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Professor Dan Chambers
Professor

Dan Chambers

Email: 

Overview

Background

Alternate email address: Daniel.Chambers@health.qld.gov.au

Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.

Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.

Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.

Qualifications

MBBS(Hons1) UQ, 1993

MED University of Birmingham, UK

Availability

Professor Dan Chambers is:
Available for supervision
Media expert

Research interests

  • Lung transplantation

  • Lung fibrosis

  • Stem cells

  • Cellular therapy

Research impacts

Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.

His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.

Works

Search Professor Dan Chambers’s works on UQ eSpace

248 works between 1998 and 2025

41 - 60 of 248 works

2023

Journal Article

Laparoscopic fundoplication after lung transplantation does not appear to alter lung function trajectory

Frankel, Adam, Kellar, Trina, Zahir, Farah, Chambers, Daniel, Hopkins, Peter and Gotley, David (2023). Laparoscopic fundoplication after lung transplantation does not appear to alter lung function trajectory. The Journal of Heart and Lung Transplantation, 42 (5), 603-609. doi: 10.1016/j.healun.2022.12.001

Laparoscopic fundoplication after lung transplantation does not appear to alter lung function trajectory

2023

Journal Article

Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients

Lucas, S. E. M., Raspin, K., Mackintosh, J., Glaspole, I., Reynolds, P. N., Chia, C., Grainge, C., Kendall, P., Troy, L., Schwartz, D. A., Wood-Baker, R., Walsh, S. L. F., Moodley, Y., Robertson, J., Macansh, S., Walters, E. H., Chambers, D., Corte, T.J. and Dickinson, J. L. (2023). Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients. Pulmonology, 29 (3), 257-260. doi: 10.1016/j.pulmoe.2022.09.002

Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients

2023

Journal Article

Sex- and race-based differences in the treatment of interstitial lung diseases in North America And Australasia

Assayag, Deborah, Adegunsoye, Ayodeji, Sheehy, Robert, Morisset, Julie, Khalil, Nasreen, Johannson, Kerri A., Marcoux, Veronica, Kolb, Martin, Fisher, Jolene H., Manganas, Helene, Wrobel, Jeremy, Wilsher, Margaret, De Boer, Sally, Mackintosh, John, Chambers, Daniel C., Glaspole, Ian, Keir, Gregory J., Lee, Cathryn T., Jablonski, Renea, Vij, Rekha, Strek, Mary E., Corte, Tamera J. and Ryerson, Christopher J. (2023). Sex- and race-based differences in the treatment of interstitial lung diseases in North America And Australasia. Chest, 163 (5), 1156-1165. doi: 10.1016/j.chest.2022.12.039

Sex- and race-based differences in the treatment of interstitial lung diseases in North America And Australasia

2023

Journal Article

Clinical utility of a standardized chronic hypersensitivity pneumonitis exposure questionnaire

Barnes, Hayley, Chambers, Daniel, Grainge, Chris, Corte, Tamera J., Bastiampillai, Shalini, Frenkel, Simon, Westall, Glen, Collard, Harold and Glaspole, Ian (2023). Clinical utility of a standardized chronic hypersensitivity pneumonitis exposure questionnaire. Respirology, 28 (4), 366-372. doi: 10.1111/resp.14404

Clinical utility of a standardized chronic hypersensitivity pneumonitis exposure questionnaire

2023

Journal Article

Mycoplasma hominis and Ureaplasma urealyticum infections in the immediate post-lung transplant period: A case series and literature review

Divithotewala, Chandima, Sweeney, Emma L., Burke, Andrew, Graves, Bianca, Stewart, Adam, Whiley, David, Heney, Claire, Hopkins, Peter M. and Chambers, Daniel C. (2023). Mycoplasma hominis and Ureaplasma urealyticum infections in the immediate post-lung transplant period: A case series and literature review. Transplant Infectious Disease, 25 (3) e14058, 1-7. doi: 10.1111/tid.14058

Mycoplasma hominis and Ureaplasma urealyticum infections in the immediate post-lung transplant period: A case series and literature review

