![Professor Stefan Thor](/sites/default/files/profiles/22014.jpeg)
Overview
Background
BSc in Biology (1988) Umea University, Sweden
PhD in Molecular Biology (1994), Umea University, Sweden. Supervisor: Thomas Edlund
Postdoc, Molecular Neurobiology (1994-1999) Salk Institute, La Jolla, USA. Mentor: John B. Thomas
Assistant Professor (1999-2004), Harvard Medical School, Boston, USA
Professor of Developmental Biology (2004-2019), Linkoping University, Sweden
Professor of Developmental Biology (2019-), University of Queensland, Brisbane, Australia
Member of the Royal Swedish Academy of Sciences (2013-)
Availability
- Professor Stefan Thor is:
- Available for supervision
Qualifications
- Doctor of Philosophy, unknown
Works
Search Professor Stefan Thor’s works on UQ eSpace
2024
Journal Article
Indirect neurogenesis in space and time
Thor, Stefan (2024). Indirect neurogenesis in space and time. Nature Reviews Neuroscience, 25 (8), 1-16. doi: 10.1038/s41583-024-00833-x
2024
Journal Article
Polycomb repressive complex 2 is critical for mouse cortical glutamatergic neuron development
Currey, Laura, Mitchell, Benjamin, Al-Khalily, Majd, McElnea, Sarah-Jayne, Kozulin, Peter, Harkins, Danyon, Pelenyi, Alexandra, Fenlon, Laura, Suarez, Rodrigo, Kurniawan, Nyoman D, Burne, Thomas H, Harris, Lachlan, Thor, Stefan and Piper, Michael (2024). Polycomb repressive complex 2 is critical for mouse cortical glutamatergic neuron development. Cerebral Cortex, 34 (7) ARTN bhae268. doi: 10.1093/cercor/bhae268
2024
Journal Article
40 years of homeodomain transcription factors in the Drosophila nervous system
Doe, Chris Q. and Thor, Stefan (2024). 40 years of homeodomain transcription factors in the Drosophila nervous system. Development, 151 (11) dev202910. doi: 10.1242/dev.202910
2024
Journal Article
A protocol for high-resolution episcopic microscopy and 3D volumetric analyses of the adult mouse brain
Mitchell, Benjamin, Mu, Erica, Currey, Laura, Whitehead, Darryl, Walters, Shaun, Thor, Stefan, Kasherman, Maria and Piper, Michael (2024). A protocol for high-resolution episcopic microscopy and 3D volumetric analyses of the adult mouse brain. Neuroscience Letters, 824 137675, 1-6. doi: 10.1016/j.neulet.2024.137675
2023
Journal Article
Cellular and molecular functions of SETD2 in the central nervous system
Mitchell, Benjamin, Thor, Stefan and Piper, Michael (2023). Cellular and molecular functions of SETD2 in the central nervous system. Journal of Cell Science, 136 (21) jcs261406, 1-11. doi: 10.1242/jcs.261406
2023
Conference Publication
Polycomb Protein EED Regulates Identity Of Glutamatergic Neurons
Currey, Laura, Mitchell, Benjamin, Harris, Lachlan, Thor, Stefan and Piper, Michael (2023). Polycomb Protein EED Regulates Identity Of Glutamatergic Neurons. IBRO 11th World Congress of Neuroscience, Granada, Spain, 9-13 September 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.ibneur.2023.08.045
2023
Journal Article
Cytocipher determines significantly different populations of cells in single cell RNA-seq data
Balderson, Brad, Piper, Michael, Thor, Stefan and Boden, Mikael (2023). Cytocipher determines significantly different populations of cells in single cell RNA-seq data. Bioinformatics, 39 (7) btad435. doi: 10.1093/bioinformatics/btad435
2023
Journal Article
Specification of the Drosophila Orcokinin A neurons by combinatorial coding
Rubio-Ferrera, Irene, Clarembaux-Badell, Luis, Baladrón-de-Juan, Pablo, Berrocal-Rubio, Miguel Ángel, Thor, Stefan, Cobeta, Ignacio Monedero and Benito-Sipos, Jonathan (2023). Specification of the Drosophila Orcokinin A neurons by combinatorial coding. Cell and Tissue Research, 391 (2), 269-286. doi: 10.1007/s00441-022-03721-x
2022
Journal Article
Dachshund acts with Abdominal-B to trigger programmed cell death in the Drosophila central nervous system at the frontiers of Abd-B expression
Clarembaux-Badell, Luis, Baladrón-de-Juan, Pablo, Gabilondo, Hugo, Rubio-Ferrera, Irene, Millán, Irene, Estella, Carlos, Valverde-Ortega, Félix S., Cobeta, Ignacio Monedero, Thor, Stefan and Benito-Sipos, Jonathan (2022). Dachshund acts with Abdominal-B to trigger programmed cell death in the Drosophila central nervous system at the frontiers of Abd-B expression. Developmental Neurobiology, 82 (6), 495-504. doi: 10.1002/dneu.22894
2022
Journal Article
Hydrocephalus in Nfix−/− mice is underpinned by changes in ependymal cell physiology
