
Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2023
Journal Article
Laparoscopic fundoplication after lung transplantation does not appear to alter lung function trajectory
Frankel, Adam, Kellar, Trina, Zahir, Farah, Chambers, Daniel, Hopkins, Peter and Gotley, David (2023). Laparoscopic fundoplication after lung transplantation does not appear to alter lung function trajectory. The Journal of Heart and Lung Transplantation, 42 (5), 603-609. doi: 10.1016/j.healun.2022.12.001
2023
Journal Article
Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients
Lucas, S. E. M., Raspin, K., Mackintosh, J., Glaspole, I., Reynolds, P. N., Chia, C., Grainge, C., Kendall, P., Troy, L., Schwartz, D. A., Wood-Baker, R., Walsh, S. L. F., Moodley, Y., Robertson, J., Macansh, S., Walters, E. H., Chambers, D., Corte, T.J. and Dickinson, J. L. (2023). Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients. Pulmonology, 29 (3), 257-260. doi: 10.1016/j.pulmoe.2022.09.002
2023
Journal Article
Sex- and race-based differences in the treatment of interstitial lung diseases in North America And Australasia
Assayag, Deborah, Adegunsoye, Ayodeji, Sheehy, Robert, Morisset, Julie, Khalil, Nasreen, Johannson, Kerri A., Marcoux, Veronica, Kolb, Martin, Fisher, Jolene H., Manganas, Helene, Wrobel, Jeremy, Wilsher, Margaret, De Boer, Sally, Mackintosh, John, Chambers, Daniel C., Glaspole, Ian, Keir, Gregory J., Lee, Cathryn T., Jablonski, Renea, Vij, Rekha, Strek, Mary E., Corte, Tamera J. and Ryerson, Christopher J. (2023). Sex- and race-based differences in the treatment of interstitial lung diseases in North America And Australasia. Chest, 163 (5), 1156-1165. doi: 10.1016/j.chest.2022.12.039
2023
Journal Article
Clinical utility of a standardized chronic hypersensitivity pneumonitis exposure questionnaire
Barnes, Hayley, Chambers, Daniel, Grainge, Chris, Corte, Tamera J., Bastiampillai, Shalini, Frenkel, Simon, Westall, Glen, Collard, Harold and Glaspole, Ian (2023). Clinical utility of a standardized chronic hypersensitivity pneumonitis exposure questionnaire. Respirology, 28 (4), 366-372. doi: 10.1111/resp.14404
2023
Journal Article
Mycoplasma hominis and Ureaplasma urealyticum infections in the immediate post-lung transplant period: A case series and literature review
Divithotewala, Chandima, Sweeney, Emma L., Burke, Andrew, Graves, Bianca, Stewart, Adam, Whiley, David, Heney, Claire, Hopkins, Peter M. and Chambers, Daniel C. (2023). Mycoplasma hominis and Ureaplasma urealyticum infections in the immediate post-lung transplant period: A case series and literature review. Transplant Infectious Disease, 25 (3) e14058, 1-7. doi: 10.1111/tid.14058
2023
Journal Article
Basal cell carcinomas in organ transplant recipients versus the general population: clinicopathologic study
Pandeya, Nirmala, Huang, Nancy, Jiyad, Zainab, Plasmeijer, Elsemieke I., Way, Mandy, Isbel, Nicole, Campbell, Scott, Chambers, Daniel C., Hopkins, Peter, Soyer, H. Peter, Whiteman, David C., Olsen, Catherine M. and Green, Adele C. (2023). Basal cell carcinomas in organ transplant recipients versus the general population: clinicopathologic study. Archives of Dermatological Research, 315 (4), 771-777. doi: 10.1007/s00403-022-02403-6
2023
Journal Article
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study
