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2011 Journal Article Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA)Ely, Fernanda, Hadler, Kieran S., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Plugis, Nicholas M., Russo, Marie T., Larrabee, James A. and Schenk, Gerhard (2011). Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA). Journal of Biological Inorganic Chemistry, 16 (5), 777-787. doi: 10.1007/s00775-011-0779-6 |
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2011 Journal Article The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screeningVella, Peter, Hussein, Waleed M., Leung, Eleanor W. W., Clayton, Daniel, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2011). The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic and Medicinal Chemistry Letters, 21 (11), 3282-3285. doi: 10.1016/j.bmcl.2011.04.027 |
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2011 Journal Article Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphataseMohd-Pahmi, Siti Hajar, Hussein, Waleed M., Schenk, Gerhard and McGeary, Ross P. (2011). Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 21 (10), 3092-3094. doi: 10.1016/j.bmcl.2011.03.024 |
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2011 Journal Article A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studiesZee, Yoke Leng Michelle, Gahan, Lawrence R. and Schenk, Gerhard (2011). A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies. Australian Journal of Chemistry, 64 (3), 258-264. doi: 10.1071/CH10424 |
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2011 Journal Article Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular weight compounds.Ugwumba, Isaac N., Ozawa, Kiyoshi, de la Cruz, Laura, Xu, Zhi-Qiang, Herlt, Anthony J., Hadler, Kieran S., Coppin, Chris, Brown, Susan E., Schenk, Gerhard, Oakeshott, John G. and Otting, Gottfried (2011). Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular weight compounds.. ASSAY and Drug Development Technologies, 9 (1), 50-57. doi: 10.1089/adt.2010.0306 |
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2011 Journal Article Improving a natural enzyme activity through incorporation of unnatural amino acidsUgwumba, Isaac N., Ozawa, Kiyoshi, Xu, Zhi-Qiang, Ely, Fernanda, Foo, Jee-Loon, Herlt, Anthony J., Coppin, Chris, Brown, Sue, Taylor, Matthew C., Ollis, David L., Mander, Lewis N., Schenk, Gerhard, Dixon, Nicholas E., Otting, Gottfried, Oakeshott, John G. and Jackson, Colin J. (2011). Improving a natural enzyme activity through incorporation of unnatural amino acids. Journal of The American Chemical Society, 133 (2), 326-333. doi: 10.1021/ja106416g |
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2011 Journal Article Phosphate ester cleavage promoted by a tetrameric iron(III) complexKantacha, A, Buchholz, R, Smith, SJ, Schenk, G and Gahan, LR (2011). Phosphate ester cleavage promoted by a tetrameric iron(III) complex. Journal of Biological Inorganic Chemistry, 16 (1), 25-32. doi: 10.1007/s00775-010-0696-0 |
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2010 Journal Article Electronic structure and spectro-structural correlations of FeIIIZnII biomimetics for purple acid phosphatases: Relevance to DNA cleavage and cytotoxic activityPeralta, RA, Bortoluzzi, AJ, de Souza, B, Jovito, R, Xavier, FR, Couto, RAA, Casellato, A, Nome, F, Dick, A, Gahan, LR, Schenk, G, Hanson, GR, de Paula, FCS, Pereira-Maia, EC, Machado, SD, Severino, PC, Pich, C, Bortolotto, T, Terenzi, H, Castellano, EE, Neves, A and Riley, MJ (2010). Electronic structure and spectro-structural correlations of FeIIIZnII biomimetics for purple acid phosphatases: Relevance to DNA cleavage and cytotoxic activity. Inorganic Chemistry, 49 (24), 11421-11438. doi: 10.1021/ic101433t |
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2010 Journal Article Tartrate-resistant acid phosphatase: A target for anti-osteoporotic chemotherapeuticsVella, Peter, McGeary, Ross P., Gahan, Lawrence R. and Schenk, Gerhard (2010). Tartrate-resistant acid phosphatase: A target for anti-osteoporotic chemotherapeutics. Current Enzyme Inhibition, 6 (3), 118-129. doi: 10.2174/157340810793384133 |
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2010 Journal Article The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysisEly, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010). The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 (3), 565-573. doi: 10.1042/BJ20101054 |
