
Overview
Background
~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Cell surface mucin glycoproteins in infection, inflammation and cancer
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Inflammatory bowel diseases
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Non-cystic fibrosis bronchiectasis
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Inflammation in the pathogenesis of type 2 diabetes
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Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases
Works
Search Professor Michael McGuckin’s works on UQ eSpace
2014
Journal Article
Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice
Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014). Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 (7), 1755-1767. doi: 10.1002/art.38638
2014
Journal Article
Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
Rogers, G. B., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S. E., Mason, A. J., McGuckin, M. A. and Bruce, K. D. (2014). Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice. Scientific Reports, 4 (1) 5437. doi: 10.1038/srep05437
2014
Journal Article
A novel microbiota stratification system predicts future exacerbations in bronchiectasis
Rogers, Geraint B., Zain, Nur Masirah M., Bruce, Kenneth D., Burr, Lucy D., Chen, Alice C., Rivett, Damian W., McGuckin, Michael A. and Serisier, David J. (2014). A novel microbiota stratification system predicts future exacerbations in bronchiectasis. Annals of the American Thoracic Society, 11 (4), 496-503. doi: 10.1513/AnnalsATS.201310-335OC
2014
Conference Publication
IL-23 and IL-24 Upregulate Pro-Inflammatory Chemokine Genes in Colonic Epithelial Cells
Lourie, R., Hasnain, S. Z., McGuckin, M. A. and Florin, T. H. (2014). IL-23 and IL-24 Upregulate Pro-Inflammatory Chemokine Genes in Colonic Epithelial Cells. 103rd Annual Meeting of the United States and Canadian Academy of Pathology (USCAP), San Diego, California, 1-7 March 2014. London, United Kingdom: Nature Publishing Group.
2014
Conference Publication
Is geographic variability of incidence and prevalence of Crohn's Disease linked to Helicobacter pylori? An ecologic study
Shah, A., Talley, N. J., Walker, M., Koloski, N., Shanahan, E. R., Morrison, M., Burger, D., Andrews, J. M., Mcguckin, M., Jones, M. and Holtmann, G. (2014). Is geographic variability of incidence and prevalence of Crohn's Disease linked to Helicobacter pylori? An ecologic study. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22-24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_6
2014
Journal Article
Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells
Speckmann, Bodo, Gerloff, Kirsten, Simms, Lisa, Oancea, Iulia, Shi, Wei, McGuckin, Michael A., Radford-Smith, Graham and Khanna, Kum Kum (2014). Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. Free Radical Biology and Medicine, 67, 265-277. doi: 10.1016/j.freeradbiomed.2013.11.001
2014
Conference Publication
Peroxisome Proliferator Activated Receptor. Gene Expression In The Airways Of Non Cystic Fibrosis Bronchiectasis Subjects Is Lower Than Healthy Controls And Inversely Correlated To Total Pseudomonas AerugINOSa Bacterial Load At Baseline Entry Into A Clinical Trial
Burr, L. D., Rogers, G., Chen, A., McGuckin, M. and Serisier, D. J. (2014). Peroxisome Proliferator Activated Receptor. Gene Expression In The Airways Of Non Cystic Fibrosis Bronchiectasis Subjects Is Lower Than Healthy Controls And Inversely Correlated To Total Pseudomonas AerugINOSa Bacterial Load At Baseline Entry Into A Clinical Trial. NEW YORK: AMER THORACIC SOC.
