Overview
Background
Dr Larisa Labzin is an ARC Future Fellow and leads the viruses and innate immunity lab at the Institute for Molecular Bioscience. Her lab studies how our innate immune system detects viral infections and deciphers diverse signals to mount an appropriate immune response, with a focus on influenza and SARS-CoV-2. The Labzin group aims to identify new therapeutic targets to prevent and treat viral infections and diseases in humans and animals.
The lab has four key research areas: (1) how viral tropism and life cycle shape innate immune sensing and inflammation; (2) how pre-existing antibodies influence innate responses to viruses and vaccines; (3) how innate immune signalling differs across patient risk groups and species; and (4) how viral-triggered inflammation drives vascular dysfunction and thrombosis. As cell biologists, the Labzin Lab studies the primary cellular targets of these viruses (respiratory epithelial cells, macrophages, and endothelial cells) using imaging, molecular biology, gene editing, and immunological approaches.
Dr Labzin started her career in innate immunity with Honours at the Institute for Molecular Bioscience (IMB) at UQ with Prof. Matt Sweet before relocating to Germany to undertake her PhD with Prof. Eicke Latz, a world leader in innate immunity (2015, University of Bonn). She was subsequently awarded an EMBO Fellowship and NHMRC CJ Martin Fellowship to undertake postdoctoral training at the MRC-Laboratory of Molecular Biology in Cambridge, UK, from 2016 to 2019. She returned to Australia in 2019 as a CJ Martin Fellow to start her independent research team at the IMB under the mentorship of Prof. Kate Schroder. She was heavily involved in science communication during the COVID-19pandemic and was a 2022 QLD Tall Poppy recipient and winner of the 2022 Australian Society of Immunology Public Engagement Award.
Availability
- Dr Larisa Labzin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Molecular Medicine, Rheinische Friedrich Wilhelms Universität Bonn
Research interests
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Human macrophage responses to viruses
Viruses trigger strong inflammatory responses. We are studying the molecular pathways in human macrophages that are triggered during viral infection
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How antibodies modulate innate immune sensing
Innate sensing of viruses is studied mainly in the context of naive infection. We want to understand how pre-existing immunity, in the form of antibodies, changes the inflammatory response to viruses.
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Conservation of Innate Immunity across species
Many species are important viral reservoirs. Yet little is understood about innate immunity in these species. We are studying key innate pathways signal in non-human species.
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How innate immune cells respond to dying cells
Many cells die during infection. How innate immune cells sense cell damage and respond accordingly is poorly understood. We are studying how cells interpret signs of danger to mount an effective immune response
Research impacts
Dr. Labzin is heavily involved in public outreach and in communicating immunology to the wider public. Dr Labzin explains how the immune system works, how vaccines work and attempts to encourage vaccine uptake. Dr Labzin's research is elucidating how the immune system contributes to disease during viral infection. Key to this is understanding why different people respond differently to viral infections. Dr Labzin's research aims to identify new pathways to target, so that we can best treat viral infections, reducing sick days, symptoms and serious complications.
Works
Search Professor Larisa Labzin’s works on UQ eSpace
2018
Journal Article
Innate immunity and neurodegeneration
Labzin, Larisa I., Heneka, Michael T. and Latz, Eicke (2018). Innate immunity and neurodegeneration. Annual Review of Medicine, 69 (1), 437-449. doi: 10.1146/annurev-med-050715-104343
2017
Journal Article
A method for the acute and rapid degradation of endogenous proteins
Clift, Dean, McEwan, William A., Labzin, Larisa I., Konieczny, Vera, Mogessie, Binyam, James, Leo C. and Schuh, Melina (2017). A method for the acute and rapid degradation of endogenous proteins. Cell, 171 (7), 1692-1706. doi: 10.1016/j.cell.2017.10.033
2017
Book Chapter
Inflammation in atherosclerosis
Lauterbach, Mario A. R., Labzin, Larisa I. and Latz, Eicke (2017). Inflammation in atherosclerosis. Inflammation - from molecular and cellular mechanisms to the clinic. (pp. 1279-1300) Weinheim, Germany: Wiley. doi: 10.1002/9783527692156.ch49
2016
Journal Article
Interferons and inflammasomes: cooperation and counterregulation in disease
Labzin, Larisa I., Lauterbach, Mario A.R. and Latz, Eicke (2016). Interferons and inflammasomes: cooperation and counterregulation in disease. Journal of Allergy and Clinical Immunology, 138 (1), 37-46. doi: 10.1016/j.jaci.2016.05.010
2016
Journal Article
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Zimmer, Sebastian, Grebe, Alena, Bakke, Siril S., Bode, Niklas, Halvorsen, Bente, Ulas, Thomas, Skjelland, Mona, De Nardo, Dominic, Labzin, Larisa I., Kerksiek, Anja, Hempel, Chris, Heneka, Michael T., Hawxhurst, Victoria, Fitzgerald, Michael L., Trebicka, Jonel, Björkhem, Ingemar, Gustafsson, Jan-Åke, Westerterp, Marit, Tall, Alan R., Wright, Samuel D., Espevik, Terje, Schultze, Joachim L., Nickenig, Georg, Lütjohann, Dieter and Latz, Eicke (2016). Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine, 8 (333) ra50, 333ra50-333ra50. doi: 10.1126/scitranslmed.aad6100
2015
Journal Article
ATF3 is a key regulator of macrophage IFN responses
