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Honorary Professor Michael McGuckin
Honorary Professor

Michael McGuckin

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Overview

Background

~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.

Availability

Honorary Professor Michael McGuckin is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Science, The University of Queensland
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Cell surface mucin glycoproteins in infection, inflammation and cancer

  • Inflammatory bowel diseases

  • Non-cystic fibrosis bronchiectasis

  • Inflammation in the pathogenesis of type 2 diabetes

  • Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases

Works

Search Professor Michael McGuckin’s works on UQ eSpace

253 works between 1987 and 2024

41 - 60 of 253 works

2018

Journal Article

Oxidative and endoplasmic reticulum stress in respiratory disease

Chen, Alice C-H, Burr, Lucy and McGuckin, Michael A. (2018). Oxidative and endoplasmic reticulum stress in respiratory disease. Clinical and Translational Immunology, 7 (6) e1019, e1019. doi: 10.1002/cti2.1019

Oxidative and endoplasmic reticulum stress in respiratory disease

2018

Conference Publication

Airways Mucus Proteome Reveals Unique and Common Pathways in Non-CF Bronchiectasis and Primary Ciliary Dyskinesia

Radicioni, G., Ramsey, K. A., McGuckin, M., Knowles, M. R., Boucher, R. C. and Kesimer, M. (2018). Airways Mucus Proteome Reveals Unique and Common Pathways in Non-CF Bronchiectasis and Primary Ciliary Dyskinesia. International Conference of the American-Thoracic-Society, San Diego Ca, May 18-23, 2018. NEW YORK: AMER THORACIC SOC.

Airways Mucus Proteome Reveals Unique and Common Pathways in Non-CF Bronchiectasis and Primary Ciliary Dyskinesia

2017

Journal Article

Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins

Fercher, Christian, Keshvari, Sahar, McGuckin, Michael A and Barnard, Ross T (2017). Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins. Experimental biology and medicine (Maywood, N.J.), 243 (2), 166-183. doi: 10.1177/1535370217748575

Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins

2017

Journal Article

Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides

Meldrum, Oliver W, Yakubov, Gleb E, Gartaula, Ghanendra, McGuckin, Michael A and Gidley, Michael J (2017). Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides. Scientific reports, 7 (1) 15794, 1-15. doi: 10.1038/s41598-017-16090-1

Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides

2017

Journal Article

Infection's Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility

Taylor, Steven L., McGuckin, Michael A., Wesselingh, Steve and Rogers, Geraint B. (2017). Infection's Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility. Trends in Microbiology, 26 (2), 92-101. doi: 10.1016/j.tim.2017.09.011

Infection's Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility

2017

Journal Article

Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies

Shen, Kunyu, Johnson, David W., Vesey, David A., McGuckin, Michael A. and Gobe, Glenda C. (2017). Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies. Cell Stress and Chaperones, 23 (3), 317-334. doi: 10.1007/s12192-017-0844-3

Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies

2017

Journal Article

Goblet cells as mucosal sentinels for immunity

McGuckin, M. A. and Hasnain, S. Z. (2017). Goblet cells as mucosal sentinels for immunity. Mucosal Immunology, 10 (5), 1118-1121. doi: 10.1038/mi.2016.132

Goblet cells as mucosal sentinels for immunity

2017

Journal Article

The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse

Borg, Danielle J., Wang, Ran, Murray, Lydia, Tong, Hui, Steptoe, Raymond J., McGuckin, Michael A. and Hasnain, Sumaira Z. (2017). The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse. Diabetologia, 60 (11), 1-6. doi: 10.1007/s00125-017-4392-2

The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse

2017

Conference Publication

Effect of Differential Exercise Intensities on Interleukin-22 in Metabolic Syndrome

Ramos, Joyce S., Dalleck, Lance C., Mielke, Gregore I., Keating, Shelley E., McGuckin, Michael, Murray, Lydia S., Hasnain, Sumaira, Fassett, Robert G. and Coombes, Jeff S. (2017). Effect of Differential Exercise Intensities on Interleukin-22 in Metabolic Syndrome. Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Denver Co, May 30-Jun 03, 2017. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1249/01.mss.0000519264.21081.61

Effect of Differential Exercise Intensities on Interleukin-22 in Metabolic Syndrome

2017

Journal Article

Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon

Nguyen, Chau T. H., Webb, Richard I., Lambert, Lynette K., Strounina, Ekaterina, Lee, Edward C., Parat, Marie-Odile, McGuckin, Michael A., Popat, Amirali, Cabot, Peter J. and Ross, Benjamin P. (2017). Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon. ACS Applied Materials and Interfaces, 9 (11), 9470-9483. doi: 10.1021/acsami.7b00411

Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon

2017

Journal Article

The cell surface mucin MUC1 limits the severity of influenza A virus infection

McAuley, J. L., Corcilius, L., Tan, H. -X., Payne, R. J., McGuckin, M. A. and Brown, L. E. (2017). The cell surface mucin MUC1 limits the severity of influenza A virus infection. Mucosal Immunology, 10 (6), 1581-1593. doi: 10.1038/mi.2017.16

The cell surface mucin MUC1 limits the severity of influenza A virus infection

2017

Journal Article

Is there a link between H. Pylori and the epidemiology of Crohn’s disease?

