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Honorary Professor Michael McGuckin
Honorary Professor

Michael McGuckin

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Overview

Background

~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.

Availability

Honorary Professor Michael McGuckin is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Science, The University of Queensland
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Cell surface mucin glycoproteins in infection, inflammation and cancer

  • Inflammatory bowel diseases

  • Non-cystic fibrosis bronchiectasis

  • Inflammation in the pathogenesis of type 2 diabetes

  • Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases

Works

Search Professor Michael McGuckin’s works on UQ eSpace

253 works between 1987 and 2024

141 - 160 of 253 works

2010

Journal Article

ER stress and the unfolded protein response in intestinal inflammation

McGuckin, Michael A., Eri, Rajaraman D., Das, Indrajit, Lourie, Rohan and Florin, Timothy H. (2010). ER stress and the unfolded protein response in intestinal inflammation. American Journal of Physiology: Gastrointestinal and Liver Physiology, 298 (6), G820-G832. doi: 10.1152/ajpgi.00063.2010

ER stress and the unfolded protein response in intestinal inflammation

2010

Journal Article

Lynch syndrome-associated breast cancers: Clinicopathologic characteristics of a case series from the colon cancer family registry

Walsh, MD, Buchanan, DD, Cummings, MC, Pearson, SA, Arnold, ST, Clendenning, M, Walters, R, McKeone, DM, Spurdle, AB, Hopper, JL, Jenkins, MA, Phillips, KD, Suthers, GK, George, J, Goldblatt, J, Muir, A, Tucker, K, Pelzer, E, Gattas, MR, Woodall, S, Parry, S, Macrae, FA, Haile, RW, Baron, JA, Potter, JD, Le Marchand, L, Bapat, B, Thibodeau, SN, Lindor, NM ... Young, JP (2010). Lynch syndrome-associated breast cancers: Clinicopathologic characteristics of a case series from the colon cancer family registry. Clinical Cancer Research, 16 (7), 2214-2224. doi: 10.1158/1078-0432.CCR-09-3058

Lynch syndrome-associated breast cancers: Clinicopathologic characteristics of a case series from the colon cancer family registry

2010

Conference Publication

Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the Colon CFR

Rosty, Christophe, Walsh, Michael, Cummings, Margaret, Buchanan, Daniel, Arnold, Sven, McKeone, Diane, Walters, Rhiannon, Hopper, John, Jenkins, Mark, Spurdle, Amanda, McGuckin, Michael, Lakhani, Sunil and Young, Joanne (2010). Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the Colon CFR. AACR 101st Annual Meeting 2010, Washington, DC, United States, 17-21 April 2010. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM10-32

Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the Colon CFR

2010

Conference Publication

Dexamethasone ameliorates intestinal epithelial cell ER stress and ER stress induced colitis

McGuckin, M. A., Das, I., Png, C. W., Tran, T., Eri, R., Lourie, R., Adams, R., Crane, D. and Florin, T. H. (2010). Dexamethasone ameliorates intestinal epithelial cell ER stress and ER stress induced colitis. Australian Gastroenterology Week 2010, Broadbeach, Qld., Australia, 20-23 October 2010. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2010.06454.x

Dexamethasone ameliorates intestinal epithelial cell ER stress and ER stress induced colitis

2010

Book Chapter

Microbes at the host surface

Linden, Sara K. and McGuckin, Michael A. (2010). Microbes at the host surface. Current research, technology and education topics in applied microbiology and microbial biotechnology. (pp. 591-596) edited by A. Mendez-Vilas. Badajoz, Spain: Formatex Research Center.

Microbes at the host surface

2009

Journal Article

MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy

Linden, Sara K., Sheng, Yong H., Every, Alison L., Miles, Kim M., Skoog, Emma C., Florin, Timothy H.J., Sutton, Philip and Mcguckin, Michael A. (2009). MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. Plos Pathogens, 5 (10) e1000617, Article No. e1000617. doi: 10.1371/journal.ppat.1000617

MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy

2009

Journal Article

Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse

Dawson, Paul A., Huxley, S., Gardiner, B., Tran, T., McAuley, J. L., Grimmond, S. M., McGuckin, M. A. and Markovich, D. (2009). Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse. Gut, 58 (7), 910-919. doi: 10.1136/gut.2007.147595

Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse

2009

Conference Publication

KCNN4 Gene Variant Is Associated with Ileal Crohn's Disease

Simms, Lisa A., Doecke, James D., Fowler, Elizabeth V., Zhao, Zhen Zhen, McGuckin, Michael A., Huang, Ning, Hayward, Nicholas K., Webb, Penelope M., Whiteman, David, Cavanaugh, Juleen, McCallum, Ruth K., Merriman, Tony R., Florin, Timothy H., Barclay, Murray L., Gearry, Richard B., Roberts, Rebecca L., Montgomery, Grant W. and Radford-Smith, Graham L. (2009). KCNN4 Gene Variant Is Associated with Ileal Crohn's Disease. Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Chicago Il, May 30-Jun 04, 2009. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

KCNN4 Gene Variant Is Associated with Ileal Crohn's Disease

2009

Conference Publication

Effect of Loss of Tolerance in a TH17 Mediated Mouse Model of ER Stress Induced Colitis