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2010 Journal Article Paradigm shift for the purple acid phosphatase reaction mechanismSchenk, Gerhard (2010). Paradigm shift for the purple acid phosphatase reaction mechanism. Chemistry Australia, 77 (7), 9-9. |
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2010 Journal Article Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzymeFoo, Jee‑Loon, Jackson, Colin J., Carr, Paul D., Kim, Hye‑Kyung, Schenk, Gerhard, Gahan, Lawrence R. and Ollis, David L. (2010). Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme. Biochemical Journal, 429 (2), 313-321. doi: 10.1042/BJ20100233 |
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2010 Journal Article The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysisMitic, Natasa, Hadler, Kieran S., Gahan, Lawrence R., Hengge, Alvan C. and Schenk, Gerhard (2010). The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysis. Journal of the American Chemical Society, 132 (20), 7049-7054. doi: 10.1021/ja910583y |
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2010 Journal Article Electronic structure analysis of the dinuclear metal center in the bioremediator glycerophosphodiesterase (GpdQ) from Enterobacter aerogenesHadler, Kieran S., Mitic, Natasa, Yip, Sylvia Hsu-Chen, Gahan, Lawrence R., Ollis, David L., Schenk, Gerhard and Larrabee, James A. (2010). Electronic structure analysis of the dinuclear metal center in the bioremediator glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Inorganic Chemistry, 49 (6), 2727-2734. doi: 10.1021/ic901950c |
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2010 Journal Article Catalytic promiscuity: Catecholase-like activity and hydrolytic DNA cleavage promoted by a mixed-valence Fe(III)Fe(II) complexNeves, Ademir, Bortoluzzi, Adailton J., Jovito, Rafael, Peralta, Rosely A., de Souza, Bernardo, Szpoganicz, Bruno, Joussef, Antônio C., Terenzi, Hernán, Severino, Patricia C., Fischer, Franciele L., Schenk, Gerhard, Riley, Mark J., Smith, Sarah J. and Gahan, Lawrence R. (2010). Catalytic promiscuity: Catecholase-like activity and hydrolytic DNA cleavage promoted by a mixed-valence Fe(III)Fe(II) complex. Journal of the Brazilian Chemical Society, 21 (7), 1201-1212. doi: 10.1590/S0103-50532010000700007 |
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2009 Journal Article Conformational sampling, catalysis, and evolution of the bacterial phosphotriesteraseJackson, C. J., Foo, J.-L., Tokuriki, N., Afriat, L., Carr, P. D., Kim, H.-K., Schenk, G., Tawfik, D. S. and Ollis, D. L. (2009). Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase. Proceedings of the National Academy of Sciences, 106 (51), 21631-21636. doi: 10.1073/pnas.0907548106 |
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2009 Journal Article Flexible and promiscuous!Schenk, G., Ollis, D. L., Hanson, G. R. and Gahan, L. R. (2009). Flexible and promiscuous!. Chemistry in Australia, 76 (10), 10-11. |
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2009 Journal Article The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysisHadler, Kieran S., Gahan, Lawrence R., Ollis, David L. and Schenk, Gerhard (2009). The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysis. Journal of Inorganic Biochemistry, 104 (2), 211-213. doi: 10.1016/j.jinorgbio.2009.10.012 |
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2009 Journal Article Structural and catalytic characterization of a heterovalent Mn(II)Mn(III) complex that mimics purple acid phosphatasesSarah Sarah J., Riley, Mark J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Schenk, Gerhard and Gahan, Lawrence R. (2009). Structural and catalytic characterization of a heterovalent Mn(II)Mn(III) complex that mimics purple acid phosphatases. Inorganic Chemistry, 48 (21), 10036-10048. doi: 10.1021/ic9005086 |
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2009 Journal Article Structural flexibility enhances the reactivity of the bioremediator glycerophosphodiesterase by fine-tuning its mechanism of hydrolysisHadler, Kieran S., Mitic, Natasa, Ely, Fernanda, Hanson, Graeme R., Gahan, Lawrence R., Larrabee, James A., Ollis, David L. and Schenk, Gerhard (2009). Structural flexibility enhances the reactivity of the bioremediator glycerophosphodiesterase by fine-tuning its mechanism of hydrolysis. Journal of the American Chemical Society, 131 (33), 11900-11908. doi: 10.1021/ja903534f |
