Honorary Professor

Kum Kum Khanna

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Availability

Honorary Professor Kum Kum Khanna is:
Available for supervision

Fields of research

Biological Sciences Oncology and carcinogenesis

Search Professor Kum Kum Khanna’s works on UQ eSpace

207 works between 1995 and 2026
All (207) Journal Article (193) Other Outputs (1) Conference Publication (13)

101 - 120 of 207 works

2012

Journal Article

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

Wu, Juan, Zhang, Xian, Zhang, Ling, Wu, Ching-Yuan, Rezaeian, Abdol Hossein, Chan, Chia-Hsin, Li, Ju-Mei, Wang, Jing, Gao, Yuan, Han, Fei, Jeong, Yun Seong, Yuan, Xiandao, Khanna, Kum Kum, Jin, Jianping, Zeng, Yi-Xin and Lin, Hui-Kuan (2012). Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1. Molecular Cell, 46 (3), 351-361. doi: 10.1016/j.molcel.2012.02.018

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

2012

Conference Publication

SSB1 is essential for embryogenesis and maintenance of genomic stability in mice

Khanna, KumKum, Shi, Wei and Bain, Amanda (2012). SSB1 is essential for embryogenesis and maintenance of genomic stability in mice. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2012-2127

SSB1 is essential for embryogenesis and maintenance of genomic stability in mice

2012

Journal Article

INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells

Morris, Christelle, Tomimatsu, Nozomi, Richard, Derek J., Cluet, David, Burma, Sandeep, Khanna, Kum Kum and Jalinot, Pierre (2012). INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. Cancer Research, 72 (8), 2006-2016. doi: 10.1158/0008-5472.CAN-11-2562

INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells

2012

Journal Article

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

Tomimatsu, Nozomi, Mukherjee, Bipasha, Deland, Katherine, Kurimasa, Akihiro, Bolderson, Emma, Khanna, Kum Kum and Burma, Sandeep (2012). Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair, 11 (4), 441-448. doi: 10.1016/j.dnarep.2012.01.006

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

2012

Journal Article

Tocotrienol as a potential anticancer agent

Ling, Ming T., Luk, Sze U., Al-Ejeh, Fares and Khanna, Kum K. (2012). Tocotrienol as a potential anticancer agent. Carcinogenesis, 33 (2), 233-239. doi: 10.1093/carcin/bgr261

Tocotrienol as a potential anticancer agent

2012

Conference Publication

Uncovering molecular mechanisms involved in metastasis to the brain

Saunus, Jodi M., Momeny, Majid, Da Silva, Leonard, Vargas, Ana Cristina, Al-Ejeh, Fares, Morrison, Brian, Khanna, Kum Kum, Grimmond, Sean, Chenevix-Trench, Georgia, Jeffree, Rosalind L., Waddell, Nicola, Simpson, Peter T. and Lakhani, Sunil R. (2012). Uncovering molecular mechanisms involved in metastasis to the brain. 14th International Biennial Congress of the Metastasis Research Society, Brisbane, QLD, Australia, 2-5 September 2012.

Uncovering molecular mechanisms involved in metastasis to the brain

2012

Journal Article

Potential roles for prions and protein-only inheritance in cancer

Antony, H., Wiegmans, A. P., Wei, M. Q., Chernoff, Y. O., Khanna, K. K. and Munn, A. L. (2012). Potential roles for prions and protein-only inheritance in cancer. Cancer metastasis reviews, 31 (1-2), 1-19. doi: 10.1007/s10555-011-9325-9

Potential roles for prions and protein-only inheritance in cancer

2012

Conference Publication

Role of HER3 in brain metastases from primary breast cancer

Saunus, Jodi M., Da Silva, Leonard, Momeny, Majid, Morrison, Brian, Lane, Annette, Smart, Chanel, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia, Simpson, Peter T. and Lakhani, Sunil R. (2012). Role of HER3 in brain metastases from primary breast cancer. 24th Lorne Cancer Conference, Lorne, VIC, Australia, 9-12 February 2012.

