![Professor Stefan Thor](/sites/default/files/profiles/22014.jpeg)
Overview
Background
BSc in Biology (1988) Umea University, Sweden
PhD in Molecular Biology (1994), Umea University, Sweden. Supervisor: Thomas Edlund
Postdoc, Molecular Neurobiology (1994-1999) Salk Institute, La Jolla, USA. Mentor: John B. Thomas
Assistant Professor (1999-2004), Harvard Medical School, Boston, USA
Professor of Developmental Biology (2004-2019), Linkoping University, Sweden
Professor of Developmental Biology (2019-), University of Queensland, Brisbane, Australia
Member of the Royal Swedish Academy of Sciences (2013-)
Availability
- Professor Stefan Thor is:
- Available for supervision
Qualifications
- Doctor of Philosophy, unknown
Works
Search Professor Stefan Thor’s works on UQ eSpace
2015
Journal Article
Novel genes involved in controlling specification of Drosophila FMRFamide neuropeptide cells
Bivik, Caroline, Bahrampour, Shahrzad, Ulvklo, Carina, Nilsson, Patrik, Angel, Anna, Fransson, Fredrik, Lundin, Erika, Renhorn, Jakob and Thor, Stefan (2015). Novel genes involved in controlling specification of Drosophila FMRFamide neuropeptide cells. Genetics, 200 (4), 1229-1244. doi: 10.1534/genetics.115.178483
2015
Journal Article
Systematic A beta analysis in Drosophila reveals high toxicity for the 1-42, 3-42 and 11-42 peptides, and emphasizes N- and C-terminal residues
Jonson, Maria, Pokrzywa, Malgorzata, Starkenberg, Annika, Hammarstrom, Per and Thor, Stefan (2015). Systematic A beta analysis in Drosophila reveals high toxicity for the 1-42, 3-42 and 11-42 peptides, and emphasizes N- and C-terminal residues. Plos One, 10 (7) 0133272, e0133272. doi: 10.1371/journal.pone.0133272
2014
Journal Article
Global programmed switch in neural daughter cell proliferation mode triggered by a temporal gene cascade
Baumgardt, Magnus, Karlsson, Daniel, Salmani, Behzad Y., Bivik, Caroline, MacDonald, Ryan B., Gunnar, Erika and Thor, Stefan (2014). Global programmed switch in neural daughter cell proliferation mode triggered by a temporal gene cascade. Developmental Cell, 30 (2), 192-208. doi: 10.1016/j.devcel.2014.06.021
2013
Journal Article
Neuroscience: stem cells in multiple time zones
Thor, Stefan (2013). Neuroscience: stem cells in multiple time zones. Nature, 498 (7455), 441-443. doi: 10.1038/nature12261
2013
Journal Article
Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage
Losada-Perez, Maria, Gabilondo, Hugo, Molina, Isabel, Turiegano, Enrique, Torroja, Laura, Thor, Stefan and Benito-Sipos, Jonathan (2013). Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage. Development, 140 (10), 2181-2189. doi: 10.1242/dev.089748
2013
Book Chapter
Development of the Drosophila embryonic ventral nerve cord: from neuroectoderm to unique neurons and glia
Benito-Sipos, J., Baumgardt, M. and Thor, S. (2013). Development of the Drosophila embryonic ventral nerve cord: from neuroectoderm to unique neurons and glia. Patterning and cell type specification in the developing CNS and PNS. (pp. 627-644) edited by John L.R. Rubenstein and Pasko Rakic. San Diego, CA, United States: Academic Press. doi: 10.1016/B978-0-12-397265-1.00073-3
2012
Journal Article
Control of neuronal cell fate and number by integration of distinct daughter cell proliferation modes with temporal progression
Ulvklo, Carina, MacDonald, Ryan, Bivik, Caroline, Baumgardt, Magnus, Karlsson, Daniel and Thor, Stefan (2012). Control of neuronal cell fate and number by integration of distinct daughter cell proliferation modes with temporal progression. Development, 139 (4), 678-689. doi: 10.1242/dev.074500
2012
Journal Article
