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Honorary Professor Michael McGuckin
Honorary Professor

Michael McGuckin

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Overview

Background

~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.

Availability

Honorary Professor Michael McGuckin is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Science, The University of Queensland
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Cell surface mucin glycoproteins in infection, inflammation and cancer

  • Inflammatory bowel diseases

  • Non-cystic fibrosis bronchiectasis

  • Inflammation in the pathogenesis of type 2 diabetes

  • Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases

Works

Search Professor Michael McGuckin’s works on UQ eSpace

253 works between 1987 and 2024

161 - 180 of 253 works

2008

Journal Article

Structure and function of the polymeric mucins in airways mucus

Thornton, David J., Rousseau, Karine and McGuckin, Michael A. (2008). Structure and function of the polymeric mucins in airways mucus. Annual Review of Physiology, 70 (1), 459-486. doi: 10.1146/annurev.physiol.70.113006.100702

Structure and function of the polymeric mucins in airways mucus

2008

Journal Article

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

Heazlewood, Chad K., Cook, Matthew C., Eri, Rajaraman, Price, Gareth R., Tauro, Sharyn B., Taupin, Douglas, Thornton, David J., Png, Chin Wen, Crockford, Tanya L., Cornall, Richard J., Adams, Rachel, Kato, Masato, Nelms, Keats A., Hong, Nancy A., Florin, Timothy H. J., Goodnow, Christopher C. and McGuckin, Michael A. (2008). Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Medicine, 5 (3) e54, 440-460. doi: 10.1371/journal.pmed.0050054

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

2008

Journal Article

Mucin dynamics in intestinal bacterial infection

Linden, Sara K., Florin, Timothy H. J. and McGuckin, Michael A. (2008). Mucin dynamics in intestinal bacterial infection. PLoS One, 3 (12) e3952, e3952.1-e3952.14. doi: 10.1371/journal.pone.0003952

Mucin dynamics in intestinal bacterial infection

2008

Journal Article

IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin

Adams, Rachel J., Heazlewood, Sharise P., Gilshenan, Kristen S., O'Brien, Mark, McGuckin, Michael A. and Florin, Timothy H. J. (2008). IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin. American Journal of Gastroenterology, 103 (2), 386-396. doi: 10.1111/j.1572-0241.2007.01577.x

IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin

2008

Journal Article

IgG Antibodies Against Common Gut Bacteria Are More Diagnostic for Crohn's Disease Than IgG Against Mannan or Flagellin

Adams, Rachel J., Heazlewood, Sharise P., Gilshenan, Kristen S., O'Brien, Mark, McGuckin, Michael A. and Florin, Timothy H. J. (2008). IgG Antibodies Against Common Gut Bacteria Are More Diagnostic for Crohn's Disease Than IgG Against Mannan or Flagellin. American Journal of Gastroenterology, 103 (2), 386-396. doi: 10.1111/j.1572-0241.2007.01577.x

IgG Antibodies Against Common Gut Bacteria Are More Diagnostic for Crohn's Disease Than IgG Against Mannan or Flagellin

2007

Journal Article

Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis

McGuckin, Michael A., Every, Alison L., Skene, Caroline D., Linden, Sara K., Chionh, Yok Teng, Swierczak, Agnieszka, McAuley, Julie, Harbour, Stacey, Kaparakis, Maria, Ferrero, Richard and Sutton, Philip (2007). Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology, 133 (4), 1210-1218. doi: 10.1053/j.gastro.2007.07.003

Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis

2007

Journal Article

Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions

Linden, Sara K., Driessen, Kim M. and McGuckin, Michael A. (2007). Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions. Helicobacter, 12 (4), 341-353. doi: 10.1111/j.1523-5378.2007.00509.x

Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions

2007

Journal Article

The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas

Walsh, Michael D., Young, Joanne P., Leggett, Barbara A., Williams, Stephanie H., Jass, Jeremy R. and McGuckin, Michael A. (2007). The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas. Human Pathology, 38 (6), 883-892. doi: 10.1016/j.humpath.2006.11.020

The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas

2007

Conference Publication

Aberrant mucin assembly links endoplasmic reticulum stress with ulcerative colitis

Mcguckin, Michael A., Eri, Rajaraman, Heazlewood, Chad K., Cook, Matthew C., Taupin, Doug R., Thornton, David J., Png, Chin Wen, Crockford, Tanya L., Cornall, Richard J., Kato, Masato, Nelms, Keats A., Hong, Nancy A., Goodnow, Christopher C. and Florin, Timothy H. (2007). Aberrant mucin assembly links endoplasmic reticulum stress with ulcerative colitis. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington Dc, May 19-24, 2007. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

Aberrant mucin assembly links endoplasmic reticulum stress with ulcerative colitis

2007

Conference Publication

Endoplasmic reticulum stress in goblet cells leads directly to intestinal inflammation with similarities to ulcerative colitis

Eri, Rajaraman D., Florin, Timothy H., Price, Gareth, Heazlewood, Chad K., Cook, Matthew C., Goodnow, Christopher C. and Mcguckin, Michael A. (2007). Endoplasmic reticulum stress in goblet cells leads directly to intestinal inflammation with similarities to ulcerative colitis. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington, DC, United States, 19-24 May 2007. Philadelphia, PA, United States: Elsevier .