Solomon, Joshua J., Danoff, Sonye K., Woodhead, Felix A., Hurwitz, Shelley, Maurer, Rie, Glaspole, Ian, Dellaripa, Paul F., Gooptu, Bibek, Vassallo, Robert, Cox, P. Gerard, Flaherty, Kevin R., Adamali, Huzaifa, Gibbons, Michael A., Troy, Lauren, Forrest, Ian A., Lasky, Joseph A., Spencer, Lisa G., Golden, Jeffrey, Scholand, Mary Beth, Chaudhuri, Nazia, Perrella, Mark A., Lynch, David A., Chambers, Daniel C., Kolb, Martin, Spino, Cathie, Raghu, Ganesh, Goldberg, Hilary J. and Rosas, Ivan (2023). Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study. The Lancet Respiratory Medicine, 11 (1), 87-96. doi: 10.1016/S2213-2600(22)00260-0
2022
Journal Article
Pregnancy in women with cystic fibrosis and diabetes: an audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era
Davidson, Sarah J., France, Megan, Callaway, Leonie K., Lust, Karin, Chambers, Daniel, Hopkins, Peter, Bell, Scott C., Burr, Lucy, Keating, Rebecca and Barrett, Helen L. (2022). Pregnancy in women with cystic fibrosis and diabetes: an audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era. Obstetric Medicine, 16 (4), 217-221. doi: 10.1177/1753495x221146342
2022
Journal Article
Epidemiology, risk factors, and outcomes of lung retransplantation: an analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry
Harhay, Michael O., Cherikh, Wida S., Toll, Alice E., Christie, Jason D., Stehlik, Josef, Chambers, Daniel, Hayes, Don and Cantu, Edward (2022). Epidemiology, risk factors, and outcomes of lung retransplantation: an analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry. The Journal of Heart and Lung Transplantation, 41 (10), 1478-1486. doi: 10.1016/j.healun.2022.06.022
2022
Journal Article
Understanding the pathogenesis of occupational coal and silica dust-associated lung disease
Vanka, Kanth Swaroop, Shukla, Shakti, Gomez, Henry M., James, Carole, Palanisami, Thava, Williams, Kenneth, Chambers, Daniel C., Britton, Warwick J., Ilic, Dusan, Hansbro, Philip Michael and Horvat, Jay Christopher (2022). Understanding the pathogenesis of occupational coal and silica dust-associated lung disease. European Respiratory Review, 31 (165) 210250, 1-17. doi: 10.1183/16000617.0250-2021
2022
Journal Article
Response to: Correspondence on 'Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis' by Hoy et al
Hua, Jeremy Tang, Zell-Baran, Lauren, Go, Leonard H T., Kramer, Mordechai R, Van Bree, Johanna B, Chambers, Daniel, Newbigin, Katrina, Deller, David, Matula, Michael, Fireman, Elizabeth, Dahbash, Mor, Martinez-Gonzalez, Cristina, León-Jimenez, Antonio, Sack, Coralynn, Ferrer Sancho, Jaume, Villar, Ana, Almberg, Kirsten S., Cohen, Robert A. and Rose, Cecile S (2022). Response to: Correspondence on 'Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis' by Hoy et al. Occupational and Environmental Medicine, 79 (12), 849-850. doi: 10.1136/oemed-2022-108512
2022
Journal Article
A phase IIb randomized study of an anti-αvβ6 monoclonal antibody in idiopathic pulmonary fibrosis
Raghu, Ganesh, Mouded, Majd, Chambers, Daniel C., Martinez, Fernando J., Richeldi, Luca, Lancaster, Lisa H., Hamblin, Mark J., Gibson, Kevin F., Rosas, Ivan O., Prasse, Antje, Zhao, Guolin, Serenko, Michael, Novikov, Natasha, McCurley, Amy, Bansal, Prashant, Stebbins, Christopher, Arefayene, Million, Ibebunjo, Stella, Violette, Shelia M., Gallagher, Diana and Behr, Jürgen (2022). A phase IIb randomized study of an anti-αvβ6 monoclonal antibody in idiopathic pulmonary fibrosis. American journal of respiratory and critical care medicine, 206 (9), 1128-1139. doi: 10.1164/rccm.202112-2824OC
