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Professor Dan Chambers
Professor

Dan Chambers

Email: 

Overview

Background

Alternate email address: Daniel.Chambers@health.qld.gov.au

Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.

Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.

Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.

Qualifications

MBBS(Hons1) UQ, 1993

MED University of Birmingham, UK

Availability

Professor Dan Chambers is:
Available for supervision
Media expert

Research interests

  • Lung transplantation

  • Lung fibrosis

  • Stem cells

  • Cellular therapy

Research impacts

Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.

His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.

Works

Search Professor Dan Chambers’s works on UQ eSpace

237 works between 1998 and 2024

1 - 20 of 237 works

Featured

2020

Journal Article

Pulmonary alveolar proteinosis after lung transplantation

Divithotawela, Chandima, Apte, Simon H., Tan, Maxine E., De Silva, Tharushi A. and Chambers, Daniel C. (2020). Pulmonary alveolar proteinosis after lung transplantation. Respirology Case Reports, 8 (5) e00566, e00566. doi: 10.1002/rcr2.566

Pulmonary alveolar proteinosis after lung transplantation

Featured

2020

Journal Article

Diagnosis and treatment of lung disease associated with alpha one‐antitrypsin deficiency: a position statement from the Thoracic Society of Australia and New Zealand*

Dummer, Jack, Dobler, Claudia C., Holmes, Mark, Chambers, Daniel, Yang, Ian A., Parkin, Lianne, Smith, Sheree, Wark, Peter, Dev, Anouk, Hodge, Sandra, Dabscheck, Eli, Gooi, Julian, Samuel, Sameh, Knowles, Steven and Holland, Anne E. (2020). Diagnosis and treatment of lung disease associated with alpha one‐antitrypsin deficiency: a position statement from the Thoracic Society of Australia and New Zealand*. Respirology, 25 (3) resp.13774, 321-335. doi: 10.1111/resp.13774

Diagnosis and treatment of lung disease associated with alpha one‐antitrypsin deficiency: a position statement from the Thoracic Society of Australia and New Zealand*

Featured

2020

Journal Article

Silicosis: an ancient disease in need of a dose of modern medicine

Hoy, Ryan and Chambers, Daniel C. (2020). Silicosis: an ancient disease in need of a dose of modern medicine. Respirology, 25 (5) resp.13766, 464-465. doi: 10.1111/resp.13766

Silicosis: an ancient disease in need of a dose of modern medicine

Featured

2020

Journal Article

Dynamics of human monocytes and airway macrophages during healthy aging and after transplant

Byrne, Adam J., Powell, Joseph E., O’Sullivan, Brendan J., Ogger, Patricia P., Hoffland, Ashley, Cook, James, Bonner, Katie L., Hewitt, Richard J., Wolf, Simone, Ghai, Poonam, Walker, Simone A., Lukowski, Samuel W., Molyneaux, Philip L., Saglani, Sejal, Chambers, Daniel C., Maher, Toby M. and Lloyd, Clare M. (2020). Dynamics of human monocytes and airway macrophages during healthy aging and after transplant. The Journal of Experimental Medicine, 217 (3) e20191236. doi: 10.1084/jem.20191236

Dynamics of human monocytes and airway macrophages during healthy aging and after transplant

Featured

2020

Journal Article

Treatment of life-threatening Pseudomonas aeruginosa infection by pheresis of inhibitory antibodies

Divithotawela, Chandima, Pham, Amy, Ledger, Emma L., Hopkins, Peter, Wells, Timothy J. and Chambers, Daniel (2020). Treatment of life-threatening Pseudomonas aeruginosa infection by pheresis of inhibitory antibodies. Journal of Heart and Lung Transplantation, 39 (1), 87-89. doi: 10.1016/j.healun.2019.10.001

Treatment of life-threatening Pseudomonas aeruginosa infection by pheresis of inhibitory antibodies

Featured

2018

Journal Article

Increasing complexity of thoracic transplantation and the rise of multiorgan transplantation around the world: Insights from the International Society for Heart and Lung Transplantation Registry

Stehlik, Josef, Chambers, Daniel C., Zuckermann, Andreas, Mehra, Mandeep R. and Khush, Kiran K. (2018). Increasing complexity of thoracic transplantation and the rise of multiorgan transplantation around the world: Insights from the International Society for Heart and Lung Transplantation Registry. The Journal of Heart and Lung Transplantation, 37 (10), 1145-1154. doi: 10.1016/j.healun.2018.07.016

Increasing complexity of thoracic transplantation and the rise of multiorgan transplantation around the world: Insights from the International Society for Heart and Lung Transplantation Registry

Featured

2018

Journal Article

Transcriptomics and single-cell RNA-sequencing

Chambers, Daniel C., Carew, Alan M., Lukowski, Samuel W. and Powell, Joseph E. (2018). Transcriptomics and single-cell RNA-sequencing. Respirology, 24 (1), 29-36. doi: 10.1111/resp.13412