Shah, Ayesha, Talley, Nicholas J., Walker, Marjorie, Koloski, Natasha, Morrison, Mark, Burger, Daniel, Andrews, Jane M., McGuckin, Michael, Jones, Mike and Holtmann, Gerald (2017). Is there a link between H. Pylori and the epidemiology of Crohn’s disease?. Digestive Diseases and Sciences, 62 (9), 1-9. doi: 10.1007/s10620-017-4496-z

Is there a link between H. Pylori and the epidemiology of Crohn’s disease?

2017

Journal Article

MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance

Sheng, Yonghua, Ng, Choa Ping, Lourie, Rohan, Shah, Esha T., He, Yaowu, Wong, Kuan Yua, Seim, Inge, Oancea, Iulia, Morais, Christudas, Jeffery, Penny L., Hooper, John, Gobe, Glenda C. and Mcguckin, Michael A. (2017). MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance. International Journal of Cancer, 140 (10), 2351-2363. doi: 10.1002/ijc.30651

MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance

2017

Journal Article

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion

Hasnain, Sumaira Z., Dawson, Paul A., Lourie, Rohan, Hutson, Peter, Tong, Hui, Grencis, Richard K., McGuckin, Michael A. and Thornton, David J. (2017). Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion. PLoS Pathogens, 13 (2) e1006218, e1006218. doi: 10.1371/journal.ppat.1006218

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion

2017

Journal Article

Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

Pujara, Naisarg, Jambhrunkar, Siddharth, Wong, Kuan Yau, McGuckin, Michael and Popat, Amirali (2017). Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate. Journal of Colloid and Interface Science, 488, 303-308. doi: 10.1016/j.jcis.2016.11.015

Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

2017

Journal Article

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A ., Hugenholtz, Philip and Hill, Geoffrey R. (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Blood, 129 (15), 2172-2185. doi: 10.1182/blood-2016-08-732628

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

2016

Journal Article

Macrolide treatment inhibits Pseudomonas aeruginosa quorum sensing in non-cystic fibrosis bronchiectasis. An analysis from the bronchiectasis and low-dose erythromycin study trial

Burr, Lucy D., Rogers, Geraint B., Chen, Alice C.-H., Hamilton, Brett R., Pool, Gertruida F., Taylor, Steven L., Venter, Deon, Bowler, Simon D., Biga, Sally and McGuckin, Michael A. (2016). Macrolide treatment inhibits Pseudomonas aeruginosa quorum sensing in non-cystic fibrosis bronchiectasis. An analysis from the bronchiectasis and low-dose erythromycin study trial. Annals of the American Thoracic Society, 13 (10), 1697-1703. doi: 10.1513/AnnalsATS.201601-044OC

Macrolide treatment inhibits Pseudomonas aeruginosa quorum sensing in non-cystic fibrosis bronchiectasis. An analysis from the bronchiectasis and low-dose erythromycin study trial

2016

Journal Article

Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol

Summerlin, Natalie, Qu, Zhi, Pujara, Naisarg, Sheng, Yong, Jambhrunkar, Siddharth, McGuckin, Michael and Popat, Amirali (2016). Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol. Colloids and Surfaces B: Biointerfaces, 144 (4), 1-7. doi: 10.1016/j.colsurfb.2016.03.076

Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol

2016

Journal Article

MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target

Sheng, Y. H., He, Y., Hasnain, S. Z., Wang, R., Tong, H., Clarke, D. T., Lourie, R., Oancea, I., Wong, K. Y., Lumley, J. W., Florin, T. H., Sutton, P., Hooper, J. D., McMillan, N. A. and McGuckin, M. A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target. Oncogene, 36 (5), 700-713. doi: 10.1038/onc.2016.241

MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target

2016

Journal Article

High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22

Gulhane, Max, Murray, Lydia, Lourie, Rohan, Tong, Hui, Sheng, Yong H., Wang, Ran, Kang, Alicia, Schreiber, Veronika, Wong, Kuan Yau, Magor, Graham, Denman, Stuart, Begun, Jakob, Florin, Timothy H., Perkins, Andrew, Cuiv, Paraic O., McGuckin, Michael A. and Hasnain, Sumaira Z. (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. Scientific Reports, 6 (1) 28990, 28990. doi: 10.1038/srep28990

High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22

Supervision

Availability

Honorary Professor Michael McGuckin is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Honorary Professor Michael McGuckin directly for media enquiries about:

  • colon cancer
  • inflammatory bowel diseases
  • inflammatory disease
  • type 2 diabetes

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