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Honorary Professor Michael McGuckin
Honorary Professor

Michael McGuckin

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Overview

Background

~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.

Availability

Honorary Professor Michael McGuckin is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Science, The University of Queensland
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Cell surface mucin glycoproteins in infection, inflammation and cancer

  • Inflammatory bowel diseases

  • Non-cystic fibrosis bronchiectasis

  • Inflammation in the pathogenesis of type 2 diabetes

  • Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases

Works

Search Professor Michael McGuckin’s works on UQ eSpace

253 works between 1987 and 2024

61 - 80 of 253 works

2016

Journal Article

Oxidative and endoplasmic reticulum stress in beta-cell dysfunction in diabetes

Hasnain, Sumaira Z., Prins, Johannes B. and McGuckin, Michael A. (2016). Oxidative and endoplasmic reticulum stress in beta-cell dysfunction in diabetes. Journal of Molecular Endocrinology, 56 (2), R33-R54. doi: 10.1530/jme-15-0232

Oxidative and endoplasmic reticulum stress in beta-cell dysfunction in diabetes

2016

Journal Article

Epithelial sel1L is required for the maintenance of intestinal homeostasis

Sun, Shengyi, Lourie, Rohan, Cohen, Sara B., Ji, Yewei, Goodrich, Julia K., Poole, Angela C., Ley, Ruth E., Denkers, Eric Y., McGuckin, Michael A., Long, Qiaoming, Duhamel, Gerald E., Simpson, Kenneth W. and Qi, Ling (2016). Epithelial sel1L is required for the maintenance of intestinal homeostasis. Molecular Biology of the Cell, 27 (3), 483-490. doi: 10.1091/mbc.E15-10-0724

Epithelial sel1L is required for the maintenance of intestinal homeostasis

2016

Conference Publication

Unravelling a novel mechanism by which cytokines induce ER stress to halt viral protein synthesis in mucosal epithelial cells

Hasnain, S. Z., Taylor, S., Wang, R., Chen, A., Oancea, I, Das, I, Tong, H., Florin, T., Serisier, D., Coulson, B., Mcauley, J., Lourie, R., Phipps, S. and Mcguckin, M. (2016). Unravelling a novel mechanism by which cytokines induce ER stress to halt viral protein synthesis in mucosal epithelial cells. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200

Unravelling a novel mechanism by which cytokines induce ER stress to halt viral protein synthesis in mucosal epithelial cells

2016

Conference Publication

High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22

Gulhane, M., Lourie, R., Tong, H., Kang, A., Schreiber, V., Magor, G., Denman, S., Begun, J., Florin, T., Perkins, A., O Cuiv, P., Mcguckin, M. and Hasnain, S. Z. (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21–26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200

High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22

2016

Journal Article

FUT2 genotype influences lung function, exacerbation frequency and airway microbiota in non-CF bronchiectasis

Taylor, Steven L., Woodman, Richard J., Chen, Alice C. H., Burr, Lucy D., Gordon, David L., McGuckin, Michael A., Wesselingh, Steve and Rogers, Geraint B. (2016). FUT2 genotype influences lung function, exacerbation frequency and airway microbiota in non-CF bronchiectasis. Thorax, 72 (4), 304-310. doi: 10.1136/thoraxjnl-2016-208775

FUT2 genotype influences lung function, exacerbation frequency and airway microbiota in non-CF bronchiectasis

2016

Conference Publication

Erythromycin Inhibits Expression Of P. AerugINOSa Quorum Sensing Genes In The Airways Of Non-Cf Bronchiectasis Subjects Recruited To The Bless Randomised Controlled Trial

Burr, L. D., Rogers, G. B., Chen, A. C., Taylor, S., Bowler, S., Serisier, D. and McGuckin, M. (2016). Erythromycin Inhibits Expression Of P. AerugINOSa Quorum Sensing Genes In The Airways Of Non-Cf Bronchiectasis Subjects Recruited To The Bless Randomised Controlled Trial. International Conference of the American-Thoracic-Society (ATS), San Francisco Ca, May 13-18, 2016. New York, NY, United States: American Thoracic Society.

Erythromycin Inhibits Expression Of P. AerugINOSa Quorum Sensing Genes In The Airways Of Non-Cf Bronchiectasis Subjects Recruited To The Bless Randomised Controlled Trial

2016

Conference Publication

MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target

Sheng, Yong H., He, Yaowu, Hasnain, Sumaira Z., Wang, Ran, Tong, Hui, Clarke, Daniel T., Lourie, Rohan, Oancea, Lulia, Wong, Kuanyau, Lumley, John W., Florin, Timothy H., Sutton, Philip, Hooper, John. D., Mcmillan, Nigel A. and Mcguckin, Michael A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target. AACR 107th Annual Meeting on Bioinformatics and Systems Biology, New Orleans, Los Angeles, 16-20 April 2016 . Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2016-3564

MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target

2015

Conference Publication

IL-22-mediated suppression of islet inflammation

McGuckin, Mike, Hasnain, Sumaira Z., Borg, Danielle J., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathon P., Forbes, Josephine M. and Prins, John B. (2015). IL-22-mediated suppression of islet inflammation. IPITA/IXA/CTS Joint Congress, Melbourne Australia, Nov 15-19, 2015. HOBOKEN: LIPPINCOTT WILLIAMS & WILKINS.