Harkins, Danyon, Harvey, Tracey J., Atterton, Cooper, Miller, Ingrid, Currey, Laura, Oishi, Sabrina, Kasherman, Maria, Davila, Raul Ayala, Harris, Lucy, Green, Kathryn, Piper, Hannah, Parton, Robert G., Thor, Stefan, Cooper, Helen M. and Piper, Michael (2022). Hydrocephalus in Nfix−/− mice is underpinned by changes in ependymal cell physiology. Cells, 11 (15) 2377, 2377. doi: 10.3390/cells11152377
2022
Journal Article
Selective role of the DNA helicase Mcm5 in BMP retrograde signaling during Drosophila neuronal differentiation
Rubio-Ferrera, Irene, Baladrón-De-Juan, Pablo, Clarembaux-Badell, Luis, Truchado-Garcia, Marta, Jordán-Álvarez, Sheila, Thor, Stefan, Benito-Sipos, Jonathan and Cobeta, Ignacio Monedero (2022). Selective role of the DNA helicase Mcm5 in BMP retrograde signaling during Drosophila neuronal differentiation. PLoS Genetics, 18 (6) e1010255, 1-17. doi: 10.1371/journal.pgen.1010255
2022
Journal Article
Selective requirement for polycomb repressor complex 2 in the generation of specific hypothalamic neuronal subtypes
Yaghmaeian Salmani, Behzad, Balderson, Brad, Bauer, Susanne, Ekman, Helen, Starkenberg, Annika, Perlmann, Thomas, Piper, Michael, Bodén, Mikael and Thor, Stefan (2022). Selective requirement for polycomb repressor complex 2 in the generation of specific hypothalamic neuronal subtypes. Development, 149 (5) dev200076. doi: 10.1242/dev.200076
2022
Journal Article
Variational autoencoding of gene landscapes during mouse CNS development uncovers layered roles of Polycomb Repressor Complex 2
Mora, Ariane, Rakar, Jonathan, Cobeta, Ignacio Monedero, Salmani, Behzad Yaghmaeian, Starkenberg, Annika, Thor, Stefan and Bodén, Mikael (2022). Variational autoencoding of gene landscapes during mouse CNS development uncovers layered roles of Polycomb Repressor Complex 2. Nucleic Acids Research, 50 (3), 1280-1296. doi: 10.1093/nar/gkac006
2021
Journal Article
TEAD family transcription factors in development and disease
Currey, Laura, Thor, Stefan and Piper, Michael (2021). TEAD family transcription factors in development and disease. Development, 148 (12) dev196675. doi: 10.1242/dev.196675
2020
Journal Article
Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R
Sandberg, Alexander, Ling, Helen, Gearing, Marla, Dombroski, Beth, Cantwell, Laura, R'Bibo, Lea, Levey, Allan, Schellenberg, Gerard D., Hardy, John, Wood, Nicholas, Fernius, Josefin, Nyström, Sofie, Svensson, Samuel, Thor, Stefan, Hammarström, Per, Revesz, Tamas and Mok, Kin Y. (2020). Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R. Neurobiology of Disease, 146 105079, 105079. doi: 10.1016/j.nbd.2020.105079
2020
Book Chapter
Genetic mechanisms controlling anterior expansion of the central nervous system
Yaghmaeian Salmani, Behzad and Thor, Stefan (2020). Genetic mechanisms controlling anterior expansion of the central nervous system. Gradients and tissue patterning. (pp. 333-361) edited by Stephen Small and James Briscoe. London, United Kingdom: Academic Press. doi: 10.1016/bs.ctdb.2019.11.005
2020
Book Chapter
The five faces of notch signalling during Drosophila melanogaster embryonic CNS development
Bahrampour, Shahrzad and Thor, Stefan (2020). The five faces of notch signalling during Drosophila melanogaster embryonic CNS development. Notch signaling in embryology and cancer: notch signaling in embryology. (pp. 39-58) edited by Jörg Reichrath and Sandra Reichrath. New York, NY, United States: Springer. doi: 10.1007/978-3-030-34436-8_3
2019
Journal Article
Drosophila neuroblast selection is gated by Notch, Snail, SoxB, and EMT gene interplay
Arefin, Badrul, Parvin, Farjana, Bahrampour, Shahrzad, Stadler, Caroline Bivik and Thor, Stefan (2019). Drosophila neuroblast selection is gated by Notch, Snail, SoxB, and EMT gene interplay. Cell Reports, 29 (11), 3636-3651.e3. doi: 10.1016/j.celrep.2019.11.038
2019
Journal Article
Amyloid fibril polymorphism and cell-specific toxicity in vivo
Jonson, Maria, Nyström, Sofie, Sandberg, Alexander, Carlback, Marcus, Michno, Wojciech, Hanrieder, Jörg, Starkenberg, Annika, Peter, K., Nilsson, R., Thor, Stefan and Hammarström, Per (2019). Amyloid fibril polymorphism and cell-specific toxicity in vivo. Amyloid, 26 (sup1), 136-137. doi: 10.1080/13506129.2019.1582488
2019
Journal Article
PIP degron-stabilized Dacapo/p21Cip1 and mutations in ago act in an anti- versus pro-proliferative manner, yet both trigger an increase in Cyclin E levels
Bivik Stadler, Caroline, Arefin, Badrul, Ekman, Helen and Thor, Stefan (2019). PIP degron-stabilized Dacapo/p21Cip1 and mutations in ago act in an anti- versus pro-proliferative manner, yet both trigger an increase in Cyclin E levels. Development, 146 (13) dev175927, dev175927. doi: 10.1242/dev.175927