2022
Journal Article
Towards truly ‘idiopathic’ pulmonary fibrosis
Mackintosh, John A. and Chambers, Daniel C. (2022). Towards truly ‘idiopathic’ pulmonary fibrosis. Respirology, 27 (9), 682-683. doi: 10.1111/resp.14320
2022
Journal Article
Phase 2B study of inhaled RVT-1601 for chronic cough in idiopathic pulmonary fibrosis: a multicenter, randomized, placebo-controlled study (SCENIC Trial)
Martinez, Fernando J., Wijsenbeek, Marlies S., Raghu, Ganesh, Flaherty, Kevin R., Maher, Toby M., Wuyts, Wim A., Kreuter, Michael, Kolb, Martin, Chambers, Daniel C., Fogarty, Charles, Mogulkoc, Nesrin, Tutuncu, Ahmet S. and Richeldi, Luca (2022). Phase 2B study of inhaled RVT-1601 for chronic cough in idiopathic pulmonary fibrosis: a multicenter, randomized, placebo-controlled study (SCENIC Trial). American Journal of Respiratory and Critical Care Medicine, 205 (9), 1084-1092. doi: 10.1164/rccm.202106-1485OC
2022
Journal Article
Markers of rejection of a lung allograft: state of the art
Silva, Tharushi de, Voisey, Joanne, Hopkins, Peter, Apte, Simon, Chambers, Daniel and O'Sullivan, Brendan (2022). Markers of rejection of a lung allograft: state of the art. Biomarkers in Medicine, 16 (6), 483-498. doi: 10.2217/bmm-2021-1013
2022
Journal Article
Genomic lung allograft surveillance: is it primer time?
Mackintosh, John A. and Chambers, Daniel C. (2022). Genomic lung allograft surveillance: is it primer time?. The Journal of Heart and Lung Transplantation, 41 (4), 467-469. doi: 10.1016/j.healun.2022.01.016
2022
Conference Publication
Polygenic risk scores in familial IPF implicates rare variants
Lucas, S., Raspin, K., Chambers, D., Glaspole, , Reynolds, P., Schwartz, D., Walters, H., Wood-Baker, R., Walsh, S., Moodley, Y., Corte, T. and Dickinson, J. (2022). Polygenic risk scores in familial IPF implicates rare variants. HOBOKEN: WILEY.
2022
Conference Publication
Clinical utility of a standardized hypersensitivity pneumonitis exposure questionnaire
Barnes, H., Chambers, D., Grainge, C., Corte, T., Bastiampillai, S., Frenkel, S., Westall, G., Collard, H. and Glaspole, (2022). Clinical utility of a standardized hypersensitivity pneumonitis exposure questionnaire. HOBOKEN: WILEY.
2022
Conference Publication
Australia and New Zealand interstitial lung disease registry (ANZ ILD) 2021 update-Progress during the pandemic
Moore, , Wrobel, J., Jackson, D., Mackintosh, J., Glaspole, , Grainge, C., Wilsher, M., Thien, F., Chambers, D., Goh, N., Edwards, A., Gallagher, H., Kwan, B., Veitch, E., Keir, G. and Corte, T. (2022). Australia and New Zealand interstitial lung disease registry (ANZ ILD) 2021 update-Progress during the pandemic. HOBOKEN: WILEY.
2022
Conference Publication
Idiopathic pulmonary fibrosis-eastern health Victoria benchmarked against national population
Chee, M., Corte, T., Jackson, D., Lee, C., Wrobel, J., Glaspole, , Grainge, C., Wilsher, M., Chambers, D., Goh, N., Edwards, A., Gallagher, H., Kwan, B., Veitch, E., Keir, G. and Thien, F. (2022). Idiopathic pulmonary fibrosis-eastern health Victoria benchmarked against national population. HOBOKEN: WILEY.
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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