Endoplasmic reticulum stress in goblet cells leads directly to intestinal inflammation with similarities to ulcerative colitis

2007

Conference Publication

Antibodies to complex microbial mixtures are a better diagnostic for Crohn's disease

Adams, Rachel J., Heazlewood, Sharise P., O'brien, Mark, Mcguckin, Michael A. and Florin, Timothy H. (2007). Antibodies to complex microbial mixtures are a better diagnostic for Crohn's disease. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington Dc, May 19-24, 2007. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

Antibodies to complex microbial mixtures are a better diagnostic for Crohn's disease

2007

Conference Publication

Effects of human mucin MUC2 on the expression of Campylobacter jejuni virulence factors

Mendz, G. L., Tu, Q. V. and McGuckin, M. A. (2007). Effects of human mucin MUC2 on the expression of Campylobacter jejuni virulence factors. OXFORD: BLACKWELL PUBLISHING.

Effects of human mucin MUC2 on the expression of Campylobacter jejuni virulence factors

2007

Journal Article

Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer

Pinzon-Charry, A., Ho, C. S. K., Maxwell, T., McGuckin, M. A., Schmidt, C., Furnival, C., Pyke, C. M. and Lopez, J. A. (2007). Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer. British Journal of Cancer, 97 (9), 1251-1259. doi: 10.1038/sj.bjc.6604018

Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer

2007

Conference Publication

Sulfate ions in mammalian physiology: Lessons from sulfate transporter null mice

Dawson, Paul Anthony, McGuckin, Michael A. and Markovich, Daniel (2007). Sulfate ions in mammalian physiology: Lessons from sulfate transporter null mice. Experimental Biology 2007 Annual Meeting, Washington, DC, United States, 28 April-2 May 2007. FEDERATION AMER SOC EXP BIOL.

Sulfate ions in mammalian physiology: Lessons from sulfate transporter null mice

2007

Journal Article

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

McAuley, Julie L., Linden, Sara K., Png, Chin Wen, King, Rebecca M., Pennington, Helen L., Gendler, Sandra J., Florin, Timothy H., Hill, Geoff R., Korolik, Victoria and McGuckin, Michael A. (2007). MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. Journal of Clinical Investigation, 117 (8), 2313-2324. doi: 10.1172/JCI26705

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

2007

Conference Publication

Muc1 mucin limits both H-pylori colonisation of the gastric mucosa and associated gastritis

Sutton, P., Every, A. L., Skene, C. D., Linden, S., Harbour, S., Ferrero, R. and McGuckin, M. (2007). Muc1 mucin limits both H-pylori colonisation of the gastric mucosa and associated gastritis. OXFORD: BLACKWELL PUBLISHING.

Muc1 mucin limits both H-pylori colonisation of the gastric mucosa and associated gastritis

2006

Conference Publication

The MUC13 cell surface mucin is highly expressed in human colorectal carcinomas

Walsh, Michael, Young, Joanne, Leggett, Barbara, Williams, Stephanie, Jeremy, Jass and McGuckin, Michael (2006). The MUC13 cell surface mucin is highly expressed in human colorectal carcinomas. 26th International Congress of the International-Academy-of-Pathology, Montreal Canada, Sep 16-21, 2006. NEW YORK: NATURE PUBLISHING GROUP.

The MUC13 cell surface mucin is highly expressed in human colorectal carcinomas

2006

Journal Article

Detection of human metapneumovirus in respiratory secretions by reverse-transcriptase polymerase chain reaction, indirect immunofluorescence, and virus isolation in human bronchial epithelial cells

Ingram, R. E., Fenwick, F., McGuckin, M., Tefari, A., Taylor, C. and Toms, G. L. (2006). Detection of human metapneumovirus in respiratory secretions by reverse-transcriptase polymerase chain reaction, indirect immunofluorescence, and virus isolation in human bronchial epithelial cells. Journal of Medical Virology, 78 (9), 1223-1231. doi: 10.1002/jmv.20685

Detection of human metapneumovirus in respiratory secretions by reverse-transcriptase polymerase chain reaction, indirect immunofluorescence, and virus isolation in human bronchial epithelial cells

2006

Journal Article

Spontaneous apoptosis of blood dendritic cells in patients with breast cancer

Pinzon-Charry, Alberto, Maxwell, Tammy, McGuckin, Michael A., Schmidt, Chris, Furnival, Colin and Lopez, Jose A. (2006). Spontaneous apoptosis of blood dendritic cells in patients with breast cancer. Breast Cancer Research, 8 (1) R5, R5.1-R5.10. doi: 10.1186/bcr1361

Spontaneous apoptosis of blood dendritic cells in patients with breast cancer

2005

Conference Publication

The mucin MUC1 limits Helicobacter pylori colonisation of the gastric mucosa

Sutton, P, McAuley, J, Skene, C, Harbour, S and McGuckin, M (2005). The mucin MUC1 limits Helicobacter pylori colonisation of the gastric mucosa. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne Australia, Nov 29-Dec 02, 2005. OXFORD: BLACKWELL PUBLISHING.

The mucin MUC1 limits Helicobacter pylori colonisation of the gastric mucosa

Supervision

Availability

Honorary Professor Michael McGuckin is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Honorary Professor Michael McGuckin directly for media enquiries about:

  • colon cancer
  • inflammatory bowel diseases
  • inflammatory disease
  • type 2 diabetes

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