
Overview
Background
~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Cell surface mucin glycoproteins in infection, inflammation and cancer
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Inflammatory bowel diseases
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Non-cystic fibrosis bronchiectasis
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Inflammation in the pathogenesis of type 2 diabetes
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Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases
Works
Search Professor Michael McGuckin’s works on UQ eSpace
2008
Journal Article
Structure and function of the polymeric mucins in airways mucus
Thornton, David J., Rousseau, Karine and McGuckin, Michael A. (2008). Structure and function of the polymeric mucins in airways mucus. Annual Review of Physiology, 70 (1), 459-486. doi: 10.1146/annurev.physiol.70.113006.100702
2008
Journal Article
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
Heazlewood, Chad K., Cook, Matthew C., Eri, Rajaraman, Price, Gareth R., Tauro, Sharyn B., Taupin, Douglas, Thornton, David J., Png, Chin Wen, Crockford, Tanya L., Cornall, Richard J., Adams, Rachel, Kato, Masato, Nelms, Keats A., Hong, Nancy A., Florin, Timothy H. J., Goodnow, Christopher C. and McGuckin, Michael A. (2008). Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Medicine, 5 (3) e54, 440-460. doi: 10.1371/journal.pmed.0050054
2008
Journal Article
Mucin dynamics in intestinal bacterial infection
Linden, Sara K., Florin, Timothy H. J. and McGuckin, Michael A. (2008). Mucin dynamics in intestinal bacterial infection. PLoS One, 3 (12) e3952, e3952.1-e3952.14. doi: 10.1371/journal.pone.0003952
2008
Journal Article
IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin
Adams, Rachel J., Heazlewood, Sharise P., Gilshenan, Kristen S., O'Brien, Mark, McGuckin, Michael A. and Florin, Timothy H. J. (2008). IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin. American Journal of Gastroenterology, 103 (2), 386-396. doi: 10.1111/j.1572-0241.2007.01577.x
2008
Journal Article
IgG Antibodies Against Common Gut Bacteria Are More Diagnostic for Crohn's Disease Than IgG Against Mannan or Flagellin
Adams, Rachel J., Heazlewood, Sharise P., Gilshenan, Kristen S., O'Brien, Mark, McGuckin, Michael A. and Florin, Timothy H. J. (2008). IgG Antibodies Against Common Gut Bacteria Are More Diagnostic for Crohn's Disease Than IgG Against Mannan or Flagellin. American Journal of Gastroenterology, 103 (2), 386-396. doi: 10.1111/j.1572-0241.2007.01577.x
2007
Journal Article
Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis
McGuckin, Michael A., Every, Alison L., Skene, Caroline D., Linden, Sara K., Chionh, Yok Teng, Swierczak, Agnieszka, McAuley, Julie, Harbour, Stacey, Kaparakis, Maria, Ferrero, Richard and Sutton, Philip (2007). Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology, 133 (4), 1210-1218. doi: 10.1053/j.gastro.2007.07.003
2007
Journal Article
Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions
Linden, Sara K., Driessen, Kim M. and McGuckin, Michael A. (2007). Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions. Helicobacter, 12 (4), 341-353. doi: 10.1111/j.1523-5378.2007.00509.x
2007
Journal Article
The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas
Walsh, Michael D., Young, Joanne P., Leggett, Barbara A., Williams, Stephanie H., Jass, Jeremy R. and McGuckin, Michael A. (2007). The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas. Human Pathology, 38 (6), 883-892. doi: 10.1016/j.humpath.2006.11.020
2007
Conference Publication
Aberrant mucin assembly links endoplasmic reticulum stress with ulcerative colitis
Mcguckin, Michael A., Eri, Rajaraman, Heazlewood, Chad K., Cook, Matthew C., Taupin, Doug R., Thornton, David J., Png, Chin Wen, Crockford, Tanya L., Cornall, Richard J., Kato, Masato, Nelms, Keats A., Hong, Nancy A., Goodnow, Christopher C. and Florin, Timothy H. (2007). Aberrant mucin assembly links endoplasmic reticulum stress with ulcerative colitis. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington Dc, May 19-24, 2007. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
2007
Conference Publication
Endoplasmic reticulum stress in goblet cells leads directly to intestinal inflammation with similarities to ulcerative colitis
Eri, Rajaraman D., Florin, Timothy H., Price, Gareth, Heazlewood, Chad K., Cook, Matthew C., Goodnow, Christopher C. and Mcguckin, Michael A. (2007). Endoplasmic reticulum stress in goblet cells leads directly to intestinal inflammation with similarities to ulcerative colitis. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington, DC, United States, 19-24 May 2007. Philadelphia, PA, United States: Elsevier .
2007
Conference Publication
Antibodies to complex microbial mixtures are a better diagnostic for Crohn's disease
Adams, Rachel J., Heazlewood, Sharise P., O'brien, Mark, Mcguckin, Michael A. and Florin, Timothy H. (2007). Antibodies to complex microbial mixtures are a better diagnostic for Crohn's disease. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington Dc, May 19-24, 2007. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
2007
Conference Publication
Effects of human mucin MUC2 on the expression of Campylobacter jejuni virulence factors
Mendz, G. L., Tu, Q. V. and McGuckin, M. A. (2007). Effects of human mucin MUC2 on the expression of Campylobacter jejuni virulence factors. OXFORD: BLACKWELL PUBLISHING.
