Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
Featured
2020
Journal Article
Pulmonary alveolar proteinosis after lung transplantation
Divithotawela, Chandima, Apte, Simon H., Tan, Maxine E., De Silva, Tharushi A. and Chambers, Daniel C. (2020). Pulmonary alveolar proteinosis after lung transplantation. Respirology Case Reports, 8 (5) e00566, e00566. doi: 10.1002/rcr2.566
Featured
2020
Journal Article
Diagnosis and treatment of lung disease associated with alpha one‐antitrypsin deficiency: a position statement from the Thoracic Society of Australia and New Zealand*
Dummer, Jack, Dobler, Claudia C., Holmes, Mark, Chambers, Daniel, Yang, Ian A., Parkin, Lianne, Smith, Sheree, Wark, Peter, Dev, Anouk, Hodge, Sandra, Dabscheck, Eli, Gooi, Julian, Samuel, Sameh, Knowles, Steven and Holland, Anne E. (2020). Diagnosis and treatment of lung disease associated with alpha one‐antitrypsin deficiency: a position statement from the Thoracic Society of Australia and New Zealand*. Respirology, 25 (3) resp.13774, 321-335. doi: 10.1111/resp.13774
Featured
2020
Journal Article
Silicosis: an ancient disease in need of a dose of modern medicine
Hoy, Ryan and Chambers, Daniel C. (2020). Silicosis: an ancient disease in need of a dose of modern medicine. Respirology, 25 (5) resp.13766, 464-465. doi: 10.1111/resp.13766
Featured
2020
Journal Article
Dynamics of human monocytes and airway macrophages during healthy aging and after transplant
Byrne, Adam J., Powell, Joseph E., O’Sullivan, Brendan J., Ogger, Patricia P., Hoffland, Ashley, Cook, James, Bonner, Katie L., Hewitt, Richard J., Wolf, Simone, Ghai, Poonam, Walker, Simone A., Lukowski, Samuel W., Molyneaux, Philip L., Saglani, Sejal, Chambers, Daniel C., Maher, Toby M. and Lloyd, Clare M. (2020). Dynamics of human monocytes and airway macrophages during healthy aging and after transplant. The Journal of Experimental Medicine, 217 (3) e20191236. doi: 10.1084/jem.20191236
Featured
2020
Journal Article
Treatment of life-threatening Pseudomonas aeruginosa infection by pheresis of inhibitory antibodies
Divithotawela, Chandima, Pham, Amy, Ledger, Emma L., Hopkins, Peter, Wells, Timothy J. and Chambers, Daniel (2020). Treatment of life-threatening Pseudomonas aeruginosa infection by pheresis of inhibitory antibodies. Journal of Heart and Lung Transplantation, 39 (1), 87-89. doi: 10.1016/j.healun.2019.10.001
Featured
2018
Journal Article
Increasing complexity of thoracic transplantation and the rise of multiorgan transplantation around the world: Insights from the International Society for Heart and Lung Transplantation Registry
Stehlik, Josef, Chambers, Daniel C., Zuckermann, Andreas, Mehra, Mandeep R. and Khush, Kiran K. (2018). Increasing complexity of thoracic transplantation and the rise of multiorgan transplantation around the world: Insights from the International Society for Heart and Lung Transplantation Registry. The Journal of Heart and Lung Transplantation, 37 (10), 1145-1154. doi: 10.1016/j.healun.2018.07.016
Featured
2018
Journal Article
Transcriptomics and single-cell RNA-sequencing
Chambers, Daniel C., Carew, Alan M., Lukowski, Samuel W. and Powell, Joseph E. (2018). Transcriptomics and single-cell RNA-sequencing. Respirology, 24 (1), 29-36. doi: 10.1111/resp.13412
Featured
2018
Journal Article
Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial
Smith, Corey, Beagley, Leone, Rehan, Sweera, Neller, Michelle A., Crooks, Pauline, Solomon, Matthew, Holmes-Liew, Chien-Li, Holmes, Mark, McKenzie, Scott, Hopkins, Peter, Campbell, Scott, Francis, Ross, Chambers, Daniel and Khanna, Rajiv (2018). Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial. Clinical Infectious Diseases, 68 (4), 632-640. doi: 10.1093/cid/ciy549
Featured
2017
Journal Article
Mesenchymal stromal cell therapy for chronic lung allograft dysfunction: results of a first-in-man study
Chambers, Daniel C., Enever, Debra, Lawrence, Sharon, Sturm, Marian J., Herrmann, Richard, Yerkovich, Stephanie, Musk, Michael and Hopkins, Peter M. A. (2017). Mesenchymal stromal cell therapy for chronic lung allograft dysfunction: results of a first-in-man study. Stem Cells Translational Medicine, 6 (4), 1152-1157. doi: 10.1002/sctm.16-0372
Featured
2016
Journal Article
Mesenchymal stromal cells are readily recoverable from lung tissue, but not the alveolar space, in healthy humans
