
Overview
Background
~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Cell surface mucin glycoproteins in infection, inflammation and cancer
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Inflammatory bowel diseases
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Non-cystic fibrosis bronchiectasis
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Inflammation in the pathogenesis of type 2 diabetes
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Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases
Works
Search Professor Michael McGuckin’s works on UQ eSpace
2012
Conference Publication
Incidence and severity of spondyloarthritis and Crohn's Ileitis are determined by interaction between the microbiota and genetic susceptibility in beta-glucan-treated SKG mice
Thomas, Ranjeny, Rehaume, Linda, Aguirre de Cárcer, Daniel, Mondot, Stan, Velasco, Jared, Benham, Helen, Ruutu, Merja, Morrison, Mark and McGuckin, Michael (2012). Incidence and severity of spondyloarthritis and Crohn's Ileitis are determined by interaction between the microbiota and genetic susceptibility in beta-glucan-treated SKG mice. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, 9-14 November 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.37735
2012
Book Chapter
Detecting, visualising, and quantifying mucins
Harrop, Ceri A., Thornton, David J. and McGuckin, Michael A. (2012). Detecting, visualising, and quantifying mucins. Mucins: Methods and Protocols. (pp. 49-66) edited by Michael A. McGuckin and David J. Thornton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8_3
2012
Journal Article
Preface: introduction to mucin biology and technical challenges of mucin research
McGuckin, Michael A. and Thornton, David J. (2012). Preface: introduction to mucin biology and technical challenges of mucin research. Mucins: Methods and Protocols, 842.
2012
Conference Publication
Protective and pathogenic effects of the IL-23 family of cytokines in spondyloarthropathy in SKG mice
Benham, Helen, Rehaume, Linda, Ruutu, Merja, Velasco, Jared, Kikly, Kristine, Strutton, Geoffrey, McGuckin, Michael and Thomas, Ranjeny (2012). Protective and pathogenic effects of the IL-23 family of cytokines in spondyloarthropathy in SKG mice. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, 9-14 November 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.37735
2011
Journal Article
The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
Sheng, Yong H., Lourie, Rohan, Linden, Sara K., Jeffery, Penny L., Roche, Deborah, Tran, Thu V., Png, Chin W., Waterhouse, Nigel, Sutton, Philip, Florin, Timothy H. J. and McGuckin, Michael A. (2011). The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut, 60 (12), 1661-1670. doi: 10.1136/gut.2011.239194
2011
Journal Article
Localized suppression of inflammation at sites of Helicobacter pylori colonization
Every, Alison L., Ng, Garrett Z., Skene, Caroline D., Harbour, Stacey N., Walduck, Anna K., McGuckin, Michael A. and Sutton, Philip (2011). Localized suppression of inflammation at sites of Helicobacter pylori colonization. Infection and Immunity, 79 (10), 4186-4192. doi: 10.1128/IAI.05602-11
2011
Conference Publication
Intestinal secretory cell ER stress and inflammation
McGuckin, Michael A., Eri, Rajaraman D., Das, Indrajit, Lourie, Rohan and Florin, Timothy H. (2011). Intestinal secretory cell ER stress and inflammation. London, United Kingdom: Portland Press. doi: 10.1042/BST0391081
2011
Journal Article
Ghrelin in gastrointestinal disease
Jeffery, Penny, McDonald, Victoria, Tippett, Emma and McGuckin, Michael (2011). Ghrelin in gastrointestinal disease. Molecular and Cellular Endocrinology, 340 (1), 35-43. doi: 10.1016/j.mce.2011.03.002
2011
Journal Article
An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity
Eri, R. D., Adams, R. J., Tran, T. V., Tong. H., Das. I., Roche, D. K., Oancea, I., Png, C. W., Jeffery, P. L., Radford-Smith, G.L., Cook, M. C., Florin, T. H. and McGuckin, M. A. (2011). An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunology, 4 (3), 354-364. doi: 10.1038/mi.2010.74
2011
Journal Article
Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase
Jeffery, Penny L., McGuckin, Michael A. and Linden, Sara K. (2011). Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase. World Journal of Gastroenterology, 17 (10), 1249-1260. doi: 10.3748/wjg.v17.i10.1249
2011
Journal Article
No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection
McPherson, Stuart, Powell, Elizabeth E., Barrie, Helen D., Clouston, Andrew D., McGuckin, Michael and Jonsson, Julie R. (2011). No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection. Journal of Gastroenterology and Hepatalogy, 26 (2), 319-327. doi: 10.1111/j.1440-1746.2010.06368.x
2011
Conference Publication
The Role of Gut Microflora and Autoreactive CD4+T Cells in the Development of Spondyloarthritis and Inflammatory Bowel Disease in Beta-Glucan-Treated SKG Mice
Ruutu, Merja, Velasco, Jared, Aguirre, Daniel, Benham, Helen, Morrison, Mark, McGuckin, Michael and Thomas, Ranjeny (2011). The Role of Gut Microflora and Autoreactive CD4+T Cells in the Development of Spondyloarthritis and Inflammatory Bowel Disease in Beta-Glucan-Treated SKG Mice. 75th Annual Scientific Meeting of the American College of Rheumatology/46th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Chicago, IL, United States, 4-9 November 2011. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.33310
2011
Conference Publication
The MUC13 Cell Surface Mucin Protects Against Intestinal Inflammation by Inhibiting Epithelial Cell Apoptosis
Sheng, YH, Lourie, R, Linden, SK, Jeffery, P, Roche, DK, Tran, TV, Png, CW, Waterhouse, N, Sutton, P, Florin, TH and McGuckin, MA (2011). The MUC13 Cell Surface Mucin Protects Against Intestinal Inflammation by Inhibiting Epithelial Cell Apoptosis. Conference on Digestive Disease Week 2011, Chicago Il, May 07-10, 2011. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
2011
Journal Article
Mucin dynamics and enteric pathogens
McGuckin, Michael A., Linden, Sara K., Sutton, Philip and Florin, Timothy H. (2011). Mucin dynamics and enteric pathogens. Nature Reviews Microbiology, 9 (4), 265-278. doi: 10.1038/nrmicro2538
2011
Conference Publication
Pepsin as a Marker of Aspiration in the Exhaled Breath Condensate of Patients with Cystic Fibrosis: a Pilot Study
Mubarak, V, Bowler, S, Serisier, D and Mcguckin, M (2011). Pepsin as a Marker of Aspiration in the Exhaled Breath Condensate of Patients with Cystic Fibrosis: a Pilot Study. Unknown, unknown, unknown. MALDEN: WILEY-BLACKWELL.
