurobio.2010.09.001 |
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2010 Journal Article Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunctionLim, Yun-An, Rhein, Virginie, Baysang, Ginette, Meier, Fides, Poljak, Anne, Raftery, Mark J., Guilhaus, Michael, Ittner, Lars M., Eckert, Anne and Gotz, Jürgen (2010). Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics, 10 (8), 1621-1633. doi: 10.1002/pmic.200900651 |
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2009 Journal Article Animal models for Alzheimer's disease and frontotemporal dementia: A perspectiveGötz, Jürgen and Götz, Naeman N. (2009). Animal models for Alzheimer's disease and frontotemporal dementia: A perspective. ASN Neuro, 1 (4) e00019, 251-264. doi: 10.1042/AN20090042 |
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2009 Journal Article Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease miceRhein, Virginie, Song, Xiaomin, Wiesner, Andreas, Ittner, Lars M., Baysang, Ginette, Meier, Fides, Ozmen, Laurence, Bluethmann, Horst, Drose, Stefan, Brandt, Ulrich, Savaskan, Egemen, Czech, Christian, Gotz, Jurgen and Eckert, Anne (2009). Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America, 106 (47), 20057-20062. doi: 10.1073/pnas.0905529106 |
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2009 Journal Article Experimental diabetes mellitus exacerbates Tau pathology in a transgenic mouse model of Alzheimer's diseaseKe, Yazi D., Delerue, Fabien, Gladbach, Amadeus, Gotz, Jurgen and Ittner, Lars M. (2009). Experimental diabetes mellitus exacerbates Tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS ONE, 4 (11) e7917, e7917.1-e7917.7. doi: 10.1371/journal.pone.0007917 |
