
Overview
Background
~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Cell surface mucin glycoproteins in infection, inflammation and cancer
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Inflammatory bowel diseases
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Non-cystic fibrosis bronchiectasis
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Inflammation in the pathogenesis of type 2 diabetes
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Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases
Works
Search Professor Michael McGuckin’s works on UQ eSpace
2010
Journal Article
ER stress and the unfolded protein response in intestinal inflammation
McGuckin, Michael A., Eri, Rajaraman D., Das, Indrajit, Lourie, Rohan and Florin, Timothy H. (2010). ER stress and the unfolded protein response in intestinal inflammation. American Journal of Physiology: Gastrointestinal and Liver Physiology, 298 (6), G820-G832. doi: 10.1152/ajpgi.00063.2010
2010
Journal Article
Lynch syndrome-associated breast cancers: Clinicopathologic characteristics of a case series from the colon cancer family registry
Walsh, MD, Buchanan, DD, Cummings, MC, Pearson, SA, Arnold, ST, Clendenning, M, Walters, R, McKeone, DM, Spurdle, AB, Hopper, JL, Jenkins, MA, Phillips, KD, Suthers, GK, George, J, Goldblatt, J, Muir, A, Tucker, K, Pelzer, E, Gattas, MR, Woodall, S, Parry, S, Macrae, FA, Haile, RW, Baron, JA, Potter, JD, Le Marchand, L, Bapat, B, Thibodeau, SN, Lindor, NM ... Young, JP (2010). Lynch syndrome-associated breast cancers: Clinicopathologic characteristics of a case series from the colon cancer family registry. Clinical Cancer Research, 16 (7), 2214-2224. doi: 10.1158/1078-0432.CCR-09-3058
2010
Conference Publication
Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the Colon CFR
Rosty, Christophe, Walsh, Michael, Cummings, Margaret, Buchanan, Daniel, Arnold, Sven, McKeone, Diane, Walters, Rhiannon, Hopper, John, Jenkins, Mark, Spurdle, Amanda, McGuckin, Michael, Lakhani, Sunil and Young, Joanne (2010). Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the Colon CFR. AACR 101st Annual Meeting 2010, Washington, DC, United States, 17-21 April 2010. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM10-32
2010
Conference Publication
Dexamethasone ameliorates intestinal epithelial cell ER stress and ER stress induced colitis
McGuckin, M. A., Das, I., Png, C. W., Tran, T., Eri, R., Lourie, R., Adams, R., Crane, D. and Florin, T. H. (2010). Dexamethasone ameliorates intestinal epithelial cell ER stress and ER stress induced colitis. Australian Gastroenterology Week 2010, Broadbeach, Qld., Australia, 20-23 October 2010. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2010.06454.x
2010
Book Chapter
Microbes at the host surface
Linden, Sara K. and McGuckin, Michael A. (2010). Microbes at the host surface. Current research, technology and education topics in applied microbiology and microbial biotechnology. (pp. 591-596) edited by A. Mendez-Vilas. Badajoz, Spain: Formatex Research Center.
2009
Journal Article
MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy
Linden, Sara K., Sheng, Yong H., Every, Alison L., Miles, Kim M., Skoog, Emma C., Florin, Timothy H.J., Sutton, Philip and Mcguckin, Michael A. (2009). MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. Plos Pathogens, 5 (10) e1000617, Article No. e1000617. doi: 10.1371/journal.ppat.1000617
2009
Journal Article
Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse
Dawson, Paul A., Huxley, S., Gardiner, B., Tran, T., McAuley, J. L., Grimmond, S. M., McGuckin, M. A. and Markovich, D. (2009). Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse. Gut, 58 (7), 910-919. doi: 10.1136/gut.2007.147595
2009
Conference Publication
KCNN4 Gene Variant Is Associated with Ileal Crohn's Disease
Simms, Lisa A., Doecke, James D., Fowler, Elizabeth V., Zhao, Zhen Zhen, McGuckin, Michael A., Huang, Ning, Hayward, Nicholas K., Webb, Penelope M., Whiteman, David, Cavanaugh, Juleen, McCallum, Ruth K., Merriman, Tony R., Florin, Timothy H., Barclay, Murray L., Gearry, Richard B., Roberts, Rebecca L., Montgomery, Grant W. and Radford-Smith, Graham L. (2009). KCNN4 Gene Variant Is Associated with Ileal Crohn's Disease. Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Chicago Il, May 30-Jun 04, 2009. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
2009
Conference Publication
Effect of Loss of Tolerance in a TH17 Mediated Mouse Model of ER Stress Induced Colitis
Tauro, Sharyn B., Eri, Rajaraman D., Jeffery, Penny, Adams, Rachel J., Tran, Thu V., Roche, Deborah, Florin, Timothy H. and McGuckin, Michael A. (2009). Effect of Loss of Tolerance in a TH17 Mediated Mouse Model of ER Stress Induced Colitis. Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Chicago Il, May 30-Jun 04, 2009. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
2009
Journal Article
Dietary Antigens in Crohn's Disease
Adams, Rachael, McGuckin, Michael and Florin, Timothy (2009). Dietary Antigens in Crohn's Disease. The American Journal of Gastroenterology, 104 (2), 526-526. doi: 10.1038/ajg.2008.79
2009
Journal Article
Mucin I (MUCI) is a novel partner for MAL2 in breast carcinoma cells
Fanayan, Susan, Shehata, Mona, Agterof, Annelies P., Mcguckin, Michael A., Alonso, Miguel A . and Byrne, Jennifer A. (2009). Mucin I (MUCI) is a novel partner for MAL2 in breast carcinoma cells. BMC Cell Biology, 10 (7) 7, 7-1-7-13. doi: 10.1186/1471-2121-10-7
2009
Journal Article
Intestinal barrier dysfunction in inflammatory bowel diseases
McGuckin, Michael A., Eri, Rajaraman, Simms, Lisa A., Florin, Timothy H. J. and Radford-Smith, Graham (2009). Intestinal barrier dysfunction in inflammatory bowel diseases. Inflammatory Bowel Diseases, 15 (1), 100-113. doi: 10.1002/ibd.20539
2009
Conference Publication
The effect of thiopurine on leukocytes in a C57BL/6 mouse model
Oancea, Iulia, Eri, Rajaraman D., McGuckin, Michael A., Duley, John A. and Florin, Timothy H. (2009). The effect of thiopurine on leukocytes in a C57BL/6 mouse model. *, *, *. Maryland Heights, MO, United States: W.B. Saunders Co..