2023

Journal Article

Basal cell carcinomas in organ transplant recipients versus the general population: clinicopathologic study

Pandeya, Nirmala, Huang, Nancy, Jiyad, Zainab, Plasmeijer, Elsemieke I., Way, Mandy, Isbel, Nicole, Campbell, Scott, Chambers, Daniel C., Hopkins, Peter, Soyer, H. Peter, Whiteman, David C., Olsen, Catherine M. and Green, Adele C. (2023). Basal cell carcinomas in organ transplant recipients versus the general population: clinicopathologic study. Archives of Dermatological Research, 315 (4), 771-777. doi: 10.1007/s00403-022-02403-6

Basal cell carcinomas in organ transplant recipients versus the general population: clinicopathologic study

2023

Journal Article

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study

Solomon, Joshua J., Danoff, Sonye K., Woodhead, Felix A., Hurwitz, Shelley, Maurer, Rie, Glaspole, Ian, Dellaripa, Paul F., Gooptu, Bibek, Vassallo, Robert, Cox, P. Gerard, Flaherty, Kevin R., Adamali, Huzaifa, Gibbons, Michael A., Troy, Lauren, Forrest, Ian A., Lasky, Joseph A., Spencer, Lisa G., Golden, Jeffrey, Scholand, Mary Beth, Chaudhuri, Nazia, Perrella, Mark A., Lynch, David A., Chambers, Daniel C., Kolb, Martin, Spino, Cathie, Raghu, Ganesh, Goldberg, Hilary J. and Rosas, Ivan (2023). Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study. The Lancet Respiratory Medicine, 11 (1), 87-96. doi: 10.1016/S2213-2600(22)00260-0

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study

2022

Journal Article

Pregnancy in women with cystic fibrosis and diabetes: an audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era

Davidson, Sarah J., France, Megan, Callaway, Leonie K., Lust, Karin, Chambers, Daniel, Hopkins, Peter, Bell, Scott C., Burr, Lucy, Keating, Rebecca and Barrett, Helen L. (2022). Pregnancy in women with cystic fibrosis and diabetes: an audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era. Obstetric Medicine, 16 (4), 217-221. doi: 10.1177/1753495x221146342

Pregnancy in women with cystic fibrosis and diabetes: an audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era

2022

Journal Article

Epidemiology, risk factors, and outcomes of lung retransplantation: an analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry

Harhay, Michael O., Cherikh, Wida S., Toll, Alice E., Christie, Jason D., Stehlik, Josef, Chambers, Daniel, Hayes, Don and Cantu, Edward (2022). Epidemiology, risk factors, and outcomes of lung retransplantation: an analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry. The Journal of Heart and Lung Transplantation, 41 (10), 1478-1486. doi: 10.1016/j.healun.2022.06.022

Epidemiology, risk factors, and outcomes of lung retransplantation: an analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry

2022

Journal Article

Understanding the pathogenesis of occupational coal and silica dust-associated lung disease

Vanka, Kanth Swaroop, Shukla, Shakti, Gomez, Henry M., James, Carole, Palanisami, Thava, Williams, Kenneth, Chambers, Daniel C., Britton, Warwick J., Ilic, Dusan, Hansbro, Philip Michael and Horvat, Jay Christopher (2022). Understanding the pathogenesis of occupational coal and silica dust-associated lung disease. European Respiratory Review, 31 (165) 210250, 1-17. doi: 10.1183/16000617.0250-2021

Understanding the pathogenesis of occupational coal and silica dust-associated lung disease

2022

Journal Article

Response to: Correspondence on 'Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis' by Hoy et al

Hua, Jeremy Tang, Zell-Baran, Lauren, Go, Leonard H T., Kramer, Mordechai R, Van Bree, Johanna B, Chambers, Daniel, Newbigin, Katrina, Deller, David, Matula, Michael, Fireman, Elizabeth, Dahbash, Mor, Martinez-Gonzalez, Cristina, León-Jimenez, Antonio, Sack, Coralynn, Ferrer Sancho, Jaume, Villar, Ana, Almberg, Kirsten S., Cohen, Robert A. and Rose, Cecile S (2022). Response to: Correspondence on 'Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis' by Hoy et al. Occupational and Environmental Medicine, 79 (12), 849-850. doi: 10.1136/oemed-2022-108512

