
Overview
Background
~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Cell surface mucin glycoproteins in infection, inflammation and cancer
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Inflammatory bowel diseases
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Non-cystic fibrosis bronchiectasis
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Inflammation in the pathogenesis of type 2 diabetes
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Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases
Works
Search Professor Michael McGuckin’s works on UQ eSpace
2020
Journal Article
Airway mucus hyperconcentration in non–cystic fibrosis bronchiectasis
Ramsey, Kathryn A., Chen, Alice C. H., Radicioni, Giorgia, Lourie, Rohan, Martin, Megan, Broomfield, Amy, Sheng, Yong H., Hasnain, Sumaira Z., Radford-Smith, Graham, Simms, Lisa A., Burr, Lucy, Thornton, David J., Bowler, Simon D., Livengood, Stephanie, Ceppe, Agathe, Knowles, Michael R., Noone, Peadar G., Donaldson, Scott H., Hill, David B., Ehre, Camille, Button, Brian, Alexis, Neil E., Kesimer, Mehmet, Boucher, Richard C. and McGuckin, Michael A. (2020). Airway mucus hyperconcentration in non–cystic fibrosis bronchiectasis. American Journal of Respiratory and Critical Care Medicine, 201 (6), 661-670. doi: 10.1164/rccm.201906-1219OC
2020
Conference Publication
Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection
Hasnain, S., Wang, R., Taylor, S., Wong, K. Y., Moniruzzaman, M., Upham, J., Spann, K., Mcguckin, M. A., Burr, L. and Phipps, S. (2020). Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777
2020
Conference Publication
Thioguanine inhibits colorectal tumorigenesis via β-catenin signalling in intestinal epithelial cells independently of immunosuppression or autophagy
Sheng, Yong H., Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh Y., He, Yaowu, Wu, Andy, Hooper, John, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira Z., McGuckin, Michael, Florin, Timothy H. and Begun, Jakob (2020). Thioguanine inhibits colorectal tumorigenesis via β-catenin signalling in intestinal epithelial cells independently of immunosuppression or autophagy. DDW 2020, Online, 2-5 May 2020. Philadelphia, PA United States: Elsevier . doi: 10.1016/s0016-5085(20)30856-8
2019
Journal Article
Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages
Dhar, Poshmaal, Sarkar, Sohinee, Ng, Garrett Z., Kalitsis, Paul, Saeed, Muhammad A., McGuckin, Michael A., Ellis, Justine A. and Sutton, Philip (2019). Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages. Human Immunology, 80 (10), 878-882. doi: 10.1016/j.humimm.2019.06.001
2019
Journal Article
Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles
Chaudhary, Zanib, Khan, Gul Majid, Abeer, Muhammad Mustafa, Pujara, Naisarg, Wan-Chi Tse, Brian, McGuckin, Michael A., Popat, Amirali and Kumeria, Tushar (2019). Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles. Biomaterials Science, 7 (12), 5002-5015. doi: 10.1039/c9bm00822e
2019
Journal Article
Lubrication by biomacromolecules: mechanisms and biomimetic strategies
Pradal, Clementine, Yakubov, Gleb E., Williams, Martin A. K., McGuckin, Michael A. and Stokes, Jason R. (2019). Lubrication by biomacromolecules: mechanisms and biomimetic strategies. Bioinspiration & Biomimetics, 14 (5) 051001, 051001. doi: 10.1088/1748-3190/ab2ac6
2019
Journal Article
CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin
He, Yaowu, Davies, Claire M., Harrington, Brittney S., Hellmers, Linh, Sheng, Yonghua, Broomfield, Amy, McGann, Thomas, Bastick, Kate, Zhong, Laurie, Wu, Andy, Maresh, Grace, McChesney, Shannon, Yau Wong, Kuan, Adams, Mark N., Sullivan, Ryan C., Palmer, James S., Burke, Lez J., Ewing, Adam D., Zhang, Xin, Margolin, David, Li, Li, Lourie, Rohan, Matsika, Admire, Srinivasan, Bhuvana, McGuckin, Michael A., Lumley, John W. and Hooper, John D. (2019). CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin. Oncogene, 39 (1), 219-233. doi: 10.1038/s41388-019-0983-3
2019
Journal Article
MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity
Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y
2019
Journal Article
Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway
Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468
2019
Journal Article
Responsive polysaccharide-grafted surfaces for biotribological applications
Pradal, Clementine, Yakubov, Gleb E., Williams, Martin A.K., McGuckin, Michael A. and Stokes, Jason R. (2019). Responsive polysaccharide-grafted surfaces for biotribological applications. Biotribology, 18 100092, 100092. doi: 10.1016/j.biotri.2019.100092
2019
Journal Article
Fibre intake is independently associated with increased circulating interleukin-22 in individuals with metabolic syndrome
Torquati, Luciana, Coombes, Jeff S., Murray, Lydia, Hasnain, Sumaira Z., Mallard, Alistair R., McGuckin, Michael A., Fassett, Robert G., Croci, Ilaria and Ramos, Joyce S. (2019). Fibre intake is independently associated with increased circulating interleukin-22 in individuals with metabolic syndrome. Nutrients, 11 (4) 815, 815. doi: 10.3390/nu11040815
2019
Journal Article
GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma
Shen, Kunyu, Vesey, David A., Ellis, Robert J., Del Vecchio, Sharon Juliet, Cho, Yeoungjee, Teixeira-Pinto, Armando, McGuckin, Michael A., Johnson, David W. and Gobe, Glenda C. (2019). GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma. PLoS One, 14 (1) e0210246, e0210246. doi: 10.1371/journal.pone.0210246
2018
Journal Article
A peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals
Hartley-Tassell, L. E., Day, C. J., Semchenko, E. A., Tram, G., Calderon-Gomez, L. I., Klipic, Z., Barry, A. M., Lam, A. K., McGuckin, M. A. and Korolik, V. (2018). A peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals. Scientific Reports, 8 (1) 12594. doi: 10.1038/s41598-018-30604-5
2018
Conference Publication
Airways mucus pathogenesis in patients with non-cystic fibrosis bronchiectasis
Ramsey, Kathryn, Radicioni, Giorgia, Hill, David, Ehre, Camille, Button, Brian, Alexis, Neil E., Knowles, Michael, Donaldson, Scott, Kesimer, Mehmet, Mcguckin, Michael and Boucher, Richard (2018). Airways mucus pathogenesis in patients with non-cystic fibrosis bronchiectasis. 28th International Congress of the European-Respiratory-Society (ERS), Paris France, Sep 15-19, 2018. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2018.PA5049
2018
Conference Publication
Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation
Wang, R., Giri, R., Moniruzzaman, M., Tong, H., Wong, K. Y., Begun, J., McGuckin, M. A. and Hasnain, S. Z. (2018). Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
2018
Conference Publication
Interleukin-22: A potential therapy to control intestinal inflammation
Moniruzzaman, M., Wang, R., Wong, K. Y., Tong, H., McGuckin, M. A. and Hasnain, S. Z. (2018). Interleukin-22: A potential therapy to control intestinal inflammation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
2018
Journal Article
PPARγ is reduced in the airways of non-CF bronchiectasis subjects and is inversely correlated with the presence of Pseudomonas aeruginosa
Burr, Lucy D., Rogers, Geraint B., Chen, Alice C.-H., Taylor, Steven L., Bowler, Simon D., Keating, Rebecca L., Martin, Megan L., Hasnain, Sumaira Z. and McGuckin, Michael A. (2018). PPARγ is reduced in the airways of non-CF bronchiectasis subjects and is inversely correlated with the presence of Pseudomonas aeruginosa. PLoS ONE, 13 (8) e0202296, e0202296. doi: 10.1371/journal.pone.0202296
2018
Conference Publication
Ubiquitin Ligase MARCH8 attenuates Graft versus Host Disease via Regulation of Gut Epithelial Cell Surface MHC II Expression
Lineburg, Katie E., Le Texier, Laetitia, Melino, Michelle, Wang, Ran, Clouston, Andrew, Blazar, Bruce R., McGuckin, Michael A., Villadangos, Jose A., Mintern, Justine D. and MacDonald, Kelli P. A. (2018). Ubiquitin Ligase MARCH8 attenuates Graft versus Host Disease via Regulation of Gut Epithelial Cell Surface MHC II Expression. 27th International Congress of the Transplantation-Society (TTS), Madrid, Spain, 30 June-5 July 2018. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/01.tp.0000543013.84163.3a