Transcriptomics and single-cell RNA-sequencing

Featured

2018

Journal Article

Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial

Smith, Corey, Beagley, Leone, Rehan, Sweera, Neller, Michelle A., Crooks, Pauline, Solomon, Matthew, Holmes-Liew, Chien-Li, Holmes, Mark, McKenzie, Scott, Hopkins, Peter, Campbell, Scott, Francis, Ross, Chambers, Daniel and Khanna, Rajiv (2018). Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial. Clinical Infectious Diseases, 68 (4), 632-640. doi: 10.1093/cid/ciy549

Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial

Featured

2017

Journal Article

Mesenchymal stromal cell therapy for chronic lung allograft dysfunction: results of a first-in-man study

Chambers, Daniel C., Enever, Debra, Lawrence, Sharon, Sturm, Marian J., Herrmann, Richard, Yerkovich, Stephanie, Musk, Michael and Hopkins, Peter M. A. (2017). Mesenchymal stromal cell therapy for chronic lung allograft dysfunction: results of a first-in-man study. Stem Cells Translational Medicine, 6 (4), 1152-1157. doi: 10.1002/sctm.16-0372

Mesenchymal stromal cell therapy for chronic lung allograft dysfunction: results of a first-in-man study

Featured

2016

Journal Article

Mesenchymal stromal cells are readily recoverable from lung tissue, but not the alveolar space, in healthy humans

Sinclair, K. A., Yerkovich, S. T., Chen, T., McQualter, J. L., Hopkins, P. M. -A., Wells, C. A. and Chambers, D. C. (2016). Mesenchymal stromal cells are readily recoverable from lung tissue, but not the alveolar space, in healthy humans. Stem Cells, 34 (10), 2548-2558. doi: 10.1002/stem.2419

Mesenchymal stromal cells are readily recoverable from lung tissue, but not the alveolar space, in healthy humans

Featured

2015

Journal Article

Erratic tacrolimus exposure, assessed using the standard deviation of trough blood levels, predicts chronic lung allograft dysfunction and survival

Gallagher, Harry M., Sarwar, Ghulam, Tse, Tracy, Sladden, Timothy M., Hii, Esmond, Yerkovich, Stephanie T., Hopkins, Peter M. and Chambers, Daniel C. (2015). Erratic tacrolimus exposure, assessed using the standard deviation of trough blood levels, predicts chronic lung allograft dysfunction and survival. Journal of Heart and Lung Transplantation, 34 (11), 1442-1448. doi: 10.1016/j.healun.2015.05.028

Erratic tacrolimus exposure, assessed using the standard deviation of trough blood levels, predicts chronic lung allograft dysfunction and survival

Featured

2015

Journal Article

In the end it's a replication problem: what measuring telomere length can tell us about idiopathic pulmonary fibrosis

Chambers, Daniel C. (2015). In the end it's a replication problem: what measuring telomere length can tell us about idiopathic pulmonary fibrosis. Respirology, 20 (6), 855-856. doi: 10.1111/resp.12580

In the end it's a replication problem: what measuring telomere length can tell us about idiopathic pulmonary fibrosis

Featured

2014

Journal Article

Lung transplantation in telomerase mutation carriers with pulmonary fibrosis

Silhan, Leann L., Shah, Pali D., Chambers, Daniel C., Snyder, Laurie D., Riise, Gerdt C., Wagner, Christa L., Hellstrom-Lindberg, Eva, Orens, Jonathan B., Mewton, Juliette F., Danoff, Sonye K., Arcasoy, Murat O. and Armanios, Mary (2014). Lung transplantation in telomerase mutation carriers with pulmonary fibrosis. European Respiratory Journal, 44 (1), 178-187. doi: 10.1183/09031936.00060014

Lung transplantation in telomerase mutation carriers with pulmonary fibrosis

Featured

2014

Journal Article

A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis

Chambers, Daniel C., Enever, Debra, Ilic, Nina, Sparks, Lisa, Whitelaw, Kylie, Ayres, John, Yerkovich, Stephanie T., Khalil, Dalia, Atkinson, Kerry M. and Hopkins, Peter M. A. (2014). A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis. Respirology, 19 (7), 1013-1018. doi: 10.1111/resp.12343

A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis

Featured

2013

Journal Article

Idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach

Chambers, Daniel C. and Hopkins, Peter M. A. (2013). Idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach. American Journal of Respiratory and Critical Care Medicine, 188 (2), 252-253. doi: 10.1164/rccm.201301-0192LE

Idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach

Featured

2013

Journal Article

Reestablishment of recipient-associated microbiota in the lung allograft is linked to reduced risk of bronchiolitis obliterans syndrome

Willner, Dana L., Hugenholtz, Philip, Yerkovich, Stephanie T., Tan, Maxine E., Daly, Joshua N., Lachner, Nancy, Hopkins, Peter M. and Chambers, Daniel C. (2013). Reestablishment of recipient-associated microbiota in the lung allograft is linked to reduced risk of bronchiolitis obliterans syndrome. American Journal of Respiratory and Critical Care Medicine, 187 (6), 640-647. doi: 10.1164/rccm.201209-1680OC

