
Overview
Background
~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Cell surface mucin glycoproteins in infection, inflammation and cancer
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Inflammatory bowel diseases
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Non-cystic fibrosis bronchiectasis
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Inflammation in the pathogenesis of type 2 diabetes
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Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases
Works
Search Professor Michael McGuckin’s works on UQ eSpace
2018
Journal Article
Oxidative and endoplasmic reticulum stress in respiratory disease
Chen, Alice C-H, Burr, Lucy and McGuckin, Michael A. (2018). Oxidative and endoplasmic reticulum stress in respiratory disease. Clinical and Translational Immunology, 7 (6) e1019, e1019. doi: 10.1002/cti2.1019
2018
Conference Publication
Airways Mucus Proteome Reveals Unique and Common Pathways in Non-CF Bronchiectasis and Primary Ciliary Dyskinesia
Radicioni, G., Ramsey, K. A., McGuckin, M., Knowles, M. R., Boucher, R. C. and Kesimer, M. (2018). Airways Mucus Proteome Reveals Unique and Common Pathways in Non-CF Bronchiectasis and Primary Ciliary Dyskinesia. International Conference of the American-Thoracic-Society, San Diego Ca, May 18-23, 2018. NEW YORK: AMER THORACIC SOC.
2017
Journal Article
Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins
Fercher, Christian, Keshvari, Sahar, McGuckin, Michael A and Barnard, Ross T (2017). Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins. Experimental biology and medicine (Maywood, N.J.), 243 (2), 166-183. doi: 10.1177/1535370217748575
2017
Journal Article
Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides
Meldrum, Oliver W, Yakubov, Gleb E, Gartaula, Ghanendra, McGuckin, Michael A and Gidley, Michael J (2017). Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides. Scientific reports, 7 (1) 15794, 1-15. doi: 10.1038/s41598-017-16090-1
2017
Journal Article
Infection's Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility
Taylor, Steven L., McGuckin, Michael A., Wesselingh, Steve and Rogers, Geraint B. (2017). Infection's Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility. Trends in Microbiology, 26 (2), 92-101. doi: 10.1016/j.tim.2017.09.011
2017
Journal Article
Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies
Shen, Kunyu, Johnson, David W., Vesey, David A., McGuckin, Michael A. and Gobe, Glenda C. (2017). Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies. Cell Stress and Chaperones, 23 (3), 317-334. doi: 10.1007/s12192-017-0844-3
2017
Journal Article
Goblet cells as mucosal sentinels for immunity
McGuckin, M. A. and Hasnain, S. Z. (2017). Goblet cells as mucosal sentinels for immunity. Mucosal Immunology, 10 (5), 1118-1121. doi: 10.1038/mi.2016.132
2017
Journal Article
The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse
Borg, Danielle J., Wang, Ran, Murray, Lydia, Tong, Hui, Steptoe, Raymond J., McGuckin, Michael A. and Hasnain, Sumaira Z. (2017). The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse. Diabetologia, 60 (11), 1-6. doi: 10.1007/s00125-017-4392-2
2017
Conference Publication
Effect of Differential Exercise Intensities on Interleukin-22 in Metabolic Syndrome
Ramos, Joyce S., Dalleck, Lance C., Mielke, Gregore I., Keating, Shelley E., McGuckin, Michael, Murray, Lydia S., Hasnain, Sumaira, Fassett, Robert G. and Coombes, Jeff S. (2017). Effect of Differential Exercise Intensities on Interleukin-22 in Metabolic Syndrome. Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Denver Co, May 30-Jun 03, 2017. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1249/01.mss.0000519264.21081.61
2017
Journal Article
Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon
Nguyen, Chau T. H., Webb, Richard I., Lambert, Lynette K., Strounina, Ekaterina, Lee, Edward C., Parat, Marie-Odile, McGuckin, Michael A., Popat, Amirali, Cabot, Peter J. and Ross, Benjamin P. (2017). Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon. ACS Applied Materials and Interfaces, 9 (11), 9470-9483. doi: 10.1021/acsami.7b00411
2017
Journal Article
The cell surface mucin MUC1 limits the severity of influenza A virus infection
McAuley, J. L., Corcilius, L., Tan, H. -X., Payne, R. J., McGuckin, M. A. and Brown, L. E. (2017). The cell surface mucin MUC1 limits the severity of influenza A virus infection. Mucosal Immunology, 10 (6), 1581-1593. doi: 10.1038/mi.2017.16
2017
Journal Article
Is there a link between H. Pylori and the epidemiology of Crohn’s disease?