Curcumin promotes a-beta fibrillation and reduces neurotoxicity in transgenic Drosophila
Caesar, Ina, Jonson, Maria, Nilsson, K. Peter R., Thor, Stefan and Hammarstrom, Per (2012). Curcumin promotes a-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. Plos One, 7 (2) e31424, e31424. doi: 10.1371/journal.pone.0031424
2011
Journal Article
Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development
Benito-Sipos, Jonathan, Ulvklo, Carina, Gabilondo, Hugo, Baumgardt, Magnus, Angel, Anna, Torroja, Laura and Thor, Stefan (2011). Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development. Development, 138 (24), 5311-5320. doi: 10.1242/dev.070946
2011
Journal Article
Insights into hox protein function from a large scale combinatorial analysis of protein domains
Merabet, Samir, Litim-Mecheri, Isma, Karlsson, Daniel, Dixit, Richa, Saadaoui, Mehdi, Monier, Bruno, Brun, Christine, Thor, Stefan, Vijayraghavan, K., Perrin, Laurent, Pradel, Jacques and Graba, Yacine (2011). Insights into hox protein function from a large scale combinatorial analysis of protein domains. PLoS Genetics, 7 (10) e1002302, e1002302. doi: 10.1371/journal.pgen.1002302
2011
Journal Article
Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues
Suska, Anke, Miguel-Aliaga, Irene and Thor, Stefan (2011). Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues. Developmental Biology, 353 (1), 72-80. doi: 10.1016/j.ydbio.2011.02.015
2010
Book Chapter
Drosophila apterous neurons: From stem cell to unique neuron
Thor, S. (2010). Drosophila apterous neurons: From stem cell to unique neuron. Encyclopedia of Neuroscience. (pp. 671-675) Elsevier Ltd. doi: 10.1016/B978-008045046-9.01034-2
2010
Journal Article
A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS
Benito-Sipos, Jonathan, Estacio-Gomez, Alicia, Moris-Sanz, Marta, Baumgardt, Magnus, Thor, Stefan and Diaz-Benjumea, Fernando J. (2010). A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS. Development, 137 (19), 3327-3336. doi: 10.1242/dev.052233
2010
Journal Article
Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues
Karlsson, Daniel, Baumgardt, Magnus and Thor, Stefan (2010). Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues. Plos Biology, 8 (5) ARTN e1000368, e1000368. doi: 10.1371/journal.pbio.1000368
2010
Journal Article
Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses
Berg, Ina, Nilsson, K. Peter R., Thor, Stefan and Hammarstrom, Per (2010). Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses. Nature Protocols, 5 (5), 935-944. doi: 10.1038/nprot.2010.41
2009
Journal Article
Neuronal subtype specification within a lineage by opposing temporal feed-forward loops
Baumgardt, Magnus, Karlsson, Daniel, Terriente, Javier, Diaz-Benjumea, Fernando J. and Thor, Stefan (2009). Neuronal subtype specification within a lineage by opposing temporal feed-forward loops. Cell, 139 (5), 969-982. doi: 10.1016/j.cell.2009.10.032
2009
Journal Article
Programmed cell death in the nervous system - a programmed cell fate?
Miguel-Aliaga, Irene and Thor, Stefan (2009). Programmed cell death in the nervous system - a programmed cell fate?. Current Opinion in Neurobiology, 19 (2), 127-133. doi: 10.1016/j.conb.2009.04.002
2009
Journal Article
Modeling familial amyloidotic polyneuropathy (Transthyretin V30M) in Drosophila melanogaster
Berg, Ina, Thor, Stefan and Hammarstrom, Per (2009). Modeling familial amyloidotic polyneuropathy (Transthyretin V30M) in Drosophila melanogaster. Neurodegenerative Diseases, 6 (3), 127-138. doi: 10.1159/000213761
2009
Book Chapter
Cell specification in the nervous system: an outlook from the Drosophila peptidergic FMRFamide Tv neuron.
