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Honorary Professor Michael McGuckin
Honorary Professor

Michael McGuckin

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Overview

Background

~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.

Availability

Honorary Professor Michael McGuckin is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Science, The University of Queensland
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Cell surface mucin glycoproteins in infection, inflammation and cancer

  • Inflammatory bowel diseases

  • Non-cystic fibrosis bronchiectasis

  • Inflammation in the pathogenesis of type 2 diabetes

  • Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases

Works

Search Professor Michael McGuckin’s works on UQ eSpace

253 works between 1987 and 2024

181 - 200 of 253 works

2005

Conference Publication

Real time per quantification of two mucolytic bacteria in IBD mucosa

Prig, CW, Heazlewood, SP, Story, D, Fowler, A, McGuckin, MA, Blackall, LL and Florin, TH (2005). Real time per quantification of two mucolytic bacteria in IBD mucosa. Annual Meeting of the American-Gastroenterological-Association/Digestive-Disease-Week, Chicago Il, May 14-19, 2005. PHILADELPHIA: W B SAUNDERS CO.

Real time per quantification of two mucolytic bacteria in IBD mucosa

2005

Journal Article

The role of cell surface epithelial mucin (MUC-1) in oropharyngeal candidiasis

Farah, C. S., Ashman, R. B., McGuckin, M. A. and McAuley, J. (2005). The role of cell surface epithelial mucin (MUC-1) in oropharyngeal candidiasis. Australian Dental Journal, 50 (S1), S14-S14. doi: 10.1111/j.1834-7819.2005.tb00377.x

The role of cell surface epithelial mucin (MUC-1) in oropharyngeal candidiasis

2005

Conference Publication

Spontaneous Apoptosis of Blood Dendritic Cells in Patients with Breast Cancer

Pinzon-Charry, Alberto, Maxwell, Tammy, McGuckin, Michael A., Schmidt, Chris, Furnival, Colin and Lopez, Jose A. (2005). Spontaneous Apoptosis of Blood Dendritic Cells in Patients with Breast Cancer. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, Conference dates. United States of America: John Wiley & Sons A/S. doi: 10.1111/j.1399-0039.2005.00523.x

Spontaneous Apoptosis of Blood Dendritic Cells in Patients with Breast Cancer

2004

Journal Article

Expression of the cell surface mucin gene family in adenocarcinomas

Packer, L. M., Williams, S. J., Callaghan, S., Gotley, D. C. and McGuckin, M. A. (2004). Expression of the cell surface mucin gene family in adenocarcinomas. International Journal of Oncology, 25 (4), 1119-1126.

Expression of the cell surface mucin gene family in adenocarcinomas

2003

Journal Article

Suppressor of cytokine signalling gene expression is elevated in breast carcinoma

Raccurt, M., Tam, S., Lau, W. F. P., Mertani, H. C., Lambert, A., Garcia-Caballero, T., Brown, R. J., McGuckin, M. A., Morel, G. and Waters, M. J. (2003). Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. British Journal of Cancer, 89 (3), 524-532. doi: 10.1038/sj.bjc.6601115

Suppressor of cytokine signalling gene expression is elevated in breast carcinoma

2003

Conference Publication

How can we disseminate psycho-oncology interventions to oncology and community settings? Results from a trial of a self-directed coping training program for women with cancer, and their closest support persons

Scott, JL, Halford, WK, McGuckin, MA, Ward, BG, Wetzig, NR and Pyke, C (2003). How can we disseminate psycho-oncology interventions to oncology and community settings? Results from a trial of a self-directed coping training program for women with cancer, and their closest support persons. CARLTON: AUSTRALIAN PSYCHOLOGICAL SOC.

How can we disseminate psycho-oncology interventions to oncology and community settings? Results from a trial of a self-directed coping training program for women with cancer, and their closest support persons

2002

Journal Article

Occult axillary lymph node metastases in breast cancer do matter: results of 10-year survival analysis

Cummings, M. C., Walsh, M. D., Hohn, B. G, Bennett, I. C., Wright, R. G. and McGuckin, M. A. (2002). Occult axillary lymph node metastases in breast cancer do matter: results of 10-year survival analysis. American Journal of Surgical Pathology, 26 (10), 1286-1295. doi: 10.1097/00000478-200210000-00005

Occult axillary lymph node metastases in breast cancer do matter: results of 10-year survival analysis

2002

Journal Article

Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins

Wreschner, Daniel H., McGuckin, Michael A., Williams, Stefanie J., Baruch, Amos, Yoeli, Merav, Ziv, Ravit, Okun, Liron, Zaretsky, Joseph, Smorodinsky, Nechama, Keydar, Iafa, Neophytou, Pavlos, Stacey, Martin, Lin, His-Shien and Gordon, Siamon (2002). Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein Science, 11 (3), 698-706. doi: 10.1110/ps.16502

Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins

2002

Journal Article

Expression of MUC1 splice variants in benign and malignant ovarian tumours

Obermair, A., Schmid, B. C., Packer, L. M., Leodolter, S., Birner, P., Ward, B. G., Crandon, A. J., McGuckin, M. A. and Zeillinger, R. (2002). Expression of MUC1 splice variants in benign and malignant ovarian tumours. International Journal of Cancer, 100 (2), 166-171. doi: 10.1002/ijc.10456

Expression of MUC1 splice variants in benign and malignant ovarian tumours

2001

Journal Article

MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells

Williams, Stephanie J., Wreschner, Daniel H., Mai Tran, Eyre, Helen J., Sutherland, Grant R. and McGuckin, Michael A. (2001). MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. Journal of Biological Chemistry, 276 (21), 18327-18336. doi: 10.1074/jbc.M008850200

MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells

2001

Journal Article

Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53

Fillippovich, I., Sorokina, N., Gatei, M., Haupt, Y., Hobson, K., Moallem, E., Spring, K., Mould, M., McGuckin, M. A., Lavin, M. F. and Khanna, K. K. (2001). Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53. Oncogene, 20 (4), 514-522. doi: 10.1038/sj.onc.1204118

Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53

2000

Journal Article

Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion

Quin, RJ and McGuckin, MA (2000). Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion. International Journal of Cancer, 87 (4), 499-506. doi: 10.1002/1097-0215(20000815)87:43.0.CO;2-9

Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion

2000

Journal Article

Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis

Biemer-Huttmann, A. E., Walsh, M. D., McGuckin, M. A., Simms, L. A., Young, J., Leggett, B. A. and Jass, J. R. (2000). Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clinical Cancer Research, 6 (5), 1909-1916.

Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis

1999

Journal Article

Combined inhibin and CA125 assays in the detection of ovarian cancer

Robertson, DM, Cahir, N, Burger, HG, Mamers, P, McCloud, PI, Pettersson, K and McGuckin, M (1999). Combined inhibin and CA125 assays in the detection of ovarian cancer. Clinical Chemistry, 45 (5), 651-658. doi: 10.1093/clinchem/45.5.651

Combined inhibin and CA125 assays in the detection of ovarian cancer

1999

Journal Article

Immunohistochemical staining patterms of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum

Biemer-Huttmann, A., Walsh, M. D., McGuckin, M. A., Ajioka, Y., Watanabe, H., Leggett, B. A. and Jass, J. R. (1999). Immunohistochemical staining patterms of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum. Journal of Histochemistry & Cytochemistry, 47 (8), 1039-1047. doi: 10.1177/002215549904700808

Immunohistochemical staining patterms of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum

1999

Conference Publication

Identification and characterisation of novel mucin genes in a mucin cluster on chromosome 7Q22

Williams, S., Antalis, T. M., Gotley, D. C. and McGuckin, M. A. (1999). Identification and characterisation of novel mucin genes in a mucin cluster on chromosome 7Q22. Surgical Research Society of Australasia Annual Scientific Mg, Cairns International Hotel, 23-25 Sept, 1999. Qld: Surgical Res. Society of Australasia.

Identification and characterisation of novel mucin genes in a mucin cluster on chromosome 7Q22

1999

Journal Article

The MUC3 gene encodes a transmembrane mucin and is alternatively spliced

Williams, S. J., Munster, D. J., Quin, R. J., Gotley, D. C. and McGuckin, M. A. (1999). The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Biochemical and Biophysical Research Communication, 261 (1), 83-89. doi: 10.1006/bbrc.1999.1001

The MUC3 gene encodes a transmembrane mucin and is alternatively spliced

1999

Journal Article

Two novel mucin genes down-regulated in colorectal cancer identified by different display

Williams, S., McGuckin, M. A., Gotley, L. D. C., Eyre, H., Sutherland, G. R. and Anatalis, T. (1999). Two novel mucin genes down-regulated in colorectal cancer identified by different display. Cancer Research, 15 (59), 4083-4089.

Two novel mucin genes down-regulated in colorectal cancer identified by different display

1999

Journal Article

Two novel mucin genes down-regulated in colorectal cancer identified by differential display

Williams, S., McGuckin, M. A., Gotley, D. C., Eyre, H. J., Sutherland, G. R. and Antalis, T. M. (1999). Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Research, 59 (16), 4083-4089.

Two novel mucin genes down-regulated in colorectal cancer identified by differential display

1999

Conference Publication

Patterns of expression of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas and traditional adenomas of the colorectum

Biemer-Huttmann, A., Walsh, M. D., McGuckin, M. A., Ajioka, Y., Watanabe, H., Leggett, B. A. and Jass, J. R. (1999). Patterns of expression of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas and traditional adenomas of the colorectum. Lorne, Vic., 11-14 Feb, 1999.

Patterns of expression of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas and traditional adenomas of the colorectum

Supervision

Availability

Honorary Professor Michael McGuckin is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Honorary Professor Michael McGuckin directly for media enquiries about:

  • colon cancer
  • inflammatory bowel diseases
  • inflammatory disease
  • type 2 diabetes

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