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Honorary Professor Michael McGuckin
Honorary Professor

Michael McGuckin

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Overview

Background

~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.

Availability

Honorary Professor Michael McGuckin is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Science, The University of Queensland
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Cell surface mucin glycoproteins in infection, inflammation and cancer

  • Inflammatory bowel diseases

  • Non-cystic fibrosis bronchiectasis

  • Inflammation in the pathogenesis of type 2 diabetes

  • Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases

Works

Search Professor Michael McGuckin’s works on UQ eSpace

253 works between 1987 and 2024

101 - 120 of 253 works

2013

Journal Article

Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation

King, Rebecca M., Day, Christopher J., Hartley-Tassell, Lauren E., Connerton, Ian F., Tiralongo, Joe, McGuckin, Michael A. and Korolik, Victoria (2013). Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation. Journal of Basic Microbiology, 53 (3), 240-250. doi: 10.1002/jobm.201100466

Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation

2013

Journal Article

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment

Dong, Ying, Stephens, Carson, Walpole, Carina, Swedberg, Joakim E., Boyle, Glen M., Parsons, Peter G., McGuckin, Michael A., Harris, Jonathan M. and Clements, Judith A. (2013). Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment. PLoS One, 8 (2) e57056, e57056.1-e57056.12. doi: 10.1371/journal.pone.0057056

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment

2013

Journal Article

There is a 'uc' in mucus, but is there mucus in UC?

McGuckin, Michael A. and Hasnain, Sumaira Z. (2013). There is a 'uc' in mucus, but is there mucus in UC?. Gut, 63 (2), 216-217. doi: 10.1136/gutjnl-2013-304602

There is a 'uc' in mucus, but is there mucus in UC?

2013

Journal Article

IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells

Hasnain, Sumaira Z., Tauro, Sharyn, Das, Indrajit, Tong, Hui, Chen, Alice C. -H., Jeffery, Penny L., McDonald, Victoria, Florin, Timothy H. and McGuckin, Michael A. (2013). IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology, 144 (2), 357-368. doi: 10.1053/j.gastro.2012.10.043

IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells

2013

Book Chapter

Introduction to mucins in cancer

McGuckin, Michael A. (2013). Introduction to mucins in cancer. Mucins and Cancer. (pp. 6-18) edited by Joyce Taylor-Papadimitriou and Joy M Burchell. London: Future Medicine Limited. doi: 10.2217/fmeb2013.13.123

Introduction to mucins in cancer

2013

Conference Publication

Incidence and Severity of Spondyloarthritis and Ileitis Are Determined by Interaction Between the Microbiota and Genetic Susceptibility in Beta-Glucan-Treated Skg Mice

Rehaume, L., Mondot, S., Aguirre de Cárcer, D., Velasco, J., Benham, H., Hasnain, S., Ruutu, M., McGuckin, M. and Morrison, M. (2013). Incidence and Severity of Spondyloarthritis and Ileitis Are Determined by Interaction Between the Microbiota and Genetic Susceptibility in Beta-Glucan-Treated Skg Mice. 54th Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with the Rheumatology Health Professionals Association, Perth, WA Australia, 18 -22 May 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/imj.12139

Incidence and Severity of Spondyloarthritis and Ileitis Are Determined by Interaction Between the Microbiota and Genetic Susceptibility in Beta-Glucan-Treated Skg Mice

2013

Journal Article

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype

Walsh, Michael D., Clendenning, Mark, Williamson, Elizabeth, Pearson, Sally-Ann, Walters, Rhiannon J., Nagler, Belinda, Packenas, David, Win, Aung K., Hopper, John L., Jenkins, Mark A., Haydon, Andrew M., Rosty, Christophe, English, Dallas R., Giles, Graham G., McGuckin, Michael A., Young, Joanne P. and Buchanan, Daniel D. (2013). Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. Modern Pathology, 26 (12), 1642-1656. doi: 10.1038/modpathol.2013.101

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype

2013

Conference Publication

Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger.

Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, D., Velasco, Jared, Benham, Helen, Hasnain, Sumaira, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip, McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2013). Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger.. 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego Ca, 25-30 October 2013. Hoboken, NJ United States: John Wiley and Sons Inc.. doi: 10.1002/art.38216

Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger.

2013

Book Chapter

Secreted effectors of the innate mucosal barrier

McGuckin, M. A., Ouellette, A. J. and Wu, G. D. (2013). Secreted effectors of the innate mucosal barrier. Principles of mucosal immunology. (pp. 37-51) edited by Phillip D. Smith, ThomasT. MacDonald and Richard S. Blumberg. London, United Kingdom: Taylor & Francis.

Secreted effectors of the innate mucosal barrier

2012

Journal Article

Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier

Hasnain, Sumaira Z., McGuckin, Michael A., Grencis, Richard K. and Thornton, David J. (2012). Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Neglected Tropical Diseases, 6 (10) e1856, e1856.1-e1856.13. doi: 10.1371/journal.pntd.0001856

Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier

2012

Journal Article

O-Linked glycome and proteome of high-molecular-mass proteins in human ovarian cancer ascites: Identification of sulfation, disialic acid and O-linked fucose

Karlsson, Niclas G. and McGuckin, Michael A. (2012). O-Linked glycome and proteome of high-molecular-mass proteins in human ovarian cancer ascites: Identification of sulfation, disialic acid and O-linked fucose. Glycobiology, 22 (7), 918-929. doi: 10.1093/glycob/cws060

O-Linked glycome and proteome of high-molecular-mass proteins in human ovarian cancer ascites: Identification of sulfation, disialic acid and O-linked fucose

Featured

2012

Journal Article

β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice

Ruutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012). β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 (7), 2211-2222. doi: 10.1002/art.34423

β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice

2012

Conference Publication

Intestinal Endoplasmic Reticulum Stress is Modulated by Inflammatory Cytokines

Hasnain, Sumaira Z., Tauro, Sharyn, Jeffery, Penny, Das, Indrajit, Tran, Thu V., Florin, Timothy H. and McGuckin, Michael A. (2012). Intestinal Endoplasmic Reticulum Stress is Modulated by Inflammatory Cytokines. Digestive Disease Week (DDW), San Diego Ca, May 19-22, 2012. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

Intestinal Endoplasmic Reticulum Stress is Modulated by Inflammatory Cytokines

2012

Journal Article

The interplay between endoplasmic reticulum stress and inflammation

Hasnain, Sumaira Z ., Lourie, Rohan, Das, Indrajit, Chen, Alice C-H. and McGuckin, Michael A. (2012). The interplay between endoplasmic reticulum stress and inflammation. Immunology and Cell Biology, 90 (3), 260-270. doi: 10.1038/icb.2011.112

The interplay between endoplasmic reticulum stress and inflammation

2012

Conference Publication

Protective and Pathogenic Effects of the Il-23 Family of Cytokines in Spondyloarthropathy in Skg Mice

Benham, H., Rehaume, L., Ruutu, M., Velasco, J., Strutton, G., McGuckin, M. and Thomas, R. (2012). Protective and Pathogenic Effects of the Il-23 Family of Cytokines in Spondyloarthropathy in Skg Mice. 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, 12-15 May 2012. Richmond Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1445-5994.2012.02759.x

Protective and Pathogenic Effects of the Il-23 Family of Cytokines in Spondyloarthropathy in Skg Mice

2012

Book Chapter

Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo

Sheng, Yong H., Hasnain, Sumaira Z, Png, Chin Wen, McGuckin, Michael A. and Lindén, Sara K. (2012). Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo. Mucins: Methods and Protocols. (pp. 297-312) edited by Michael A. McGuckin and David J. Thornton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8_18

Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo

2012

Book Chapter

T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation

Eri, Rajaraman, McGuckin, Michael A. and Wadley, Robert (2012). T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation. Leucocytes: methods and protocols. (pp. 261-275) New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_19