Shah, Ayesha, Talley, Nicholas J., Walker, Marjorie, Koloski, Natasha, Morrison, Mark, Burger, Daniel, Andrews, Jane M., McGuckin, Michael, Jones, Mike and Holtmann, Gerald (2017). Is there a link between H. Pylori and the epidemiology of Crohn’s disease?. Digestive Diseases and Sciences, 62 (9), 1-9. doi: 10.1007/s10620-017-4496-z
2017
Journal Article
MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance
Sheng, Yonghua, Ng, Choa Ping, Lourie, Rohan, Shah, Esha T., He, Yaowu, Wong, Kuan Yua, Seim, Inge, Oancea, Iulia, Morais, Christudas, Jeffery, Penny L., Hooper, John, Gobe, Glenda C. and Mcguckin, Michael A. (2017). MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance. International Journal of Cancer, 140 (10), 2351-2363. doi: 10.1002/ijc.30651
2017
Journal Article
Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion
Hasnain, Sumaira Z., Dawson, Paul A., Lourie, Rohan, Hutson, Peter, Tong, Hui, Grencis, Richard K., McGuckin, Michael A. and Thornton, David J. (2017). Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion. PLoS Pathogens, 13 (2) e1006218, e1006218. doi: 10.1371/journal.ppat.1006218
2017
Journal Article
Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate
Pujara, Naisarg, Jambhrunkar, Siddharth, Wong, Kuan Yau, McGuckin, Michael and Popat, Amirali (2017). Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate. Journal of Colloid and Interface Science, 488, 303-308. doi: 10.1016/j.jcis.2016.11.015
2017
Journal Article
Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome
Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A ., Hugenholtz, Philip and Hill, Geoffrey R. (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Blood, 129 (15), 2172-2185. doi: 10.1182/blood-2016-08-732628
2016
Journal Article
Macrolide treatment inhibits Pseudomonas aeruginosa quorum sensing in non-cystic fibrosis bronchiectasis. An analysis from the bronchiectasis and low-dose erythromycin study trial
Burr, Lucy D., Rogers, Geraint B., Chen, Alice C.-H., Hamilton, Brett R., Pool, Gertruida F., Taylor, Steven L., Venter, Deon, Bowler, Simon D., Biga, Sally and McGuckin, Michael A. (2016). Macrolide treatment inhibits Pseudomonas aeruginosa quorum sensing in non-cystic fibrosis bronchiectasis. An analysis from the bronchiectasis and low-dose erythromycin study trial. Annals of the American Thoracic Society, 13 (10), 1697-1703. doi: 10.1513/AnnalsATS.201601-044OC
2016
Journal Article
Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol
Summerlin, Natalie, Qu, Zhi, Pujara, Naisarg, Sheng, Yong, Jambhrunkar, Siddharth, McGuckin, Michael and Popat, Amirali (2016). Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol. Colloids and Surfaces B: Biointerfaces, 144 (4), 1-7. doi: 10.1016/j.colsurfb.2016.03.076
2016
Journal Article
MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target
Sheng, Y. H., He, Y., Hasnain, S. Z., Wang, R., Tong, H., Clarke, D. T., Lourie, R., Oancea, I., Wong, K. Y., Lumley, J. W., Florin, T. H., Sutton, P., Hooper, J. D., McMillan, N. A. and McGuckin, M. A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target. Oncogene, 36 (5), 700-713. doi: 10.1038/onc.2016.241
2016
Journal Article
High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22
Gulhane, Max, Murray, Lydia, Lourie, Rohan, Tong, Hui, Sheng, Yong H., Wang, Ran, Kang, Alicia, Schreiber, Veronika, Wong, Kuan Yau, Magor, Graham, Denman, Stuart, Begun, Jakob, Florin, Timothy H., Perkins, Andrew, Cuiv, Paraic O., McGuckin, Michael A. and Hasnain, Sumaira Z. (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. Scientific Reports, 6 (1) 28990, 28990. doi: 10.1038/srep28990
Supervision
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
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Supervision history
Completed supervision
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2017
Doctor Philosophy
An Investigation into The Effect of Erythromycin on Pseudomonas aeruginosa Quorum Sensing in Non-CF Bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
Principal Advisor
Other advisors: Dr Sumaira Hasnain
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2015
Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
Principal Advisor
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2012
Doctor Philosophy
Investigations of the Biochemistry and Physiology of Mice with a Mutation in the Muc2 Intestinal Mucin Gene
Principal Advisor
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2009
Doctor Philosophy
Biology of CA125 in ovarian cancer biology
Principal Advisor
Other advisors: Professor Andreas Obermair
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2005
Doctor Philosophy
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
Principal Advisor
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2004
Doctor Philosophy
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
Principal Advisor
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2024
Doctor Philosophy
Examining the Role of Endogenous and Exogenous Interleukin-22 Signaling in Metabolic Dysfunction-Associated Steatotic Liver Disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald, Dr Sumaira Hasnain
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Dr Ran Wang, Dr Sumaira Hasnain
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2020
Doctor Philosophy
Novel dietary factors in diabetic and non-diabetic kidney disease
Associate Advisor
Other advisors: Dr Danielle Borg, Honorary Professor Josephine Forbes
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2020
Doctor Philosophy
Local Delivery of Anti-inflammatory drugs with Functionalized Silica Nanoparticles for Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Sumaira Hasnain, Professor Amirali Popat
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2019
Doctor Philosophy
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
Associate Advisor
Other advisors: Professor Mike Gidley
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2018
Doctor Philosophy
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
Associate Advisor
Other advisors: Dr Ben Ross, Professor Amirali Popat
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2009
Doctor Philosophy
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
Associate Advisor
Media
Enquiries
Contact Honorary Professor Michael McGuckin directly for media enquiries about:
- colon cancer
- inflammatory bowel diseases
- inflammatory disease
- type 2 diabetes
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