Overview
Background
BSc in Biology (1988) Umea University, Sweden
PhD in Molecular Biology (1994), Umea University, Sweden. Supervisor: Thomas Edlund
Postdoc, Molecular Neurobiology (1994-1999) Salk Institute, La Jolla, USA. Mentor: John B. Thomas
Assistant Professor (1999-2004), Harvard Medical School, Boston, USA
Professor of Developmental Biology (2004-2019), Linkoping University, Sweden
Professor of Developmental Biology (2019-), University of Queensland, Brisbane, Australia
Member of the Royal Swedish Academy of Sciences (2013-)
Availability
- Professor Stefan Thor is:
- Available for supervision
Qualifications
- Doctor of Philosophy, unknown
Works
Search Professor Stefan Thor’s works on UQ eSpace
1999
Journal Article
A LIM-homeodomain combinatorial code for motor-neuron pathway selection
Thor, Stefan, Andersson, Siv G. E. , Tomlinson, Andrew and Thomas, John B. (1999). A LIM-homeodomain combinatorial code for motor-neuron pathway selection. Nature, 397 (6714), 76-80. doi: 10.1038/16275
1998
Journal Article
Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor
Benveniste, R.J., Thor, S., Thomas, J.B. and Taghert, P.H. (1998). Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development, 125 (23), 4757-4765.
1998
Journal Article
Function and specificity of LIM domains in Drosophila nervous system and wing development
O'Keefe, D.D., Thor, S and Thomas, J.B. (1998). Function and specificity of LIM domains in Drosophila nervous system and wing development. Development, 125 (19), 3915-3923.
1997
Journal Article
The Drosophila islet gene governs axon pathfinding and neurotransmitter identity
Thor, S and Thomas, JB (1997). The Drosophila islet gene governs axon pathfinding and neurotransmitter identity. Neuron, 18 (3), 397-409. doi: 10.1016/S0896-6273(00)81241-6
1995
Journal Article
Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish
Appel, B., Korzh, V., Glasgow, E., Thor, S., Edlund, T., Dawid, I. B. and Eisen, J. S. (1995). Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development, 121 (12), 4117-4125.
1995
Journal Article
The genetics of brain development: Conserved programs in flies and mice
Thor, Stefan (1995). The genetics of brain development: Conserved programs in flies and mice. Neuron, 15 (5), 975-977. doi: 10.1016/0896-6273(95)90084-5
1995
Journal Article
Islet expression of Rhombotin and Isl-1 suggests cell type specific exposure of LIM-domain epitopes
Lund, Kaare , Petersen, Jacob S., Jensen, Jan , Blume, Niels , Edlund, Thomas , Thor, Stefan and Madsen, Ole D. (1995). Islet expression of Rhombotin and Isl-1 suggests cell type specific exposure of LIM-domain epitopes. Endocrine, 3 (6), 399-408. doi: 10.1007/BF02935644
1995
Journal Article
Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous
Lundgren, S. E., Callahan, C. A., Thor, S. and Thomas, A. B. (1995). Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous. Development, 121 (6), 1769-1773.
1993
Journal Article
Zebrafish primary neurons initiate expression of the LIM homeodomain protein Isl-1 at the end of gastrulation
Korzh, V. , Edlund, T. and Thor, S. (1993). Zebrafish primary neurons initiate expression of the LIM homeodomain protein Isl-1 at the end of gastrulation. Development, 118 (2), 417-425.
1992
Journal Article
Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1
Ericson, J., Thor, S., Edlund, T., Jessell, T. M. and Yamada, T. (1992). Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science, 256 (5063), 1555-1560. doi: 10.1126/science.1350865
1991
Journal Article
The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat
Thor, Stefan, Ericson, Johan, Brännström, Thomas and Edlund, Thomas (1991). The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron, 7 (6), 881-889. doi: 10.1016/0896-6273(91)90334-V
1991
Journal Article
Novel Insulin Promoter- and Enhancer-Binding Proteins That Discriminate between Pancreatic Alpha and Beta Cells
Ohlsson, Helena, Thor, Stefan and Edlund, Thomas (1991). Novel Insulin Promoter- and Enhancer-Binding Proteins That Discriminate between Pancreatic Alpha and Beta Cells. Molecular Endocrinology, 5 (7), 897-904. doi: 10.1210/mend-5-7-897
1990
Journal Article
Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain
Karlsson, Olof, Thor, Stefan, Norberg, Torbjörn, Ohlsson, Helena and Edlund, Thomas (1990). Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain. Nature, 344 (6269), 879-882. doi: 10.1038/344879a0
1989
Conference Publication
Cis- and transacting elements regulating insulin gene transcription
Ohlsson, H., Karlsson, O., Norberg, T., Thor, S. and Edlund, T. (1989). Cis- and transacting elements regulating insulin gene transcription. Elsevier Science Publishers B.V..
