
Overview
Background
~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Cell surface mucin glycoproteins in infection, inflammation and cancer
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Inflammatory bowel diseases
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Non-cystic fibrosis bronchiectasis
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Inflammation in the pathogenesis of type 2 diabetes
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Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases
Works
Search Professor Michael McGuckin’s works on UQ eSpace
2005
Conference Publication
Real time per quantification of two mucolytic bacteria in IBD mucosa
Prig, CW, Heazlewood, SP, Story, D, Fowler, A, McGuckin, MA, Blackall, LL and Florin, TH (2005). Real time per quantification of two mucolytic bacteria in IBD mucosa. Annual Meeting of the American-Gastroenterological-Association/Digestive-Disease-Week, Chicago Il, May 14-19, 2005. PHILADELPHIA: W B SAUNDERS CO.
2005
Journal Article
The role of cell surface epithelial mucin (MUC-1) in oropharyngeal candidiasis
Farah, C. S., Ashman, R. B., McGuckin, M. A. and McAuley, J. (2005). The role of cell surface epithelial mucin (MUC-1) in oropharyngeal candidiasis. Australian Dental Journal, 50 (S1), S14-S14. doi: 10.1111/j.1834-7819.2005.tb00377.x
2005
Conference Publication
Spontaneous Apoptosis of Blood Dendritic Cells in Patients with Breast Cancer
Pinzon-Charry, Alberto, Maxwell, Tammy, McGuckin, Michael A., Schmidt, Chris, Furnival, Colin and Lopez, Jose A. (2005). Spontaneous Apoptosis of Blood Dendritic Cells in Patients with Breast Cancer. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, Conference dates. United States of America: John Wiley & Sons A/S. doi: 10.1111/j.1399-0039.2005.00523.x
2004
Journal Article
Expression of the cell surface mucin gene family in adenocarcinomas
Packer, L. M., Williams, S. J., Callaghan, S., Gotley, D. C. and McGuckin, M. A. (2004). Expression of the cell surface mucin gene family in adenocarcinomas. International Journal of Oncology, 25 (4), 1119-1126.
2003
Journal Article
Suppressor of cytokine signalling gene expression is elevated in breast carcinoma
Raccurt, M., Tam, S., Lau, W. F. P., Mertani, H. C., Lambert, A., Garcia-Caballero, T., Brown, R. J., McGuckin, M. A., Morel, G. and Waters, M. J. (2003). Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. British Journal of Cancer, 89 (3), 524-532. doi: 10.1038/sj.bjc.6601115
2003
Conference Publication
How can we disseminate psycho-oncology interventions to oncology and community settings? Results from a trial of a self-directed coping training program for women with cancer, and their closest support persons
Scott, JL, Halford, WK, McGuckin, MA, Ward, BG, Wetzig, NR and Pyke, C (2003). How can we disseminate psycho-oncology interventions to oncology and community settings? Results from a trial of a self-directed coping training program for women with cancer, and their closest support persons. CARLTON: AUSTRALIAN PSYCHOLOGICAL SOC.
2002
Journal Article
Occult axillary lymph node metastases in breast cancer do matter: results of 10-year survival analysis
Cummings, M. C., Walsh, M. D., Hohn, B. G, Bennett, I. C., Wright, R. G. and McGuckin, M. A. (2002). Occult axillary lymph node metastases in breast cancer do matter: results of 10-year survival analysis. American Journal of Surgical Pathology, 26 (10), 1286-1295. doi: 10.1097/00000478-200210000-00005
2002
Journal Article
Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins
Wreschner, Daniel H., McGuckin, Michael A., Williams, Stefanie J., Baruch, Amos, Yoeli, Merav, Ziv, Ravit, Okun, Liron, Zaretsky, Joseph, Smorodinsky, Nechama, Keydar, Iafa, Neophytou, Pavlos, Stacey, Martin, Lin, His-Shien and Gordon, Siamon (2002). Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein Science, 11 (3), 698-706. doi: 10.1110/ps.16502
2002
Journal Article
Expression of MUC1 splice variants in benign and malignant ovarian tumours
Obermair, A., Schmid, B. C., Packer, L. M., Leodolter, S., Birner, P., Ward, B. G., Crandon, A. J., McGuckin, M. A. and Zeillinger, R. (2002). Expression of MUC1 splice variants in benign and malignant ovarian tumours. International Journal of Cancer, 100 (2), 166-171. doi: 10.1002/ijc.10456
2001
Journal Article
MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells
Williams, Stephanie J., Wreschner, Daniel H., Mai Tran, Eyre, Helen J., Sutherland, Grant R. and McGuckin, Michael A. (2001). MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. Journal of Biological Chemistry, 276 (21), 18327-18336. doi: 10.1074/jbc.M008850200
2001
Journal Article
Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53
Fillippovich, I., Sorokina, N., Gatei, M., Haupt, Y., Hobson, K., Moallem, E., Spring, K., Mould, M., McGuckin, M. A., Lavin, M. F. and Khanna, K. K. (2001). Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53. Oncogene, 20 (4), 514-522. doi: 10.1038/sj.onc.1204118
2000
Journal Article
Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion
Quin, RJ and McGuckin, MA (2000). Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion. International Journal of Cancer, 87 (4), 499-506. doi: 10.1002/1097-0215(20000815)87:43.0.CO;2-9
2000
Journal Article
Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis
Biemer-Huttmann, A. E., Walsh, M. D., McGuckin, M. A., Simms, L. A., Young, J., Leggett, B. A. and Jass, J. R. (2000). Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clinical Cancer Research, 6 (5), 1909-1916.