2011
Conference Publication
Microbiome shifts with 6-thioguanine provide insights about IBD and its treatment
De Carcer, D. Aguirre, Oancea, I., Das, I., Mcguckin, M., Duley, J., Morrison, M. and Florin, T. (2011). Microbiome shifts with 6-thioguanine provide insights about IBD and its treatment. Australian Gastroenterology Week 2011, South Bank, QLD, Australia, 12–15 September 2011. MALDEN: WILEY-BLACKWELL. doi: 10.1111/j.1440-1746.2011.06820.x
2010
Journal Article
Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
Png, CW, Linden, SK, Gilshenan, KS, Zoetendal, EG, McSweeney, CS, Sly, LI, McGuckin, MA and Florin, THJ (2010). Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. American Journal of Gastroenterology, 105 (11), 2420-2428. doi: 10.1038/ajg.2010.281
2010
Conference Publication
Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the colon CFR
Walsh, M. D., Cummings, M. C., Buchanan, D. D., Arnold, S., Mckeone, D. M., Walters, R., Hopper, J. L., Jenkins, M. A., Mcguckin, M. A. and Young, J. (2010). Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the colon CFR. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
2010
Journal Article
KCNN4 gene variant is associated with ileal Crohn's disease in the Australian and New Zealand population
Simms, Lisa A., Doecke, James D., Roberts, Rebecca L., Fowler, Elizabeth V., Zhao, Zhen Zhen, McGuckin, Michael A., Huang, Ning, Hayward, Nicholas K., Webb, Penelope M., Whiteman, David C., Cavanaugh, Juleen A., McCallum, Ruth, Florin, Timothy H. J., Barclay, Murray L., Gearry, Richard B., Merriman, Tony R., Montgomery, Grant W. and Radford-Smith, Graham L. (2010). KCNN4 gene variant is associated with ileal Crohn's disease in the Australian and New Zealand population. American Journal of Gastroenterology, 105 (10), 2209-2217. doi: 10.1038/ajg.2010.161
2010
Journal Article
Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms
Tan, Lorwai, Psaltis, Alkis, Baker, Leonie M., Mcguckin, Mike, Rousseau, Karine and Wormald, Peter-John (2010). Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms. American Journal of Rhinology & Allergy, 24 (5), 319-324. doi: 10.2500/ajra.2010.24.3504
Supervision
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
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Supervision history
Completed supervision
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2017
Doctor Philosophy
An Investigation into The Effect of Erythromycin on Pseudomonas aeruginosa Quorum Sensing in Non-CF Bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
Principal Advisor
Other advisors: Dr Sumaira Hasnain
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2012
Doctor Philosophy
Investigations of the Biochemistry and Physiology of Mice with a Mutation in the Muc2 Intestinal Mucin Gene
Principal Advisor
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2009
Doctor Philosophy
Biology of CA125 in ovarian cancer biology
Principal Advisor
Other advisors: Professor Andreas Obermair
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2005
Doctor Philosophy
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
Principal Advisor
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2004
Doctor Philosophy
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
Principal Advisor
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2024
Doctor Philosophy
Examining the Role of Endogenous and Exogenous Interleukin-22 Signaling in Metabolic Dysfunction-Associated Steatotic Liver Disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald, Dr Sumaira Hasnain
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Dr Ran Wang, Dr Sumaira Hasnain
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2020
Doctor Philosophy
Novel dietary factors in diabetic and non-diabetic kidney disease
Associate Advisor
Other advisors: Dr Danielle Borg, Honorary Professor Josephine Forbes
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2020
Doctor Philosophy
Local Delivery of Anti-inflammatory drugs with Functionalized Silica Nanoparticles for Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Sumaira Hasnain, Professor Amirali Popat
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2019
Doctor Philosophy
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
Associate Advisor
Other advisors: Professor Mike Gidley
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2018
Doctor Philosophy
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
Associate Advisor
Other advisors: Dr Ben Ross, Professor Amirali Popat
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2009
Doctor Philosophy
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
Associate Advisor
Media
Enquiries
Contact Honorary Professor Michael McGuckin directly for media enquiries about:
- colon cancer
- inflammatory bowel diseases
- inflammatory disease
- type 2 diabetes
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