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Honorary Professor Michael McGuckin
Honorary Professor

Michael McGuckin

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Overview

Background

~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.

Availability

Honorary Professor Michael McGuckin is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Science, The University of Queensland
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Cell surface mucin glycoproteins in infection, inflammation and cancer

  • Inflammatory bowel diseases

  • Non-cystic fibrosis bronchiectasis

  • Inflammation in the pathogenesis of type 2 diabetes

  • Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases

Works

Search Professor Michael McGuckin’s works on UQ eSpace

253 works between 1987 and 2024

121 - 140 of 253 works

2012

Conference Publication

Incidence and severity of spondyloarthritis and Crohn's Ileitis are determined by interaction between the microbiota and genetic susceptibility in beta-glucan-treated SKG mice

Thomas, Ranjeny, Rehaume, Linda, Aguirre de Cárcer, Daniel, Mondot, Stan, Velasco, Jared, Benham, Helen, Ruutu, Merja, Morrison, Mark and McGuckin, Michael (2012). Incidence and severity of spondyloarthritis and Crohn's Ileitis are determined by interaction between the microbiota and genetic susceptibility in beta-glucan-treated SKG mice. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, 9-14 November 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.37735

Incidence and severity of spondyloarthritis and Crohn's Ileitis are determined by interaction between the microbiota and genetic susceptibility in beta-glucan-treated SKG mice

2012

Book Chapter

Detecting, visualising, and quantifying mucins

Harrop, Ceri A., Thornton, David J. and McGuckin, Michael A. (2012). Detecting, visualising, and quantifying mucins. Mucins: Methods and Protocols. (pp. 49-66) edited by Michael A. McGuckin and David J. Thornton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8_3

Detecting, visualising, and quantifying mucins

2012

Journal Article

Preface: introduction to mucin biology and technical challenges of mucin research

McGuckin, Michael A. and Thornton, David J. (2012). Preface: introduction to mucin biology and technical challenges of mucin research. Mucins: Methods and Protocols, 842.

Preface: introduction to mucin biology and technical challenges of mucin research

2012

Conference Publication

Protective and pathogenic effects of the IL-23 family of cytokines in spondyloarthropathy in SKG mice

Benham, Helen, Rehaume, Linda, Ruutu, Merja, Velasco, Jared, Kikly, Kristine, Strutton, Geoffrey, McGuckin, Michael and Thomas, Ranjeny (2012). Protective and pathogenic effects of the IL-23 family of cytokines in spondyloarthropathy in SKG mice. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, 9-14 November 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.37735

Protective and pathogenic effects of the IL-23 family of cytokines in spondyloarthropathy in SKG mice

2011

Journal Article

The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis

Sheng, Yong H., Lourie, Rohan, Linden, Sara K., Jeffery, Penny L., Roche, Deborah, Tran, Thu V., Png, Chin W., Waterhouse, Nigel, Sutton, Philip, Florin, Timothy H. J. and McGuckin, Michael A. (2011). The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut, 60 (12), 1661-1670. doi: 10.1136/gut.2011.239194

The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis

2011

Journal Article

Localized suppression of inflammation at sites of Helicobacter pylori colonization

Every, Alison L., Ng, Garrett Z., Skene, Caroline D., Harbour, Stacey N., Walduck, Anna K., McGuckin, Michael A. and Sutton, Philip (2011). Localized suppression of inflammation at sites of Helicobacter pylori colonization. Infection and Immunity, 79 (10), 4186-4192. doi: 10.1128/IAI.05602-11

Localized suppression of inflammation at sites of Helicobacter pylori colonization

2011

Conference Publication

Intestinal secretory cell ER stress and inflammation

McGuckin, Michael A., Eri, Rajaraman D., Das, Indrajit, Lourie, Rohan and Florin, Timothy H. (2011). Intestinal secretory cell ER stress and inflammation. London, United Kingdom: Portland Press. doi: 10.1042/BST0391081

Intestinal secretory cell ER stress and inflammation

2011

Journal Article

Ghrelin in gastrointestinal disease

Jeffery, Penny, McDonald, Victoria, Tippett, Emma and McGuckin, Michael (2011). Ghrelin in gastrointestinal disease. Molecular and Cellular Endocrinology, 340 (1), 35-43. doi: 10.1016/j.mce.2011.03.002

Ghrelin in gastrointestinal disease

2011

Journal Article

An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity

Eri, R. D., Adams, R. J., Tran, T. V., Tong. H., Das. I., Roche, D. K., Oancea, I., Png, C. W., Jeffery, P. L., Radford-Smith, G.L., Cook, M. C., Florin, T. H. and McGuckin, M. A. (2011). An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunology, 4 (3), 354-364. doi: 10.1038/mi.2010.74

An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity

2011

Journal Article

Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase

Jeffery, Penny L., McGuckin, Michael A. and Linden, Sara K. (2011). Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase. World Journal of Gastroenterology, 17 (10), 1249-1260. doi: 10.3748/wjg.v17.i10.1249

Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase

2011

Journal Article

No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection

McPherson, Stuart, Powell, Elizabeth E., Barrie, Helen D., Clouston, Andrew D., McGuckin, Michael and Jonsson, Julie R. (2011). No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection. Journal of Gastroenterology and Hepatalogy, 26 (2), 319-327. doi: 10.1111/j.1440-1746.2010.06368.x