Supervision
Availability
- Professor Stefan Thor is:
- Available for supervision
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Available projects
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The role of the hypothalamic neuropeptide Npvf in mouse fertility and sleep-wake behaviours
The hypothalamic neuropeptide Npvf is expressed by a very small subset of neurons within the hypothalamus. Npvf has been implicated in fertility, seasonal mating behaviour and sleep-wake behaviours, in several different mammalian species, as well as in the zebrafish. But these studies have been based upon correlative experiments, RNAi and peptide injections, and the Npvf gene has hitherto not beek knocked out. we have geneerated a condititional null allele of Npvf. This project aims to address the effect of a null mutation in Npvf upon a set of mouse behaviours.
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The role of the mouse Tead1/Vgll2 transcription factors in dictating hypothalamic cell fate
The hypothalamic neuropeptide Npvf is expressed by a very small subset of neurons within the hypothalamus. Npvf has been implicated in fertility, seasonal mating behaviour and sleep-wake behaviours. Using single cell transcriptional profiling, we and others have identified the transcription factors Tead1 and Vgll2 as selectively expressed in Npvf neurons in the mouse hypothalamus. The Tead and Vgll families typically interact and form a complex. We have generated a mouse Tead1 knock-out, and found that the Npvf neurons are missing. The project aims to address the underlying reason for the phenotype. We are also in the process of obtaining the mouse Vgll2 knockout, to be able to compare the effects of this knock-out with that of Tead1.
Supervision history
Current supervision
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Doctor Philosophy
Generating complex brain organoids from human stem cells
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
-
Doctor Philosophy
Developing an in vitro human sleep system
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
-
Doctor Philosophy
Decoding the genetic pathways governing cell diversity in the mammalian hypothalamus
Principal Advisor
Other advisors: Professor Michael Piper, Professor Mikael Boden
-
Doctor Philosophy
Generating hypothalamic neurons from human stem cells
Principal Advisor
Other advisors: Professor Michael Piper, Professor Ernst Wolvetang
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Doctor Philosophy
Elucidating the role of Human Aminoacyl multi- tRNA synthetase complex (MSC) in Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
Associate Advisor
Other advisors: Associate Professor Jessica Mar, Dr Mohammed Shaker, Professor Ernst Wolvetang
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Doctor Philosophy
Do cell types exist in a continuum? Single-cell bioinformatics across species, over time and space
Associate Advisor
Other advisors: Professor Mikael Boden
-
Doctor Philosophy
Bioinformatics of epigenetics at multiple scales: from evolution of epigenetic factors to tracing their marks in organellar development
Associate Advisor
Other advisors: Professor Mikael Boden
-
Doctor Philosophy
How epigenetic modifiers regulate brain size
Associate Advisor
Other advisors: Professor Michael Piper
-
Doctor Philosophy
How SETD2 shapes cortical development
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Michael Piper
-
Doctor Philosophy
The role of transcription factor Tead1 in cortical development
Associate Advisor
Other advisors: Professor Michael Piper
-
Doctor Philosophy
Understanding cell state changes during metamorphosis in Amphimedon queenslandica
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
Completed supervision
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2023
Doctor Philosophy
The role of the Polycomb protein Eed in the mouse cerebral cortex
Associate Advisor
Other advisors: Professor Michael Piper
-
2023
Doctor Philosophy
Cell Type Definition from Single Cell RNA-seq
Associate Advisor
Other advisors: Professor Michael Piper, Associate Professor Jessica Mar, Professor Mikael Boden
-
2023
Doctor Philosophy
Machine learning models of epigenetic dynamics driving cell fate
Associate Advisor
Other advisors: Associate Professor Jessica Mar, Professor Mikael Boden
Media
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