Reestablishment of recipient-associated microbiota in the lung allograft is linked to reduced risk of bronchiolitis obliterans syndrome

Featured

2012

Journal Article

Excellent clinical outcomes from a national donation-after-determination- of-cardiac-death lung transplant collaborative

Levvey, B. J., Harkess, M., Hopkins, P., Chambers, D., Merry, C., Glanville, A. R. and Snell, G. I. (2012). Excellent clinical outcomes from a national donation-after-determination- of-cardiac-death lung transplant collaborative. American Journal of Transplantation, 12 (9), 2406-2413. doi: 10.1111/j.1600-6143.2012.04193.x

Excellent clinical outcomes from a national donation-after-determination- of-cardiac-death lung transplant collaborative

Featured

2008

Journal Article

Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia

Wong, P. M., Lees, A. N., Louw, J., Lee, F. Y., French, N., Gain, K., Murray, C. P., Wilson, A. and Chambers, D. C. (2008). Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia. European Respiratory Journal, 32 (2), 321-328. doi: 10.1183/09031936.00127107

Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia

2024

Journal Article

Cloaking antibodies are prevalent in Burkholderia cepacia complex infection and their removal restores serum killing

Pham, Amy, Tan, Kellynn K. Y., Ledger, Emma L., Smith, Daniel J., Reid, David W., Burr, Lucy, Chambers, Daniel C. and Wells, Timothy J. (2024). Cloaking antibodies are prevalent in Burkholderia cepacia complex infection and their removal restores serum killing. Frontiers in Cellular and Infection Microbiology, 14 1426773. doi: 10.3389/fcimb.2024.1426773

Cloaking antibodies are prevalent in Burkholderia cepacia complex infection and their removal restores serum killing

2024

Conference Publication

Cellular Genomics of Bronchoalveolar Lavage Reveals Insight into Mechanisms of Human Pulmonary Fibrosis

Zhang, L.-Y., Apte, S., Lutzky, V., Groves, P., Tan, M., de Silva, T.A., Nguyen, Q., Powell, J., Chambers, D. and O'Sullivan, B. (2024). Cellular Genomics of Bronchoalveolar Lavage Reveals Insight into Mechanisms of Human Pulmonary Fibrosis. American Thoracic Society 2024 International Conference, San Diego, CA United States, 17-22 May 2024. New York, NY United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2580

Cellular Genomics of Bronchoalveolar Lavage Reveals Insight into Mechanisms of Human Pulmonary Fibrosis

Funding

Current funding

  • 2024
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2023 - 2028
    Lung Diseases Research
    Research Donation Generic
    Open grant
  • 2023 - 2025
    Implementation of anti-racism strategies to improve health outcomes for First Nations peoples in a large urban hospital
    NHMRC MRFF - Indigenous Health Research Grant
    Open grant
  • 2023 - 2028
    A randomised clinical trial of a digital self-management package for people with Interstitial Lung Disease (the REBUILD-SM trial) (MRFF CRC led by USYD)
    University of Sydney
    Open grant
  • 2022 - 2027
    CRE for Interstitial Lung Disease - towards Individualised Care (NHMRC CRE led by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2027
    The SiroSkin study: A multi-centre randomised double-blind placebo-controlled trial of 1% topical sirolimus in the chemoprevention of facial squamous cell carcinomas in solid organ... (Stream 7)
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2021 - 2025
    Silicosis - Harnessing new ideas to conquer the re-emergence of an ancient lung disease - The SHIELD Study
    NHMRC MRFF EPCDR Silicosis Research
    Open grant
  • 2020 - 2026
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant

Past funding

  • 2018 - 2022
    Prevention and treatment of idiopathic and post-transplant pulmonary fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Ambulatory oxygen for interstitial lung disease (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2018 - 2023
    Modulation of lung regeneration and remodeling by the innate immune system (NHMRC Project Grant led by RMIT University)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2017 - 2022
    Centre for Research Excellence in Pulmonary Fibrosis (NHMRC CRE administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2016 - 2023
    Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Cell Therapy Facility at TPCH
    Mayne Bequest Fund
    Open grant
  • 2016 - 2020
    Protecting the endothelial glycocalyx to improve transplant rates and outcomes
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Bronchopulmonary Dysplasia - A Regenerative Medicine Approach (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2015
    Optimising organ function during ex-vivo lung perfusion - role of the endothelial glycocalyx
    UQ Academic Title Holder Research Fund
    Open grant
  • 2011 - 2014
    Assessment of airway rejection in lung transplantation - no longer B grade?
    Roche Organ Transplant Resarch Foundation
    Open grant

Supervision

Availability

Professor Dan Chambers is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The human pulmonary fibrosis transcriptome at single cell resolution

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care

    Associate Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Dan Chambers directly for media enquiries about:

  • Idiopathic pulmonary fibrosis
  • Lung fibrosis
  • Lung transplantation
  • Silicosis
  • Stem cell therapy

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au