IL-22-mediated suppression of islet inflammation

2015

Journal Article

Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis

Taylor, Steven L., Rogers, Geraint B., Chen, Alice C.-H., Burr, Lucy D., McGuckin, Michael A. and Serisier, David J. (2015). Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis. Annals of the American Thoracic Society, 12 (5), 701-707. doi: 10.1513/AnnalsATS.201411-513OC

Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis

2015

Journal Article

Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model

Wang, Ran, Hasnain, Sumaira Z., Tong, Hui, Das, Indrajit, Che-Hao Chen, Alice, Oancea, Iulia, Proctor, Martina, Florin, Timothy H., Eri, Rajaraman D. and McGuckin, Michael A. (2015). Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model. Inflammatory Bowel Diseases, 21 (5), 973-984. doi: 10.1097/MIB.0000000000000353

Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model

2015

Journal Article

The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome

Ng, Garrett Z., Menheniott, Trevelyan R., Every, Alison L., Stent, Andrew, Judd, Louise M., Chionh, Yok Teng, Dhar, Poshmaal, Komen, Jasper C., Giraud, Andrew S., Wang, Timothy C., McGuckin, Michael A. and Sutton, Philip (2015). The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome. Gut, 65 (7), 1-13. doi: 10.1136/gutjnl-2014-307175

The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome

2015

Journal Article

Adult non-cystic fibrosis bronchiectasis is characterised by airway luminal Th17 pathway activation

Chen, Alice C.-H., Martin, Megan L., Lourie, Rohan, Rogers, Geraint B., Burr, Lucy D., Hasnain, Sumaira Z., Bowler, Simon D., McGuckin, Michael A. and Serisier, David J. (2015). Adult non-cystic fibrosis bronchiectasis is characterised by airway luminal Th17 pathway activation. PLoS ONE, 10 (3) e0119325, e0119325. doi: 10.1371/journal.pone.0119325

Adult non-cystic fibrosis bronchiectasis is characterised by airway luminal Th17 pathway activation

2015

Conference Publication

High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease

Gulhane, M., Murray, L., Wang, R., Tong, H., Mcguckin, M. and Hasnain, S. (2015). High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13094

High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease

2015

Conference Publication

Sub inhibitory erythromycin reduces the expression of key P. aeruginosa virulence determinants in vitro

Burr, L., Rogers, G., Taylor, S., McGuckin, M. and Serisier, D. (2015). Sub inhibitory erythromycin reduces the expression of key P. aeruginosa virulence determinants in vitro. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Gold Coast, Australia, 27 March – 1 April 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12495_14

Sub inhibitory erythromycin reduces the expression of key P. aeruginosa virulence determinants in vitro

2015

Conference Publication

IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION

McGuckin, Mike, Hasnain, Sumaira Z., Borg, Danielle J., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathon P., Forbes, Josephine M. and Prins, John B. (2015). IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION. Joint Congress of the International-Pancreas-and-Islet-Transplantation-Association, International-Xenotransplantation-Association and Cell-Transplant-Society, Melbourne Australia, Nov 15-19, 2015. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION

2015

Conference Publication

Sub inhibitory erythromycin reduces the expression of key P. aeruginosa virulence determinants in non-CF bronchiectasis subjects

Burr, L., Rogers, G., Taylor, S., McGuckin, M. and Serisier, D. (2015). Sub inhibitory erythromycin reduces the expression of key P. aeruginosa virulence determinants in non-CF bronchiectasis subjects. Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015, Queensland Australia, Mar 27-Apr 01, 2015. Hoboken, NJ United States: Wiley-Blackwell.

Sub inhibitory erythromycin reduces the expression of key P. aeruginosa virulence determinants in non-CF bronchiectasis subjects

2015

Conference Publication

Collagen protease levels vary with airway microbiota composition and lung function in bronchiectasis

Taylor, S., Rogers, G., Chen, A., Burr, L., McGuckin, M. and Serisier, D. (2015). Collagen protease levels vary with airway microbiota composition and lung function in bronchiectasis. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Gold Coast, Australia, 27 March – 1 April 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12495_14

Collagen protease levels vary with airway microbiota composition and lung function in bronchiectasis

2015

Book Chapter

Mucins and mucus

McGuckin, Michael A., Thornton, David J. and Whitsett, Jeffrey A. (2015). Mucins and mucus. Mucosal immunology: fourth edition. (pp. 231-250) edited by Jiri Mestecky, Warren Strober, Michael W. Russell, Brian L. Kelsall, Hilde Cheroutre and Bart N. Lambrecht. Kidlington, Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-12-415847-4.00014-8

Mucins and mucus

2014

Journal Article

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonghua H., Ng, Choa Ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014). Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12), 1417-1426. doi: 10.1038/nm.3705

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

Featured

2014

Journal Article

ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice

Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014). ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 (10), 2780-2792. doi: 10.1002/art.38773

ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice

Supervision

Availability

Honorary Professor Michael McGuckin is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Honorary Professor Michael McGuckin directly for media enquiries about:

  • colon cancer
  • inflammatory bowel diseases
  • inflammatory disease
  • type 2 diabetes

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