Response to: Correspondence on 'Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis' by Hoy et al

2022

Journal Article

A phase IIb randomized study of an anti-αvβ6 monoclonal antibody in idiopathic pulmonary fibrosis

Raghu, Ganesh, Mouded, Majd, Chambers, Daniel C., Martinez, Fernando J., Richeldi, Luca, Lancaster, Lisa H., Hamblin, Mark J., Gibson, Kevin F., Rosas, Ivan O., Prasse, Antje, Zhao, Guolin, Serenko, Michael, Novikov, Natasha, McCurley, Amy, Bansal, Prashant, Stebbins, Christopher, Arefayene, Million, Ibebunjo, Stella, Violette, Shelia M., Gallagher, Diana and Behr, Jürgen (2022). A phase IIb randomized study of an anti-αvβ6 monoclonal antibody in idiopathic pulmonary fibrosis. American journal of respiratory and critical care medicine, 206 (9), 1128-1139. doi: 10.1164/rccm.202112-2824OC

A phase IIb randomized study of an anti-αvβ6 monoclonal antibody in idiopathic pulmonary fibrosis

2022

Journal Article

Towards truly ‘idiopathic’ pulmonary fibrosis

Mackintosh, John A. and Chambers, Daniel C. (2022). Towards truly ‘idiopathic’ pulmonary fibrosis. Respirology, 27 (9), 682-683. doi: 10.1111/resp.14320

Towards truly ‘idiopathic’ pulmonary fibrosis

2022

Journal Article

Phase 2B study of inhaled RVT-1601 for chronic cough in idiopathic pulmonary fibrosis: a multicenter, randomized, placebo-controlled study (SCENIC Trial)

Martinez, Fernando J., Wijsenbeek, Marlies S., Raghu, Ganesh, Flaherty, Kevin R., Maher, Toby M., Wuyts, Wim A., Kreuter, Michael, Kolb, Martin, Chambers, Daniel C., Fogarty, Charles, Mogulkoc, Nesrin, Tutuncu, Ahmet S. and Richeldi, Luca (2022). Phase 2B study of inhaled RVT-1601 for chronic cough in idiopathic pulmonary fibrosis: a multicenter, randomized, placebo-controlled study (SCENIC Trial). American Journal of Respiratory and Critical Care Medicine, 205 (9), 1084-1092. doi: 10.1164/rccm.202106-1485OC

Phase 2B study of inhaled RVT-1601 for chronic cough in idiopathic pulmonary fibrosis: a multicenter, randomized, placebo-controlled study (SCENIC Trial)

2022

Journal Article

Markers of rejection of a lung allograft: state of the art

Silva, Tharushi de, Voisey, Joanne, Hopkins, Peter, Apte, Simon, Chambers, Daniel and O'Sullivan, Brendan (2022). Markers of rejection of a lung allograft: state of the art. Biomarkers in Medicine, 16 (6), 483-498. doi: 10.2217/bmm-2021-1013

Markers of rejection of a lung allograft: state of the art

2022

Journal Article

Genomic lung allograft surveillance: is it primer time?

Mackintosh, John A. and Chambers, Daniel C. (2022). Genomic lung allograft surveillance: is it primer time?. The Journal of Heart and Lung Transplantation, 41 (4), 467-469. doi: 10.1016/j.healun.2022.01.016

Genomic lung allograft surveillance: is it primer time?

2022

Conference Publication

Polygenic risk scores in familial IPF implicates rare variants

Lucas, S., Raspin, K., Chambers, D., Glaspole, , Reynolds, P., Schwartz, D., Walters, H., Wood-Baker, R., Walsh, S., Moodley, Y., Corte, T. and Dickinson, J. (2022). Polygenic risk scores in familial IPF implicates rare variants. HOBOKEN: WILEY.