2018
Journal Article
Enterococcus faecalis AHG0090 is a genetically tractable bacterium and produces a secreted peptidic bioactive that suppresses nuclear factor Kappa B activation in human gut epithelial cells
Ó Cuív, Páraic, Giri, Rabina, Hoedt, Emily C., McGuckin, Michael A., Begun, Jakob and Morrison, Mark (2018). Enterococcus faecalis AHG0090 is a genetically tractable bacterium and produces a secreted peptidic bioactive that suppresses nuclear factor Kappa B activation in human gut epithelial cells. Frontiers in Immunology, 9 (April) 790, 790. doi: 10.3389/fimmu.2018.00790
2018
Journal Article
Mucin gel assembly is controlled by a collective action of non-mucin proteins, disulfide bridges, Ca2+- mediated links, and hydrogen bonding
Medrum, Oliver W., Yakubov, Gleb E., Bonilla, Mauricio R., Deshmukh, Omkar, McGuckin, Michael A. and Gidley, Michael J. (2018). Mucin gel assembly is controlled by a collective action of non-mucin proteins, disulfide bridges, Ca2+- mediated links, and hydrogen bonding. Scientific Reports, 8 (1) 5802, 5802. doi: 10.1038/s41598-018-24223-3
Supervision
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
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Supervision history
Completed supervision
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2017
Doctor Philosophy
An Investigation into The Effect of Erythromycin on Pseudomonas aeruginosa Quorum Sensing in Non-CF Bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
Principal Advisor
Other advisors: Dr Sumaira Hasnain
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2012
Doctor Philosophy
Investigations of the Biochemistry and Physiology of Mice with a Mutation in the Muc2 Intestinal Mucin Gene
Principal Advisor
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2009
Doctor Philosophy
Biology of CA125 in ovarian cancer biology
Principal Advisor
Other advisors: Professor Andreas Obermair
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2005
Doctor Philosophy
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
Principal Advisor
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2004
Doctor Philosophy
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
Principal Advisor
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2024
Doctor Philosophy
Examining the Role of Endogenous and Exogenous Interleukin-22 Signaling in Metabolic Dysfunction-Associated Steatotic Liver Disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald, Dr Sumaira Hasnain
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Dr Ran Wang, Dr Sumaira Hasnain
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2020
Doctor Philosophy
Novel dietary factors in diabetic and non-diabetic kidney disease
Associate Advisor
Other advisors: Dr Danielle Borg, Honorary Professor Josephine Forbes
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2020
Doctor Philosophy
Local Delivery of Anti-inflammatory drugs with Functionalized Silica Nanoparticles for Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Sumaira Hasnain, Professor Amirali Popat
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2019
Doctor Philosophy
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
Associate Advisor
Other advisors: Professor Mike Gidley
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2018
Doctor Philosophy
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
Associate Advisor
Other advisors: Dr Ben Ross, Professor Amirali Popat
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2009
Doctor Philosophy
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
Associate Advisor
Media
Enquiries
Contact Honorary Professor Michael McGuckin directly for media enquiries about:
- colon cancer
- inflammatory bowel diseases
- inflammatory disease
- type 2 diabetes
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