Supervision
Availability
- Professor Stefan Thor is:
- Available for supervision
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Available projects
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The role of the hypothalamic neuropeptide Npvf in mouse fertility and sleep-wake behaviours
The hypothalamic neuropeptide Npvf is expressed by a very small subset of neurons within the hypothalamus. Npvf has been implicated in fertility, seasonal mating behaviour and sleep-wake behaviours, in several different mammalian species, as well as in the zebrafish. But these studies have been based upon correlative experiments, RNAi and peptide injections, and the Npvf gene has hitherto not beek knocked out. we have geneerated a condititional null allele of Npvf. This project aims to address the effect of a null mutation in Npvf upon a set of mouse behaviours.
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The role of the mouse Tead1/Vgll2 transcription factors in dictating hypothalamic cell fate
The hypothalamic neuropeptide Npvf is expressed by a very small subset of neurons within the hypothalamus. Npvf has been implicated in fertility, seasonal mating behaviour and sleep-wake behaviours. Using single cell transcriptional profiling, we and others have identified the transcription factors Tead1 and Vgll2 as selectively expressed in Npvf neurons in the mouse hypothalamus. The Tead and Vgll families typically interact and form a complex. We have generated a mouse Tead1 knock-out, and found that the Npvf neurons are missing. The project aims to address the underlying reason for the phenotype. We are also in the process of obtaining the mouse Vgll2 knockout, to be able to compare the effects of this knock-out with that of Tead1.
Supervision history
Current supervision
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Doctor Philosophy
Generating complex brain organoids from human stem cells
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
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Doctor Philosophy
Developing an in vitro human sleep system
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
-
Doctor Philosophy
Decoding the genetic pathways governing cell diversity in the mammalian hypothalamus
Principal Advisor
Other advisors: Professor Michael Piper, Professor Mikael Boden
-
Doctor Philosophy
Generating hypothalamic neurons from human stem cells
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
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Doctor Philosophy
Elucidating the role of Human Aminoacyl multi- tRNA synthetase complex (MSC) in Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
Associate Advisor
Other advisors: Associate Professor Jessica Mar, Dr Mohammed Shaker, Professor Ernst Wolvetang
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Doctor Philosophy
Do cell types exist in a continuum? Single-cell bioinformatics across species, over time and space
Associate Advisor
Other advisors: Professor Mikael Boden
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Doctor Philosophy
Bioinformatics of epigenetics at multiple scales: from evolution of epigenetic factors to tracing their marks in organellar development
Associate Advisor
Other advisors: Professor Mikael Boden
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Doctor Philosophy
How epigenetic modifiers regulate brain size
Associate Advisor
Other advisors: Professor Michael Piper
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Doctor Philosophy
How SETD2 shapes cortical development
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Michael Piper
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Doctor Philosophy
The role of transcription factor Tead1 in cortical development
Associate Advisor
Other advisors: Professor Michael Piper
-
Doctor Philosophy
Understanding cell state changes during metamorphosis in Amphimedon queenslandica
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
Completed supervision
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2023
Doctor Philosophy
The role of the Polycomb protein Eed in the mouse cerebral cortex
Associate Advisor
Other advisors: Professor Michael Piper
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2023
Doctor Philosophy
Cell Type Definition from Single Cell RNA-seq
Associate Advisor
Other advisors: Professor Michael Piper, Associate Professor Jessica Mar, Professor Mikael Boden
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2023
Doctor Philosophy
Machine learning models of epigenetic dynamics driving cell fate
Associate Advisor
Other advisors: Associate Professor Jessica Mar, Professor Mikael Boden
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