1999
Journal Article
Combined inhibin and CA125 assays in the detection of ovarian cancer
Robertson, DM, Cahir, N, Burger, HG, Mamers, P, McCloud, PI, Pettersson, K and McGuckin, M (1999). Combined inhibin and CA125 assays in the detection of ovarian cancer. Clinical Chemistry, 45 (5), 651-658. doi: 10.1093/clinchem/45.5.651
1999
Journal Article
Immunohistochemical staining patterms of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum
Biemer-Huttmann, A., Walsh, M. D., McGuckin, M. A., Ajioka, Y., Watanabe, H., Leggett, B. A. and Jass, J. R. (1999). Immunohistochemical staining patterms of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum. Journal of Histochemistry & Cytochemistry, 47 (8), 1039-1047. doi: 10.1177/002215549904700808
1999
Conference Publication
Identification and characterisation of novel mucin genes in a mucin cluster on chromosome 7Q22
Williams, S., Antalis, T. M., Gotley, D. C. and McGuckin, M. A. (1999). Identification and characterisation of novel mucin genes in a mucin cluster on chromosome 7Q22. Surgical Research Society of Australasia Annual Scientific Mg, Cairns International Hotel, 23-25 Sept, 1999. Qld: Surgical Res. Society of Australasia.
1999
Journal Article
The MUC3 gene encodes a transmembrane mucin and is alternatively spliced
Williams, S. J., Munster, D. J., Quin, R. J., Gotley, D. C. and McGuckin, M. A. (1999). The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Biochemical and Biophysical Research Communication, 261 (1), 83-89. doi: 10.1006/bbrc.1999.1001
1999
Journal Article
Two novel mucin genes down-regulated in colorectal cancer identified by different display
Williams, S., McGuckin, M. A., Gotley, L. D. C., Eyre, H., Sutherland, G. R. and Anatalis, T. (1999). Two novel mucin genes down-regulated in colorectal cancer identified by different display. Cancer Research, 15 (59), 4083-4089.
1999
Journal Article
Two novel mucin genes down-regulated in colorectal cancer identified by differential display
Williams, S., McGuckin, M. A., Gotley, D. C., Eyre, H. J., Sutherland, G. R. and Antalis, T. M. (1999). Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Research, 59 (16), 4083-4089.
1999
Conference Publication
Patterns of expression of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas and traditional adenomas of the colorectum
Biemer-Huttmann, A., Walsh, M. D., McGuckin, M. A., Ajioka, Y., Watanabe, H., Leggett, B. A. and Jass, J. R. (1999). Patterns of expression of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas and traditional adenomas of the colorectum. Lorne, Vic., 11-14 Feb, 1999.
Supervision
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
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Supervision history
Completed supervision
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2017
Doctor Philosophy
An Investigation into The Effect of Erythromycin on Pseudomonas aeruginosa Quorum Sensing in Non-CF Bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
Principal Advisor
Other advisors: Dr Sumaira Hasnain
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2012
Doctor Philosophy
Investigations of the Biochemistry and Physiology of Mice with a Mutation in the Muc2 Intestinal Mucin Gene
Principal Advisor
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2009
Doctor Philosophy
Biology of CA125 in ovarian cancer biology
Principal Advisor
Other advisors: Professor Andreas Obermair
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2005
Doctor Philosophy
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
Principal Advisor
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2004
Doctor Philosophy
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
Principal Advisor
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2024
Doctor Philosophy
Examining the Role of Endogenous and Exogenous Interleukin-22 Signaling in Metabolic Dysfunction-Associated Steatotic Liver Disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald, Dr Sumaira Hasnain
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Dr Ran Wang, Dr Sumaira Hasnain
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2020
Doctor Philosophy
Novel dietary factors in diabetic and non-diabetic kidney disease
Associate Advisor
Other advisors: Dr Danielle Borg, Honorary Professor Josephine Forbes
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2020
Doctor Philosophy
Local Delivery of Anti-inflammatory drugs with Functionalized Silica Nanoparticles for Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Sumaira Hasnain, Professor Amirali Popat
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2019
Doctor Philosophy
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
Associate Advisor
Other advisors: Professor Mike Gidley
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2018
Doctor Philosophy
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
Associate Advisor
Other advisors: Dr Ben Ross, Professor Amirali Popat
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2009
Doctor Philosophy
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
Associate Advisor
Media
Enquiries
Contact Honorary Professor Michael McGuckin directly for media enquiries about:
- colon cancer
- inflammatory bowel diseases
- inflammatory disease
- type 2 diabetes
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