2008
Journal Article
Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection
Every, Alison L., Chionh, Yok-Teng, Skene, Caroline D., McGuckin, Michael A. and Sutton, Philip (2008). Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection. Helicobacter, 13 (6), 489-493. doi: 10.1111/j.1523-5378.2008.00644.x
2008
Conference Publication
DNA mismatch repair deficiency in breast cancers arising in breast/colon families
Walsh, M., Cummings, M., Buchanan, D., Arnold, S., McKeone, D., Walters, R., Jass, J., Hopper, J., Jenkins, M., Spurdle, A., McGuckin, M. and Young, J. (2008). DNA mismatch repair deficiency in breast cancers arising in breast/colon families. 27th International Congress of the International-Academy-of-Pathology, Athens Greece, Oct 12-17, 2008. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
2008
Conference Publication
Inhibition of endoplasmic stress by dexamethasone: a novel action relevant to ulcerative colitis?
Das, I., Eri, R., Ping, C. W., Tran, T., Adams, R., McGuckin, M. A. and Florin, T. H. (2008). Inhibition of endoplasmic stress by dexamethasone: a novel action relevant to ulcerative colitis?. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
2008
Journal Article
Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants
Tu, Quoc V., McGuckin, Michael A. and Mendz, George L. (2008). Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants. Journal of Medical Microbiology, 57 (7), 795-802. doi: 10.1099/jmm.0.47752-0
2008
Journal Article
Listeria monocytogenes internalins bind to the human intestinal mucin MUC2
Linden, Sara K., Bierne, Hélène, Sabet, Christophe, Png, Chin Wen, Florin, Timothy H., McGuckin, Michael A. and Cossart, Pascale (2008). Listeria monocytogenes internalins bind to the human intestinal mucin MUC2. Archives of Microbiology, 190 (1), 101-104. doi: 10.1007/s00203-008-0358-6
2008
Journal Article
Mucins in the mucosal barrier to infection
Linden, S. K., Sutton, P., Karlsson, N.G., Korolik, V. and McGuckin, M. A. (2008). Mucins in the mucosal barrier to infection. Mucosal Immunology, 1 (3), 183-197. doi: 10.1038/mi.2008.5
2008
Conference Publication
Muc1 limits H-pylori infection fly acting as a releasable decoy
Linden, Sara K., Miles, Kim M., Florin, Timothy H., Dubois, Andre and McGuckin, Michael A. (2008). Muc1 limits H-pylori infection fly acting as a releasable decoy. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
Supervision
Availability
- Honorary Professor Michael McGuckin is:
- Available for supervision
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Supervision history
Completed supervision
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2017
Doctor Philosophy
An Investigation into The Effect of Erythromycin on Pseudomonas aeruginosa Quorum Sensing in Non-CF Bronchiectasis
Principal Advisor
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2015
Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
Principal Advisor
Other advisors: Dr Sumaira Hasnain
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2015
Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
Principal Advisor
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2012
Doctor Philosophy
Investigations of the Biochemistry and Physiology of Mice with a Mutation in the Muc2 Intestinal Mucin Gene
Principal Advisor
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2009
Doctor Philosophy
Biology of CA125 in ovarian cancer biology
Principal Advisor
Other advisors: Professor Andreas Obermair
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2005
Doctor Philosophy
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
Principal Advisor
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2004
Doctor Philosophy
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
Principal Advisor
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2024
Doctor Philosophy
Examining the Role of Endogenous and Exogenous Interleukin-22 Signaling in Metabolic Dysfunction-Associated Steatotic Liver Disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald, Dr Sumaira Hasnain
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2020
Doctor Philosophy
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
Associate Advisor
Other advisors: Dr Ran Wang, Dr Sumaira Hasnain
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2020
Doctor Philosophy
Novel dietary factors in diabetic and non-diabetic kidney disease
Associate Advisor
Other advisors: Dr Danielle Borg, Honorary Professor Josephine Forbes
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2020
Doctor Philosophy
Local Delivery of Anti-inflammatory drugs with Functionalized Silica Nanoparticles for Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Sumaira Hasnain, Professor Amirali Popat
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2019
Doctor Philosophy
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
Associate Advisor
Other advisors: Professor Mike Gidley
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2018
Doctor Philosophy
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
Associate Advisor
Other advisors: Dr Ben Ross, Professor Amirali Popat
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2009
Doctor Philosophy
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
Associate Advisor
Media
Enquiries
Contact Honorary Professor Michael McGuckin directly for media enquiries about:
- colon cancer
- inflammatory bowel diseases
- inflammatory disease
- type 2 diabetes
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