Sinclair, K. A., Yerkovich, S. T., Chen, T., McQualter, J. L., Hopkins, P. M. -A., Wells, C. A. and Chambers, D. C. (2016). Mesenchymal stromal cells are readily recoverable from lung tissue, but not the alveolar space, in healthy humans. Stem Cells, 34 (10), 2548-2558. doi: 10.1002/stem.2419
Featured
2015
Journal Article
Erratic tacrolimus exposure, assessed using the standard deviation of trough blood levels, predicts chronic lung allograft dysfunction and survival
Gallagher, Harry M., Sarwar, Ghulam, Tse, Tracy, Sladden, Timothy M., Hii, Esmond, Yerkovich, Stephanie T., Hopkins, Peter M. and Chambers, Daniel C. (2015). Erratic tacrolimus exposure, assessed using the standard deviation of trough blood levels, predicts chronic lung allograft dysfunction and survival. Journal of Heart and Lung Transplantation, 34 (11), 1442-1448. doi: 10.1016/j.healun.2015.05.028
Featured
2015
Journal Article
In the end it's a replication problem: what measuring telomere length can tell us about idiopathic pulmonary fibrosis
Chambers, Daniel C. (2015). In the end it's a replication problem: what measuring telomere length can tell us about idiopathic pulmonary fibrosis. Respirology, 20 (6), 855-856. doi: 10.1111/resp.12580
Featured
2014
Journal Article
Lung transplantation in telomerase mutation carriers with pulmonary fibrosis
Silhan, Leann L., Shah, Pali D., Chambers, Daniel C., Snyder, Laurie D., Riise, Gerdt C., Wagner, Christa L., Hellstrom-Lindberg, Eva, Orens, Jonathan B., Mewton, Juliette F., Danoff, Sonye K., Arcasoy, Murat O. and Armanios, Mary (2014). Lung transplantation in telomerase mutation carriers with pulmonary fibrosis. European Respiratory Journal, 44 (1), 178-187. doi: 10.1183/09031936.00060014
Featured
2014
Journal Article
A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis
Chambers, Daniel C., Enever, Debra, Ilic, Nina, Sparks, Lisa, Whitelaw, Kylie, Ayres, John, Yerkovich, Stephanie T., Khalil, Dalia, Atkinson, Kerry M. and Hopkins, Peter M. A. (2014). A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis. Respirology, 19 (7), 1013-1018. doi: 10.1111/resp.12343
Featured
2013
Journal Article
Idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach
Chambers, Daniel C. and Hopkins, Peter M. A. (2013). Idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach. American Journal of Respiratory and Critical Care Medicine, 188 (2), 252-253. doi: 10.1164/rccm.201301-0192LE
Featured
2013
Journal Article
Reestablishment of recipient-associated microbiota in the lung allograft is linked to reduced risk of bronchiolitis obliterans syndrome
Willner, Dana L., Hugenholtz, Philip, Yerkovich, Stephanie T., Tan, Maxine E., Daly, Joshua N., Lachner, Nancy, Hopkins, Peter M. and Chambers, Daniel C. (2013). Reestablishment of recipient-associated microbiota in the lung allograft is linked to reduced risk of bronchiolitis obliterans syndrome. American Journal of Respiratory and Critical Care Medicine, 187 (6), 640-647. doi: 10.1164/rccm.201209-1680OC
Featured
2012
Journal Article
Excellent clinical outcomes from a national donation-after-determination- of-cardiac-death lung transplant collaborative
Levvey, B. J., Harkess, M., Hopkins, P., Chambers, D., Merry, C., Glanville, A. R. and Snell, G. I. (2012). Excellent clinical outcomes from a national donation-after-determination- of-cardiac-death lung transplant collaborative. American Journal of Transplantation, 12 (9), 2406-2413. doi: 10.1111/j.1600-6143.2012.04193.x
Featured
2008
Journal Article
Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia
Wong, P. M., Lees, A. N., Louw, J., Lee, F. Y., French, N., Gain, K., Murray, C. P., Wilson, A. and Chambers, D. C. (2008). Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia. European Respiratory Journal, 32 (2), 321-328. doi: 10.1183/09031936.00127107
2024
Journal Article
Silicosis—Where to from here?
Barnes, Hayley and Chambers, Daniel C. (2024). Silicosis—Where to from here?. Respirology, 29 (12), 1020-1022. doi: 10.1111/resp.14853
2024
Journal Article
Towards Early Prediction of Chronic Allograft Dysfunction using Molecular Biomarkers
Bell, Peter T and Chambers, Daniel C (2024). Towards Early Prediction of Chronic Allograft Dysfunction using Molecular Biomarkers. The Journal of Heart and Lung Transplantation. doi: 10.1016/j.healun.2024.11.001
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Dr Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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