2007
Journal Article
Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer
Pinzon-Charry, A., Ho, C. S. K., Maxwell, T., McGuckin, M. A., Schmidt, C., Furnival, C., Pyke, C. M. and Lopez, J. A. (2007). Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer. British Journal of Cancer, 97 (9), 1251-1259. doi: 10.1038/sj.bjc.6604018
2007
Conference Publication
Sulfate ions in mammalian physiology: Lessons from sulfate transporter null mice
Dawson, Paul Anthony, McGuckin, Michael A. and Markovich, Daniel (2007). Sulfate ions in mammalian physiology: Lessons from sulfate transporter null mice. Experimental Biology 2007 Annual Meeting, Washington, DC, United States, 28 April-2 May 2007. FEDERATION AMER SOC EXP BIOL.
2007
Journal Article
MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
McAuley, Julie L., Linden, Sara K., Png, Chin Wen, King, Rebecca M., Pennington, Helen L., Gendler, Sandra J., Florin, Timothy H., Hill, Geoff R., Korolik, Victoria and McGuckin, Michael A. (2007). MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. Journal of Clinical Investigation, 117 (8), 2313-2324. doi: 10.1172/JCI26705
2007
Conference Publication
Muc1 mucin limits both H-pylori colonisation of the gastric mucosa and associated gastritis
Sutton, P., Every, A. L., Skene, C. D., Linden, S., Harbour, S., Ferrero, R. and McGuckin, M. (2007). Muc1 mucin limits both H-pylori colonisation of the gastric mucosa and associated gastritis. OXFORD: BLACKWELL PUBLISHING.
2006
Conference Publication
The MUC13 cell surface mucin is highly expressed in human colorectal carcinomas
Walsh, Michael, Young, Joanne, Leggett, Barbara, Williams, Stephanie, Jeremy, Jass and McGuckin, Michael (2006). The MUC13 cell surface mucin is highly expressed in human colorectal carcinomas. 26th International Congress of the International-Academy-of-Pathology, Montreal Canada, Sep 16-21, 2006. NEW YORK: NATURE PUBLISHING GROUP.
2006
Journal Article
Detection of human metapneumovirus in respiratory secretions by reverse-transcriptase polymerase chain reaction, indirect immunofluorescence, and virus isolation in human bronchial epithelial cells
Ingram, R. E., Fenwick, F., McGuckin, M., Tefari, A., Taylor, C. and Toms, G. L. (2006). Detection of human metapneumovirus in respiratory secretions by reverse-transcriptase polymerase chain reaction, indirect immunofluorescence, and virus isolation in human bronchial epithelial cells. Journal of Medical Virology, 78 (9), 1223-1231. doi: 10.1002/jmv.20685
2006
Journal Article
Spontaneous apoptosis of blood dendritic cells in patients with breast cancer
Pinzon-Charry, Alberto, Maxwell, Tammy, McGuckin, Michael A., Schmidt, Chris, Furnival, Colin and Lopez, Jose A. (2006). Spontaneous apoptosis of blood dendritic cells in patients with breast cancer. Breast Cancer Research, 8 (1) R5, R5.1-R5.10. doi: 10.1186/bcr1361
2005
Conference Publication
The mucin MUC1 limits Helicobacter pylori colonisation of the gastric mucosa
Sutton, P, McAuley, J, Skene, C, Harbour, S and McGuckin, M (2005). The mucin MUC1 limits Helicobacter pylori colonisation of the gastric mucosa. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne Australia, Nov 29-Dec 02, 2005. OXFORD: BLACKWELL PUBLISHING.
Supervision
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
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Supervision history
Completed supervision
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2017
Doctor Philosophy
An Investigation into The Effect of Erythromycin on Pseudomonas aeruginosa Quorum Sensing in Non-CF Bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
Principal Advisor
Other advisors: Dr Sumaira Hasnain
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2012
Doctor Philosophy
Investigations of the Biochemistry and Physiology of Mice with a Mutation in the Muc2 Intestinal Mucin Gene
Principal Advisor
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2009
Doctor Philosophy
Biology of CA125 in ovarian cancer biology
Principal Advisor
Other advisors: Professor Andreas Obermair
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2005
Doctor Philosophy
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
Principal Advisor
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2004
Doctor Philosophy
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
Principal Advisor
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2024
Doctor Philosophy
Examining the Role of Endogenous and Exogenous Interleukin-22 Signaling in Metabolic Dysfunction-Associated Steatotic Liver Disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald, Dr Sumaira Hasnain
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Dr Ran Wang, Dr Sumaira Hasnain
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2020
Doctor Philosophy
Novel dietary factors in diabetic and non-diabetic kidney disease
Associate Advisor
Other advisors: Dr Danielle Borg, Honorary Professor Josephine Forbes
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2020
Doctor Philosophy
Local Delivery of Anti-inflammatory drugs with Functionalized Silica Nanoparticles for Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Sumaira Hasnain, Professor Amirali Popat
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2019
Doctor Philosophy
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
Associate Advisor
Other advisors: Professor Mike Gidley
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2018
Doctor Philosophy
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
Associate Advisor
Other advisors: Dr Ben Ross, Professor Amirali Popat
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2009
Doctor Philosophy
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
Associate Advisor
Media
Enquiries
Contact Honorary Professor Michael McGuckin directly for media enquiries about:
- colon cancer
- inflammatory bowel diseases
- inflammatory disease
- type 2 diabetes
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