Polygenic risk scores in familial IPF implicates rare variants

2022

Conference Publication

Clinical utility of a standardized hypersensitivity pneumonitis exposure questionnaire

Barnes, H., Chambers, D., Grainge, C., Corte, T., Bastiampillai, S., Frenkel, S., Westall, G., Collard, H. and Glaspole, (2022). Clinical utility of a standardized hypersensitivity pneumonitis exposure questionnaire. HOBOKEN: WILEY.

Clinical utility of a standardized hypersensitivity pneumonitis exposure questionnaire

2022

Conference Publication

Australia and New Zealand interstitial lung disease registry (ANZ ILD) 2021 update-Progress during the pandemic

Moore, , Wrobel, J., Jackson, D., Mackintosh, J., Glaspole, , Grainge, C., Wilsher, M., Thien, F., Chambers, D., Goh, N., Edwards, A., Gallagher, H., Kwan, B., Veitch, E., Keir, G. and Corte, T. (2022). Australia and New Zealand interstitial lung disease registry (ANZ ILD) 2021 update-Progress during the pandemic. HOBOKEN: WILEY.

Australia and New Zealand interstitial lung disease registry (ANZ ILD) 2021 update-Progress during the pandemic

2022

Conference Publication

Idiopathic pulmonary fibrosis-eastern health Victoria benchmarked against national population

Chee, M., Corte, T., Jackson, D., Lee, C., Wrobel, J., Glaspole, , Grainge, C., Wilsher, M., Chambers, D., Goh, N., Edwards, A., Gallagher, H., Kwan, B., Veitch, E., Keir, G. and Thien, F. (2022). Idiopathic pulmonary fibrosis-eastern health Victoria benchmarked against national population. HOBOKEN: WILEY.

Idiopathic pulmonary fibrosis-eastern health Victoria benchmarked against national population

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2023 - 2028
    Lung Diseases Research
    Research Donation Generic
    Open grant
  • 2023 - 2028
    A randomised clinical trial of a digital self-management package for people with Interstitial Lung Disease (the REBUILD-SM trial) (MRFF CRC led by USYD)
    University of Sydney
    Open grant
  • 2022 - 2027
    CRE for Interstitial Lung Disease - towards Individualised Care (NHMRC CRE led by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2027
    The SiroSkin study: A multi-centre randomised double-blind placebo-controlled trial of 1% topical sirolimus in the chemoprevention of facial squamous cell carcinomas in solid organ... (Stream 7)
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2021 - 2025
    Silicosis - Harnessing new ideas to conquer the re-emergence of an ancient lung disease - The SHIELD Study
    NHMRC MRFF EPCDR Silicosis Research
    Open grant
  • 2020 - 2026
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2016 - 2026
    Cell Therapy Facility at TPCH
    Mayne Bequest Fund
    Open grant

Past funding

  • 2018 - 2022
    Prevention and treatment of idiopathic and post-transplant pulmonary fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Ambulatory oxygen for interstitial lung disease (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2018 - 2023
    Modulation of lung regeneration and remodeling by the innate immune system (NHMRC Project Grant led by RMIT University)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2017 - 2022
    Centre for Research Excellence in Pulmonary Fibrosis (NHMRC CRE administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2016 - 2023
    Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Protecting the endothelial glycocalyx to improve transplant rates and outcomes
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Bronchopulmonary Dysplasia - A Regenerative Medicine Approach (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2015
    Optimising organ function during ex-vivo lung perfusion - role of the endothelial glycocalyx
    UQ Academic Title Holder Research Fund
    Open grant
  • 2011 - 2014
    Assessment of airway rejection in lung transplantation - no longer B grade?
    Roche Organ Transplant Resarch Foundation
    Open grant

Supervision

Availability

Professor Dan Chambers is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The human pulmonary fibrosis transcriptome at single cell resolution

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care

    Associate Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Dan Chambers directly for media enquiries about:

  • Idiopathic pulmonary fibrosis
  • Lung fibrosis
  • Lung transplantation
  • Silicosis
  • Stem cell therapy

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au