2014
Conference Publication
Clinical Benefits of Long-Term, Low-Dose Erythromycin in Bronchiectasis Are Not Due to Modulation of Sputum Mucin Content
Chen, A., Martin, M., Lourie, R., Burr, L., Hasnain, S., Bowler, S., Mcguckin, M. and Serisier, D. (2014). Clinical Benefits of Long-Term, Low-Dose Erythromycin in Bronchiectasis Are Not Due to Modulation of Sputum Mucin Content. Annual Scientific Meeting of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2014, Adelaide, SA Australia, 4-9 April 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12263_6
2014
Conference Publication
IL-22 May Maintain Colonic Mucosal Barrier Function by Overriding ROS-Induced ER Stress and Chemokine Production in Colonic Epithelial Cells
Lourie, Rohan, Hasnain, Sumaira Z., McGuckin, Michael A. and Florin, Timothy H. (2014). IL-22 May Maintain Colonic Mucosal Barrier Function by Overriding ROS-Induced ER Stress and Chemokine Production in Colonic Epithelial Cells. Digestive Disease Week 2014, Chicago, Illinois, 3-6 May 2014. Maryland Heights, MO, United States: W.B. Saunders Co..
2014
Conference Publication
Direct Adverse Effects of IL-23 on Epithelial Cells Underline Greater Efficacy of Neutralizing IL-23 in Suppressing Murine Colitis
Wang, Ran, Hasnain, Sumaira Z., Tong, Hui, Lourie, Rohan, Florin, Timothy H. and McGuckin, Michael A. (2014). Direct Adverse Effects of IL-23 on Epithelial Cells Underline Greater Efficacy of Neutralizing IL-23 in Suppressing Murine Colitis. 55th Annual Meeting of the Society for Surgery of the Alimentary Tract (SSAT) / Digestive Disease Week (DDW), Chicago, Il, United States, May 03-06, 2014. Maryland Heights, MO, United States: W.B. Saunders Co.. doi: 10.1016/S0016-5085(14)62987-5
2014
Conference Publication
Human Neutrophil Elastase Activity and Matrix Metalloproteinase Activity Are Markers of Disease Severity in Non-Cf Bronchiectasis
Chen, A., Lourie, R., Martin, M., Burr, L., Hasnain, S., Fantino, E., Bowler, S., Mcguckin, M. and Serisier, D. (2014). Human Neutrophil Elastase Activity and Matrix Metalloproteinase Activity Are Markers of Disease Severity in Non-Cf Bronchiectasis. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2014 Annual Scientific Meetings, Adelaide Australia, 4-9 April 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12263_6
2013
Conference Publication
Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery
Winkler, Ingrid G., Barbier, Valerie, Nutt, Heather L., Hasnain, Sumaira Z., Levesque, Jean-Pierre, Magnani, John L. and McGuckin, Michael A. (2013). Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, Dec 07-10, 2013. WASHINGTON: AMER SOC HEMATOLOGY.
2013
Journal Article
Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins
Walsh, Michael D., Cummings, Margaret C., Pearson, Sally-Ann, Clendenning, Mark, Walters, Rhiannon J., Nagler, Belinda, Hopper, John L., Jenkins, Mark A., Suthers, Graeme K., Goldblatt, Jack, Tucker, Kathy, Gattas, Michael R., Arnold, Julie L., Parry, Susan, Macrae, Finlay A., McGuckin, Michael A., Young, Joanne P. and Buchanan, Daniel D. (2013). Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins. Modern Pathology, 26 (7), 944-954. doi: 10.1038/modpathol.2012.232
2013
Journal Article
Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation
Navabi, Nazanin, McGuckin, Michael A. and Linden, Sara K. (2013). Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation. PLoS One, 8 (7) e68761, e68761.1-e68761.15. doi: 10.1371/journal.pone.0068761
2013
Journal Article
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins
Das, Indrajit, Png, Chin Wen, Oancea, Iulia, Hasnain, Sumaira Z., Lourie, Rohan, Proctor, Martina, Eri, Rajaraman D., Sheng, Yong, Crane, Denis I., Florin, Timothy H. and McGuckin, Michael A. (2013). Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. Journal of Experimental Medicine, 210 (6), 1201-1216. doi: 10.1084/jem.20121268
2013
Journal Article
MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli
Sheng, Y. H., Triyana, S., Wang, R., Das, I., Gerloff, K., Florin, T. H., Sutton, P. and McGuckin, M. A. (2013). MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunology, 6 (3), 557-568. doi: 10.1038/mi.2012.98
2013
Journal Article
A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity
Oancea, Iulia, Png, Chin Wen, Das, Indrajit, Lourie, Rohan, Winkler, Ingrid G., Eri, Rajaraman, Subramaniam, Nathan, Jinnah, H. A., McWhinney, Brett C., Levesque, Jean-Pierre, McGuckin, Michael A., Duley, John A. and Florin, Timothy H. J. (2013). A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity. Gut, 62 (4), 594-605. doi: 10.1136/gutjnl-2012-302274
2013
Journal Article
A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system
Gorrell, Rebecca J., Guan, Jyeswei, Xin, Yue, Tafreshi, Mona Anoushiravani, Hutton, Melanie L., McGuckin, Michael A., Ferrero, Richard L. and Kwok, Terry (2013). A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system. Cellular Microbiology, 15 (4), 554-570. doi: 10.1111/cmi.12055
2013
Journal Article
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice
Sina, Christian, Lipinski, Simone, Gavrilova, Olga, Aden, Konrad, Rehman, Ateequr, Till, Andreas, Rittger, Andrea, Podschun, Rainer, Meyer-Hoffert, Ulf, Haesler, Robert, Midtling, Emilie, Puetsep, Katrin, McGuckin, Michael A., Schreiber, Stefan, Saftig, Paul and Rosenstiel, Philip (2013). Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice. Gut, 62 (4), 520-530. doi: 10.1136/gutjnl-2011-300076
2013
Journal Article
Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial
Serisier, David J., Martin, Megan L., McGuckin, Michael A., Lourie, Rohan, Chen, Alice C., Brain, Barbara, Biga, Sally, Schlebusch, Sanmarié, Dash, Peter and Bowler, Simon D. (2013). Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial. JAMA: The Journal of the American Medical Association, 309 (12), 1260-1267. doi: 10.1001/jama.2013.2290
Supervision
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
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Supervision history
Completed supervision
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2017
Doctor Philosophy
An Investigation into The Effect of Erythromycin on Pseudomonas aeruginosa Quorum Sensing in Non-CF Bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
Principal Advisor
Other advisors: Dr Sumaira Hasnain
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2012
Doctor Philosophy
Investigations of the Biochemistry and Physiology of Mice with a Mutation in the Muc2 Intestinal Mucin Gene
Principal Advisor
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2009
Doctor Philosophy
Biology of CA125 in ovarian cancer biology
Principal Advisor
Other advisors: Professor Andreas Obermair
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2005
Doctor Philosophy
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
Principal Advisor
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2004
Doctor Philosophy
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
Principal Advisor
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2024
Doctor Philosophy
Examining the Role of Endogenous and Exogenous Interleukin-22 Signaling in Metabolic Dysfunction-Associated Steatotic Liver Disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald, Dr Sumaira Hasnain
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Dr Ran Wang, Dr Sumaira Hasnain
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2020
Doctor Philosophy
Novel dietary factors in diabetic and non-diabetic kidney disease
Associate Advisor
Other advisors: Dr Danielle Borg, Honorary Professor Josephine Forbes
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2020
Doctor Philosophy
Local Delivery of Anti-inflammatory drugs with Functionalized Silica Nanoparticles for Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Sumaira Hasnain, Professor Amirali Popat
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2019
Doctor Philosophy
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
Associate Advisor
Other advisors: Professor Mike Gidley
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2018
Doctor Philosophy
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
Associate Advisor
Other advisors: Dr Ben Ross, Professor Amirali Popat
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2009
Doctor Philosophy
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
Associate Advisor
Media
Enquiries
Contact Honorary Professor Michael McGuckin directly for media enquiries about:
- colon cancer
- inflammatory bowel diseases
- inflammatory disease
- type 2 diabetes
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