T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation

2012

Conference Publication

The role of intestinal microbiota in the development of spondyloarthritis in fungal beta-glucan-treated autoimmune prone skg mice

Rehaume, L., Aguirre de Cárcer, D., Velasco, J., Benham, H., Ruutu, M., Mondot, S., Morrison, M. and McGuckin, M. (2012). The role of intestinal microbiota in the development of spondyloarthritis in fungal beta-glucan-treated autoimmune prone skg mice. 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, 12-15 May 2012. Richmond Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1445-5994.2012.02759.x

The role of intestinal microbiota in the development of spondyloarthritis in fungal beta-glucan-treated autoimmune prone skg mice

2012

Book

Mucins: methods and protocols

Michael A. McGuckin and David J. Thornton eds. (2012). Mucins: methods and protocols. Methods in Molecular Biology, New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8

Mucins: methods and protocols

2012

Journal Article

Mucins in inflammatory bowel diseases and colorectal cancer

Sheng, Yong H., Hasnain, Sumaira Z., Florin, Timothy H. J. and McGuckin, Michael A. (2012). Mucins in inflammatory bowel diseases and colorectal cancer. Journal of Gastroenterology and Hepatology, 27 (1), 28-38. doi: 10.1111/j.1440-1746.2011.06909.x

Mucins in inflammatory bowel diseases and colorectal cancer

Funding

Past funding

  • 2017 - 2020
    Invention of a Genetic Toolkit for Immunomodulatory Gut Bacteria to Expedite the Development of New Crohn's Disease Therapeutics
    United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
    Open grant
  • 2016 - 2017
    Elucidation of the Mechanism of IL-22-Mediated Suppression of Beta-Cell Stress in Diabetes
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Pancreatic targeting of IL-22 therapy for diabetes
    NHMRC Development Grant
    Open grant
  • 2015 - 2017
    Engineering biomimetic lubrication with mucin
    ARC Discovery Projects
    Open grant
  • 2015 - 2019
    IL-22 as a Suppressor of Pancreatic Beta-Cell Stress and a Treatment for Diabetes
    NHMRC Project Grant
    Open grant
  • 2015
    Pancreatic targeting of IL-22 therapy for diabetes
    UQ Collaboration and Industry Engagement Fund - Seed Research Grant
    Open grant
  • 2014 - 2015
    A new approach to tackling chemotherapy-induced mucositis
    Cancer Council Queensland
    Open grant
  • 2014 - 2016
    Cell Surface Mucins in Gastrointestinal Infection, Inflammation and Cancer Development
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    NHMRC Research Fellowship (PRF): Understanding and Treating Inflammatory Disease
    NHMRC Research Fellowship
    Open grant
  • 2013 - 2015
    ER Stress as a Contributing Factor in Inflammatory Disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    How Muc1 regulates the inflammasome in the gut (NHMRC Project Grant administered by Murdoch Childrens Research Institute)
    Murdoch Childrens Research Institute
    Open grant
  • 2013
    NHMRC Research Fellowship (SRF B): Uncoupled Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2013
    Targeting MUC13 to sensitise colorectal cancer cells to apoptosis
    Cancer Council Queensland
    Open grant
  • 2012 - 2014
    Pathogenesis of a new mouse model of ankylosing spondylitis
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Comprehensive cell imaging facility (ARC LIEF Grant administered by QUT)
    ARC LIEF Collaborating/Partner Organisation Contributions
    Open grant
  • 2008 - 2010
    Assessment of endoplasmic reticulum stress and mutations in mucin oligomerization domains in ulcerative colitis
    NHMRC Project Grant
    Open grant
  • 2004
    The Role of Cell Surface Epithelial Mucin (MUC1) In Oropharyngeal Candidiasis
    Australian Dental Research Fund Inc
    Open grant

Supervision

Availability

Honorary Professor Michael McGuckin is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Completed supervision

Media

Enquiries

Contact Honorary Professor Michael McGuckin directly for media enquiries about:

  • colon cancer
  • inflammatory bowel diseases
  • inflammatory disease
  • type 2 diabetes

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