Labzin, Larisa I., Schmidt, Susanne V., Masters, Seth L., Beyer, Marc, Krebs, Wolfgang, Klee, Kathrin, Stahl, Rainer, Lütjohann, Dieter, Schultze, Joachim L., Latz, Eicke and De Nardo, Dominic (2015). ATF3 is a key regulator of macrophage IFN responses. Journal of Immunology, 195 (9), 4446-4455. doi: 10.4049/jimmunol.1500204
2014
Journal Article
Optimization of transcription factor binding map accuracy utilizing knockout-mouse models
Krebs, Wolfgang, Schmidt, Susanne V., Goren, Alon, De Nardo, Dominic, Labzin, Larisa, Bovier, Anton, Ulas, Thomas, Theis, Heidi, Kraut, Michael, Latz, Eicke, Beyer, Marc and Schultze, Joachim L. (2014). Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Research, 42 (21), 13051-13060. doi: 10.1093/nar/gku1078
2014
Journal Article
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
Xue, Jia, Schmidt, Susanne V., Sander, Jil, Draffehn, Astrid, Krebs, Wolfgang, Quester, Inga, DeNardo, Dominic, Gohel, Trupti D., Emde, Martina, Schmidleithner, Lisa, Ganesan, Hariharasudan, Nino-Castro, Andrea, Mallmann, Michael R., Labzin, Larisa, Theis, Heidi, Kraut, Michael, Beyer, Marc, Latz, Eicke, Freeman, Tom C., Ulas, Thomas and Schultze, Joachim L. (2014). Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity, 40 (2), 274-288. doi: 10.1016/j.immuni.2014.01.006
2014
Journal Article
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3
De Nardo, Dominic, Labzin, Larisa I., Kono, Hajime, Seki, Reiko, Schmidt, Susanne V., Beyer, Marc, Xu, Dakang, Zimmer, Sebastian, Lahrmann, Catharina, Schildberg, Frank A., Vogelhuber, Johanna, Kraut, Michael, Ulas, Thomas, Kerksiek, Anja, Krebs, Wolfgang, Bode, Niklas, Grebe, Alena, Fitzgerald, Michael L., Hernandez, Nicholas J., Williams, Bryan R.G., Knolle, Percy, Kneilling, Manfred, Röcken, Martin, Lütjohann, Dieter, Wright, Samuel D., Schultze, Joachim L. and Latz, Eicke (2014). High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nature Immunology, 15 (2), 152-160. doi: 10.1038/ni.2784
2014
Journal Article
Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms
Pelka, Karin, Phulphagar, Kshiti, Zimmermann, Jana, Stahl, Rainer, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Spille, Jan-Hendrik, Labzin, Larisa I., Agrawal, Sudhir, Kandimalla, Ekambar R., Casanova, Jean-Laurent, Hornung, Veit, Marshak-Rothstein, Ann, Höning, Stefan and Latz, Eicke (2014). Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. Journal of Immunology, 193 (7), 3257-3261. doi: 10.4049/jimmunol.1301886
2013
Journal Article
Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages
Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281
2012
Journal Article
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109
2012
Book Chapter
Inflammasomopathies: diseases linked to the NLRP3 inflammasome
De Nardo, Dominic, Vogelhuber, Johanna, Labzin, Larisa, Langhoff, Pia and Latz, Eicke (2012). Inflammasomopathies: diseases linked to the NLRP3 inflammasome. New-opathies: an emerging molecular reclassification of human disease. (pp. 23-65) edited by Errol C. Friedberg, Diego H. Castrillon, Rene L. Galindo and Keith Wharton. Singapore: World Scientific. doi: 10.1142/9789814355698_0002
2010
Journal Article
Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases
Christ, Angelika N., Labzin, Larisa, Bourne, Gregory T., Fukunishi, Hirotada, Weber, Jane E., Sweet, Matthew J., Smythe, Mark L. and Flanagan, Jack U. (2010). Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases. Journal of Medicinal Chemistry, 53 (15), 5536-5548. doi: 10.1021/jm100194a
2010
Journal Article
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS
Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363
Supervision
Availability
- Dr Larisa Labzin is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
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Please contact me if you are interested in projects in our group
Supervision history
Current supervision
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Doctor Philosophy
Antibodies in the endothelium: the role of the endothelium in Vaccine-Induced Immune Thrombotic Thrombocytopenia
Principal Advisor
Other advisors: Associate Professor Anne Lagendijk, Professor Michael O'Sullivan
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Doctor Philosophy
Novel mechanisms for improved efficiency of primordial germ cells modifications in Quail model
Associate Advisor
Other advisors: Dr Mel White
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Doctor Philosophy
The intersection between calcium signaling and coronavirus infection
Associate Advisor
Other advisors: Professor Gregory Monteith, Dr Melanie Robitaille
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Doctor Philosophy
Mechanisms of virus-induced NLRP1 Inflammasome Signalling
Associate Advisor
Other advisors: Professor Kate Schroder
Completed supervision
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2026
Doctor Philosophy
Endothelial cell contributions to COVID-19-associated coagulopathies
Principal Advisor
Other advisors: Professor Kate Schroder, Dr Emma Gordon, Dr Keng Chew
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2026
Doctor Philosophy
Antibodies enhance proinflammatory cytokine release from human macrophages sensing influenza A virus proteins
Principal Advisor
Other advisors: Professor Kate Schroder, Professor Kirsty Short
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2025
Doctor Philosophy
Molecular pathways by which human epithelia and macrophages sense and respond to Influenza A virus infection.
Principal Advisor
Other advisors: Professor Kate Schroder, Professor Kirsty Short
Media
Enquiries
Contact Dr Larisa Labzin directly for media enquiries about:
- inflammation
- influenza
- vaccine
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