
Overview
Background
~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Cell surface mucin glycoproteins in infection, inflammation and cancer
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Inflammatory bowel diseases
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Non-cystic fibrosis bronchiectasis
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Inflammation in the pathogenesis of type 2 diabetes
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Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases
Works
Search Professor Michael McGuckin’s works on UQ eSpace
1999
Journal Article
Heterogeneity of MUC1 expression by human breast carcinoma cell lines in vivo and in vitro
Walsh, M. D., Luckie, S. M., Cummings, M. C., Antalis, T. M. and McGuckin, M. A. (1999). Heterogeneity of MUC1 expression by human breast carcinoma cell lines in vivo and in vitro. Breast Cancer Research & Treatment, 58 (3), 253-264. doi: 10.1023/A:1006345301364
1999
Conference Publication
Identification and characterisation of novel mucin genes
Williams, S., Antalis, T. M., Gotley, D. C. and McGuckin, M. A. (1999). Identification and characterisation of novel mucin genes. Australian Gastroenterology Week 1999, Brisbane Convention Centre, 4th - 8th October, 1999. Carlton, Vic: Blackwell Science Asia.
1998
Journal Article
Peritoneal fluid from ovarian cancer patients stimulates MUC1 epithelial mucin expression in ovarian cancer cell lines
Munster, DJ, Quin, RJ, Bansal, AS, Ward, BG and McGuckin, MA (1998). Peritoneal fluid from ovarian cancer patients stimulates MUC1 epithelial mucin expression in ovarian cancer cell lines. International Journal of Cancer, 76 (3), 393-398. doi: 10.1002/(SICI)1097-0215(19980504)76:33.0.CO;2-C
1998
Journal Article
Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines
McGuckin, MA, Quin, RJ and Ward, BG (1998). Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines. International Journal of Oncology, 12 (4), 939-945. doi: 10.3892/ijo.12.4.939
1998
Journal Article
Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women
Richards, ER, Devine, PL, Quin, RJ, Fontenot, JD, Ward, BG and McGuckin, MA (1998). Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women. Cancer Immunology Immunotherapy, 46 (5), 245-252. doi: 10.1007/s002620050484
1997
Journal Article
Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours
Dong, Y, Walsh, MD, Cummings, MC, Wright, RG, Khoo, SK, Parsons, PG and McGuckin, MA (1997). Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours. Journal of Pathology, 183 (3), 311-317. doi: 10.1002/(SICI)1096-9896(199711)183:33.0.CO;2-2
1997
Journal Article
Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer
Dong, Y, Walsh, MD, McGuckin, MA, Cummings, MC, Gabrielli, BG, Wright, GR, Hurst, T, Khoo, SK and Parsons, PG (1997). Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer. International Journal of Cancer, 74 (4), 407-415. doi: 10.1002/(SICI)1097-0215(19970822)74:43.0.CO;2-Z
1997
Journal Article
Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16(INK4A) in ovarian cancer is associated with progression and unfavourable prognosis
Dong, Y, Walsh, MD, McGuckin, MA, Gabrielli, BG, Cummings, MC, Wright, RC, Hurst, T, Khoo, SK and Parsons, PG (1997). Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16(INK4A) in ovarian cancer is associated with progression and unfavourable prognosis. International Journal of Cancer, 74 (1), 57-63. doi: 10.1002/(SICI)1097-0215(19970220)74:13.0.CO;2-F
1996
Journal Article
Occult axillary node metastases in breast cancer: Their detection and prognostic significance
McGuckin, M. A., Cummings, M. C., Walsh, M. D., Hohn, B. G., Bennett, I. C. and Wright, R. G. (1996). Occult axillary node metastases in breast cancer: Their detection and prognostic significance. British Journal of Cancer, 73 (1), 88-95. doi: 10.1038/bjc.1996.16
1996
Journal Article
Early steps in the biosynthesis of MUC2 epithelial mucin in colon cancer cells
McGuckin M.A., Devine P.L. and Ward B.G. (1996). Early steps in the biosynthesis of MUC2 epithelial mucin in colon cancer cells. Biochemistry and Cell Biology, 74 (1), 87-93. doi: 10.1139/o96-009
1995
Journal Article
Prostate-specific antigen (PSA) and cancer-associated serum antigen (CASA) in distinguishing benign and malignant prostate disease
Devine, PL, Walsh, MD, McGuckin, MA, Quin, RJ, Hohn, BG, Claque, A and Samaratunga, H (1995). Prostate-specific antigen (PSA) and cancer-associated serum antigen (CASA) in distinguishing benign and malignant prostate disease. International Journal of Biological Markers, 10 (4), 221-225. doi: 10.1177/172460089501000406
1995
Journal Article
CA15-3, CASA, MSA, AND TPS AS DIAGNOSTIC SERUM MARKERS IN BREAST-CANCER
DEVINE, PL, DUROUX, MA, QUIN, RJ, MCGUCKIN, MA, JOY, GJ, WARD, BG and POLLARD, CW (1995). CA15-3, CASA, MSA, AND TPS AS DIAGNOSTIC SERUM MARKERS IN BREAST-CANCER. Breast Cancer Research and Treatment, 34 (3), 245-251. doi: 10.1007/BF00689716
1995
Journal Article
Prognostic-Significance of Muc1 Epithelial Mucin Expression in Breast-Cancer
McGuckin, MA, Walsh, MD, Hohn, BG, Ward, BG and Wright, RG (1995). Prognostic-Significance of Muc1 Epithelial Mucin Expression in Breast-Cancer. Human Pathology, 26 (4), 432-439. doi: 10.1016/0046-8177(95)90146-9
1995
Journal Article
THE MUCIN MARKER, CASA, IN OVARIAN-CANCER
MCGUCKIN, MA and DEVINE, PL (1995). THE MUCIN MARKER, CASA, IN OVARIAN-CANCER. Tumordiagnostik & Therapie, 16 (1), 1-6.