Tauro, Sharyn B., Eri, Rajaraman D., Jeffery, Penny, Adams, Rachel J., Tran, Thu V., Roche, Deborah, Florin, Timothy H. and McGuckin, Michael A. (2009). Effect of Loss of Tolerance in a TH17 Mediated Mouse Model of ER Stress Induced Colitis. Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Chicago Il, May 30-Jun 04, 2009. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

Effect of Loss of Tolerance in a TH17 Mediated Mouse Model of ER Stress Induced Colitis

2009

Journal Article

Dietary Antigens in Crohn's Disease

Adams, Rachael, McGuckin, Michael and Florin, Timothy (2009). Dietary Antigens in Crohn's Disease. The American Journal of Gastroenterology, 104 (2), 526-526. doi: 10.1038/ajg.2008.79

Dietary Antigens in Crohn's Disease

2009

Journal Article

Mucin I (MUCI) is a novel partner for MAL2 in breast carcinoma cells

Fanayan, Susan, Shehata, Mona, Agterof, Annelies P., Mcguckin, Michael A., Alonso, Miguel A . and Byrne, Jennifer A. (2009). Mucin I (MUCI) is a novel partner for MAL2 in breast carcinoma cells. BMC Cell Biology, 10 (7) 7, 7-1-7-13. doi: 10.1186/1471-2121-10-7

Mucin I (MUCI) is a novel partner for MAL2 in breast carcinoma cells

2009

Journal Article

Intestinal barrier dysfunction in inflammatory bowel diseases

McGuckin, Michael A., Eri, Rajaraman, Simms, Lisa A., Florin, Timothy H. J. and Radford-Smith, Graham (2009). Intestinal barrier dysfunction in inflammatory bowel diseases. Inflammatory Bowel Diseases, 15 (1), 100-113. doi: 10.1002/ibd.20539

Intestinal barrier dysfunction in inflammatory bowel diseases

2009

Conference Publication

The effect of thiopurine on leukocytes in a C57BL/6 mouse model

Oancea, Iulia, Eri, Rajaraman D., McGuckin, Michael A., Duley, John A. and Florin, Timothy H. (2009). The effect of thiopurine on leukocytes in a C57BL/6 mouse model. *, *, *. Maryland Heights, MO, United States: W.B. Saunders Co..

The effect of thiopurine on leukocytes in a C57BL/6 mouse model

2008

Journal Article

Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection

Every, Alison L., Chionh, Yok-Teng, Skene, Caroline D., McGuckin, Michael A. and Sutton, Philip (2008). Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection. Helicobacter, 13 (6), 489-493. doi: 10.1111/j.1523-5378.2008.00644.x

Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection

2008

Conference Publication

DNA mismatch repair deficiency in breast cancers arising in breast/colon families

Walsh, M., Cummings, M., Buchanan, D., Arnold, S., McKeone, D., Walters, R., Jass, J., Hopper, J., Jenkins, M., Spurdle, A., McGuckin, M. and Young, J. (2008). DNA mismatch repair deficiency in breast cancers arising in breast/colon families. 27th International Congress of the International-Academy-of-Pathology, Athens Greece, Oct 12-17, 2008. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.

DNA mismatch repair deficiency in breast cancers arising in breast/colon families

2008

Conference Publication

Inhibition of endoplasmic stress by dexamethasone: a novel action relevant to ulcerative colitis?

Das, I., Eri, R., Ping, C. W., Tran, T., Adams, R., McGuckin, M. A. and Florin, T. H. (2008). Inhibition of endoplasmic stress by dexamethasone: a novel action relevant to ulcerative colitis?. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.

Inhibition of endoplasmic stress by dexamethasone: a novel action relevant to ulcerative colitis?

2008

Journal Article

Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants

Tu, Quoc V., McGuckin, Michael A. and Mendz, George L. (2008). Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants. Journal of Medical Microbiology, 57 (7), 795-802. doi: 10.1099/jmm.0.47752-0

Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants

2008

Journal Article

Listeria monocytogenes internalins bind to the human intestinal mucin MUC2

Linden, Sara K., Bierne, Hélène, Sabet, Christophe, Png, Chin Wen, Florin, Timothy H., McGuckin, Michael A. and Cossart, Pascale (2008). Listeria monocytogenes internalins bind to the human intestinal mucin MUC2. Archives of Microbiology, 190 (1), 101-104. doi: 10.1007/s00203-008-0358-6

Listeria monocytogenes internalins bind to the human intestinal mucin MUC2

2008

Journal Article

Mucins in the mucosal barrier to infection

Linden, S. K., Sutton, P., Karlsson, N.G., Korolik, V. and McGuckin, M. A. (2008). Mucins in the mucosal barrier to infection. Mucosal Immunology, 1 (3), 183-197. doi: 10.1038/mi.2008.5

Mucins in the mucosal barrier to infection

2008

Conference Publication

Muc1 limits H-pylori infection fly acting as a releasable decoy

Linden, Sara K., Miles, Kim M., Florin, Timothy H., Dubois, Andre and McGuckin, Michael A. (2008). Muc1 limits H-pylori infection fly acting as a releasable decoy. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

Muc1 limits H-pylori infection fly acting as a releasable decoy

Supervision

Availability

Honorary Professor Michael McGuckin is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Honorary Professor Michael McGuckin directly for media enquiries about:

  • colon cancer
  • inflammatory bowel diseases
  • inflammatory disease
  • type 2 diabetes

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