No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection

2011

Conference Publication

The Role of Gut Microflora and Autoreactive CD4+T Cells in the Development of Spondyloarthritis and Inflammatory Bowel Disease in Beta-Glucan-Treated SKG Mice

Ruutu, Merja, Velasco, Jared, Aguirre, Daniel, Benham, Helen, Morrison, Mark, McGuckin, Michael and Thomas, Ranjeny (2011). The Role of Gut Microflora and Autoreactive CD4+T Cells in the Development of Spondyloarthritis and Inflammatory Bowel Disease in Beta-Glucan-Treated SKG Mice. 75th Annual Scientific Meeting of the American College of Rheumatology/46th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Chicago, IL, United States, 4-9 November 2011. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.33310

The Role of Gut Microflora and Autoreactive CD4+T Cells in the Development of Spondyloarthritis and Inflammatory Bowel Disease in Beta-Glucan-Treated SKG Mice

2011

Conference Publication

The MUC13 Cell Surface Mucin Protects Against Intestinal Inflammation by Inhibiting Epithelial Cell Apoptosis

Sheng, YH, Lourie, R, Linden, SK, Jeffery, P, Roche, DK, Tran, TV, Png, CW, Waterhouse, N, Sutton, P, Florin, TH and McGuckin, MA (2011). The MUC13 Cell Surface Mucin Protects Against Intestinal Inflammation by Inhibiting Epithelial Cell Apoptosis. Conference on Digestive Disease Week 2011, Chicago Il, May 07-10, 2011. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

The MUC13 Cell Surface Mucin Protects Against Intestinal Inflammation by Inhibiting Epithelial Cell Apoptosis

2011

Journal Article

Mucin dynamics and enteric pathogens

McGuckin, Michael A., Linden, Sara K., Sutton, Philip and Florin, Timothy H. (2011). Mucin dynamics and enteric pathogens. Nature Reviews Microbiology, 9 (4), 265-278. doi: 10.1038/nrmicro2538

Mucin dynamics and enteric pathogens

2011

Conference Publication

Pepsin as a Marker of Aspiration in the Exhaled Breath Condensate of Patients with Cystic Fibrosis: a Pilot Study

Mubarak, V, Bowler, S, Serisier, D and Mcguckin, M (2011). Pepsin as a Marker of Aspiration in the Exhaled Breath Condensate of Patients with Cystic Fibrosis: a Pilot Study. Unknown, unknown, unknown. MALDEN: WILEY-BLACKWELL.

Pepsin as a Marker of Aspiration in the Exhaled Breath Condensate of Patients with Cystic Fibrosis: a Pilot Study

2011

Conference Publication

Microbiome shifts with 6-thioguanine provide insights about IBD and its treatment

De Carcer, D. Aguirre, Oancea, I., Das, I., Mcguckin, M., Duley, J., Morrison, M. and Florin, T. (2011). Microbiome shifts with 6-thioguanine provide insights about IBD and its treatment. Australian Gastroenterology Week 2011, South Bank, QLD, Australia, 12–15 September 2011. MALDEN: WILEY-BLACKWELL. doi: 10.1111/j.1440-1746.2011.06820.x

Microbiome shifts with 6-thioguanine provide insights about IBD and its treatment

2010

Journal Article

Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria

Png, CW, Linden, SK, Gilshenan, KS, Zoetendal, EG, McSweeney, CS, Sly, LI, McGuckin, MA and Florin, THJ (2010). Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. American Journal of Gastroenterology, 105 (11), 2420-2428. doi: 10.1038/ajg.2010.281

Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria

2010

Conference Publication

Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the colon CFR

Walsh, M. D., Cummings, M. C., Buchanan, D. D., Arnold, S., Mckeone, D. M., Walters, R., Hopper, J. L., Jenkins, M. A., Mcguckin, M. A. and Young, J. (2010). Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the colon CFR. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.

Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the colon CFR

2010

Journal Article

KCNN4 gene variant is associated with ileal Crohn's disease in the Australian and New Zealand population

Simms, Lisa A., Doecke, James D., Roberts, Rebecca L., Fowler, Elizabeth V., Zhao, Zhen Zhen, McGuckin, Michael A., Huang, Ning, Hayward, Nicholas K., Webb, Penelope M., Whiteman, David C., Cavanaugh, Juleen A., McCallum, Ruth, Florin, Timothy H. J., Barclay, Murray L., Gearry, Richard B., Merriman, Tony R., Montgomery, Grant W. and Radford-Smith, Graham L. (2010). KCNN4 gene variant is associated with ileal Crohn's disease in the Australian and New Zealand population. American Journal of Gastroenterology, 105 (10), 2209-2217. doi: 10.1038/ajg.2010.161

KCNN4 gene variant is associated with ileal Crohn's disease in the Australian and New Zealand population

2010

Journal Article

Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms

Tan, Lorwai, Psaltis, Alkis, Baker, Leonie M., Mcguckin, Mike, Rousseau, Karine and Wormald, Peter-John (2010). Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms. American Journal of Rhinology & Allergy, 24 (5), 319-324. doi: 10.2500/ajra.2010.24.3504

Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms

Supervision

Availability

Honorary Professor Michael McGuckin is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Honorary Professor Michael McGuckin directly for media enquiries about:

  • colon cancer
  • inflammatory bowel diseases
  • inflammatory disease
  • type 2 diabetes

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