1995
Journal Article
Predictive value of the combination of serum markers, CA125, CASA and TPS in ovarian cancer
Devine, PL, McGuckin, MA, Quin, RJ and Ward, BG (1995). Predictive value of the combination of serum markers, CA125, CASA and TPS in ovarian cancer. International Journal of Gynecological Cancer, 5 (3), 170-178. doi: 10.1046/j.1525-1438.1995.05030170.x
1995
Journal Article
Heterogeneity in production, secretion and glycosylation of MUC1 epithelial mucin by primary cultures of ovarian carcinoma
McGuckin M.A., Hurst T.G. and Ward B.G. (1995). Heterogeneity in production, secretion and glycosylation of MUC1 epithelial mucin by primary cultures of ovarian carcinoma. International Journal of Cancer, 63 (3), 412-418. doi: 10.1002/ijc.2910630319
1995
Journal Article
The mucin marker, CASA, in ovarian cancer
McGuckin M.A. and Devine P.L. (1995). The mucin marker, CASA, in ovarian cancer. Tumor Diagnostik und Therapie, 16 (1), 1-6.
1994
Journal Article
Effect of Interferon-Gamma and Tumor-Necrosis-Factor-Alpha On Sensitivity to Cisplatin in Ovarian-Carcinoma Cell-Lines
Clark, S, McGuckin, MA, Hurst, T and Ward, BG (1994). Effect of Interferon-Gamma and Tumor-Necrosis-Factor-Alpha On Sensitivity to Cisplatin in Ovarian-Carcinoma Cell-Lines. Cancer Immunology Immunotherapy, 39 (2), 100-104. doi: 10.1007/BF01525315
1994
Journal Article
Serum markers Casa, Cea, Cyfra-21-1, Msa, Nse, Tpa and Tps in lung-cancer
Devine, P.L., Yarker, J.Y., Fong, K.M., McGuckin, M.A., Scells, B., Ward, B.G., Thynne, G.S. and Zimmerman, P.V. (1994). Serum markers Casa, Cea, Cyfra-21-1, Msa, Nse, Tpa and Tps in lung-cancer. International Journal of Oncology, 4 (5), 1129-1135.
1994
Journal Article
Serum markers CASA, CEA, CYFRA 21-1, MSA, NSE, TPA and TPS in lung cancer
Devine, P. L., Yarker, J. Y., Fong, K. M., McGuckin, M. A., Scells, B., Ward, B. G., Thynne, G. S. and Zimmerman, P. V. (1994) Serum markers CASA, CEA, CYFRA 21-1, MSA, NSE, TPA and TPS in lung cancer. International Journal of Oncology, 4 5: 1129-1134.
Supervision
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
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Supervision history
Completed supervision
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2017
Doctor Philosophy
An Investigation into The Effect of Erythromycin on Pseudomonas aeruginosa Quorum Sensing in Non-CF Bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
Principal Advisor
Other advisors: Dr Sumaira Hasnain
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2015
Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
Principal Advisor
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2012
Doctor Philosophy
Investigations of the Biochemistry and Physiology of Mice with a Mutation in the Muc2 Intestinal Mucin Gene
Principal Advisor
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2009
Doctor Philosophy
Biology of CA125 in ovarian cancer biology
Principal Advisor
Other advisors: Professor Andreas Obermair
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2005
Doctor Philosophy
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
Principal Advisor
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2004
Doctor Philosophy
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
Principal Advisor
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2024
Doctor Philosophy
Examining the Role of Endogenous and Exogenous Interleukin-22 Signaling in Metabolic Dysfunction-Associated Steatotic Liver Disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald, Dr Sumaira Hasnain
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Dr Ran Wang, Dr Sumaira Hasnain
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2020
Doctor Philosophy
Novel dietary factors in diabetic and non-diabetic kidney disease
Associate Advisor
Other advisors: Dr Danielle Borg, Honorary Professor Josephine Forbes
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2020
Doctor Philosophy
Local Delivery of Anti-inflammatory drugs with Functionalized Silica Nanoparticles for Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Sumaira Hasnain, Professor Amirali Popat
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2019
Doctor Philosophy
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
Associate Advisor
Other advisors: Professor Mike Gidley
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2018
Doctor Philosophy
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
Associate Advisor
Other advisors: Dr Ben Ross, Professor Amirali Popat
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2009
Doctor Philosophy
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
Associate Advisor
Media
Enquiries
Contact Honorary Professor Michael McGuckin directly for media enquiries about:
- colon cancer
- inflammatory bowel diseases
- inflammatory disease
- type 2 diabetes
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