Thor, S. (2009). Cell specification in the nervous system: an outlook from the Drosophila peptidergic FMRFamide Tv neuron.. Encyclopedia of neuroscience. (pp. 671-675) Oxford, United Kingdom: Academic Press.
2008
Journal Article
Neuroscience: light moulds plastic brains
Thor, Stefan (2008). Neuroscience: light moulds plastic brains. Nature, 456 (7219), 177-178. doi: 10.1038/456177a
Supervision
Availability
- Professor Stefan Thor is:
- Available for supervision
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Available projects
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The role of the hypothalamic neuropeptide Npvf in mouse fertility and sleep-wake behaviours
The hypothalamic neuropeptide Npvf is expressed by a very small subset of neurons within the hypothalamus. Npvf has been implicated in fertility, seasonal mating behaviour and sleep-wake behaviours, in several different mammalian species, as well as in the zebrafish. But these studies have been based upon correlative experiments, RNAi and peptide injections, and the Npvf gene has hitherto not beek knocked out. we have geneerated a condititional null allele of Npvf. This project aims to address the effect of a null mutation in Npvf upon a set of mouse behaviours.
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The role of the mouse Tead1/Vgll2 transcription factors in dictating hypothalamic cell fate
The hypothalamic neuropeptide Npvf is expressed by a very small subset of neurons within the hypothalamus. Npvf has been implicated in fertility, seasonal mating behaviour and sleep-wake behaviours. Using single cell transcriptional profiling, we and others have identified the transcription factors Tead1 and Vgll2 as selectively expressed in Npvf neurons in the mouse hypothalamus. The Tead and Vgll families typically interact and form a complex. We have generated a mouse Tead1 knock-out, and found that the Npvf neurons are missing. The project aims to address the underlying reason for the phenotype. We are also in the process of obtaining the mouse Vgll2 knockout, to be able to compare the effects of this knock-out with that of Tead1.
Supervision history
Current supervision
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Doctor Philosophy
Decoding the genetic pathways governing cell diversity in the mammalian hypothalamus
Principal Advisor
Other advisors: Professor Michael Piper, Professor Mikael Boden
-
Doctor Philosophy
Generating hypothalamic neurons from human stem cells
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
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Doctor Philosophy
Generating complex brain organoids from human stem cells
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
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Doctor Philosophy
Developing an in vitro human sleep system
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
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Doctor Philosophy
Do cell types exist in a continuum? Single-cell bioinformatics across species, over time and space
Associate Advisor
Other advisors: Professor Mikael Boden
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Doctor Philosophy
Bioinformatics of epigenetics at multiple scales: from evolution of epigenetic factors to tracing their marks in organellar development
Associate Advisor
Other advisors: Professor Mikael Boden
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Doctor Philosophy
How epigenetic modifiers regulate brain size
Associate Advisor
Other advisors: Professor Michael Piper
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Doctor Philosophy
How SETD2 shapes cortical development
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Michael Piper
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Doctor Philosophy
The role of transcription factor Tead1 in cortical development
Associate Advisor
Other advisors: Professor Michael Piper
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Doctor Philosophy
Understanding cell state changes during metamorphosis in Amphimedon queenslandica
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
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Doctor Philosophy
Elucidating the role of Human Aminoacyl multi- tRNA synthetase complex (MSC) in Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
Associate Advisor
Other advisors: Associate Professor Jessica Mar, Dr Mohammed Shaker, Professor Ernst Wolvetang
Completed supervision
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2023
Doctor Philosophy
The role of the Polycomb protein Eed in the mouse cerebral cortex
Associate Advisor
Other advisors: Professor Michael Piper
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2023
Doctor Philosophy
Cell Type Definition from Single Cell RNA-seq
Associate Advisor
Other advisors: Professor Michael Piper, Associate Professor Jessica Mar, Professor Mikael Boden
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2023
Doctor Philosophy
Machine learning models of epigenetic dynamics driving cell fate
Associate Advisor
Other advisors: Associate Professor Jessica Mar, Professor Mikael Boden
Media
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