Role of HER3 in brain metastases from primary breast cancer

2011

Journal Article

ATM protein kinase: The linchpin of cellular defenses to stress

Bhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin and Khanna, Kum Kum (2011). ATM protein kinase: The linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences, 68 (18), 2977-3006. doi: 10.1007/s00018-011-0683-9

ATM protein kinase: The linchpin of cellular defenses to stress

2011

Journal Article

Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons

Jung, Cha-Gyun, Uhm, Kyung-Ok, Miura, Yutaka, Hosono, Takashi, Horike, Hirofumi, Khanna, Kum Kum, Kim, Mi-Jeong and Michikawa, Makoto (2011). Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons. Molecular Neurodegeneration, 6 (47) 47, 1-14. doi: 10.1186/1750-1326-6-47

Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons

2011

Journal Article

Rare variants in the ATM gene and risk of breast cancer

Goldgar, David E., Healey, Sue, Dowty, James G., Da Silva, Leonard, Chen, Xiaoqing, Spurdle, Amanda B., Terry, Mary B., Daly, Mary J., Buys, Saundra M., Southey, Melissa C., Andrulis, Irene, John, Esther M., Breast Cancer Family Registry, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Khanna, Kum K., Hopper, John L., Oefner, Peter J., Lakhani, Sunil and Chenevix-Trench, Georgia (2011). Rare variants in the ATM gene and risk of breast cancer. Breast Cancer Research, 13 (4) R73, R73-1-R73-9. doi: 10.1186/bcr2919

Rare variants in the ATM gene and risk of breast cancer

2011

Journal Article

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

Richard, Derek J., Cubeddu, Liza, Urquhart, Aaron J., Bain, Amanda, Bolderson, Emma, Menon, Dinoop, White, Malcolm F. and Khanna, Kum Kum (2011). hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Research, 39 (9), 3643-3651. doi: 10.1093/nar/gkq1340

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

2011

Journal Article

Breast cancer stem cells: Treatment resistance and therapeutic opportunities

AL-Ejeh, Fares, Smart, Chanel E., Morrison, Brian J., Chenevix-Trench, Georgia, Lopez, J. Alejandro, Lakhani, Sunil R., Brown, Michael P. and Khanna, Kum Kum (2011). Breast cancer stem cells: Treatment resistance and therapeutic opportunities. Carcinogenesis, 32 (5), 650-658. doi: 10.1093/carcin/bgr028

Breast cancer stem cells: Treatment resistance and therapeutic opportunities

2011

Journal Article

A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice

Youngson, N. A., Vickaryous, N., van der Horst, A., Epp, T., Harten, S., Fleming, J. S., Khanna, K. K., de Kretser, D. M. and Whitelaw, Emma (2011). A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mammalian Genome, 22 (3-4), 235-248. doi: 10.1007/s00335-011-9317-7

A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice

2011

Journal Article

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

Richard, Derek J., Savage, Kienan, Bolderson, Emma, Cubeddu, Liza, So, Sairei, Ghita, Mihaela, Chen, David J., White, Malcolm F., Richard, Kerry, Prise, Kevin M., Schettino, Giuseppe and Khanna, Kum Kum (2011). hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Research, 39 (5), 1692-1702. doi: 10.1093/nar/gkq1098

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

2011

Journal Article

Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges

Simpson, Peter T., Vargas, Ana Christina, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2011). Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges. Human Pathology, 42 (2), 153-165. doi: 10.1016/j.humpath.2010.07.008

Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges

2011

Journal Article

Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families

Johnson, Julie, Healey, Sue, Khanna, Kum Kum, kConFab and Chenevix-Trench, Georgia (2011). Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families. Breast Cancer Research and Treatment, 129 (1), 255-263. doi: 10.1007/s10549-011-1539-6

Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families

2010

Journal Article

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

Schoenmakers, Erik, Agostini, Maura, Mitchell, Catherine, Schoenmakers, Nadia, Papp, Laura, Rajanayagam, Odelia, Padidela, Raja, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Prevosto, Claudia, Luan, Jian'an, Montano, Sergio, Lu, Jun, Castanet, Mireille, Clemons, Nick, Groeneveld, Matthijs, Castets, Perrine, Karbaschi, Mahsa, Aitken, Sri, Dixon, Adrian, Williams, Jane, Campi, Irene, Blount, Margaret, Burton, Hannah, Muntoni, Francesco, O'Donovan, Dominic, Dean, Andrew, Warren, Anne, Brierley, Charlotte ... Chatterjee, Krishna (2010). Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. Journal of Clinical Investigation, 120 (12), 4220-4235. doi: 10.1172/JCI43653

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

2010

Journal Article

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

Al-Ejeh, F., Kumar, R., Wiegmans, A., Lakhani, S.R., Brown, M.P. and Khanna, K.K. (2010). Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene, 29 (46), 6085-6098. doi: 10.1038/onc.2010.407

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

2010

Journal Article

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

Kim, TS, Kawaguchi, M, Suzuki, M, Jung, CG, Asai, K, Shibamoto, Y, Lavin, MF, Khanna, KK and Miura, Y (2010). The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. DMM Disease Models and Mechanisms, 3 (11-12), 752-762. doi: 10.1242/dmm.004689

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

Current funding

  • 2026 - 2028
    Optimisation of endometrial cancer treatment using ex vivo Patient-Derived Organoids/tumouroids.
    Mary Elizabeth Courier Research Scholarship
    Open grant
  • 2026 - 2029
    Targeting PP2A to sensitize ovarian cancers to immune checkpoint blockade therapy
    Ovarian Cancer Research Foundation Research Grants
    Open grant
  • 2024 - 2026
    Targeting the redox niche in triple-negative breast cancer to treat brain metastases
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant
  • 2024 - 2027
    Targeting metstatic breast cancer by oligonucleotide therapeutics with the FDA lipid nanoparticles (LNP) delivery system.
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant
  • 2022 - 2026
    Targeting CEP55 in Triple-Negative Breast Cancer (US DoD CDMRP grant administered by QIMR)
    Queensland Institute of Medical Research
    Open grant

Past funding

  • 2024
    Exploitation of immunogenicity of Cep 55 to enhance efficacy of therapy for triple-negative breast cancer
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant

Availability

Honorary Professor Kum Kum Khanna is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Functional validation of therapeutic targets for basal breast cancer

    Principal Advisor

  • Doctor Philosophy

    Drug Repurposing for Biomarker Discovery and Therapeutic Sensitisation in Triple Negative Breast Cancer (TNBC) and High Grade Serous Ovarian Cancer (HGSOC)

    Principal Advisor

  • Doctor Philosophy

    A mitotic switch: serine 125 phosphorylation of MLKL links cell division to cell fate

    Principal Advisor

  • Doctor Philosophy

    Discovering therapies of metastatic and recurrenttriple-negative breast cancer using next generation 3D models

    Principal Advisor

  • Doctor Philosophy

    Optimising systemic therapies of metastatic and recurrent triple-negative breast cancer using next generation 3D models

    Principal Advisor

  • Doctor Philosophy

    Designing Therapeutic Strategies Targeting KRAS

    Associate Advisor

    Other advisors: Honorary Professor Rajiv Khanna

  • Doctor Philosophy

    Investigating the diagnostic and functional significance of specific epigenomic features in triple-negative breast cancer (TNBC)

    Associate Advisor

    Other advisors: Dr Jodi Saunus

  • Doctor Philosophy

    Breaking barriers: unlocking the potential of cytomegalovirus-specific T cells in allogeneic CAR T cell therapies

    Associate Advisor

    Other advisors: Honorary Professor Rajiv Khanna

Completed supervision

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