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2013 Journal Article Synthesis, magnetic properties, and phosphoesterase activity of dinuclear cobalt(II) complexesDaumann, Lena J., Comba, Peter, Larrabee, James A., Schenk, Gerhard, Stranger, Robert, Cavigiasso, German and Gahan, Lawrence R. (2013). Synthesis, magnetic properties, and phosphoesterase activity of dinuclear cobalt(II) complexes. Inorganic Chemistry, 52 (4), 2029-2043. doi: 10.1021/ic302418x |
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2013 Journal Article Purple acid phosphatase: a journey into the function and mechanism of a colorful enzymeSchenk, Gerhard, Mitić, Nataša, Hanson, Graeme R. and Comba, Peter (2013). Purple acid phosphatase: a journey into the function and mechanism of a colorful enzyme. Coordination Chemistry Reviews, 257 (2), 473-482. doi: 10.1016/j.ccr.2012.03.020 |
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2013 Journal Article Promiscuity comes at a price: catalytic versatility vs efficiency in different metal ion derivatives of the potential bioremediator GpdQDaumann, Lena J., McCarthy, Bianca Y., Hadler, Kieran S., Murray, Tracy P., Gahan, Lawrence R., Larrabee, James A., Ollis, David L. and Schenk, Gerhard (2013). Promiscuity comes at a price: catalytic versatility vs efficiency in different metal ion derivatives of the potential bioremediator GpdQ. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1834 (1), 425-432. doi: 10.1016/j.bbapap.2012.02.004 |
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2012 Journal Article Spectroscopic characterization of the active (FeFeIII)-Fe-III and (FeFeII)-Fe-III forms of a purple acid phosphatase model systemComba, Peter, Gahan, Lawrence R., Mereacre, Valeriu, Hanson, Graeme R., Powell, Annie K., Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012). Spectroscopic characterization of the active (FeFeIII)-Fe-III and (FeFeII)-Fe-III forms of a purple acid phosphatase model system. Inorganic Chemistry, 51 (22), 12195-12209. doi: 10.1021/ic301347t |
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2012 Journal Article Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeuticsFeder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001 |
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2012 Journal Article Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycleWong, Sze-Ho, Lonhienne, Thierry G. A., Winzor, Donald J., Schenk, Gerhard and Guddat, Luke W. (2012). Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of Molecular Biology, 424 (3-4), 168-179. doi: 10.1016/j.jmb.2012.09.018 |
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2012 Journal Article Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosaHussein, Waleed M., Fatahala, Samar S., Mohamed, Zainab M., McGeary, Ross P., Schenk, Gerhard, Ollis, David L. and Mohamed, Mosaad S. (2012). Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Chemical Biology and Drug Design, 80 (4), 500-515. doi: 10.1111/j.1747-0285.2012.01440.x |
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2012 Journal Article Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reactionSchenk, Gerhard, Mitić, Nataša, Gahan, Lawrence R., Ollis, David L., McGeary, Ross P. and Guddat, Luke W. (2012). Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction. Accounts of Chemical Research, 45 (9), 1593-1603. doi: 10.1021/ar300067g |
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2012 Journal Article Cadmium(II) complexes: Mimics of organophosphate pesticide degrading enzymes and metallo-β-lactamasesDaumann, Lena J., Gahan, Lawrence R., Comba, Peter and Schenk, Gerhard (2012). Cadmium(II) complexes: Mimics of organophosphate pesticide degrading enzymes and metallo-β-lactamases. Inorganic Chemistry, 51 (14), 7669-7681. doi: 10.1021/ic300687y |
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2012 Journal Article Penicillin inhibitors of purple acid phosphataseFaridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012). Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 (7), 2555-2559. doi: 10.1016/j.bmcl.2012.01.123 |
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2012 Journal Article Monoesterase activity of a purple acid phosphatase mimic with a cyclam platformComba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Mereacre, Valeriu, Noble, Christopher J., Powell, Annie K., Prisecaru, Ion, Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012). Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform. Chemistry: A European Journal, 18 (6), 1700-1710. doi: 10.1002/chem.201100229 |
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2012 Journal Article Spectroscopic and catalytic characterization of a functional (FeFeII)-Fe-III biomimetic for the active site of uteroferrin and protein cleavageSmith, Sarah J., Peralta, Rosely A., Jovito, Rafael, Horn, Adolfo, Bortoluzzi, Adailton J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Gahan, Lawrence R., Schenk, Gerhard, Nascimento, Otaciro R., Cavalett, Angelica, Bortolotto, Tiago, Razzera, Guilherme, Terenzi, Hernan, Neves, Ademir and Riley, Mark J. (2012). Spectroscopic and catalytic characterization of a functional (FeFeII)-Fe-III biomimetic for the active site of uteroferrin and protein cleavage. Inorganic Chemistry, 51 (4), 2065-2078. doi: 10.1021/ic201711p |
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2012 Journal Article Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacterEly, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012). Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 (1), 19-22. doi: 10.1016/j.jinorgbio.2011.09.015 |
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2012 Journal Article 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitorsFaridoon, Hussein, Waleed M., Vella, Peter, Ul Islam, Nazar, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2012). 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 22 (1), 380-386. doi: 10.1016/j.bmcl.2011.10.116 |
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2012 Journal Article The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimeticsDaumann, Lena J., Dalle, Kristian E., Schenk, Gerhard, McGeary, Ross P., Bernhardt, Paul V., Ollis, David L. and Gahan, Lawrence R. (2012). The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics. Dalton Transactions, 41 (6), 1695-1708. doi: 10.1039/c1dt11187f |
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2011 Journal Article Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosaMohamed, Mosaad S., Hussein, Waleed M., McGeary, Ross P., Vella, Peter, Schenk, Gerhard and Abd El-hameed, Rania H. (2011). Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. European Journal of Medicinal Chemistry, 46 (12), 6075-6082. doi: 10.1016/j.ejmech.2011.10.030 |
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2011 Journal Article Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzymeYip, Sylvia H-C., Foo, Jee-Loon, Schenk, Gerhard, Gahan, Lawrence R., Carr, Paul D. and Ollis, David L. (2011). Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme. Protein Engineering Design and Selection, 24 (12), 861-872. doi: 10.1093/protein/gzr048 |
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2011 Journal Article Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA)Ely, Fernanda, Hadler, Kieran S., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Plugis, Nicholas M., Russo, Marie T., Larrabee, James A. and Schenk, Gerhard (2011). Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA). Journal of Biological Inorganic Chemistry, 16 (5), 777-787. doi: 10.1007/s00775-011-0779-6 |
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2011 Journal Article The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screeningVella, Peter, Hussein, Waleed M., Leung, Eleanor W. W., Clayton, Daniel, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2011). The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic and Medicinal Chemistry Letters, 21 (11), 3282-3285. doi: 10.1016/j.bmcl.2011.04.027 |
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2011 Journal Article Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphataseMohd-Pahmi, Siti Hajar, Hussein, Waleed M., Schenk, Gerhard and McGeary, Ross P. (2011). Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 21 (10), 3092-3094. doi: 10.1016/j.bmcl.2011.03.024 |
